David E Harrison

Summary

Affiliation: The Jackson Laboratory
Country: USA

Publications

  1. pmc Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
    David E Harrison
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Nature 460:392-5. 2009
  2. ncbi request reprint PohnB6F1: a cross of wild and domestic mice that is a new model of extended female reproductive life span
    Kevin Flurkey
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Gerontol A Biol Sci Med Sci 62:1187-98. 2007
  3. pmc Genetic coregulation of age of female sexual maturation and lifespan through circulating IGF1 among inbred mouse strains
    Rong Yuan
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 109:8224-9. 2012
  4. pmc Genetic regulation of life span, metabolism, and body weight in Pohn, a new wild-derived mouse strain
    Rong Yuan
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Gerontol A Biol Sci Med Sci 68:27-35. 2013
  5. ncbi request reprint Genetic regulation of hematopoietic stem cell exhaustion during development and growth
    Rong Yuan
    The Jackson Laboratory, Bar Harbor, ME, USA
    Exp Hematol 33:243-50. 2005
  6. pmc Heterozygous kit mutants with little or no apparent anemia exhibit large defects in overall hematopoietic stem cell function
    Yashoda Sharma
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Exp Hematol 35:214-220. 2007
  7. ncbi request reprint Hematopoietic senescence is postponed and hematopoietic stem cell function is enhanced by dietary restriction
    Jichun Chen
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Exp Hematol 31:1097-103. 2003
  8. pmc Life extension by diet restriction and N-acetyl-L-cysteine in genetically heterogeneous mice
    Kevin Flurkey
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    J Gerontol A Biol Sci Med Sci 65:1275-84. 2010
  9. ncbi request reprint Mice severely deficient in growth hormone have normal hematopoiesis
    Yashoda Sharma
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Exp Hematol 33:776-83. 2005
  10. pmc Effects of dietary restriction on hematopoietic stem-cell aging are genetically regulated
    Robin P Ertl
    Jackson Laboratory, Bar Harbor, ME 04609, USA
    Blood 111:1709-16. 2008

Collaborators

Detail Information

Publications18

  1. pmc Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
    David E Harrison
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Nature 460:392-5. 2009
    ..These findings have implications for further development of interventions targeting mTOR for the treatment and prevention of age-related diseases...
  2. ncbi request reprint PohnB6F1: a cross of wild and domestic mice that is a new model of extended female reproductive life span
    Kevin Flurkey
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Gerontol A Biol Sci Med Sci 62:1187-98. 2007
    ..Possibly, out-crossing Pohn mice unmasked cryptic alleles that promote extended female reproduction. This work establishes the PohnB6F1 hybrid as a new model for delayed reproductive aging...
  3. pmc Genetic coregulation of age of female sexual maturation and lifespan through circulating IGF1 among inbred mouse strains
    Rong Yuan
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 109:8224-9. 2012
    ....
  4. pmc Genetic regulation of life span, metabolism, and body weight in Pohn, a new wild-derived mouse strain
    Rong Yuan
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Gerontol A Biol Sci Med Sci 68:27-35. 2013
    ..Overall, by using Pohn mice, we identified new QTL for longevity-related traits, thus facilitating the exploration of the genetic regulation of aging...
  5. ncbi request reprint Genetic regulation of hematopoietic stem cell exhaustion during development and growth
    Rong Yuan
    The Jackson Laboratory, Bar Harbor, ME, USA
    Exp Hematol 33:243-50. 2005
    ..Our objective is to determine whether HSC exhaustion during development from fetus to adult also is more severe for BALB than for B6 mice...
  6. pmc Heterozygous kit mutants with little or no apparent anemia exhibit large defects in overall hematopoietic stem cell function
    Yashoda Sharma
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Exp Hematol 35:214-220. 2007
    ..This study tests how each mutation affects HSC function...
  7. ncbi request reprint Hematopoietic senescence is postponed and hematopoietic stem cell function is enhanced by dietary restriction
    Jichun Chen
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Exp Hematol 31:1097-103. 2003
    ..The aim of this study was to test dietary restriction (DR) as an intervention to alleviate senescence-associated functional defects in hematopoietic stem cells (HSCs)...
  8. pmc Life extension by diet restriction and N-acetyl-L-cysteine in genetically heterogeneous mice
    Kevin Flurkey
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    J Gerontol A Biol Sci Med Sci 65:1275-84. 2010
    ..The other agents had no significant effects on life span. The use of UM-HET3 mice helps assure that these results are not the result of unresponsiveness of a single genotype but that they more broadly represent laboratory mice...
  9. ncbi request reprint Mice severely deficient in growth hormone have normal hematopoiesis
    Yashoda Sharma
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Exp Hematol 33:776-83. 2005
    ....
  10. pmc Effects of dietary restriction on hematopoietic stem-cell aging are genetically regulated
    Robin P Ertl
    Jackson Laboratory, Bar Harbor, ME 04609, USA
    Blood 111:1709-16. 2008
    ..That DR increases or maintains stem-cell function with age, while decreasing cancer, has far-reaching health implications...
  11. ncbi request reprint Quantitative trait loci regulating relative lymphocyte proportions in mouse peripheral blood
    Jichun Chen
    The Jackson Laboratory, Bar Harbor, ME 04609 1500, USA
    Blood 99:561-6. 2002
    ..In both BXD RI and B6SJLF2 mice, QTLs regulating B-cell proportions showed no significant effect on T-cell proportions and vice versa. Thus, PB B- and T-lymphocyte proportions are regulated separately by different genetic elements...
  12. ncbi request reprint Altered growth characteristics of skin fibroblasts from wild-derived mice, and genetic loci regulating fibroblast clone size
    Rong Yuan
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Aging Cell 5:203-12. 2006
    ..These enzymes may protect Pohn TSFs from oxidation...
  13. pmc Fetal myocardium in the kidney capsule: an in vivo model of repopulation of myocytes by bone marrow cells
    Eric Y Zhang
    The Jackson Laboratory, Bar Harbor, Maine, United States of America
    PLoS ONE 7:e31099. 2012
    ..The novel in vivo model of fetal myocardium in the kidney capsule appears to be valuable for testing repopulating abilities of potential cardiac progenitors...
  14. pmc Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels
    Rong Yuan
    The Jackson Aging Center at The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Aging Cell 8:277-87. 2009
    ..53, P < 0.01). These results support the hypothesis that the IGF1 pathway plays a key role in regulating longevity in mice and indicates that common genetic mechanisms may exist for regulating IGF1 levels and lifespan...
  15. ncbi request reprint Pituitary removal in adult mice increases life span
    R Wilson Powers
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Mech Ageing Dev 127:658-9. 2006
    ..These results demonstrate pituitary hormone withdrawal can extend life span even if these hormones are removed relatively late in life...
  16. ncbi request reprint Adipose tissue transplantation protects ob/ob mice from obesity, normalizes insulin sensitivity and restores fertility
    Simon Klebanov
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    J Endocrinol 186:203-11. 2005
    ..Thus, WAT transplantation was effective for both prevention and therapy. In the future, WAT transplantation may become a useful alternative to hormone replacement in treating not only lipodystropy, but also certain types of obesity...
  17. ncbi request reprint Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice
    Michael TeKippe
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Exp Hematol 31:521-7. 2003
    ..To study the effects of transformation-related protein 53 (Trp53) and other genes on hematopoiesis and hematopoietic stem cells (HSCs)...
  18. ncbi request reprint A reduced peripheral blood CD4(+) lymphocyte proportion is a consistent ageing phenotype
    Jichun Chen
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Mech Ageing Dev 123:145-53. 2002
    ..Thus, a reduced proportion of peripheral blood CD4(+) lymphocytes is a consistent ageing phenotype in a wide range of Mus musculus strains...

Research Grants41

  1. Lifespan Extension Despite Greatly Elevated Insulin and Body Fat
    David E Harrison; Fiscal Year: 2010
    ..Effects of DR that extend life spans in both normal control and ob/ob mice in this study are likely targets for interventions to retard aging and extend healthy lifespan in human beings. ..
  2. How Insulin/IGF-1 Deficiencies Retard Mammalian Aging
    David E Harrison; Fiscal Year: 2010
    ..Understanding how reductions in function of the insulin and IGF-1 pathways delay aspects of mammalian aging may suggest treatments to improve health as human beings age. ..
  3. Hematopoietic Stem Cells (HSCs) as Juvenile Protective Factors that Alter Aging
    David E Harrison; Fiscal Year: 2010
    ....
  4. Diet Restriction (DR) Regulates Stem Cell Aging
    David Harrison; Fiscal Year: 2007
    ..The assays are feasible due to the genetic resources and animal expertise at The Jackson Laboratory, as well as the applicants' extensive experience in evaluating HSC functions. ..
  5. How Insulin/IGF-1 Deficiencies Retard Mammalian Aging
    David Harrison; Fiscal Year: 2007
    ..Understanding how reductions in function of the insulin and IGF-1 pathways delay aspects of mammalian aging may suggest treatments to improve health as human beings age. ..
  6. EXPERIMENTAL HEMATOLOGY-IMMUNOLOGY
    David Harrison; Fiscal Year: 2007
    ..The primary training facility is TJL, a private, independent research center. TJL is an NIH Basic Cancer Research Center, raises 3 million mice annually, and has held NIH research training grants continuously since 1956...
  7. Interventions That Retard Mammalian Aging
    David Harrison; Fiscal Year: 2007
    ..Results in these systems may suggest mechanisms by which the interventions retard aging. ..
  8. Interventions That Retard Mammalian Aging
    David Harrison; Fiscal Year: 2007
    ..Results in these systems may suggest mechanisms by which the interventions retard aging. ..
  9. How Insulin/IGF-1 Deficiencies Retard Mammalian Aging
    David Harrison; Fiscal Year: 2009
    ..Understanding how reductions in function of the insulin and IGF-1 pathways delay aspects of mammalian aging may suggest treatments to improve health as human beings age. ..
  10. Hematopoietic Stem Cells (HSCs) as Juvenile Protective Factors that Alter Aging
    David Harrison; Fiscal Year: 2009
    ....
  11. Shock Center for Aging Research at The Jackson Laborato*
    David Harrison; Fiscal Year: 2007
    ..abstract_text> ..
  12. MOUSE MODELS WITH DELAYED PATHOLOGIES
    David Harrison; Fiscal Year: 2005
    ..As already shown for Leg1(a) and Leg2(a), alleles that extend maximum life spans by 10% or more can be detected. ..
  13. GENETIC LOCUS EXTENDING LIFE AND REDUCING INSULIN
    David Harrison; Fiscal Year: 2005
    ..Candidate genes will be tested to see whether MOLD alleles differ from those of NZW, LP and BALB. The gene will ultimately be identified by homologous recombination. ..
  14. Regulation of Primitive Hematopoietic Stem Cell Function
    David Harrison; Fiscal Year: 2005
    ..1 cM. Candidate genes will be tested in transgenics and ultimately identified by homologous recombination. ..
  15. GENETIC EFFECTS ON PRIMITIVE CORD BLOOD STEM CELLS
    David Harrison; Fiscal Year: 2000
    ..Clinical use of cord blood often requires freezing. Effects of various freezing methods on PHSC function will be tested using genetically disparate cell types. ..
  16. Regulation of Hyper Hemopoietic Stem Cell Function
    David Harrison; Fiscal Year: 2004
    ..Allophenics will be produced by fusing early CXB-12 embryos with F1 embryos, genetically marked to distinguish PHSC progeny. Identity, number and function of individual PHSC will be defined by competitive dilution. ..