J F Harper

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Subcellular targeting of nine calcium-dependent protein kinase isoforms from Arabidopsis
    Christian Dammann
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Plant Physiol 132:1840-8. 2003
  2. ncbi request reprint A novel calmodulin-regulated Ca2+-ATPase (ACA2) from Arabidopsis with an N-terminal autoinhibitory domain
    J F Harper
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 273:1099-106. 1998
  3. ncbi request reprint Decoding Ca(2+) signals through plant protein kinases
    Jeffrey F Harper
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Annu Rev Plant Biol 55:263-88. 2004
  4. ncbi request reprint Dissecting calcium oscillators in plant cells
    J F Harper
    Dept of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Trends Plant Sci 6:395-7. 2001
  5. ncbi request reprint Autoinhibition of a calmodulin-dependent calcium pump involves a structure in the stalk that connects the transmembrane domain to the ATPase catalytic domain
    A C Curran
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 275:30301-8. 2000
  6. ncbi request reprint Cameleon calcium indicator reports cytoplasmic calcium dynamics in Arabidopsis guard cells
    G J Allen
    Department of Biology, University of California, San Diego, La Jolla, CA 92093 0116, USA
    Plant J 19:735-47. 1999
  7. ncbi request reprint Alteration of stimulus-specific guard cell calcium oscillations and stomatal closing in Arabidopsis det3 mutant
    G J Allen
    Cell and Developmental Biology Section, Division of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093 0116, USA
    Science 289:2338-42. 2000
  8. pmc Phylogenetic relationships within cation transporter families of Arabidopsis
    P Maser
    Division of Biology, Cell and Developmental Biology Section and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0116, USA
    Plant Physiol 126:1646-67. 2001
  9. ncbi request reprint Evidence for a role in growth and salt resistance of a plasma membrane H+-ATPase in the root endodermis
    V Vitart
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Plant J 27:191-201. 2001
  10. pmc Systematic trans-genomic comparison of protein kinases between Arabidopsis and Saccharomyces cerevisiae
    Degeng Wang
    San Diego Supercomputer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0537, USA
    Plant Physiol 132:2152-65. 2003

Collaborators

Detail Information

Publications31

  1. pmc Subcellular targeting of nine calcium-dependent protein kinase isoforms from Arabidopsis
    Christian Dammann
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Plant Physiol 132:1840-8. 2003
    ..The observation of a peroxisome-located CDPK suggests a mechanism for calcium regulation of peroxisomal functions involved in oxidative stress and lipid metabolism...
  2. ncbi request reprint A novel calmodulin-regulated Ca2+-ATPase (ACA2) from Arabidopsis with an N-terminal autoinhibitory domain
    J F Harper
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 273:1099-106. 1998
    ..Thus, ACA2 encodes a novel calmodulin-regulated Ca2+-ATPase distinguished by a unique N-terminal regulatory domain and a non-plasma membrane localization...
  3. ncbi request reprint Decoding Ca(2+) signals through plant protein kinases
    Jeffrey F Harper
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Annu Rev Plant Biol 55:263-88. 2004
    ..Thus, Ca(2+)-regulated kinases provide potential nodes of cross-talk for multiple signaling pathways that integrate Ca(2+) signals into all aspects of plant growth and development...
  4. ncbi request reprint Dissecting calcium oscillators in plant cells
    J F Harper
    Dept of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Trends Plant Sci 6:395-7. 2001
    ..The identification of pumps and antiporters in different subcellular locations is helping to dissect the complexities of Ca2+ signaling in plants...
  5. ncbi request reprint Autoinhibition of a calmodulin-dependent calcium pump involves a structure in the stalk that connects the transmembrane domain to the ATPase catalytic domain
    A C Curran
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 275:30301-8. 2000
    ..Together, these results suggest that a structural feature of the stalk is of general importance in regulating diverse P-type ATPases...
  6. ncbi request reprint Cameleon calcium indicator reports cytoplasmic calcium dynamics in Arabidopsis guard cells
    G J Allen
    Department of Biology, University of California, San Diego, La Jolla, CA 92093 0116, USA
    Plant J 19:735-47. 1999
    ..This technical advance in combination with cell biological and molecular genetic approaches will become an invaluable tool in the dissection of plant cell signal transduction pathways...
  7. ncbi request reprint Alteration of stimulus-specific guard cell calcium oscillations and stomatal closing in Arabidopsis det3 mutant
    G J Allen
    Cell and Developmental Biology Section, Division of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093 0116, USA
    Science 289:2338-42. 2000
    ..Moreover, in det3 guard cells, experimentally imposing external calcium-induced oscillations rescued stomatal closure. These data provide genetic evidence that stimulus-specific calcium oscillations are necessary for stomatal closure...
  8. pmc Phylogenetic relationships within cation transporter families of Arabidopsis
    P Maser
    Division of Biology, Cell and Developmental Biology Section and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0116, USA
    Plant Physiol 126:1646-67. 2001
    ..To facilitate their further study, the PlantsT database (http://plantst.sdsc.edu) has been created that includes alignments of the analyzed cation transporters and their chromosomal locations...
  9. ncbi request reprint Evidence for a role in growth and salt resistance of a plasma membrane H+-ATPase in the root endodermis
    V Vitart
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Plant J 27:191-201. 2001
    ....
  10. pmc Systematic trans-genomic comparison of protein kinases between Arabidopsis and Saccharomyces cerevisiae
    Degeng Wang
    San Diego Supercomputer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0537, USA
    Plant Physiol 132:2152-65. 2003
    ....
  11. ncbi request reprint The plasma membrane H(+)-ATPase gene family in Arabidopsis: genomic sequence of AHA10 which is expressed primarily in developing seeds
    J F Harper
    Scripps Research Institute, Department of Cell Biology, La Jolla, CA 92037
    Mol Gen Genet 244:572-87. 1994
    ..Our results indicate that one function of this unusually large H(+)-ATPase gene family is to allow for expression of different isoforms in different cell types...
  12. ncbi request reprint Structural independence of the two EF-hand domains of caltractin
    Sudha Veeraraghavan
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 277:28564-71. 2002
    ..Thus, the C-terminal domain appears to also be capable of sensing Ca2+ signals but is activated by the binding of a single ion...
  13. pmc Genomic comparison of P-type ATPase ion pumps in Arabidopsis and rice
    Ivan Baxter
    Department of Cell Biology, Plant Division, The Scripps Research Institute, La Jolla, California 92037, USA
    Plant Physiol 132:618-28. 2003
    ....
  14. pmc The Arabidopsis P4-ATPase ALA3 localizes to the golgi and requires a beta-subunit to function in lipid translocation and secretory vesicle formation
    Lisbeth Rosager Poulsen
    Danish National Research Foundation, University of Copenhagen, DK 1871 Frederiksberg C, Denmark
    Plant Cell 20:658-76. 2008
    ..We propose that the ALIS1 protein is a beta-subunit of ALA3 and that this protein complex forms an important part of the Golgi machinery required for secretory processes during plant development...
  15. ncbi request reprint The origin and function of calmodulin regulated Ca2+ pumps in plants
    Yann Boursiac
    Biochemistry Department MS200, Fleischmann Agriculture Building, University of Nevada, Reno, NV 89557, USA
    J Bioenerg Biomembr 39:409-14. 2007
    ..For the 14 Ca2+ pumps present in the model plant Arabidopsis, molecular genetic analyses are providing exciting insights into their function in diverse aspects of plant growth and development...
  16. ncbi request reprint Structure of the regulatory apparatus of a calcium-dependent protein kinase (CDPK): a novel mode of calmodulin-target recognition
    Vidya Chandran
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    J Mol Biol 357:400-10. 2006
    ....
  17. ncbi request reprint Plants, symbiosis and parasites: a calcium signalling connection
    Jeffrey F Harper
    Department of Biochemistry, MS200, University of Nevada, Reno, Nevada 89557, USA
    Nat Rev Mol Cell Biol 6:555-66. 2005
    ..In Arabidopsis thaliana, the analysis of 42 isoforms of CDPK and related kinases is expected to delineate Ca(2+) signalling pathways in all aspects of plant biology...
  18. pmc A distinct endosomal Ca2+/Mn2+ pump affects root growth through the secretory process
    Xiyan Li
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742 5815, USA
    Plant Physiol 147:1675-89. 2008
    ....
  19. ncbi request reprint Evidence for differing roles for each lobe of the calmodulin-like domain in a calcium-dependent protein kinase
    John Christodoulou
    Center for Structural Biology and Department of Biochemistry and Physics, Vanderbilt University, Nashville, Tennessee 37232 0146, USA
    J Biol Chem 279:29092-100. 2004
    ..Activation then occurs when Ca(2+) levels rise to fill the two weaker affinity binding sites in the N-lobe, thereby triggering a conformational change that leads to release of the autoinhibitory region...
  20. pmc Calcium at the crossroads of signaling
    Dale Sanders
    Biology Department, University of York, York YO10 5YW, United Kingdom
    Plant Cell 14:S401-17. 2002
  21. pmc The Arabidopsis CDPK-SnRK superfamily of protein kinases
    Estelle M Hrabak
    Department of Plant Biology and Program in Genetics, University of New Hampshire, 46 College Road, Durham 03824, USA
    Plant Physiol 132:666-80. 2003
    ..The PlantsP database provides a resource of continuously updated information on protein kinases from Arabidopsis and other plants...
  22. pmc An endoplasmic reticulum-bound Ca(2+)/Mn(2+) pump, ECA1, supports plant growth and confers tolerance to Mn(2+) stress
    Zhongyi Wu
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA
    Plant Physiol 130:128-37. 2002
    ....
  23. pmc The ACA10 Ca2+-ATPase regulates adult vegetative development and inflorescence architecture in Arabidopsis
    Lynn George
    Department of Plant Sciences and Plant Pathology, Montana State University, Bozeman, Montana 59717, USA
    Plant Physiol 146:716-28. 2008
    ..The correspondence between cif1 and mutations in ACA10 establishes a genetic link between calcium transport, vegetative phase change, and inflorescence architecture...
  24. pmc A cyclic nucleotide-gated channel is essential for polarized tip growth of pollen
    Sabine Frietsch
    Biochemistry Department MS200, University of Nevada, Reno, NV 89557, USA
    Proc Natl Acad Sci U S A 104:14531-6. 2007
    ..These results identify a CNGC that is essential to an organism's life cycle and raise the possibility that CNGCs have a widespread role in regulating cell-growth dynamics in both plant and animals...
  25. ncbi request reprint An isotope labeling strategy for quantifying the degree of phosphorylation at multiple sites in proteins
    Adrian D Hegeman
    Biotechnology Center, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Am Soc Mass Spectrom 15:647-53. 2004
    ....
  26. pmc Characterization of the yeast ionome: a genome-wide analysis of nutrient mineral and trace element homeostasis in Saccharomyces cerevisiae
    David J Eide
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Genome Biol 6:R77. 2005
    ..We refer to the resulting accumulation profile as the yeast 'ionome'...
  27. ncbi request reprint Genomic scale profiling of nutrient and trace elements in Arabidopsis thaliana
    Brett Lahner
    Center for Plant Environmental Stress Physiology, Horticulture Building, 625 Agriculture Mall Drive, Purdue University, West Lafayette, Indiana 47907, USA
    Nat Biotechnol 21:1215-21. 2003
    ..thaliana genome is involved in regulating the plant's nutrient and trace element content. These results demonstrate the utility of elemental profiling as a useful functional genomics tool...
  28. pmc A plasma membrane H+-ATPase is required for the formation of proanthocyanidins in the seed coat endothelium of Arabidopsis thaliana
    Ivan R Baxter
    Center for Phytoremediation Research and Development, Purdue University, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 102:2649-54. 2005
    ..Thus, the specific effect of aha10 on vacuolar and PA biogenesis provides genetic evidence to support an unexpected endomembrane function for a member of the plasma membrane H+-ATPase family...
  29. pmc P-type ATPase heavy metal transporters with roles in essential zinc homeostasis in Arabidopsis
    Dawar Hussain
    Department of Genetics, University of Melbourne, Australia 3010
    Plant Cell 16:1327-39. 2004
    ..hma2 and hma4 mutations both conferred increased sensitivity to Cd in a phytochelatin-deficient mutant background, suggesting that they may also influence Cd detoxification...
  30. pmc A plant plasma membrane Ca2+ pump is required for normal pollen tube growth and fertilization
    Morten Schiøtt
    Department of Plant Biology, Royal Veterinary and Agricultural University, Thorvaldsensvej 40, DK 1871 Frederiksberg, Denmark
    Proc Natl Acad Sci U S A 101:9502-7. 2004
    ..These findings identify a plasma membrane Ca(2+) transporter as a key regulator of pollen development and fertilization in flowering plants...
  31. ncbi request reprint 1H, 15N and 13C assignments of the regulatory domains of calcium-dependent protein kinase (CDPK)
    John Christodoulou
    J Biomol NMR 23:249-50. 2002