Research Topics
| Hend A HannaSummaryAffiliation: The University of Texas Country: USA Publications
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Detail Information
Publications
Differential time to positivity: a useful method for diagnosing catheter-related bloodstream infectionsIssam Raad
Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Ann Intern Med 140:18-25. 2004..Accurate diagnosis of such infections results in proper management of patients and in reducing unnecessary removal of catheters...
Comparative in vitro efficacies and antimicrobial durabilities of novel antimicrobial central venous cathetersHend Hanna
University of Texas MD Anderson Cancer Center, Department of Infectious Diseases, Infection Control and Employee Health, Houston, TX 77030, USA
Antimicrob Agents Chemother 50:3283-8. 2006..Central venous catheters impregnated with the novel investigational antiseptic gendine showed in vitro efficacy and provided protection against bacterial adherence more than other approved novel antimicrobial-coated CVCs...- Long-term silicone central venous catheters impregnated with minocycline and rifampin decrease rates of catheter-related bloodstream infection in cancer patients: a prospective randomized clinical trialHend Hanna
The University of Texas M D Anderson Cancer Center, Department of Infectious Diseases, 1515 Holcombe Blvd, Houston, TX 77030, USA
J Clin Oncol 22:3163-71. 2004..To evaluate the efficacy of long-term nontunneled silicone catheters impregnated with minocycline and rifampin (M-R) in reducing catheter-related bloodstream infections... - Antibiotic-impregnated catheters associated with significant decrease in nosocomial and multidrug-resistant bacteremias in critically ill patientsHend A Hanna
Department of Infectious Diseases, Infection Control, and Employee Health Unit 402, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Chest 124:1030-8. 2003..To evaluate the impact of using central venous catheters (CVCs) impregnated with the combination of minocycline and rifampin on nosocomial bloodstream infections (BSIs), morbidity, and mortality in cancer patients in the ICU... - Multiple-species candidemia in patients with cancerMaha R Boktour
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 101:1860-5. 2004.... - Vancomycin-resistant Enterococcus faecium: catheter colonization, esp gene, and decreased susceptibility to antibiotics in biofilmIssam I Raad
Department of Infectious Diseases, Infection Control and Employee Health Unit 402, The University of Texas M D Anderson Cancer Center, P O Box 301402, Houston, Texas 77230 1402, USA
Antimicrob Agents Chemother 49:5046-50. 2005..In biofilm, daptomycin and minocycline were the most active antibiotics against VREF, and linezolid was the least active... - Antiseptic effect of a novel alcohol-free mouthwash: a convenient prophylactic alternative for high-risk patientsPaul Bahna
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 402, Houston, TX 77030, United States
Oral Oncol 43:159-64. 2007..A novel alcohol-free mouthwash solution, that has low concentration of chlorhexidine, showed antiseptic effect against planktonic and biofilm forms of C. albicans and against K. pneumoniae, P. aeruginosa, and MRSA... - Catheter-related vancomycin-resistant Enterococcus faecium bacteremia: clinical and molecular epidemiologyIssam I Raad
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Infect Control Hosp Epidemiol 26:658-61. 2005..To study the clinical and molecular epidemiology of vancomycin-resistant Enterococcus faecium organisms causing catheter-related bacteremia in patients with cancer... 
Role of ethylene diamine tetra-acetic acid (EDTA) in catheter lock solutions: EDTA enhances the antifungal activity of amphotericin B lipid complex against Candida embedded in biofilmIssam I Raad
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Int J Antimicrob Agents 32:515-8. 2008..04). In patients with catheter-related candidaemia when catheter removal is not feasible, the combination of ABLC+EDTA may be considered for antifungal catheter lock solution as part of a catheter salvage therapy...- A rapid method of impregnating endotracheal tubes and urinary catheters with gendine: a novel antiseptic agentGassan Chaiban
The University of Texas M. D. Anderson Cancer Center, Department of Infectious Diseases, Infection Control and Employee Health, 1515 Holcombe Blvd, Houston, TX 77030, USA
J Antimicrob Chemother 55:51-6. 2005..Furthermore, these coated devices were shown to be non-cytotoxic... - Impact of high-dose granulocyte transfusions in patients with cancer with candidemia: retrospective case-control analysis of 491 episodes of Candida species bloodstream infectionsAmar Safdar
Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 101:2859-65. 2004..The authors sought to determine the impact of high-dose (approximately 5.5 x 10(10) cells) GTX in patients with candidemia... - Chest tube-related empyema due to methicillin-resistant Staphylococcus aureus: could the chest tube be coated with antiseptics?Harrys A Torres
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
Infect Control Hosp Epidemiol 27:195-7. 2006..Chest tube-related MRSA empyema might complicate tube thoracostomy, and coating the chest tube with antiseptic agents could prevent this complication... - Amphotericin B lipid complex versus liposomal amphotericin B monotherapy for invasive aspergillosis in patients with hematologic malignancyRay Y Hachem
Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77230 1402, USA
Cancer 112:1282-7. 2008..There are limited data comparing the efficacy and safety of these 2 agents in the treatment of IA in patients with cancer... - Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilmIssam Raad
The University of Texas M D Anderson Cancer Center, Department of Infectious Diseases, Infection Control and Employee Health, Houston, TX 77030, USA
Antimicrob Agents Chemother 51:1656-60. 2007..In summary, daptomycin, minocycline, and tigecycline should be considered further for antibiotic lock therapy, and rifampin should be considered for enhanced antistaphylococcal activity but not as a single agent... - Optimal antimicrobial catheter lock solution, using different combinations of minocycline, EDTA, and 25-percent ethanol, rapidly eradicates organisms embedded in biofilmIssam Raad
Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Antimicrob Agents Chemother 51:78-83. 2007..We conclude that M-EDTA in 25% ethanol is highly effective at rapidly eradicating S. aureus and C. parapsilosis embedded in biofilm adhering to catheter segments... - Clinical experience with minocycline and rifampin-impregnated central venous catheters in bone marrow transplantation recipients: efficacy and low risk of developing staphylococcal resistanceIoannis Chatzinikolaou
Department of Infectious Diseases, Infectious Control and Employee Health, University of Texas, M. D. Anderson Cancer Center, Houston 77030, USA
Infect Control Hosp Epidemiol 24:961-3. 2003.... - Minocycline-ethylenediaminetetraacetate lock solution for the prevention of implantable port infections in children with cancerIoannis Chatzinikolaou
Division of Internal Medicine, Department of Infectious Diseases, Infection Control, and Employee Health, University of Texas, M. D. Anderson Cancer Center, Houston, TX 77030, USA
Clin Infect Dis 36:116-9. 2003..M-EDTA is a promising lock solution in long-term catheters... - Antibiotic-coated hemodialysis catheters for the prevention of vascular catheter-related infections: a prospective, randomized studyIoannis Chatzinikolaou
University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Am J Med 115:352-7. 2003..006). CONCLUSION: The use of polyurethane hemodialysis catheters impregnated with minocycline and rifampin decreases the risk of catheter-related infection in patients with acute renal failure... - Clinical-use-associated decrease in susceptibility of vancomycin-resistant Enterococcus faecium to linezolid: a comparison with quinupristin-dalfopristinIssam I Raad
Department of Infectious Diseases, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Antimicrob Agents Chemother 48:3583-5. 2004..More than 6 months after their clinical use, a decrease in susceptibility was noted for only linezolid at 83%. This was related in part to a single G2576U gene mutation in domain V of the 23S rRNA gene... - Treatment of febrile neutropenic patients with cancer who require hospitalization: a prospective randomized study comparing imipenem and cefepimeIssam I Raad
Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Cancer 98:1039-47. 2003.... - Nocardiosis in cancer patientsHarrys A Torres
Department of Infectious Diseases, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA
Medicine (Baltimore) 81:388-97. 2002..The present study confirms that timely diagnosis, the site of NOC, the type of, the presence of comorbidities, and cytomegalovirus coinfection influence the outcome of patients with cancer and NOC... - Orthopaedic metal devices coated with a novel antiseptic dye for the prevention of bacterial infectionsPaul Bahna
Department of Infectious Diseases, Infection Control and Employee Health Unit 402, The University of Texas M D Anderson Cancer Center, PO Box 301402, Houston, TX 77230 1402, USA
Int J Antimicrob Agents 29:593-6. 2007..01), resulting in 90% reduction in MRSA biofilm adherence compared with uncoated control rods. Results indicate that gendine-coated metal rods are highly efficacious in the prevention of MRSA biofilm... - Central venous catheter-related bacteremia due to gram-negative bacilli: significance of catheter removal in preventing relapseHend Hanna
The University of Texas M. D. Anderson Cancer Center, Department of Infectious Diseases, Infection Control and Employee Health (Unit 402, 1515 Holcombe Blvd, Houston, TX 77030, USA
Infect Control Hosp Epidemiol 25:646-9. 2004..13; 95% confidence interval, 0.02-0.75; P = .02). CONCLUSION: In patients with documented catheter-related GNB, CVCs should be removed within 48 to 72 hours to prevent relapse... - Breakthrough candidemia in patients with cancer differs from de novo candidemia in host factors and Candida species but not intensityDimitrios P Kontoyiannis
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD. Anderson Cancer Center, Houston 77030, USA
Infect Control Hosp Epidemiol 23:542-5. 2002..CONCLUSIONS: In breakthrough candidemia, the same risk factors seen in de novo candidemia were encountered, although more frequently. C. glabrata and C. krusei are the leading causes of breakthrough candidemia in patients with cancer... - The importance of two-step tuberculin skin testing for newly employed healthcare workersElizabeth C Frenzel
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas, Houston, TX 77230 1402, USA
Infect Control Hosp Epidemiol 27:512-4. 2006..Boosted reactions were significantly associated with male sex and older age. A verbal history of previous tuberculin skin test results was not a reliable indicator of baseline tuberculin skin test status at the time of hire... - Polymerase chain reaction on blood for the diagnosis of invasive pulmonary aspergillosis in cancer patientsIssam Raad
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 94:1032-6. 2002..Two prospective studies confirmed this finding but included a small number of IPA cases... - Diagnosis of invasive pulmonary aspergillosis using polymerase chain reaction-based detection of aspergillus in BALIssam Raad
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Chest 121:1171-6. 2002..To assess the value of Aspergillus polymerase chain reaction (PCR) test performed on the BAL in diagnosing invasive pulmonary aspergillosis (IPA)... - EDTA as an adjunct antifungal agent for invasive pulmonary aspergillosis in a rodent modelRay Hachem
Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M D Anderson Cancer Center, P O Box 301402, Houston, TX 77030 1402, USA
Antimicrob Agents Chemother 50:1823-7. 2006.... - Management of central venous catheters in patients with cancer and candidemiaIssam Raad
Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Clin Infect Dis 38:1119-27. 2004..03). CVC removal < or =72 h after onset should be considered in patients with suspected catheter-related candidemia who have no evidence of dissemination, recent corticosteroid therapy, or chemotherapy... - Clinical and radiologic predictors of invasive pulmonary aspergillosis in cancer patients: should the European Organization for Research and Treatment of Cancer/Mycosis Study Group (EORTC/MSG) criteria be revised?Ray Hachem
Department of Infectious Diseases, University of Texas MD Anderson Cancer Center, Houston, 77030, USA
Cancer 106:1581-6. 2006..The outcome of such infections depends on early diagnosis and prompt initiation of therapy. The objective of the current study was to determine the significant predictive factors that characterize IPA in patients with cancer... - In vitro and ex vivo activities of minocycline and EDTA against microorganisms embedded in biofilm on catheter surfacesIssam Raad
Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Antimicrob Agents Chemother 47:3580-5. 2003..01). We concluded that M-EDTA is highly active in eradicating microorganisms embedded in fresh and mature biofilm adhering to catheter surfaces... - Relationship between myalgias/arthralgias occurring in patients receiving quinupristin/dalfopristin and biliary dysfunctionIssam Raad
M D Anderson Cancer Center, Department of Infectious Diseases, 1515 Holcombe Blvd, Unit 402, Houston, TX 77030, USA
J Antimicrob Chemother 53:1105-8. 2004..To determine whether myalgias/arthralgias occurring in cancer patients who receive quinupristin/dalfopristin are associated with biliary tract dysfunction... - Intravascular catheter-related infections: advances in diagnosis, prevention, and managementIssam Raad
Department of Infectious Diseases, Infection Control and Employee Health, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Lancet Infect Dis 7:645-57. 2007.... - Itraconazole added to a lipid formulation of amphotericin B does not improve outcome of primary treatment of invasive aspergillosisDimitrios P Kontoyiannis
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 103:2334-7. 2005..Itraconazole (ITC), a triazole with activity against Aspergillus, has been used in combination with AMB or lipid formulations of AMB (LipoAMB) in the treatment of IA, although the efficacy of this strategy is uncertain... - Prospective, randomized study comparing quinupristin-dalfopristin with linezolid in the treatment of vancomycin-resistant Enterococcus faecium infectionsIssam Raad
Departments of Infectious Diseases, Infection Control and Employee Health, University of Texas M D Anderson Cancer Center, Texas 77030, USA
J Antimicrob Chemother 53:646-9. 2004..The objective of this study was to compare the safety and efficacy of the two drugs in the treatment of VREF infections in cancer patients... - The changing epidemiology of invasive candidiasis: Candida glabrata and Candida krusei as the leading causes of candidemia in hematologic malignancyRay Hachem
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Cancer 112:2493-9. 2008..The objective of the current retrospective study was to compare the epidemiology of candidemia and its risk factors in patients who had hematologic malignancies(HM) with those in patients who had solid tumors (ST)... - Intravascular catheter-related infections: new horizons and recent advancesIssam I Raad
Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Arch Intern Med 162:871-8. 2002.... - Differential quantitative blood cultures for the diagnosis of catheter-related bloodstream infections associated with short- and long-term catheters: a prospective studyIoannis Chatzinikolaou
The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA
Diagn Microbiol Infect Dis 50:167-72. 2004..In conclusion, DQBCs are not diagnostic of CRBSIs for short-term CVCs. In long-term CVCs, DQBCs at 2:1 or greater or 5:1 or greater are sensitive but associated with low specificity and positive predictive value... - Central venous catheter and Stenotrophomonas maltophilia bacteremia in cancer patientsMaha Boktour
Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77230, USA
Cancer 106:1967-73. 2006..Catheter-related S. maltophilia bacteremias occurred more frequently in noncritically ill, nonneutropenic patients, and prompt removal of the catheter was found to be associated with a better prognosis... - Impact of surveillance for vancomycin-resistant enterococci on controlling a bloodstream outbreak among patients with hematologic malignancyRay Hachem
Department of Infectious Diseases, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Infect Control Hosp Epidemiol 25:391-4. 2004.... - The epidemiology of Candida glabrata and Candida albicans fungemia in immunocompromised patients with cancerGerald P Bodey
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Am J Med 112:380-5. 2002..glabrata than against C. albicans (20/38 [53%] vs. 57/74 [77%], P = 0.008). CONCLUSION: C. glabrata has emerged as an important cause of candidemia, especially among neutropenic patients who receive fluconazole prophylaxis... - Masking of neutropenic patients on transport from hospital rooms is associated with a decrease in nosocomial aspergillosis during constructionIssam Raad
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA
Infect Control Hosp Epidemiol 23:41-3. 2002..24 per 1,000 hospital patient-days during fiscal years 1996 to 1999 (P < .001). High-efficiency masks reduced nosocomial aspergillosis during hospital construction... - Efficacy and safety of weekly dalbavancin therapy for catheter-related bloodstream infection caused by gram-positive pathogensIssam Raad
The M. D. Anderson Cancer Center, Houston, TX, USA
Clin Infect Dis 40:374-80. 2005..CONCLUSIONS: Dalbavancin thus appears to be an effective and well-tolerated treatment option for adult patients with CR-BSIs caused by CoNS and S. aureus, including MRSA... - Correlation between early clinical response after catheter removal and diagnosis of catheter-related bloodstream infectionBassam Shukrallah
The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Diagn Microbiol Infect Dis 58:453-7. 2007..However, response to antimicrobial therapy at >or=48 h after CVC removal was less likely to be diagnostic of CRBSI and could reflect a response to antimicrobial therapy irrespective of the source of the bloodstream infections... - Prospective study of the value of quantitative culture of organisms from blood collected through central venous catheters in differentiating between contamination and bloodstream infectionIoannis Chatzinikolaou
University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
J Clin Microbiol 44:1834-5. 2006..Quantitative cultures of organisms from blood collected through central venous catheters were found to be highly sensitive, specific, and predictive of bacteremia, especially when a cutoff point of 15 colonies of skin organisms was used... - Epidemiology, molecular mycology, and environmental sources of Fusarium infection in patients with cancerIssam Raad
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA
Infect Control Hosp Epidemiol 23:532-7. 2002..CONCLUSION: The most likely source of fusariosis was the external environment rather than nosocomial sources, such as water... - Risk factors for vancomycin-resistant Enterococcus (VRE) infection in colonized patients with cancerRola Husni
The University of Texas M.D. Anderson Cancer Center, Department of Infectious Diseases, Infection Control and Employee Health, Houston, Texas 77030, USA
Infect Control Hosp Epidemiol 23:102-3. 2002..Therefore, colonized neutropenic patients with cancer who have previously used oral vancomycin are most prone to VRE infection... - Risk factors for infections with multidrug-resistant Stenotrophomonas maltophilia in patients with cancerShoaib R Ansari
Department of Infectious Diseases, Infection Control, and Employee Health, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 109:2615-22. 2007..In the current study, the risk factors were determined for the emergence of multidrug-resistant (MDR) S. maltophilia...