Shino Hanabuchi

Summary

Affiliation: MD Anderson Cancer Center
Location: Houston, USA

Publications

  1. ncbi Potential immunogenicity of adult T cell leukemia cells in vivo
    Kiyoshi Kurihara
    Department of Immunotherapeutics, Medical Research Division, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Int J Cancer 114:257-67. 2005
  2. ncbi Human TSLP promotes CD40 ligand-induced IL-12 production by myeloid dendritic cells but maintains their Th2 priming potential
    Norihiko Watanabe
    DNAX Research Institute, Palo Alto, CA, USA
    Blood 105:4749-51. 2005
  3. ncbi Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL)
    Shino Hanabuchi
    Department of Immunology and Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, 7455 Fannin, Unit 910, Houston, 77030 1903, USA
    Blood 107:3617-23. 2006
  4. pmc OX40 ligand shuts down IL-10-producing regulatory T cells
    Tomoki Ito
    Department of Immunology and Center for Cancer Immunology Research, University of Texas M D Anderson Cancer Center, Houston, 77030 1903, USA
    Proc Natl Acad Sci U S A 103:13138-43. 2006
  5. pmc IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells
    Yui Hsi Wang
    Department of Immunology and Center of Cancer Immunology Research, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 204:1837-47. 2007
  6. pmc Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery
    Tomoki Ito
    Department of Immunology and Center of Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 28:870-80. 2008
  7. pmc Vorinostat inhibits STAT6-mediated TH2 cytokine and TARC production and induces cell death in Hodgkin lymphoma cell lines
    Daniela Buglio
    Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Blood 112:1424-33. 2008
  8. pmc Identification of IL-17-producing FOXP3+ regulatory T cells in humans
    Kui Shin Voo
    Department of Immunology, Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 106:4793-8. 2009
  9. pmc Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction
    Wei Cao
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
    J Exp Med 206:1603-14. 2009
  10. pmc TSLP and IL-7 use two different mechanisms to regulate human CD4+ T cell homeostasis
    Ning Lu
    Department of Immunology, Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 206:2111-9. 2009

Collaborators

Detail Information

Publications34

  1. ncbi Potential immunogenicity of adult T cell leukemia cells in vivo
    Kiyoshi Kurihara
    Department of Immunotherapeutics, Medical Research Division, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Int J Cancer 114:257-67. 2005
    ....
  2. ncbi Human TSLP promotes CD40 ligand-induced IL-12 production by myeloid dendritic cells but maintains their Th2 priming potential
    Norihiko Watanabe
    DNAX Research Institute, Palo Alto, CA, USA
    Blood 105:4749-51. 2005
    ..Thus, TSLP is a major regulatory cytokine for IL-12 production by DCs, and TSLP-activated DCs could promote the persistence of Th2 inflammation even in the presence of IL-12-inducing signals...
  3. ncbi Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL)
    Shino Hanabuchi
    Department of Immunology and Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, 7455 Fannin, Unit 910, Houston, 77030 1903, USA
    Blood 107:3617-23. 2006
    ..This study reveals a novel function of GITR/GITRL in pDC-mediated coactivation of NK cells...
  4. pmc OX40 ligand shuts down IL-10-producing regulatory T cells
    Tomoki Ito
    Department of Immunology and Center for Cancer Immunology Research, University of Texas M D Anderson Cancer Center, Houston, 77030 1903, USA
    Proc Natl Acad Sci U S A 103:13138-43. 2006
    ..These two novel functions of OX40L shed light on the mechanism by which OX40/OX40L regulates immunity and tolerance...
  5. pmc IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells
    Yui Hsi Wang
    Department of Immunology and Center of Cancer Immunology Research, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 204:1837-47. 2007
    ..Our results provide a plausible explanation that IL-25 produced by innate effector eosinophils and basophils may augment the allergic inflammation by enhancing the maintenance and functions of adaptive Th2 memory cells...
  6. pmc Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery
    Tomoki Ito
    Department of Immunology and Center of Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 28:870-80. 2008
    ....
  7. pmc Vorinostat inhibits STAT6-mediated TH2 cytokine and TARC production and induces cell death in Hodgkin lymphoma cell lines
    Daniela Buglio
    Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Blood 112:1424-33. 2008
    ....
  8. pmc Identification of IL-17-producing FOXP3+ regulatory T cells in humans
    Kui Shin Voo
    Department of Immunology, Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 106:4793-8. 2009
    ..IL-17-producing Treg cells may play critical roles in antimicrobial defense, while controlling autoimmunity and inflammation...
  9. pmc Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction
    Wei Cao
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
    J Exp Med 206:1603-14. 2009
    ..Readily induced by IFN and other proinflammatory cytokines, BST2 may modulate the human pDC's IFN responses through ILT7 in a negative feedback fashion...
  10. pmc TSLP and IL-7 use two different mechanisms to regulate human CD4+ T cell homeostasis
    Ning Lu
    Department of Immunology, Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Med 206:2111-9. 2009
    ..5%. TSLP could only induce naive CD4(+) T cells to differentiate into Th2 cells in the presence of allogeneic mDCs. These results demonstrate that IL-7 and TSLP use different mechanisms to regulate human CD4(+) T cell homeostasis...
  11. pmc TSLP production by epithelial cells exposed to immunodeficiency virus triggers DC-mediated mucosal infection of CD4+ T cells
    Danielle Fontenot
    Departments of Immunology and Veterinary Sciences, The University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    Proc Natl Acad Sci U S A 106:16776-81. 2009
    ..The cross talk between mucosal epithelial cells and DC, mediated by HIV-induced TSLP, may be an important mechanism for the high rate of HIV infection in women through the vaginal mucosa...
  12. pmc Distinct signal codes generate dendritic cell functional plasticity
    Kazuhiko Arima
    Department of Immunology and Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, 7455 Fannin, Unit 901, Houston, TX 77030, USA
    Sci Signal 3:ra4. 2010
    ..Therefore, we propose that the functional plasticity of DCs relies on elaborate signal codes that are generated by different stimuli...
  13. pmc Thymic stromal lymphopoietin-activated plasmacytoid dendritic cells induce the generation of FOXP3+ regulatory T cells in human thymus
    Shino Hanabuchi
    Department of Immunology and Center for Cancer Immunology Research, University of Texas MD Anderson Cancer Center, Houston, TX 77030 1903, USA
    J Immunol 184:2999-3007. 2010
    ..The inability of TSLP to induce DC maturation without producing Th1- or Th2-polarizing cytokines may provide a thymic niche for T(R) development...
  14. pmc Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells
    Taeil Kim
    Department of Immunology, Center for Cancer Immunology Research, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 107:15181-6. 2010
    ..This study demonstrates that DHX9/DHX36 represent the MyD88-dependent DNA sensors in the cytosol of pDCs and suggests a much broader role for DHX helicases in viral sensing...
  15. ncbi In vivo role of pDCs in regulating adaptive immunity
    Shino Hanabuchi
    Department of Immunology, MD Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA
    Immunity 35:851-3. 2011
    ..Plasmacytoid dendritic cells (pDCs) have potential influence on innate and adaptive immune responses. In this issue of Immunity, Takagi et al. (2011) established mice lacking pDCs and explored the impact of pDC ablation in vivo...
  16. ncbi Immunological risks of adult T-cell leukemia at primary HTLV-I infection
    Mari Kannagi
    Department of Immunotherapeutics, Medical Research Division, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Trends Microbiol 12:346-52. 2004
    ....
  17. pmc Repression of tax expression is associated both with resistance of human T-cell leukemia virus type 1-infected T cells to killing by tax-specific cytotoxic T lymphocytes and with impaired tumorigenicity in a rat model
    Machiko Nomura
    Department of Immunotherapeutics, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    J Virol 78:3827-36. 2004
    ..Our results provide insights into the mechanisms how the host immune system can survey and inhibit the growth of HTLV-1-infected cells during the long latent period before the onset of ATL...
  18. pmc Fas and its ligand in a general mechanism of T-cell-mediated cytotoxicity
    S Hanabuchi
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    Proc Natl Acad Sci U S A 91:4930-4. 1994
    ..Interestingly, CD4+ T cells prepared from gld/gld mice did not mediate the Fas-mediated cytotoxicity, indicating defective expression of functional Fas ligand in gld mice...
  19. pmc Oral administration of human T-cell leukemia virus type 1 induces immune unresponsiveness with persistent infection in adult rats
    H Kato
    Department of Immunotherapeutics, Medical Research Division, Tokyo Medical and Dental University, Tokyo 113, Japan
    J Virol 72:7289-93. 1998
    ..This immune unresponsiveness at primary infection may subsequently affect the host defense ability against HTLV-1...
  20. pmc Establishment of a seronegative human T-cell leukemia virus type 1 (HTLV-1) carrier state in rats inoculated with a syngeneic HTLV-1-immortalized T-cell line preferentially expressing Tax
    Y Koya
    Department of Immunotherapeutics, Tokyo Medical and Dental University, Medical Research Division, Tokyo 113, Japan
    J Virol 73:6436-43. 1999
    ....
  21. pmc Development of human T-cell leukemia virus type 1-transformed tumors in rats following suppression of T-cell immunity by CD80 and CD86 blockade
    S Hanabuchi
    Department of Immunotherapeutics, Tokyo Medical and Dental University, Medical Research Division, Japan
    J Virol 74:428-35. 2000
    ..Our results suggest that HTLV-1-specific cell-mediated immunity plays a critical role in immunosurveillance against HTLV-1-transformed tumor development in vivo...
  22. ncbi Immunological aspects of rat models of HTLV type 1-infected T lymphoproliferative disease
    M Kannagi
    Department of Immunotherapeutics, Tokyo Medical and Dental University, Medical Research Division, Tokyo 113, Japan
    AIDS Res Hum Retroviruses 16:1737-40. 2000
    ....
  23. ncbi Regression of human T-cell leukemia virus type I (HTLV-I)-associated lymphomas in a rat model: peptide-induced T-cell immunity
    S Hanabuchi
    Department of Immunotherapeutics, Tokyo Medical and Dental University, Medical Research Division, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
    J Natl Cancer Inst 93:1775-83. 2001
    ..CONCLUSIONS: This study indicated a potential therapeutic effect of peptide-based vaccination against HTLV-I-induced lymphoproliferative disease...
  24. ncbi [Immunological analysis and experimental immunotherapy for HTLV-I-infected T lymphoproliferative disease in a rat model]
    Takashi Ohashi
    Department of Immunotherapeutics, Medical and Dental Research Division, Tokyo Medical and Dental University
    Nihon Rinsho Meneki Gakkai Kaishi 25:65-9. 2002
  25. pmc Correlation of major histocompatibility complex class I downregulation with resistance of human T-cell leukemia virus type 1-infected T cells to cytotoxic T-lymphocyte killing in a rat model
    Takashi Ohashi
    Department of Immunotherapeutics, Tokyo Medical and Dental University, Medical and Dental Research Division, Tokyo 113 8519, Japan
    J Virol 76:7010-9. 2002
    ..This may be one of the mechanisms for persistence of HTLV-1-infected cells that evade CTL lysis and potentially develop ATL...
  26. pmc Expansion of human T-cell leukemia virus type 1 (HTLV-1) reservoir in orally infected rats: inverse correlation with HTLV-1-specific cellular immune response
    Atsuhiko Hasegawa
    Department of Immunotherapeutics, Graduate School, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    J Virol 77:2956-63. 2003
    ....
  27. pmc Human dendritic cells activated by TSLP and CD40L induce proallergic cytotoxic T cells
    Michel Gilliet
    DNAX Research Institute, Palo Alto, CA 94304, USA
    J Exp Med 197:1059-63. 2003
    ....
  28. ncbi Graft-versus-Tax response in adult T-cell leukemia patients after hematopoietic stem cell transplantation
    Nanae Harashima
    Department of Immunotherapeutics, Tokyo Medical and Dental University, Medical Research Division, Tokyo, Japan
    Cancer Res 64:391-9. 2004
    ..These observations suggested that reconstituted immunity against antigen presentation in ATL patients after HSCT resulted in strong and selective graft-versus-HTLV-I response, which might contribute to graft-versus-leukemia effects...
  29. ncbi Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+ T cell homeostatic expansion
    Norihiko Watanabe
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304 1104, USA
    Nat Immunol 5:426-34. 2004
    ..These results, together with findings of TSLP expression in epithelial cells of mucosal lymphoid tissues and thymus, indicate that TSLP is involved in DC-mediated CD4(+) T cell homeostasis...
  30. pmc TSLP and immune homeostasis
    Shino Hanabuchi
    Department of Immunology, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, TX 77004, USA
    Allergol Int 61:19-25. 2012
    ..Here, we review recent progress made on how TSLP expressed within the thymus and peripheral lymphoid and non-lymphoid tissues regulates DC-mediated T-cell development in the thymus and T-cell homeostasis in the periphery...