J Han

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi Limiting inflammatory responses during activation of innate immunity
    Jiahuai Han
    The Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China
    Nat Immunol 6:1198-205. 2005
  2. ncbi Glucocorticoids synergize with IL-1beta to induce TLR2 expression via MAP Kinase Phosphatase-1-dependent dual Inhibition of MAPK JNK and p38 in epithelial cells
    Akihiro Sakai
    Gonda Department of Cell and Molecular Biology, House Ear Institute, and University of Southern California, Los Angeles, CA 90057, USA
    BMC Mol Biol 5:2. 2004
  3. ncbi Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation
    J Han
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 386:296-9. 1997
  4. ncbi Regulation of MEF2 by p38 MAPK and its implication in cardiomyocyte biology
    J Han
    Department of Immunology, The Scripps Research Institute, La Jolla, CA, USA
    Trends Cardiovasc Med 10:19-22. 2000
  5. ncbi The pathways to tumor suppression via route p38
    Jiahuai Han
    Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China
    Trends Biochem Sci 32:364-71. 2007
  6. ncbi Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta
    Y Jiang
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 272:30122-8. 1997
  7. ncbi Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest
    X Wang
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Cell Biol 20:4543-52. 2000
  8. ncbi Regulation of the MEF2 family of transcription factors by p38
    M Zhao
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Cell Biol 19:21-30. 1999
  9. ncbi PRAK, a novel protein kinase regulated by the p38 MAP kinase
    L New
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    EMBO J 17:3372-84. 1998
  10. ncbi Molecular cloning and characterization of a human protein kinase that specifically activates c-Jun N-terminal kinase
    J Yang
    Department of Immunology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Gene 212:95-102. 1998

Research Grants

  1. Macrophage Death and Sepsis
    Jiahuai Han; Fiscal Year: 2006
  2. CELLULAR ACTIVATION MECHANISMS IN SEPTIC SHOCK
    Jiahuai Han; Fiscal Year: 2006
  3. Molecular Mechanisms of Anthrax-Induced Macrophage Death
    Jiahuai Han; Fiscal Year: 2007
  4. Function of microRNA in pro-inflammatory gene expression
    Jiahuai Han; Fiscal Year: 2007
  5. Function of microRNA in pro-inflammatory gene expression
    Jiahuai Han; Fiscal Year: 2009
  6. Function of microRNA in pro-inflammatory gene expression
    Jiahuai Han; Fiscal Year: 2010
  7. CELLULAR ACTIVATION MECHANISMS IN SEPTIC SHOCK
    Jiahuai Han; Fiscal Year: 2001
  8. Macrophage Death and Sepsis
    Jiahuai Han; Fiscal Year: 2003
  9. CELLULAR ACTIVATION MECHANISMS IN SEPTIC SHOCK
    Jiahuai Han; Fiscal Year: 2010

Collaborators

Detail Information

Publications109 found, 100 shown here

  1. ncbi Limiting inflammatory responses during activation of innate immunity
    Jiahuai Han
    The Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China
    Nat Immunol 6:1198-205. 2005
    ..Here we review elements of innate immunity that lead to inflammation and some of the host mechanisms that allow for the resolution of the inflammatory responses...
  2. ncbi Glucocorticoids synergize with IL-1beta to induce TLR2 expression via MAP Kinase Phosphatase-1-dependent dual Inhibition of MAPK JNK and p38 in epithelial cells
    Akihiro Sakai
    Gonda Department of Cell and Molecular Biology, House Ear Institute, and University of Southern California, Los Angeles, CA 90057, USA
    BMC Mol Biol 5:2. 2004
    ..The increased expression of TLR2 in response to bacteria-induced cytokines has been thought to be crucial for the accelerated immune response and resensitization of epithelial cells to invading pathogens...
  3. ncbi Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation
    J Han
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 386:296-9. 1997
    ..One consequence of MEF2C activation is increased c-jun gene transcription. Our results show that p38 may influence host defence and inflammation by maintaining the balance of c-Jun protein consumed during infection...
  4. ncbi Regulation of MEF2 by p38 MAPK and its implication in cardiomyocyte biology
    J Han
    Department of Immunology, The Scripps Research Institute, La Jolla, CA, USA
    Trends Cardiovasc Med 10:19-22. 2000
    ..This review weighs the accumulating evidence for a p38 MAPK-MEF2 signal transduction cascade and discusses its role in cardiac myocyte biology...
  5. ncbi The pathways to tumor suppression via route p38
    Jiahuai Han
    Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China
    Trends Biochem Sci 32:364-71. 2007
    ..These findings reveal a tumor-suppressing function of the p38 pathway, and indicate that components of the p38 pathway are potential targets for novel cancer therapies...
  6. ncbi Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta
    Y Jiang
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 272:30122-8. 1997
    ..Nonetheless important differences exist among the four members of the p38 group of enzymes, and thus each may have highly specific, individual contributions to biologic events involving activation of the p38 pathways...
  7. ncbi Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest
    X Wang
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Cell Biol 20:4543-52. 2000
    ....
  8. ncbi Regulation of the MEF2 family of transcription factors by p38
    M Zhao
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Cell Biol 19:21-30. 1999
    ..These results demonstrate that the MAP kinase signaling pathway can discriminate between different MEF2 isoforms and can regulate MEF2-dependent genes through posttranslational activation of preexisting MEF2 protein...
  9. ncbi PRAK, a novel protein kinase regulated by the p38 MAP kinase
    L New
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    EMBO J 17:3372-84. 1998
    ..An in-gel kinase assay demonstrated that PRAK is a major stress-activated kinase that can phosphorylate small heat shock protein, suggesting a potential role for PRAK in mediating stress-induced HSP27 phosphorylation in vivo...
  10. ncbi Molecular cloning and characterization of a human protein kinase that specifically activates c-Jun N-terminal kinase
    J Yang
    Department of Immunology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Gene 212:95-102. 1998
    ..In conclusion, we have cloned the human homolog of murine MKK7 alpha, which may be an alternative spliced form of human JNKK2 involved in transducing specific upstream signals to regulate JNK activity in vivo...
  11. ncbi Gene suppression by tristetraprolin and release by the p38 pathway
    W Zhu
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Am J Physiol Lung Cell Mol Physiol 281:L499-508. 2001
    ..In conclusion, TTP plays an important role in maintaining gene quiescence, and this quenching effect on transcription can be released by p38 phosphorylation of TTP...
  12. ncbi SB203580 promotes EGF-stimulated early morphological differentiation in PC12 cell through activating ERK pathway
    L New
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Cell Biochem 83:585-96. 2001
    ..Our data provided further evidence for the threshold theory that differentiation is determined by the duration of ERK activation...
  13. ncbi Cloning and characterization of RLPK, a novel RSK-related protein kinase
    L New
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 274:1026-32. 1999
    ..These data suggest that RLPK is structurally similar to previously isolated RSKs, but its regulatory mechanism may be distinct from either p70(RSK) or p90(RSK)s...
  14. ncbi Identification and characterization of a predominant isoform of human MKK3
    J Han
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    FEBS Lett 403:19-22. 1997
    ..Northern blotting analysis showed that MKK3b mRNA is much more abundant than MKK3. Functional characterization based on the activation of p38 revealed that MKK3b is more efficient than MKK3 in mediating downstream signalling events...
  15. ncbi Characterization of the structure and function of a novel MAP kinase kinase (MKK6)
    J Han
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 271:2886-91. 1996
    ..This suggests novel mechanisms regulating activation and/or function of various forms of MKK6...
  16. ncbi BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C
    Y Kato
    The Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    EMBO J 16:7054-66. 1997
    ..Taken together, these results strongly suggest that in some cell types the MEK5/BMK1 MAP kinase signaling pathway regulates serum-induced early gene expression through the transcription factor MEF2C...
  17. ncbi Coordinate activation of endogenous p38alpha, beta, gamma, and delta by inflammatory stimuli
    C Fearns
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Leukoc Biol 67:705-11. 2000
    ..The kinetics of activation of each of the p38s were similar for each stimulus used, suggesting a common upstream activation pathway. Simultaneous activation of the p38s suggests that all four may be important in inflammation...
  18. ncbi Activation of p38 in stimulated human neutrophils: phosphorylation of the oxidase component p47phox by p38 and ERK but not by JNK
    J el Benna
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Arch Biochem Biophys 334:395-400. 1996
    ....
  19. ncbi The primary structure of p38 gamma: a new member of p38 group of MAP kinases
    Z Li
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA
    Biochem Biophys Res Commun 228:334-40. 1996
    ..We suggest p38 gamma may have unique functions when compared with other members of the p38 group due to its restricted tissue expression and apparent substrate preferences...
  20. ncbi Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)
    Y Jiang
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 271:17920-6. 1996
    ..The data reported here suggest that while closely related, p38beta and p38 may be regulated by differing mechanisms and may exert their actions on separate downstream targets...
  21. ncbi Urokinase plasminogen activator/urokinase-specific surface receptor expression and matrix invasion by breast cancer cells requires constitutive p38alpha mitogen-activated protein kinase activity
    S Huang
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 275:12266-72. 2000
    ..These studies suggest that p38alpha MAPK signaling pathway is important for the maintenance of breast cancer invasive phenotype by promoting the stabilities of uPA and uPAR mRNA...
  22. ncbi Resistance to tumor necrosis factor-induced cell death mediated by PMCA4 deficiency
    K Ono
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell Biol 21:8276-88. 2001
    ..Thus, increase of the volume of acidic compartment is a part of the cell death process, and the antideath effect of calcium is mediated, at least in part, by inhibition of the TNF-induced increase in VAC...
  23. ncbi Apoptosis by pan-caspase inhibitors in lipopolysaccharide-activated macrophages
    S O Kim
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Am J Physiol Lung Cell Mol Physiol 281:L1095-105. 2001
    ....
  24. ncbi Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells
    Y Wang
    Department of Medicine, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 273:5423-6. 1998
    ..The cytopathic response, as a result of co-activation of both JNK and p38, may contribute to the loss of contractile function and viability of cardiomyocytes following hemodynamic overload and cardiac ischemia/reperfusion injury...
  25. ncbi Extracellular hmgb1 functions as an innate immune-mediator implicated in murine cardiac allograft acute rejection
    Y Huang
    Laboratory of Transplantation, Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Am J Transplant 7:799-808. 2007
    ..The enhanced graft survival is associated with reduced allograft expression of TNFalpha, IFNgamma and Hmgb1 and impaired Th1 immune response...
  26. ncbi Molecular cloning of human p38 MAP kinase
    J Han
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
    Biochim Biophys Acta 1265:224-7. 1995
    ..The highly conserved nature of p38 suggests the importance of its function in regulating cellular responses...
  27. ncbi A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
    J Han
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
    Science 265:808-11. 1994
    ..Both HOG1 and p38 are tyrosine phosphorylated after extracellular changes in osmolarity. These findings link a signaling pathway in mammalian cells with a pathway in yeast that is responsive to physiological stress...
  28. ncbi Development of cataractous macrophthalmia in mice expressing an active MEK1 in the lens
    X Gong
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Invest Ophthalmol Vis Sci 42:539-48. 2001
    ..To characterize the extracellular signal-regulated kinase (ERK) pathway in the lens and to try to understand how this pathway contributes to lens function and cataractogenesis...
  29. ncbi Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
    K Hoebe
    Department of Immunology, IMM 31, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 424:743-8. 2003
    ..This reveals that an alternative MyD88-dependent 'adaptor X' pathway is present in some, but not all, macrophages, and implies afferent immune specialization...
  30. ncbi Pan-caspase inhibitor zVAD enhances cell death in RAW246.7 macrophages
    S O Kim
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA
    J Endotoxin Res 7:292-6. 2001
    ..Death of LPS-activated macrophages may be controlled by an anti-apoptotic caspase...
  31. ncbi Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding
    J Han
    Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 276:40903-9. 2001
    ..Consequently, alpha4 phosphorylation is a biochemical mechanism to modulate paxillin binding to alpha4 integrins with consequent regulation of alpha4 integrin-dependent cellular functions...
  32. ncbi The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function
    B Oertli
    Department of Vascular Biology, The Scripps Research Institute, La Jolla, California, CA 92037, USA
    Oncogene 19:4961-9. 2000
    ..Consequently, these studies provide insight into the structural basis of the interactions between R-Ras and its candidate effectors and suggest the existence of novel mechanisms through which this GTPase could regulate cell adhesion...
  33. ncbi Metaxin is required for tumor necrosis factor-induced cell death
    X Wang
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    EMBO Rep 2:628-33. 2001
    ..Interfering with metaxin prevented TNF-induced necrotic cell death in L929 cells and apoptosis in MCF-7 cells. Our work has thus defined a novel component in the death pathway used by TNF and some other death stimuli...
  34. ncbi Primary structure of BMK1: a new mammalian map kinase
    J D Lee
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA
    Biochem Biophys Res Commun 213:715-24. 1995
    ..This suggests BMK1 may regulate signaling events distinct from those controlled by the ERK group of enzymes...
  35. ncbi Determinants that control the distinct subcellular localization of p38alpha-PRAK and p38beta-PRAK complexes
    Qinxi Li
    The Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China
    J Biol Chem 283:11014-23. 2008
    ..In conclusion, multiple determinants control the distinct subcellular localization of p38alpha-PRAK and p38beta-PRAK complexes, and the location of PRAK plays a role in its function...
  36. ncbi Calcineurin negatively regulates TLR-mediated activation pathways
    Young Jun Kang
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    J Immunol 179:4598-607. 2007
    ..Collectively, these results suggest that calcineurin negatively regulates TLR-mediated activation pathways in macrophages by inhibiting the adaptor proteins MyD88 and TRIF, and a subset of TLRs...
  37. ncbi Multiple activation mechanisms of p38alpha mitogen-activated protein kinase
    Young Jun Kang
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 281:26225-34. 2006
    ..Therefore, multiple mechanisms of p38alpha activation exist that can influence each other, be simultaneously activated by a given stimulus, and/or be selectively used by different stimuli in a cell type-specific manner...
  38. ncbi The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence
    Lixin Hong
    Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, Fujian, China
    Cancer Res 70:8547-57. 2010
    ....
  39. ncbi PRAK is essential for ras-induced senescence and tumor suppression
    Peiqing Sun
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 128:295-308. 2007
    ..Furthermore, we show that PRAK activates p53 by direct phosphorylation. We propose that phosphorylation of p53 by PRAK following activation of p38 MAPK by ras plays an important role in ras-induced senescence and tumor suppression...
  40. ncbi p38alpha and p38gamma mediate oncogenic ras-induced senescence through differential mechanisms
    Jinny Kwong
    Department of Molecular Biology and Kellogg School of Science and Technology, The Scripps Research Institute, La Jolla, California 91037, USA
    J Biol Chem 284:11237-46. 2009
    ....
  41. ncbi Regulation of PRAK subcellular location by p38 MAP kinases
    Liguo New
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Biol Cell 14:2603-16. 2003
    ..The p38 MAPKs not only regulate PRAK activity and PRAK activation-related translocation, but also dock PRAK to selected subcellular locations in resting cells...
  42. ncbi MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha
    Baoxue Ge
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 295:1291-4. 2002
    ..These findings suggest that alternative activation pathways contribute to the biological responses of p38alpha to various stimuli...
  43. ncbi Beta-actin is required for mitochondria clustering and ROS generation in TNF-induced, caspase-independent cell death
    Jinquan Li
    The Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, Fujian, China
    J Cell Sci 117:4673-80. 2004
    ..Our findings suggest that a full complement of actin is required for transduction of a cell death signal to mitochondria in TNF-treated L929 cells...
  44. ncbi Activation and signaling of the p38 MAP kinase pathway
    Tyler Zarubin
    Department of Immunology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Res 15:11-8. 2005
    ..Upstream and downstream components of p38 are described and questions remaining to be answered are posed. Finally, we propose several directions for future research on p38...
  45. ncbi Inflammatory signaling and cellular senescence
    Jian Lin Ren
    Department of Gastroenterology, Zhongshan Hospital, Xiamen University, Xiamen, China
    Cell Signal 21:378-83. 2009
    ..The purpose of the present review is to discuss the dual roles of the inflammatory cytokines produced by senescent cells in the pathogenesis of cancer, and the signaling pathway mediating their role in cellular senescence...
  46. ncbi Axin determines cell fate by controlling the p53 activation threshold after DNA damage
    Qinxi Li
    Xiamen University, Fujian, China
    Nat Cell Biol 11:1128-34. 2009
    ..Thus, Axin is a critical determinant in p53-dependent tumour suppression in which Pirh2 and Tip60 have different roles in triggering cell-cycle arrest or apoptosis depending on the severity of genotoxic stress...
  47. ncbi Spatial heterogeneity of calcium transient alternans during the early phase of myocardial ischemia in the blood-perfused rabbit heart
    Y W Qian
    Cardiovascular Division, Stanford University School of Medicine, Stanford, CA, USA
    Circulation 104:2082-7. 2001
    ..CONCLUSIONS: These results demonstrate marked spatial heterogeneity of the [Ca(2+)](i) transient during the early phase of ischemia, which could produce electrical instability and arrhythmias in large mammalian hearts...
  48. ncbi Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation
    Wen Luo
    Department of Biology, Xiamen University, Xiamen, Fujian 361005, China
    J Biol Chem 278:37451-8. 2003
    ..Our findings will provide new insights into how scaffold proteins mediate ultimate activation of different mitogen-activated protein kinase kinase kinases...
  49. ncbi Rac1-MKK3-p38-MAPKAPK2 pathway promotes urokinase plasminogen activator mRNA stability in invasive breast cancer cells
    Qiwei Han
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 277:48379-85. 2002
    ....
  50. ncbi TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1
    Baoxue Ge
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 278:2286-93. 2003
    ....
  51. ncbi Activation of p38 and determination of its activity
    Huamin Zhou
    School of Life Sciences, Xiamen University, Xiamen, Fujian, China
    Methods Mol Biol 661:75-89. 2010
    ..Here, our methodology mainly highlights how endogenous or exogenous p38 can be activated and its upstream kinases and downstream substrates identified...
  52. ncbi Autophagy contributes to caspase-independent macrophage cell death
    Yue Xu
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 281:19179-87. 2006
    ..This paper reveals that TRIF, RIP1, and ROS production, as well as PARP activation, are involved in inducing autophagy, which contributes to caspase-independent macrophage cell death...
  53. ncbi Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation
    Young Jun Kang
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 180:5075-82. 2008
    ..Our in vivo studies with two murine models showed that p38alpha is involved in sepsis. Collectively, our data demonstrate that p38alpha is an important player in inflammatory responses...
  54. ncbi Differential requirement of MKK4 and MKK7 in JNK activation by distinct scaffold proteins
    Haiying Zou
    Department of Biomedical Sciences, The Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Fujian 361005, China
    FEBS Lett 581:196-202. 2007
    ..Our results demonstrate that Axin, Dvl, and LMP-1 differentially utilize MKK4 and MKK7 for JNK activation...
  55. ncbi TNF-alpha stimulation inhibits siRNA-mediated RNA interference through a mechanism involving poly-(A) tail stabilization
    Johann Mols
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochim Biophys Acta 1779:712-9. 2008
    ..This is the first report showing that a specific siRNA-mediated mRNA degradation can be regulated by inflammatory stimuli, and that deadenylation is involved in this siRNA-mediated mRNA decay...
  56. ncbi Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation
    Yue Xu
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 281:8788-95. 2006
    ..Therefore, our study uncovers that RIP1, TRAF2, and JNK comprise a pathway to mediate the signaling from PARP-1 overactivation to mitochondrial dysfunction...
  57. ncbi Nod1-dependent control of tumor growth
    Jean da Silva Correia
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:1840-5. 2006
    ..Conversely, overexpression of Nod1 in MCF-7 cells results in inhibition of estrogen-dependent tumor growth and reduction of estrogen-induced proliferative responses in vitro...
  58. ncbi Epithelial p38alpha controls immune cell recruitment in the colonic mucosa
    Young Jun Kang
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS Pathog 6:e1000934. 2010
    ..Thus, p38alpha in IECs contributes to the host immune responses against enteric bacteria by the recruitment of immune cells...
  59. ncbi Distinct effects of p38alpha deletion in myeloid lineage and gut epithelia in mouse models of inflammatory bowel disease
    Motoyuki Otsuka
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92307, USA
    Gastroenterology 138:1255-65, 1265.e1-9. 2010
    ..We investigated the effects of p38alpha inhibition in myeloid versus colonic epithelium...
  60. ncbi Determinants that control the specific interactions between TAB1 and p38alpha
    Huamin Zhou
    The Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Fujian, China
    Mol Cell Biol 26:3824-34. 2006
    ..This suggests that TAB1-induced autophosphorylation of p38alpha results from conformational changes that are similar but unique to those seen in p38alpha interactions with its substrates and activating kinases...
  61. ncbi Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages
    Young Jun Kang
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Immunol 8:601-9. 2007
    ..Our results indicate that two different TLR4 complexes sequentially form and selectively control early and late TNF production...
  62. ncbi Distinct roles of basal steady-state and induced H-ferritin in tumor necrosis factor-induced death in L929 cells
    Changchuan Xie
    The Scripps Research Institute Department of Immunology Imm 32, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell Biol 25:6673-81. 2005
    ....
  63. ncbi Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression
    Motoyuki Otsuka
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Immunity 27:123-34. 2007
    ..Our data suggest that host miRNA can play a role in host interactions with viruses...
  64. ncbi [Construction of a novel gene therapy lentiviral vector for drug resistant selection and detection in vivo]
    Chenyu Xu
    National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen 361005, China
    Sheng Wu Gong Cheng Xue Bao 24:256-61. 2008
    ..This lays the foundation for the further research in gene therapy and can also help identify lentivirus titer...
  65. ncbi A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida
    Yanning Rui
    Key Laboratory of Ministry of Education for Cell Biology, School of Life Sciences, Xiamen University, Fujian 361005, Xiamen, China
    Dev Cell 13:268-82. 2007
    ..We have thus identified a dorsalization pathway that is exerted by Axin/JNK signaling and its inhibitor Aida during vertebrate embryogenesis...
  66. ncbi The role of the p38 pathway in adaptive immunity
    Ryan Cook
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Mol Immunol 4:253-9. 2007
    ..In this review we attempt to highlight some of the major discoveries that have been made regarding p38's role in adaptive immunity, and also to discuss the possible future implications of these discoveries...
  67. ncbi Orphan nuclear receptor Nur77 is involved in caspase-independent macrophage cell death
    Sung Ouk Kim
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    J Exp Med 197:1441-52. 2003
    ..This paper delineates the dual signaling pathways that are required for Nur77 induction in macrophages and demonstrates a role of Nur77 in caspase-independent cell death...
  68. ncbi RISC-target interaction: cleavage and translational suppression
    Arjen van den Berg
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochim Biophys Acta 1779:668-77. 2008
    ....
  69. ncbi Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels
    Ella Bossy-Wetzel
    Center for Neuroscience and Aging, The Burnham Institute, La Jolla, CA 92037, USA
    Neuron 41:351-65. 2004
    ..Thus, these data establish a new form of crosstalk between NO and Zn2+ apoptotic signal transduction pathways that may contribute to neurodegeneration...
  70. ncbi Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways
    Kasper Hoebe
    The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Immunol 4:1223-9. 2003
    ..These findings show that UCM involves an autocrine or paracrine loop, and indicate that an alternative TLR3-independent, Trif-independent pathway contributes to dsRNA-induced UCM...
  71. ncbi ERK promotes hydrogen peroxide-induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells
    Shougang Zhuang
    Dept of Pharmaceutical Sciences, Medical Univ of South Carolina, 280 Calhoun St, POB 250140, Charleston, SC 29425, USA
    Am J Physiol Renal Physiol 292:F440-7. 2007
    ..We suggest that ERK elicits apoptosis in epithelial cells by activating caspase-3 and inhibiting Akt pathways and elicits nuclear condensation through caspase-3 and histone H2B phosophorylation during oxidant injury...
  72. ncbi Phosphatidylinositol ether lipid analogues that inhibit AKT also independently activate the stress kinase, p38alpha, through MKK3/6-independent and -dependent mechanisms
    Joell J Gills
    Medical Oncology Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, MD 20889, USA
    J Biol Chem 282:27020-9. 2007
    ..Independent modulation of Akt and p38alpha could account for the profound cytotoxicity of PIAs...
  73. ncbi Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells
    Young Sam Keum
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Cancer Res 66:8804-13. 2006
    ..In addition, our study shows that p38 MAPK can phosphorylate Nrf2 and promotes the association between Nrf2 and Keap1 proteins, thereby potentially inhibiting nuclear translocation of Nrf2...
  74. ncbi Glucocorticoids synergistically enhance nontypeable Haemophilus influenzae-induced Toll-like receptor 2 expression via a negative cross-talk with p38 MAP kinase
    Tsuyoshi Shuto
    Gonda Department of Cell and Molecular Biology, House Ear Institute, and the Department of Otolaryngology, University of Southern California, Los Angeles, CA 90057, USA
    J Biol Chem 277:17263-70. 2002
    ....
  75. ncbi Novel cytoplasmic proteins of nontypeable Haemophilus influenzae up-regulate human MUC5AC mucin transcription via a positive p38 mitogen-activated protein kinase pathway and a negative phosphoinositide 3-kinase-Akt pathway
    Beinan Wang
    Gonda Department of Cell and Molecular Biology, House Ear Institute, University of Southern California, Los Angeles, California 90057, USA
    J Biol Chem 277:949-57. 2002
    ..These studies may bring new insights into molecular pathogenesis of NTHi infections and lead to novel therapeutic intervention for COME and COPD...
  76. ncbi Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA(1), p42 and p38alpha
    Feng Hao
    Department of Pathobiology, College of Veterinary Medicine, The University of Tennessee, Knoxville, TN 37996, USA
    Biochim Biophys Acta 1771:883-92. 2007
    ..The results of the present study suggest that LPA, the receptor LPA(1), ERK2 and p38alpha are important regulators for prostate cancer cell invasion and thus could play a significant role in the development of metastasis...
  77. ncbi XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization
    Miao Lu
    Department of Biochemistry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Mol Cell 26:689-702. 2007
    ..Disruption of BIR1 dimerization abolishes XIAP-mediated NF-kappaB activation, implicating a proximity-induced mechanism for TAK1 activation...
  78. ncbi Evidence that age-related changes in p38 MAP kinase contribute to the decreased steroid production by the adrenocortical cells from old rats
    Parveen Abidi
    Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Aging Cell 7:168-78. 2008
    ..Collectively, these results indicate that p38 MAPK functions as a signaling effector in oxidative stress-induced inhibition of steroidogenesis during aging...
  79. ncbi p38 MAP kinase activation mediates gamma-globin gene induction in erythroid progenitors
    Betty S Pace
    Department of Molecular and Cell Biology, University of Texas at Dallas, Richardson, Tex 75083, USA
    Exp Hematol 31:1089-96. 2003
    ..Two histone deacetylase inhibitors (HDAIs), sodium butyrate (NB), and trichostatin (TSA) and hemin were analyzed. In addition, the effect of direct activation of p38 MAPK on gamma-globin gene activity was studied...
  80. ncbi Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-kappa B ligand signaling
    Kim C Mansky
    Department of Molecular Genetics and the Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 277:11077-83. 2002
    ..These results indicate that MITF is a target for the RANKL signaling pathway in osteoclasts and that phosphorylation of MITF leads to an increase in osteoclast-specific gene expression...
  81. ncbi Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways
    Yi Zhang
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    J Biol Chem 277:17706-12. 2002
    ..Furthermore, our data suggest that CKI may provide a possible switch mechanism for Axin function in the regulation of Wnt and JNK pathways...
  82. ncbi The p38 and JNK pathways cooperate to trans-activate vitamin D receptor via c-Jun/AP-1 and sensitize human breast cancer cells to vitamin D(3)-induced growth inhibition
    Xiaomei Qi
    Department of Radiation Oncology, Loyola University of Chicago, Maywood, Illinois 60153, USA
    J Biol Chem 277:25884-92. 2002
    ....
  83. ncbi p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation
    Irene E Zohn
    Howard Hughes Medical Institute, Department of Pediatrics, Section of Developmental Biology, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    Cell 125:957-69. 2006
    ..Finally, p38 regulates E-cadherin protein expression downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by Fibroblast Growth Factor (Fgf) signaling and Snail...
  84. ncbi Retinoblastoma suppression of matrix metalloproteinase 1, but not interleukin-6, through a p38-dependent pathway in rheumatoid arthritis synovial fibroblasts
    Kathleen Bradley
    Saint Louis University, School of Medicine, St Louis, Missouri 63104, USA
    Arthritis Rheum 50:78-87. 2004
    ..Therefore, we sought to determine if the tumor suppressor gene product retinoblastoma (Rb), a negative regulator of cell cycle activity, inhibits IL-6, MMP-1, and p38 in RA synovial fibroblasts...
  85. ncbi Estrogen receptor inhibits c-Jun-dependent stress-induced cell death by binding and modifying c-Jun activity in human breast cancer cells
    Xiaomei Qi
    Department of Radiation Oncology and Division of Biochemistry of the Department of Cell Biology, Neurobiology, and Anatomy, Loyola University of Chicago, Maywood, Illinois 05163
    J Biol Chem 279:6769-77. 2004
    ..Together, our studies reveal a novel function of ER in stress response by modification of c-Jun activity...
  86. ncbi Activation of the p38 MAP kinase pathway is required for foam cell formation from macrophages exposed to oxidized LDL
    Ming Zhao
    Division of Pathology II, Faculty of Health Sciences, Linkoping University, Sweden
    APMIS 110:458-68. 2002
    ..Our results for the first time demonstrate a regulation of CD36 by p38, and the importance of the p38 pathway in regulation of foam cell formation...
  87. ncbi Characterization of a neurotrophin signaling mechanism that mediates neuron survival in a temporally specific pattern
    Aryaman Shalizi
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 23:7326-36. 2003
    ..These findings define a novel mechanism that underlies the antiapoptotic effect of neurotrophins in a temporally defined pattern in the developing mammalian brain...
  88. ncbi Smad3 mediates transforming growth factor-beta-induced collagenase-3 (matrix metalloproteinase-13) expression in human gingival fibroblasts. Evidence for cross-talk between Smad3 and p38 signaling pathways
    Suvi Katri Leivonen
    Centre for Biotechnology, University of Turku and Abo Akademi University, FIN 20520 Turku, Finland
    J Biol Chem 277:46338-46. 2002
    ..e. Smad3 and p38alpha). In addition, these findings provide evidence for a novel type of cross-talk between Smad and p38 mitogen-activated protein kinase signaling cascades, which involves activation of Smad3 by p38alpha...
  89. ncbi p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2
    Song Ping Li
    Turku Centre for Biotechnology, University of Turku, Finland
    Cancer Res 63:3473-7. 2003
    ..In addition, we show that in all transformed cell lines we have studied thus far, the function of this pathway is impaired...
  90. ncbi Requisite role of p38 MAPK in mural cell recruitment during angiogenesis in the rat aorta model
    Wen hui Zhu
    Department of Pathology, University of Washington, Seattle, WA, USA
    J Vasc Res 40:140-8. 2003
    ..These results indicate that the p38 MAPK signaling pathway plays a critical role in mural cell recruitment during neovascularization and may represent a therapeutic target in angiogenesis-related disorders...
  91. ncbi Inhibition of p38 MAPK by glucocorticoids via induction of MAPK phosphatase-1 enhances nontypeable Haemophilus influenzae-induced expression of toll-like receptor 2
    Akira Imasato
    Gonda Department of Cell and Molecular Biology, House Ear Institute, and the Department of Otolaryngology, University of Southern California, Los Angeles, California 90057, USA
    J Biol Chem 277:47444-50. 2002
    ....
  92. ncbi Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway
    Hiroaki Iwasa
    Laboratory of Molecular and Cellular Assembly, Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, Yokohama 226 8501, Japan
    Genes Cells 8:131-44. 2003
    ..However, it remains unclear how a common set of senescence phenotypes is indistinguishably induced in various types of senescence...
  93. ncbi p38 isoforms have opposite effects on AP-1-dependent transcription through regulation of c-Jun. The determinant roles of the isoforms in the p38 MAPK signal specificity
    Rocky Pramanik
    Department of Radiation Oncology, Neurobiology and Anatomy, Loyola University of Chicago, Maywood, Illinois 60153, USA
    J Biol Chem 278:4831-9. 2003
    ....
  94. ncbi Differentiation state-selective roles of p38 isoforms in human intestinal epithelial cell anoikis
    Pierre H Vachon
    Canadian Institutes of Health Research Group on the Functional Development and Physiopathology of the Digestive Tract, Quebec, Canada
    Gastroenterology 123:1980-91. 2002
    ..Little is known of the signaling events implicated in the induction of human enterocytic anoikis. In the present study, we analyzed the role of the stress-activated protein kinase p38 in this process...
  95. ncbi Synergistic activation of NF-kappaB by nontypeable Haemophilus influenzae and tumor necrosis factor alpha
    Takahiro Watanabe
    Gonda Department of Cell and Molecular Biology, House Ear Institute, University of Southern California, Los Angeles, CA 90057, USA
    Proc Natl Acad Sci U S A 101:3563-8. 2004
    ..These studies should deepen our understanding of the molecular mechanisms underlying the combinatorial regulation of inflammation and lead to development of therapeutic strategies for NTHi-induced infections...
  96. ncbi Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein
    Guoxiang Shen
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    J Biol Chem 279:23052-60. 2004
    ....
  97. ncbi p38 MAPK activation selectively induces cell death in K-ras-mutated human colon cancer cells through regulation of vitamin D receptor
    Xiaomei Qi
    Department of Radiation Oncology, Loyola University of Chicago, Maywood, IL 60153, USA
    J Biol Chem 279:22138-44. 2004
    ..Hence, p38 pathway activation selectively induces cell death in K-ras-mutated human colon cancer cells by mechanisms involving the suppression of VDR activity...
  98. ncbi TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling
    Gang Lu
    Molecular Biology Institute and Department of Anesthesiology and Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Biol Chem 281:6087-95. 2006
    ..These results suggest a previously unknown mechanism for stress-MAP kinase regulation in mammalian cells...
  99. ncbi Vascular smooth muscle cell proliferation requires both p38 and BMK1 MAP kinases
    Ming Zhao
    Division of Pathology II, Faculty of Health Sciences, Linkoping University, Linkoping SE 581 85, Sweden
    Arch Biochem Biophys 400:199-207. 2002
    ..These results may have implications for the future design of pharmacologic agents for inhibition of VSMC growth...
  100. ncbi Nuclear protein NP60 regulates p38 MAPK activity
    Jing Fu
    National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, People s Republic of China
    J Cell Sci 119:115-23. 2006
    ..Our results indicate that NP60 mediates stress activation of p38alpha and regulates p38alpha signaling in a specific way...
  101. ncbi Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3
    Zhenyu Li
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA
    Blood 107:965-72. 2006
    ..Thus, p38 plays an important role in mediating PKG-dependent activation of ERK. These data delineate a novel signaling pathway in which platelet agonists sequentially activate PKG, p38, and ERK pathways leading to integrin activation...

Research Grants26

  1. Macrophage Death and Sepsis
    Jiahuai Han; Fiscal Year: 2006
    ..Our study will also lead to a better understanding of how macrophage apoptosis is controlled, which is needed to develop therapeutically useful strategies to selectively promote or inhibit macrophage death. ..
  2. CELLULAR ACTIVATION MECHANISMS IN SEPTIC SHOCK
    Jiahuai Han; Fiscal Year: 2006
    ..Understanding the mechanisms for bacterial components-induced cellular responses will help to develop therapeutic procedures for the treatment of septic shock. ..
  3. Molecular Mechanisms of Anthrax-Induced Macrophage Death
    Jiahuai Han; Fiscal Year: 2007
    ..The information obtained in this study will be very valuable in developing new strategies for the treatment of anthrax infection. ..
  4. Function of microRNA in pro-inflammatory gene expression
    Jiahuai Han; Fiscal Year: 2007
    ..Understanding the function of miRNA in mRNA stability of pro-inflammatory genes should provide new avenues for developing novel anti-inflammatory agents. ..
  5. Function of microRNA in pro-inflammatory gene expression
    Jiahuai Han; Fiscal Year: 2009
    ..Understanding the function of miRNA in mRNA stability of pro-inflammatory genes should provide new avenues for developing novel anti-inflammatoryagents. ..
  6. Function of microRNA in pro-inflammatory gene expression
    Jiahuai Han; Fiscal Year: 2010
    ..Understanding the function of miRNA in mRNA stability of pro-inflammatory genes should provide new avenues for developing novel anti-inflammatoryagents. ..
  7. CELLULAR ACTIVATION MECHANISMS IN SEPTIC SHOCK
    Jiahuai Han; Fiscal Year: 2001
    ..A combination of biochemical, immunologic and molecular biologic approaches will be used. These studies may lead to new approaches to control the injurious effects of LPS. ..
  8. Macrophage Death and Sepsis
    Jiahuai Han; Fiscal Year: 2003
    ..Our study will also lead to a better understanding of how macrophage apoptosis is controlled, which is needed to develop therapeutically useful strategies to selectively promote or inhibit macrophage death. ..
  9. CELLULAR ACTIVATION MECHANISMS IN SEPTIC SHOCK
    Jiahuai Han; Fiscal Year: 2010
    ..The proposed work will fill in some gaps in our understanding of the cellular activation mechanisms that occur in sepsis, which should provide useful information for developing new treatments for septic shock. ..