Dawn D Han

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc Cocaine reward and locomotion stimulation in mice with reduced dopamine transporter expression
    Michael R Tilley
    Department of Pharmacology The Ohio State University College of Medicine, Columbus, OH, USA
    BMC Neurosci 8:42. 2007
  2. pmc Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs
    Dawn D Han
    Department of Pharmacology, The Ohio State University College of Medicine, USA
    BMC Pharmacol 6:6. 2006
  3. ncbi request reprint Direct evidence that two cysteines in the dopamine transporter form a disulfide bond
    Rong Chen
    Department of Pharmacology, The Ohio State University College of Medicine, 333 West 10th Avenue, Columbus, OH 43210, USA
    Mol Cell Biochem 298:41-8. 2007
  4. pmc Behavior of knock-in mice with a cocaine-insensitive dopamine transporter after virogenetic restoration of cocaine sensitivity in the striatum
    Brian O'Neill
    Department of Pharmacology, The Ohio State University, 333 West 10th Avenue, 5184b Graves Hall, Columbus, OH 43210, USA Neuroscience Graduate Studies Program, The Ohio State University, Columbus, OH 43210, USA
    Neuropharmacology 79:626-33. 2014
  5. pmc Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter
    Rong Chen
    Department of Pharmacology, Ohio State University, 5184b Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 103:9333-8. 2006
  6. pmc Fluorescence-based evaluation of shRNA efficacy
    B J Naughton
    Department of Pharmacology, The Ohio State University College of Medicine, Columbus, OH 43210, USA
    Anal Biochem 417:162-4. 2011
  7. pmc Dopamine transporter inhibition is necessary for cocaine-induced increases in dendritic spine density in the nucleus accumbens
    Bradley J Martin
    Department of Pharmacology, The Ohio State University, Columbus, Ohio 43210, USA
    Synapse 65:490-6. 2011
  8. ncbi request reprint Cause and solutions to the polymerase chain reaction smear problem in genotyping
    Dawn D Han
    Department of Pharmacology, The Ohio State University College of Medicine, 333 West 10th Avenue, Columbus, 43210, USA
    Anal Biochem 353:296-8. 2006
  9. ncbi request reprint Conserved serine residues in serotonin transporter contribute to high-affinity cocaine binding
    Howard H Gu
    Department of Pharmacology, The Ohio State University College of Medicine, 333 West 10th Avenue, Columbus, OH 43210, USA
    Biochem Biophys Res Commun 343:1179-85. 2006
  10. pmc Dopamine transporter gene variant affecting expression in human brain is associated with bipolar disorder
    Julia K Pinsonneault
    Department of Pharmacology, The Ohio State University, Columbus, OH 43210 1239, USA
    Neuropsychopharmacology 36:1644-55. 2011

Collaborators

Detail Information

Publications12

  1. pmc Cocaine reward and locomotion stimulation in mice with reduced dopamine transporter expression
    Michael R Tilley
    Department of Pharmacology The Ohio State University College of Medicine, Columbus, OH, USA
    BMC Neurosci 8:42. 2007
    ..Therefore, the objective of this study is to determine how elevated dopaminergic tone affects how mice respond to cocaine...
  2. pmc Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs
    Dawn D Han
    Department of Pharmacology, The Ohio State University College of Medicine, USA
    BMC Pharmacol 6:6. 2006
    ..In addition, the drug potencies of the 3 monoamine transporters from mouse have not been compared in the same experiments or along side the human transporters. Further studies and systematic comparisons are needed...
  3. ncbi request reprint Direct evidence that two cysteines in the dopamine transporter form a disulfide bond
    Rong Chen
    Department of Pharmacology, The Ohio State University College of Medicine, 333 West 10th Avenue, Columbus, OH 43210, USA
    Mol Cell Biochem 298:41-8. 2007
    ..Our results and previous results are consistent with the notion that the disulfide bond between EL2 cysteines is required for DAT biosynthesis and/or its delivery to the cell surface...
  4. pmc Behavior of knock-in mice with a cocaine-insensitive dopamine transporter after virogenetic restoration of cocaine sensitivity in the striatum
    Brian O'Neill
    Department of Pharmacology, The Ohio State University, 333 West 10th Avenue, 5184b Graves Hall, Columbus, OH 43210, USA Neuroscience Graduate Studies Program, The Ohio State University, Columbus, OH 43210, USA
    Neuropharmacology 79:626-33. 2014
    ..Therefore, the locus or loci underlying cocaine-induced reward remain underdetermined. It is possible that multiple dopamine-related brain regions are involved in producing the robust rewarding effect of cocaine. ..
  5. pmc Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter
    Rong Chen
    Department of Pharmacology, Ohio State University, 5184b Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 103:9333-8. 2006
    ..This mouse model is unique in that it is specifically designed to differentiate the role of DAT from the roles of NET and SERT in cocaine-induced biochemical and behavioral effects...
  6. pmc Fluorescence-based evaluation of shRNA efficacy
    B J Naughton
    Department of Pharmacology, The Ohio State University College of Medicine, Columbus, OH 43210, USA
    Anal Biochem 417:162-4. 2011
    ..We show that software predicted shRNAs have varying efficacies and only 2 of the 7 tested shRNAs significantly knocked down their targets...
  7. pmc Dopamine transporter inhibition is necessary for cocaine-induced increases in dendritic spine density in the nucleus accumbens
    Bradley J Martin
    Department of Pharmacology, The Ohio State University, Columbus, Ohio 43210, USA
    Synapse 65:490-6. 2011
    ..These data show that cocaine-induced increases in dendritic spine density in the NAC require DAT inhibition. Thus, DAT-inhibition may play a role in mediating the long-lasting neural changes associated with drug addiction...
  8. ncbi request reprint Cause and solutions to the polymerase chain reaction smear problem in genotyping
    Dawn D Han
    Department of Pharmacology, The Ohio State University College of Medicine, 333 West 10th Avenue, Columbus, 43210, USA
    Anal Biochem 353:296-8. 2006
  9. ncbi request reprint Conserved serine residues in serotonin transporter contribute to high-affinity cocaine binding
    Howard H Gu
    Department of Pharmacology, The Ohio State University College of Medicine, 333 West 10th Avenue, Columbus, OH 43210, USA
    Biochem Biophys Res Commun 343:1179-85. 2006
    ..Mutations at the corresponding residues in dopamine transporter also changed cocaine affinity. Our results suggest that the conserved serine residues in SERT contribute to high-affinity cocaine binding...
  10. pmc Dopamine transporter gene variant affecting expression in human brain is associated with bipolar disorder
    Julia K Pinsonneault
    Department of Pharmacology, The Ohio State University, Columbus, OH 43210 1239, USA
    Neuropsychopharmacology 36:1644-55. 2011
    ..1, p = 0.03). This result was replicated in a second bipolar/control population (OR = 1.65, p = 0.01), supporting a critical role for DAT regulation in bipolar disorder...
  11. ncbi request reprint A triple mutation in the second transmembrane domain of mouse dopamine transporter markedly decreases sensitivity to cocaine and methylphenidate
    Rong Chen
    Department of Pharmacology, The Ohio State University College of Medicine, Columbus, Ohio, USA
    J Neurochem 94:352-9. 2005
    ..Such functional but cocaine-insensitive DAT mutants can be used to generate a knock-in mouse line to study the role of DAT in cocaine addiction...
  12. ncbi request reprint Molecular cloning and functional characterization of the dopamine transporter from Eloria noyesi, a caterpillar pest of cocaine-rich coca plants
    Rong Chen
    Department of Pharmacology, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, United States
    Gene 366:152-60. 2006
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