Dawn D Han

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi Cocaine reward and locomotion stimulation in mice with reduced dopamine transporter expression
    Michael R Tilley
    Department of Pharmacology The Ohio State University College of Medicine, Columbus, OH, USA
    BMC Neurosci 8:42. 2007
  2. ncbi Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs
    Dawn D Han
    Department of Pharmacology, The Ohio State University College of Medicine, USA
    BMC Pharmacol 6:6. 2006
  3. ncbi Direct evidence that two cysteines in the dopamine transporter form a disulfide bond
    Rong Chen
    Department of Pharmacology, The Ohio State University College of Medicine, 333 West 10th Avenue, Columbus, OH 43210, USA
    Mol Cell Biochem 298:41-8. 2007
  4. ncbi Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter
    Rong Chen
    Department of Pharmacology, Ohio State University, 5184b Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 103:9333-8. 2006
  5. ncbi Fluorescence-based evaluation of shRNA efficacy
    B J Naughton
    Department of Pharmacology, The Ohio State University College of Medicine, Columbus, OH 43210, USA
    Anal Biochem 417:162-4. 2011
  6. ncbi Dopamine transporter inhibition is necessary for cocaine-induced increases in dendritic spine density in the nucleus accumbens
    Bradley J Martin
    Department of Pharmacology, The Ohio State University, Columbus, Ohio 43210, USA
    Synapse 65:490-6. 2011
  7. ncbi Cause and solutions to the polymerase chain reaction smear problem in genotyping
    Dawn D Han
    Department of Pharmacology, The Ohio State University College of Medicine, 333 West 10th Avenue, Columbus, 43210, USA
    Anal Biochem 353:296-8. 2006
  8. ncbi Conserved serine residues in serotonin transporter contribute to high-affinity cocaine binding
    Howard H Gu
    Department of Pharmacology, The Ohio State University College of Medicine, 333 West 10th Avenue, Columbus, OH 43210, USA
    Biochem Biophys Res Commun 343:1179-85. 2006
  9. ncbi Dopamine transporter gene variant affecting expression in human brain is associated with bipolar disorder
    Julia K Pinsonneault
    Department of Pharmacology, The Ohio State University, Columbus, OH 43210 1239, USA
    Neuropsychopharmacology 36:1644-55. 2011
  10. ncbi A triple mutation in the second transmembrane domain of mouse dopamine transporter markedly decreases sensitivity to cocaine and methylphenidate
    Rong Chen
    Department of Pharmacology, The Ohio State University College of Medicine, Columbus, Ohio, USA
    J Neurochem 94:352-9. 2005

Collaborators

Detail Information

Publications11

  1. ncbi Cocaine reward and locomotion stimulation in mice with reduced dopamine transporter expression
    Michael R Tilley
    Department of Pharmacology The Ohio State University College of Medicine, Columbus, OH, USA
    BMC Neurosci 8:42. 2007
    ..Therefore, the objective of this study is to determine how elevated dopaminergic tone affects how mice respond to cocaine...
  2. ncbi Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs
    Dawn D Han
    Department of Pharmacology, The Ohio State University College of Medicine, USA
    BMC Pharmacol 6:6. 2006
    ..In addition, the drug potencies of the 3 monoamine transporters from mouse have not been compared in the same experiments or along side the human transporters. Further studies and systematic comparisons are needed...
  3. ncbi Direct evidence that two cysteines in the dopamine transporter form a disulfide bond
    Rong Chen
    Department of Pharmacology, The Ohio State University College of Medicine, 333 West 10th Avenue, Columbus, OH 43210, USA
    Mol Cell Biochem 298:41-8. 2007
    ..Our results and previous results are consistent with the notion that the disulfide bond between EL2 cysteines is required for DAT biosynthesis and/or its delivery to the cell surface...
  4. ncbi Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter
    Rong Chen
    Department of Pharmacology, Ohio State University, 5184b Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 103:9333-8. 2006
    ..This mouse model is unique in that it is specifically designed to differentiate the role of DAT from the roles of NET and SERT in cocaine-induced biochemical and behavioral effects...
  5. ncbi Fluorescence-based evaluation of shRNA efficacy
    B J Naughton
    Department of Pharmacology, The Ohio State University College of Medicine, Columbus, OH 43210, USA
    Anal Biochem 417:162-4. 2011
    ..We show that software predicted shRNAs have varying efficacies and only 2 of the 7 tested shRNAs significantly knocked down their targets...
  6. ncbi Dopamine transporter inhibition is necessary for cocaine-induced increases in dendritic spine density in the nucleus accumbens
    Bradley J Martin
    Department of Pharmacology, The Ohio State University, Columbus, Ohio 43210, USA
    Synapse 65:490-6. 2011
    ..These data show that cocaine-induced increases in dendritic spine density in the NAC require DAT inhibition. Thus, DAT-inhibition may play a role in mediating the long-lasting neural changes associated with drug addiction...
  7. ncbi Cause and solutions to the polymerase chain reaction smear problem in genotyping
    Dawn D Han
    Department of Pharmacology, The Ohio State University College of Medicine, 333 West 10th Avenue, Columbus, 43210, USA
    Anal Biochem 353:296-8. 2006
  8. ncbi Conserved serine residues in serotonin transporter contribute to high-affinity cocaine binding
    Howard H Gu
    Department of Pharmacology, The Ohio State University College of Medicine, 333 West 10th Avenue, Columbus, OH 43210, USA
    Biochem Biophys Res Commun 343:1179-85. 2006
    ..Mutations at the corresponding residues in dopamine transporter also changed cocaine affinity. Our results suggest that the conserved serine residues in SERT contribute to high-affinity cocaine binding...
  9. ncbi Dopamine transporter gene variant affecting expression in human brain is associated with bipolar disorder
    Julia K Pinsonneault
    Department of Pharmacology, The Ohio State University, Columbus, OH 43210 1239, USA
    Neuropsychopharmacology 36:1644-55. 2011
    ..1, p = 0.03). This result was replicated in a second bipolar/control population (OR = 1.65, p = 0.01), supporting a critical role for DAT regulation in bipolar disorder...
  10. ncbi A triple mutation in the second transmembrane domain of mouse dopamine transporter markedly decreases sensitivity to cocaine and methylphenidate
    Rong Chen
    Department of Pharmacology, The Ohio State University College of Medicine, Columbus, Ohio, USA
    J Neurochem 94:352-9. 2005
    ..Such functional but cocaine-insensitive DAT mutants can be used to generate a knock-in mouse line to study the role of DAT in cocaine addiction...
  11. ncbi Molecular cloning and functional characterization of the dopamine transporter from Eloria noyesi, a caterpillar pest of cocaine-rich coca plants
    Rong Chen
    Department of Pharmacology, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, United States
    Gene 366:152-60. 2006
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