Research Topics
Species | A N HamirSummaryAffiliation: The University of Texas Country: USA Publications
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Detail Information
Publications
PrPSc detection in formalin-fixed paraffin-embedded tissue by ELISAEric M Nicholson
Virus and Prion Research Unit, 1920 Dayton Ave, National Animal Disease Center, USDA, Agricultural Research Service, Ames, Iowa 50010, USA
BMC Res Notes 4:432. 2011..abstract:..- Evaluation of two sets of immunohistochemical and Western blot confirmatory methods in the detection of typical and atypical BSE casesChiara Porcario
CEA, Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d Aosta, Via Bologna 148, 10154, Turin, Italy
BMC Res Notes 4:376. 2011..abstract:.. 
Characterization of a US sheep scrapie isolate with short incubation timeA N Hamir
National Animal Disease Center, ARS, USDA, Ames, IA, USA
Vet Pathol 46:1205-12. 2009..This indicates that inoculum No. x124 appears to induce scrapie in shorter time than inoculum No. 13-7, especially in sheep homozygous or heterozygous for valine at codon 136...- Spontaneous idiopathic arteritis of the testicular artery in raccoons (Procyon lotor)A N Hamir
National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA, USA
Vet Pathol 46:1129-32. 2009..To our knowledge multifocal arteritis confined to the testicular artery has not previously been documented in raccoons... 
Systemic Staphylococcus aureus infection in a free-ranging raccoon (Procyon lotor)Amir N Hamir
Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon 973311, USA
J Wildl Dis 46:665-8. 2010..In this case, S. aureus was obtained as a pure culture, but microscopic examination did not show large numbers of bacterial colonies as seen in other species with such lesions...- Pulmonary idiopathic alveolar ossification in a raccoon (Procyon lotor)Amir N Hamir
Department of Veterinary Medicine and Surgery, MD Anderson Cancer Center, Houston, Texas, USA
J Am Assoc Lab Anim Sci 49:642-3. 2010..The other histopathologic lesions have been documented to occur as incidental findings in raccoons and do not appear to have any apparent association with the formation of osseous foci in the lungs of the animal described... - Recovery from and clearance of rabies virus in a domestic ferretAmir N Hamir
Department of Veterinary Medicine and Surgery Unit 63, MD Anderson Cancer Center, Houston, Texas, USA
J Am Assoc Lab Anim Sci 50:248-51. 2011..Multifocal areas of involvement showed mononuclear cuffing of blood vessels. In a few areas, the cuffing extended to the meninges. Rabies virus antigen was not detected by immunohistochemistry of tissue sections... - Spontaneous lesions in aged captive raccoons (Procyon lotor)Amir N Hamir
National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, Iowa, USA
J Am Assoc Lab Anim Sci 50:322-5. 2011..Therefore, the lesions found in these raccoons from central Iowa may differ from those of other raccoon populations... - Experimental transmission of chronic wasting disease (CWD) from elk and white-tailed deer to fallow deer by intracerebral route: final reportAmir N Hamir
National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, 1920 Dayton Avenue, PO Box 70, Ames, Iowa, USA
Can J Vet Res 75:152-6. 2011..This study demonstrates that intracerebrally inoculated fallow deer not only amplify CWD prions, but also develop lesions of spongiform encephalopathy... - Experimental inoculation of raccoons (Procyon lotor) with Spiroplasma mirum and transmissible mink encephalopathy (TME)Amir N Hamir
National Animal Disease Center, Agricultural Research Service, U S Department of Agriculture, Ames, Iowa 50010, USA
Can J Vet Res 75:18-24. 2011..mirum by polymerase chain reaction (PCR) and for PrP(d) by IHC and WB techniques. The results of this study indicate that Spiroplasma mirum does not induce TSE-like disease in raccoons... - Pathology of neurologic disorders of raccoons (Procyon lotor)Amir N Hamir
National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA, USA
J Vet Diagn Invest 23:873-84. 2011.... - Preliminary observations on the experimental transmission of chronic wasting disease (CWD) from elk and white-tailed deer to fallow deerA N Hamir
National Animal Disease Center, ARS, USDA, 2300 Dayton Avenue, P O Box 70, Ames, IA 50010, USA
J Comp Pathol 138:121-30. 2008..Four years after CWD inoculation, the remaining five inoculated and two control deer are alive and apparently healthy... - Experimental transmission of chronic wasting disease (CWD) of elk (Cervus elaphus nelsoni), white-tailed deer (Odocoileus virginianus), and mule deer (Odocoileus hemionus hemionus) to white-tailed deer by intracerebral routeA N Hamir
National Animal Disease Center, ARS, USDA, 2300 Dayton Avenue, PO Box 70, Ames, IA 50010, USA
Vet Pathol 45:297-306. 2008..However, this observation does not imply that these CWD agents would necessarily behave similarly in other recipient species... - Characterization of a Sarcocystis neurona isolate (SN6) from a naturally infected horse from OregonJ P Dubey
United States Department of Agriculture, Agricultural Research Service, Beltsville Agricultural Research Center, Maryland 20705 2350, USA
J Eukaryot Microbiol 46:500-6. 1999..neurona schizonts and merozoites were found in encephalitic lesions. The parasite in tissue sections of mice reacted with S. neurona-specific antibodies and S. neurona was reisolated from the brain of knockout mice... - Preliminary findings on the experimental transmission of chronic wasting disease agent of mule deer to cattleA N Hamir
National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
J Vet Diagn Invest 13:91-6. 2001..These preliminary findings demonstrate that diagnostic techniques currently used for bovine spongiform encephalopathy (BSE) surveillance would also detect CWD in cattle should it occur naturally... - Polymorphisms of the prion gene promoter region that influence classical bovine spongiform encephalopathy susceptibility are not applicable to other transmissible spongiform encephalopathies in cattleB W Brunelle
Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA, ARS, Ames, IA 50010, USA
J Anim Sci 85:3142-7. 2007..This genetic discrepancy demonstrates that atypical BSE progresses differently in the host relative to classical BSE. These results are consistent with the notion that atypical BSE originates spontaneously in cattle... - Serial passage of sheep scrapie inoculum in Suffolk sheepA N Hamir
National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
Vet Pathol 46:39-44. 2009.... - Characteristics of a recent isolate of Sarcocystis neurona (SN7) from a horse and loss of pathogenicity of isolates SN6 and SN7 by passages in cell cultureJ P Dubey
United States Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Beltsville Agricultural Research Center, MD 20705 2350, USA
Vet Parasitol 95:155-66. 2001..These results suggest that prolonged passage in cell culture may affect the pathogenicity of some isolates of S. neurona... - Susceptibility of cattle to first-passage intracerebral inoculation with chronic wasting disease agent from white-tailed deerA N Hamir
National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
Vet Pathol 44:487-93. 2007..Also, the absence of SE and a distinctive IHC pattern of CWDwtd and CWDmd in cattle suggests that it should be possible to distinguish these conditions from other TSEs that have been experimentally transmitted to cattle... - Retinal function and morphology are altered in cattle infected with the prion disease transmissible mink encephalopathyJ D Smith
Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, Ames, IA, USA
Vet Pathol 46:810-8. 2009..Our results support future efforts to focus on the retina for the development of new strategies for the diagnosis of TSEs... - Experimental transmission of US scrapie agent by nasal, peritoneal, and conjunctival routes to genetically susceptible sheepA N Hamir
National Disease Center, ARS, USDA, Ames, IA 50010, USA
Vet Pathol 45:7-11. 2008..These results indicate that the upper respiratory tract, specifically the pharyngeal tonsil, may serve as a portal of entry for prion protein in scrapie-infected environments... - Use of capillary electrophoresis and fluorescent labeled peptides to detect the abnormal prion protein in the blood of animals that are infected with a transmissible spongiform encephalopathyM J Schmerr
National Animal Disease Center, MWA, ARS, US Department of Agriculture, Ames, IA 50010, USA
J Chromatogr A 853:207-14. 1999..This assay makes a pre-clinical assay possible for these diseases and could be adapted to test for the abnormal prion protein in process materials that are used for manufacture of pharmaceuticals and products for human consumption... - Diagnosis of preclinical and subclinical scrapie in a naturally infected sheep flock utilizing currently available postmortem diagnostic techniquesA N Hamir
National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
J Vet Diagn Invest 13:152-4. 2001..An additional ewe, which did not have histopathologic changes in the brain but was positive by IHC and western blot,was considered a preclinical case of scrapie. None of the sheep had amyloid in the brain stem... - Experimental second passage of chronic wasting disease (CWD(mule deer)) agent to cattleA N Hamir
Agricultural Research Service, United States Department of Agriculture, National Animal Disease Center, 2300 Dayton Avenue, P.O. Box 70, Ames, IA 50010, USA
J Comp Pathol 134:63-9. 2006.... - Second passage of sheep scrapie and transmissible mink encephalopathy (TME) agents in raccoons (Procyon lotor)A N Hamir
National Animal Disease Center, ARS, USDA, 2300 Dayton Avenue, Ames, IA 50010, USA
Vet Pathol 42:844-51. 2005.... - Myocarditis and encephalitis associated with Sarcocystis neurona infection in raccoons (Procyon lotor)A N Hamir
National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
Vet Parasitol 95:335-40. 2001..neurona in the current study is of interest. Pathologists should consider the possible association of S. neurona with myocardial inflammation in other S. neurona susceptible animals... - Experimental inoculation of scrapie and chronic wasting disease agents in raccoons (Procyon lotor)A N Hamir
National Animal Disease Center, ARS, USDA, 2300 Dayton Avenue, PO Box 70, Ames, IA 50010, USA
Vet Rec 153:121-3. 2003 - Idiopathic disseminated intracytoplasmic neuronal vacuolation in a neonatal Holstein calf born in the USAA N Hamir
National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
J Vet Diagn Invest 13:349-51. 2001..These results indicate that the clinical signs in this calf were not associated with transmissible spongiform encephalopathy. Neuronal vacuolation has not previously been documented in calves... - First and second cattle passage of transmissible mink encephalopathy by intracerebral inoculationA N Hamir
National Animal Disease Center, ARS, USDA, 2300 Dayton AvenuePO Box 70, Ames, IA 50010, USA
Vet Pathol 43:118-26. 2006..However, it would be a diagnostic challenge to differentiate TME in cattle from BSE by clinical signs, neuropathology, or the presence of PrP(res) by IHC and WB... - Resistance of cattle to scrapie by the oral routeR C Cutlip
Agricultural Research Service, National Animal Disease Center, United States Department of Agriculture, Ames, Iowa 50010
Can J Vet Res 65:131-2. 2001..This work indicates that cattle are highly resistant to North American scrapie by the oral route... - Retinal cell types are differentially affected in sheep with scrapieJ D Smith
Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50010, USA
J Comp Pathol 138:12-22. 2008..These results demonstrate alterations of immunoreactivity patterns for proteins associated with specific cell types in retinas with PrP(Sc) accumulation, despite an absence of microscopical evidence of retinal degeneration... - Exposure of sheep scrapie brain homogenate to rumen-simulating conditions does not result in a reduction of PrP(Sc) levelsE M Nicholson
Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, Ames, IA 50010, USA
Lett Appl Microbiol 44:631-6. 2007..Experiments were designed to evaluate the potential of rumen-simulating conditions to reduce PrP(Sc) levels... - Abnormal prion protein in ectopic lymphoid tissue in a kidney of an asymptomatic white-tailed deer experimentally inoculated with the agent of chronic wasting diseaseA N Hamir
National Animal Disease Center, ARS, USDA, 2300 Dayton Avenue, PO Box 70, Ames, IA 50010, USA
Vet Pathol 43:367-9. 2006..The demonstration of PrPres in lymphoid tissue in the kidney of this deer corroborates a recently published finding of PrPres in lymphoid follicles of organs other than CNS and lymphoid tissues in laboratory animals with TSE (scrapie)... - Abnormal prion accumulation associated with retinal pathology in experimentally inoculated scrapie-affected sheepJ J Greenlee
Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA Agricultural Research Service, 2300 Dayton Ave, Ames, IA 50010, USA
Vet Pathol 43:733-9. 2006..This is the first report of a prion disease in a natural host that describes the accumulation of PrP(Sc) in retina associated with retinal pathology in the absence of overt morphologic changes indicative of retinal degeneration... - Failure to detect prion protein (PrPres) by immunohistochemistry in striated muscle tissues of animals experimentally inoculated with agents of transmissible spongiform encephalopathyA N Hamir
National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, 2300 Dayton Avenue, PO Box 70, Ames, IA 50010, USA
Vet Pathol 41:78-81. 2004..Further testing of muscle tissues is needed to confirm the findings of the present study... - Naturally occurring spirochetes in the colonic mucosa of raccoons (Procyon lotor)A N Hamir
National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
Vet Pathol 38:233-6. 2001..5 microm in diameter). The slender spirochete did not resemble any of the known spirochete genera and failed to grow on medium used to propagate oral treponemes and members of the genus Brachyspira... - Cartilaginous metaplasia in the sclera of Suffolk sheepJ D Smith
Virus and Prion Research Unit, USDA ARS National Animal Disease Center, 1920 Dayton Avenue, PO Box 70, Ames, IA 50010, USA
Vet Pathol 48:827-9. 2011..7% of eyes examined, respectively. The clinical significance of this previously unreported finding is unknown... - Preliminary observations on the experimental transmission of scrapie to elk (Cervus elaphus nelsoni) by intracerebral inoculationA N Hamir
National Animal Disease Center, Agricultural Research Service, United States Department of Agricultural, Ames, IA 50010, USA
Vet Pathol 40:81-5. 2003.... - Diagnostic exercise: astrocytoma with involvement of medulla oblongata, spinal cord, and spinal nerves in a raccoon (Procyon lotor)A N Hamir
College of Veterinary Medicine, Oregon State University, Corvallis, OR, USA
Vet Pathol 45:949-51. 2008..This appears to be the only reported case of astrocytoma that involved multiple anatomic sites in the central nervous system of this raccoon... - Campylobacter jejuni and Arcobacter species associated with intussusception in a raccoon (Procyon lotor)A N Hamir
National Animal Disease Center, ARS, USDA, 2300 Dayton Road, Ames, IA 50010, USA
Vet Rec 155:338-40. 2004 - Sarcocystis neurona infections in raccoons (Procyon lotor): evidence for natural infection with sarcocysts, transmission of infection to opossums (Didelphis virginiana), and experimental induction of neurologic disease in raccoonsJ P Dubey
United States Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Parasite Biology, Epidemiology and Systematics Laboratory, Building 1001, Beltsville, MD 20705 2350, USA
Vet Parasitol 100:117-29. 2001..neurona-associated encephalomyelitis was found in raccoons killed 14 and 22 days after feeding sporocysts; schizonts and merozoites were seen in encephalitic lesions... - Cerebral larva migrans in a raccoon (Procyon lotor)A N Hamir
National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA 50010, USA
Vet Pathol 36:618-20. 1999..Morphologic characteristics indicated that the nematode was an ascarid larva. However, it was smaller than the larva of Baylisascaris sp. This appears to be the first documented case of cerebral larva migrans in a raccoon... - Acute fatal toxoplasmosis in squirrels (Sciurus carolensis) with bradyzoites in visceral tissuesJ P Dubey
United States Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Animal Parasitic Diseases Laboratory, Beltsville, Maryland 20705 2350, USA
J Parasitol 92:658-9. 2006..Tissue cysts were seen in several organs, including lung alveoli. The presence of tissue cysts in alveoli of pet squirrels maybe of public health concern if tissue cysts excreted in nasal secretions are swallowed by children... - Granulomatous orchitis associated with Histoplasma-like organisms in porcupines (Erethizon dorsatum)A N Hamir
National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
Vet Rec 150:251-2. 2002 - Preclinical diagnosis of scrapie by immunohistochemistry of third eyelid lymphoid tissueK I O'Rourke
Animal Disease Research Unit, Animal Research Service, U S Department of Agriculture, College of Veterinary Medicine, Washington State University, Pullman 99164 6630, USA
J Clin Microbiol 38:3254-9. 2000..Immunohistochemistry assay of routinely formalin-fixed lymphoid tissues with a cocktail of pan-specific MAbs is a practical, readily standardized live-animal and preclinical test for ovine scrapie...