S R Hamilton

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. doi request reprint Molecular pathology
    Stanley R Hamilton
    Division of Pathology and Laboratory Medicine, Department of Pathology, Unit 085, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mol Oncol 6:177-81. 2012
  2. doi request reprint Targeted therapy of cancer: new roles for pathologists in colorectal cancer
    Stanley R Hamilton
    Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 21:S23-30. 2008
  3. ncbi request reprint Colon cancer testing and screening
    S R Hamilton
    Division of Pathology and Laboratory Medicine, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Arch Pathol Lab Med 123:1027-9. 1999
  4. pmc Histopathological identification of colon cancer with microsatellite instability
    J Alexander
    Department of Pathology, Division of Gastrointestinal Liver Pathology, The Johns Hopkins University School of Medicine and Hospital, Baltimore, Maryland, USA
    Am J Pathol 158:527-35. 2001
  5. pmc Genetic alterations in Barrett esophagus and adenocarcinomas of the esophagus and esophagogastric junction region
    T T Wu
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    Am J Pathol 153:287-94. 1998
  6. doi request reprint MicroRNAs, ultraconserved genes and colorectal cancers
    Simona Rossi
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Biochem Cell Biol 42:1291-7. 2010
  7. pmc The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesis
    Imad Shureiqi
    Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Cancer Res 65:11486-92. 2005
  8. pmc Improving signal intensities for genes with low-expression on oligonucleotide microarrays
    Latha Ramdas
    Department of Pathology, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    BMC Genomics 5:35. 2004
  9. pmc Association of microRNA expression with microsatellite instability status in colorectal adenocarcinoma
    Jonathan S L Earle
    Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, 8515 Fannin St, NAO1 061a, Houston, Texas 77054, USA
    J Mol Diagn 12:433-40. 2010
  10. ncbi request reprint Analysis of dose-response effects on gene expression data with comparison of two microarray platforms
    Jianhua Hu
    Department of Biostatistics and Applied Mathematics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Bioinformatics 21:3524-9. 2005

Detail Information

Publications86

  1. doi request reprint Molecular pathology
    Stanley R Hamilton
    Division of Pathology and Laboratory Medicine, Department of Pathology, Unit 085, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mol Oncol 6:177-81. 2012
    ..This brief review addresses some of the specific roles of molecular pathology in that continuum...
  2. doi request reprint Targeted therapy of cancer: new roles for pathologists in colorectal cancer
    Stanley R Hamilton
    Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 21:S23-30. 2008
    ..Clinical trials driven by molecular targets and agents directed against them, and understanding of the conflicting data on utility of markers reported in the literature, are needed to advance the field...
  3. ncbi request reprint Colon cancer testing and screening
    S R Hamilton
    Division of Pathology and Laboratory Medicine, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Arch Pathol Lab Med 123:1027-9. 1999
    ..It seems certain that molecular methods will become increasingly important in improving the outcome of patients with colorectal neoplasia and in contributing to continued decline of the death rate from this common cancer...
  4. pmc Histopathological identification of colon cancer with microsatellite instability
    J Alexander
    Department of Pathology, Division of Gastrointestinal Liver Pathology, The Johns Hopkins University School of Medicine and Hospital, Baltimore, Maryland, USA
    Am J Pathol 158:527-35. 2001
    ..Our findings indicate that histopathological evaluation can be used to prioritize sporadic colon cancers for MSI studies, but morphological prediction of MSI-H has low sensitivity, requiring molecular analysis for therapeutic decisions...
  5. pmc Genetic alterations in Barrett esophagus and adenocarcinomas of the esophagus and esophagogastric junction region
    T T Wu
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    Am J Pathol 153:287-94. 1998
    ..Allelic loss of both 17p and 18q in esophageal adenocarcinoma identifies patients with poor prognosis...
  6. doi request reprint MicroRNAs, ultraconserved genes and colorectal cancers
    Simona Rossi
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Biochem Cell Biol 42:1291-7. 2010
    ....
  7. pmc The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesis
    Imad Shureiqi
    Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Cancer Res 65:11486-92. 2005
    ..Therefore, 15-LOX-1 down-regulation rather than a shift in the balance of LOXs is likely the dominant alteration in LOX metabolism which contributes to colorectal tumorigenesis by repressing apoptosis...
  8. pmc Improving signal intensities for genes with low-expression on oligonucleotide microarrays
    Latha Ramdas
    Department of Pathology, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    BMC Genomics 5:35. 2004
    ..We evaluated the effects of oligonucleotide probe length and concentration on signal intensity measurements of the expression levels of genes in a target sample...
  9. pmc Association of microRNA expression with microsatellite instability status in colorectal adenocarcinoma
    Jonathan S L Earle
    Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, 8515 Fannin St, NAO1 061a, Houston, Texas 77054, USA
    J Mol Diagn 12:433-40. 2010
    ....
  10. ncbi request reprint Analysis of dose-response effects on gene expression data with comparison of two microarray platforms
    Jianhua Hu
    Department of Biostatistics and Applied Mathematics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Bioinformatics 21:3524-9. 2005
    ..A specific challenge is to detect genes with expression levels that change according to dose levels in a non-random manner, but nonetheless may be considered as potential biomarkers...
  11. pmc Expression of gastric pyloric mucin, MUC6, in colorectal serrated polyps
    Angela N Bartley
    Department of Pathology, University of Arizona, Tucson, AZ, USA
    Mod Pathol 23:169-76. 2010
    ..We conclude that MUC6 expression is strongly associated with proximal location of serrated polyps, but only has modest utility as a tissue biomarker for sessile serrated adenoma...
  12. ncbi request reprint Robust estimation of protein expression ratios with lysate microarray technology
    Cristian Mircean
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, USA
    Bioinformatics 21:1935-42. 2005
    ..This study aims to develop suitable algorithms that yield accurate representations of the relative expression levels in different samples from multiple data points...
  13. pmc Concordant DNA methylation in synchronous colorectal carcinomas
    Kazuo Konishi
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 2:814-22. 2009
    ..Screening for and secondary prevention of colon cancer should take this fact into account...
  14. ncbi request reprint Transcriptional activation of the carboxylesterase 2 gene by the p53 pathway
    Woonyoung Choi
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Biol Ther 5:1450-6. 2006
    ..In addition, the degree of homology in the p53-binding element may determine the strength of p53 regulation...
  15. ncbi request reprint Apoptotic response to 5-fluorouracil treatment is mediated by reduced polyamines, non-autocrine Fas ligand and induced tumor necrosis factor receptor 2
    Wei Zhang
    Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas, M D Anderson Cancer Center Houston, Texas USA
    Cancer Biol Ther 2:572-8. 2003
    ....
  16. pmc Data extraction from composite oligonucleotide microarrays
    Ilya Shmulevich
    Cancer Genomics Laboratory, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 85, Houston, TX 77030, USA
    Nucleic Acids Res 31:e36. 2003
    ..We propose a novel approach to design so-called composite microarrays, which allow more replicates to be obtained without increasing the number of printed spots...
  17. pmc Concordant CpG island methylation in hyperplastic polyposis
    Annie On On Chan
    Department of Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4095, USA
    Am J Pathol 160:529-36. 2002
    ..The hypermethylator phenotype is related to patient-specific factors, such as carcinogenic exposure or genetic predisposition...
  18. pmc Molecular predictors of survival after adjuvant chemotherapy for colon cancer
    T Watanabe
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, USA
    N Engl J Med 344:1196-206. 2001
    ....
  19. pmc Sources of nonlinearity in cDNA microarray expression measurements
    L Ramdas
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Genome Biol 2:RESEARCH0047. 2001
    ....
  20. pmc CpG island methylation in colorectal adenomas
    A Rashid
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4095, USA
    Am J Pathol 159:1129-35. 2001
    ..Methylation is distinct from microsatellite instability and develops in individual adenomas rather than resulting from a field defect in an individual patient...
  21. pmc Genetic alterations in hepatocellular carcinomas: association between loss of chromosome 4q and p53 gene mutations
    A Rashid
    Department of Pathology, The Johns Hopkins Oncology Center, The John Hopkins School of Medicine, Baltimore, MD 21205 2196, USA
    Br J Cancer 80:59-66. 1999
    ..01). These data indicate a possible interaction between p53 gene mutation and 4q loss in the pathogenesis of HCC...
  22. ncbi request reprint RNA amplification strategies for cDNA microarray experiments
    J Wang
    University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Biotechniques 34:394-400. 2003
    ..When the critical issue is the amount of starting RNA, we recommend the conventional second-strand cDNA synthesis as the preferred amplification method...
  23. ncbi request reprint MGMT promoter methylation and field defect in sporadic colorectal cancer
    Lanlan Shen
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 97:1330-8. 2005
    ..The DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) is frequently methylated in colorectal cancer. We hypothesized that MGMT methylation could be one of the mediators of field cancerization in the colon mucosa...
  24. pmc BRAF mutations in aberrant crypt foci and hyperplastic polyposis
    Robyn Beach
    Department of Pathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030 4095, USA
    Am J Pathol 166:1069-75. 2005
    ..Our study shows that BRAF mutation status is heterogeneous among patients with multiple/large HPs and/or hyperplastic polyposis, suggesting differences in pathogenesis of HPs that indicate subsets within this phenotype...
  25. ncbi request reprint Inactivation of IkappaB contributes to transcriptional activation of spermidine/spermine N(1)-acetyltransferase
    Woonyoung Choi
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Mol Carcinog 45:685-93. 2006
    ..Further, dominant negative IkappaB attenuated the CHX and DENSPM-induced SSAT expression and mitochondria damage. These results taken together suggest that the inhibition of IkappaB and activation of NFkappaB activate SSAT...
  26. ncbi request reprint Frequent CpG island methylation in precursor lesions and early gastric adenocarcinomas
    Jae Hyuk Lee
    Department of Pathology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 23:4646-54. 2004
    ..Methylation of the p16 gene may contribute to the malignant transformation of gastric precursor lesions...
  27. pmc CpG island methylation in aberrant crypt foci of the colorectum
    Annie On On Chan
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4095, USA
    Am J Pathol 160:1823-30. 2002
    ....
  28. pmc Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer
    Lanlan Shen
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, TX 77030
    Proc Natl Acad Sci U S A 104:18654-9. 2007
    ..Together, our integrated genetic and epigenetic analysis reveals that colon cancers correspond to three molecularly distinct subclasses of disease...
  29. pmc Frequent CpG island methylation in serrated adenomas of the colorectum
    Seun Ja Park
    Department of Pathology, University of Texas, M D Anderson Cancer Center, Houston, Texas 77030 4095, USA
    Am J Pathol 162:815-22. 2003
    ..Our results indicate that CpG island methylation is common in sporadic serrated adenomas and may play an important role in their pathogenesis...
  30. pmc Association between DNA methylation and shortened survival in patients with advanced colorectal cancer treated with 5-fluorouracil based chemotherapy
    Lanlan Shen
    The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 13:6093-8. 2007
    ..We sought to determine the prognostic significance of CIMP in advanced colorectal cancer patients treated with 5-fluorouracil (5-FU) in an Eastern Cooperative Oncology Group clinical trial...
  31. ncbi request reprint Cancer genomics: promises and complexities
    W Zhang
    Cancer Genomics and Proteomics Program, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 7:2159-67. 2001
    ..In this article, we review some of the developments pertinent to cancer research, discuss potentially problematic areas associated with them, and comment on future trends and issues...
  32. pmc Sporadic fundic gland polyps: common gastric polyps arising through activating mutations in the beta-catenin gene
    S C Abraham
    Department of Pathology, Division of Gastroenterology, The Johns Hopkins University School of Medicine, Ross Building, Room 632, 720 Rutland Ave, Baltimore, MD 21205 2196, USA
    Am J Pathol 158:1005-10. 2001
    ..Sporadic FGPs are therefore the only lesions of the gastrointestinal tract to demonstrate beta-catenin mutations while lacking dysplastic morphology...
  33. ncbi request reprint Phenotype of microsatellite-stable colorectal carcinomas with CpG island methylation
    Lucian R Chirieac
    Department of Pathology, Division of Pathology and Laboratory Medicine, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Surg Pathol 29:429-36. 2005
    ..5, P = 0.03). Our epigenotype-phenotype correlation study shows that microsatellite-stable CRC with CpG island methylation have a distinctive pathologic phenotype with both similarities to and differences from MSI-H tumors...
  34. pmc Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells
    Quan Lin
    Division of Pathology and Laboratory Medicine, Box 72, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Am J Pathol 167:969-80. 2005
    ..Our findings illustrate the biological importance of JAK3/STAT3 activation in the oncogenesis of colon cancer and provide novel evidence that JAK3 is expressed and contributes to STAT3 activation in this malignant neoplasm...
  35. ncbi request reprint Differing DNA methylation patterns and gene mutation frequencies in colorectal carcinomas from Middle Eastern countries
    Annie O Chan
    Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Cancer Res 11:8281-7. 2005
    ..International differences in molecular pathology have not been studied extensively but have implications for the management of patients in different countries and of immigrant patients...
  36. pmc Combination of 5-fluorouracil and N1,N11-diethylnorspermine markedly activates spermidine/spermine N1-acetyltransferase expression, depletes polyamines, and synergistically induces apoptosis in colon carcinoma cells
    Woonyoung Choi
    Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 280:3295-304. 2005
    ..Our findings demonstrate the importance of the polyamine pathway in 5-FU effects and suggest that the combination of 5-FU with DENSPM has potential for development as therapy for colorectal carcinoma...
  37. pmc Microsatellite instability in the peripheral blood leukocytes of HNPCC patients
    Mary I Coolbaugh-Murphy
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Hum Mutat 31:317-24. 2010
    ....
  38. ncbi request reprint Prognostic significance of CpG island methylator phenotype and microsatellite instability in gastric carcinoma
    Changhyeok An
    Department of Pathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4096
    Clin Cancer Res 11:656-63. 2005
    ..The aim of this study was to evaluate the prognostic value of the CpG island methylator phenotype (CIMP) and microsatellite instability (MSI) in gastric cancer...
  39. ncbi request reprint Mucinous and nonmucinous appendiceal adenocarcinomas: different clinicopathological features but similar genetic alterations
    Wareef Kabbani
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, USA
    Mod Pathol 15:599-605. 2002
    ..0002). Our findings suggest that mucinous and nonmucinous carcinomas of appendix have similar genetic alterations, but different clinical presentation and prognosis...
  40. doi request reprint Expression of MAP4K4 is associated with worse prognosis in patients with stage II pancreatic ductal adenocarcinoma
    John J Liang
    Department of Pathology, The University of Texas M D Anderson Cancer, Houston, TX 77030, USA
    Clin Cancer Res 14:7043-9. 2008
    ..MAP4K4 plays an important role in transformation, invasiveness, adhesion, and cell migration. However, the expression of MAP4K4 and its significance in pancreatic ductal adenocarcinoma (PDA) has not been studied...
  41. ncbi request reprint Expression of annexin A1 in esophageal and esophagogastric junction adenocarcinomas: association with poor outcome
    Kim L Wang
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Clin Cancer Res 12:4598-604. 2006
    ..However, the role of ANXA1 in esophageal adenocarcinoma is unclear. Our goal was to evaluate ANXA1 expression and determine its prognostic significance in adenocarcinoma of the esophagus and esophagogastric junction...
  42. ncbi request reprint The significance of neuroendocrine differentiation in adenocarcinoma of the esophagus and esophagogastric junction after preoperative chemoradiation
    Kim L Wang
    Departments of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 107:1467-74. 2006
    ....
  43. ncbi request reprint Expression of activated platelet-derived growth factor receptor in stromal cells of human colon carcinomas is associated with metastatic potential
    Yasuhiko Kitadai
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230 1429, USA
    Int J Cancer 119:2567-74. 2006
    ..In conclusion, the expression of PDGF-Rbeta in stromal cells is influenced by the organ-specific microenvironment and is associated with metastatic potential...
  44. pmc Inverse relationship between APC gene mutation in gastric adenomas and development of adenocarcinoma
    Jae Hyuk Lee
    Department of Pathology, MD Anderson Cancer Center, Houston, Texas 77030, USA
    Am J Pathol 161:611-8. 2002
    ..Gastric adenomas or dysplasias without APC mutations but with or without MSI may have a different biological behavior, and are precursors of intestinal-type of gastric adenocarcinomas...
  45. ncbi request reprint SOX9 is required for the differentiation of paneth cells in the intestinal epithelium
    Yuko Mori-Akiyama
    Department of Molecular Geneticsm, The University of Texas, M D Anderson Cancer Center, Houston, Texas, USA
    Gastroenterology 133:539-46. 2007
    ..In the intestine, Sox9 is expressed in the epithelial cells of the crypts and is a target of Wnt signaling...
  46. ncbi request reprint Activation of polyamine catabolism by N1, N11-diethylnorspermine alters the cellular localization of mTOR and downregulates mTOR protein level in glioblastoma cells
    Rongcai Jiang
    Department of Pathology, The University of Texas, MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Biol Ther 6:1644-8. 2007
    ..We conclude that the activation of polyamine catabolism alters the cellular location of mTOR, thus negatively affecting mTOR-mediated protein synthesis and leading to the death of glioblastoma cells...
  47. pmc Contrasting molecular pathology of colorectal carcinoma in Egyptian and Western patients
    A S Soliman
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Br J Cancer 85:1037-46. 2001
    ..Our findings show that the molecular pathology of colorectal cancer in older as well as younger Egyptians has unique differences from Western patients, and schistosomiasis influences the molecular pathogenesis of some tumours...
  48. ncbi request reprint Monitoring of cDNA microarray with common primer target and hybridization specificity with selected targets
    L Hu
    The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Biotechniques 32:528, 530-2, 534. 2002
    ..Hence, hybridization specificity was demonstrated by obtaining fluorescent signals solely from the genes corresponding to the target...
  49. ncbi request reprint Sulindac suppresses tumorigenesis in the Min mouse
    Y Beazer-Barclay
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Carcinogenesis 17:1757-60. 1996
    ..The conservation of sulindac activity in the Min mouse provides an opportunity to explore the mechanism of sulindac suppression as well as to test other potential chemopreventive agents...
  50. ncbi request reprint Significance of the depth of tumor invasion and lymph node metastasis in superficially invasive (T1) esophageal adenocarcinoma
    Lixia Liu
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Surg Pathol 29:1079-85. 2005
    ....
  51. ncbi request reprint Analysis of signaling pathways in 90 cancer cell lines by protein lysate array
    Kanchana Natarajan Mendes
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Proteome Res 6:2753-67. 2007
    ..Another important issue is whether and how transduction signaling molecules are heterogeneously expressed and activated in different cancer cells within and between cancer cell types...
  52. ncbi request reprint Allelic alterations in pancreatic endocrine tumors identified by genome-wide single nucleotide polymorphism analysis
    Yasuhiko Nagano
    Department of Pathology, MD Anderson Cancer Center, The University of Texas, 1515 Holcombe Boulevard, Box 85, Houston, Texas 77030 4095, USA
    Endocr Relat Cancer 14:483-92. 2007
    ..4 +/- 3.1 cm compared with 2.3 +/- 1.3 cm for low AI (P = 0.03). Our study shows that genome-wide allelotyping is a powerful new tool for the analysis of AI in PETs...
  53. ncbi request reprint P14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53
    Lanlan Shen
    Department of Leukemia, The University of Texas at M D Anderson Cancer Center, Houston, Texas 77030, USA
    Gastroenterology 124:626-33. 2003
    ..The p14 (ARF) gene on chromosome 9p is deleted and/or silenced by hypermethylation in a subset of human malignancies. There is evidence suggesting that p14 suppresses tumorigenicity by stabilizing the p53 protein...
  54. ncbi request reprint CpG island methylation in carcinoid and pancreatic endocrine tumors
    Annie On On Chan
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Oncogene 22:924-34. 2003
    ..03). Loss of p16 protein expression correlated with methylation of p16 gene in carcinoid tumors (p = 0.006). Our study indicates that methylation profile of carcinoid tumors differs from PETs, reflecting different molecular pathogenesis...
  55. pmc Intratumoral heterogeneity for expression of tyrosine kinase growth factor receptors in human colon cancer surgical specimens and orthotopic tumors
    Toshio Kuwai
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Pathol 172:358-66. 2008
    ..This heterogeneity in receptor expression among different tumor cells suggests that targeting a single tyrosine kinase may not yield eradication of the disease...
  56. pmc Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma
    Yutaka Suehiro
    Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Cancer Res 14:2560-9. 2008
    ....
  57. doi request reprint The previously undescribed ZKSCAN3 (ZNF306) is a novel "driver" of colorectal cancer progression
    Lin Yang
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 68:4321-30. 2008
    ..Thus, the hitherto uncharacterized ZKSCAN3 adds to an expanding set of encoded products contributing to the progression of colorectal cancer...
  58. pmc Sporadic fundic gland polyps with epithelial dysplasia : evidence for preferential targeting for mutations in the adenomatous polyposis coli gene
    Susan C Abraham
    Department of Pathology, Division of Gastrointestinal Liver Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Pathol 161:1735-42. 2002
    ..The lack of microsatellite instability in FGPs in this study and of K-ras mutations in a previous study suggests that secondary genetic alterations are rare in both dysplastic and nondysplastic FGPs...
  59. doi request reprint Proteasome-mediated degradation and functions of hematopoietic progenitor kinase 1 in pancreatic cancer
    Hua Wang
    Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 69:1063-70. 2009
    ..Thus, HPK1 may function as a novel tumor suppressor and its loss plays a critical role in pancreatic cancer...
  60. doi request reprint NGAL decreases E-cadherin-mediated cell-cell adhesion and increases cell motility and invasion through Rac1 in colon carcinoma cells
    Limei Hu
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Lab Invest 89:531-48. 2009
    ..NGAL may therefore be a new target for therapeutic intervention in colorectal carcinoma...
  61. pmc Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil-based adjuvant therapy in colon cancer
    Daniel J Sargent
    Division of Biomedical Statistics and Informatics, Department of Pathology, Mayo Clinic, Rochester, MN 55905, USA
    J Clin Oncol 28:3219-26. 2010
    ..We examined MMR status as a predictor of adjuvant therapy benefit in patients with stages II and III colon cancer...
  62. ncbi request reprint Tyrosine kinase receptor RON in human pancreatic cancer: expression, function, and validation as a target
    E Ramsay Camp
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 109:1030-9. 2007
    ..It was hypothesized that RON, a tyrosine kinase receptor related to c-MET, would be expressed in human pancreatic cancer cells, induce EMT, and would thus serve as a target for therapy in a preclinical model...
  63. ncbi request reprint Comparison of epigenetic and genetic alterations in mucinous cystic neoplasm and serous microcystic adenoma of pancreas
    Sang Geol Kim
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4095, USA
    Mod Pathol 16:1086-94. 2003
    ..The differences in genetic alterations but not epigenetic alterations may explain the pathogenesis and progression to malignancy of these cystic tumors of pancreas...
  64. ncbi request reprint Loss of chromosome 18q and DPC4 (Smad4) mutations in appendiceal adenocarcinomas
    Dipen Maru
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 23:859-64. 2004
    ..The presence of chromosome 18q loss and DPC4 mutations in appendiceal adenocarcinomas suggests involvement of DPC4 and nearby genes on chromosome 18q (DCC and/or JV-18) in the pathogenesis of appendiceal adenocarcinomas...
  65. pmc Induction of apoptosis in tumor-associated endothelial cells and therapy of orthotopic human pancreatic carcinoma in nude mice
    Kenji Yokoi
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Neoplasia 7:696-704. 2005
    ....
  66. ncbi request reprint Dual inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation by AEE788 reduces growth and metastasis of human colon carcinoma in an orthotopic nude mouse model
    Kenji Yokoi
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77230 1429, USA
    Cancer Res 65:3716-25. 2005
    ....
  67. ncbi request reprint Serum amyloid A as a tumor marker in sera of nude mice with orthotopic human pancreatic cancer and in plasma of patients with pancreatic cancer
    Kenji Yokoi
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Oncol 27:1361-9. 2005
    ..Although SAA is not specific for pancreatic cancer and not sensitive enough to detect stage I patients, it may be a candidate biomarker for detecting and monitoring the progressive growth of pancreatic cancer...
  68. ncbi request reprint Epigenetic alterations in neuroendocrine tumors: methylation of RAS-association domain family 1, isoform A and p16 genes are associated with metastasis
    Lixia Liu
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 18:1632-40. 2005
    ..044). Our study shows that in neuroendocrine tumors epigenetic alterations vary by tumor subsite and clinicopathologic features, including age of onset, histopathologic type and metastasis status...
  69. ncbi request reprint Reduced expression of cytokeratin 20 in colorectal carcinomas with high levels of microsatellite instability
    David K McGregor
    Departments of Pathology and Hematopathology, Division of Pathology and Laboratory Medicine, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Surg Pathol 28:712-8. 2004
    ..Our results also indicate that regulation of CK20 gene expression involves molecular pathways that are altered by MSI-H...
  70. ncbi request reprint The number of lymph nodes with metastasis predicts survival in patients with esophageal or esophagogastric junction adenocarcinoma who receive preoperative chemoradiation
    Yan Gu
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 106:1017-25. 2006
    ..However, the prognostic significance of the number of LNs with residual metastasis remains unclear...
  71. ncbi request reprint Overexpression of caspase-3 in hepatocellular carcinomas
    Rajendra Persad
    Department of Pathology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030 4095, USA
    Mod Pathol 17:861-7. 2004
    ..01). Caspase-3 overexpression in HCCs by immunohistochemistry was associated with serum alpha-fetoprotein (AFP) levels (P=0.01). In conclusion, caspase-3 is frequently overexpressed in HCCs and is associated with high serum levels of AFP...
  72. ncbi request reprint Genetic alterations in goblet cell carcinoids of the vermiform appendix and comparison with gastrointestinal carcinoid tumors
    Mirela Stancu
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mod Pathol 16:1189-98. 2003
    ..These findings suggest that allelic loss of chromosomes 11q, 16q, and 18q in goblet cell carcinoids and ileal carcinoids may have an important role in the pathogenesis of these tumors...
  73. ncbi request reprint Identification of combination gene sets for glioma classification
    Seungchan Kim
    Department of Electrical Engineering, Texas A and M University, College Station, Texas 77840, USA
    Mol Cancer Ther 1:1229-36. 2002
    ..Two-gene and three-gene combinations thus provide robust classifiers possessing the potential to translate expression microarray results into diagnostic histopathological assays for clinical utilization...
  74. ncbi request reprint Stool DNA and occult blood testing for screen detection of colorectal neoplasia
    David A Ahlquist
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Intern Med 149:441-50, W81. 2008
    ..Stool DNA testing is a new approach to colorectal cancer detection. Few data are available from the screening setting...
  75. ncbi request reprint Detection of APC mutations in fecal DNA from patients with colorectal tumors
    Giovanni Traverso
    Graduate Program in Human Genetics, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins School of Medicine, Baltimore, USA
    N Engl J Med 346:311-20. 2002
    ..The purpose of our study was to determine the feasibility of detecting APC mutations in fecal DNA with the use of newly developed methods...
  76. pmc Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer
    Christine M Ribic
    Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Toronto
    N Engl J Med 349:247-57. 2003
    ..We investigated the usefulness of microsatellite-instability status as a predictor of the benefit of adjuvant chemotherapy with fluorouracil in stage II and stage III colon cancer...
  77. ncbi request reprint Differing molecular pathology of pancreatic adenocarcinoma in Egyptian and United States patients
    Amr S Soliman
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
    Int J Cancer 119:1455-61. 2006
    ..Our study identifies that there are differences in the types of mutations found in tumors from pancreatic carcinoma patients in Egypt and the US, and suggests that environmental factors may explain these differences...
  78. ncbi request reprint Will identifying or targeting altered marker expression in response to cytotoxic therapy be of prognostic or therapeutic value?
    Christopher H Crane
    J Clin Oncol 21:3381-2. 2003
  79. ncbi request reprint Detection of proximal colorectal cancers through analysis of faecal DNA
    Giovanni Traverso
    Lancet 359:403-4. 2002
    ..Using a sensitive method for microsatellite mutation detection, we found that 18 of 46 cancers had microsatellite alterations and that identical mutations could be identified in the faecal DNA of 17 of these 18 cases...
  80. ncbi request reprint Oral contraceptives and polyp regression in familial adenomatous polyposis
    Francis M Giardiello
    Department of Medicine, The Johns Hopkins University School f Medicine, Baltimore, MD 21205, USA
    Gastroenterology 128:1077-80. 2005
    ..This report represents the regression of colorectal adenomas with the use of estrogen/progesterone compounds...
  81. pmc Primary chemoprevention of familial adenomatous polyposis with sulindac
    Francis M Giardiello
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA
    N Engl J Med 346:1054-9. 2002
    ..Nonsteroidal antiinflammatory drugs can cause regression of adenomas, but whether they can prevent adenomas is unknown...
  82. pmc Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability
    Asad Umar
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Natl Cancer Inst 96:261-8. 2004
    ....
  83. pmc Prostanoids, ornithine decarboxylase, and polyamines in primary chemoprevention of familial adenomatous polyposis
    Francis M Giardiello
    Department of Medicine, and Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Gastroenterology 126:425-31. 2004
    ..The usefulness of colorectal mucosal compounds to predict the effect on adenoma development of primary chemoprevention with the nonsteroidal anti-inflammatory drug sulindac was evaluated...
  84. ncbi request reprint Expressions of two adenomatous polyposis coli and E-cadherin proteins on human colorectal cancers
    Koh Furuta
    Department of Clinical Chemistry and Laboratory Medicine, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, 104 0045, Tokyo, Japan
    Virchows Arch 442:266-70. 2003
    ..This suggests that the normal APC and E-cadherin protein expressions in benign epithelium are progressively and independently lost in the sporadic colorectal cancers...
  85. pmc Associations of Ki-ras proto-oncogene mutation and p53 gene overexpression in sporadic colorectal adenomas with demographic and clinicopathologic characteristics
    Janine G Einspahr
    Department of Medicine, Arizona Cancer Center, P O Box 245024, Tucson, AZ 85724, USA
    Cancer Epidemiol Biomarkers Prev 15:1443-50. 2006
    ....
  86. ncbi request reprint Differences in K-ras and p53 gene mutations among pancreatic adenocarcinomas associated with regional environmental pollution
    Amr S Soliman
    Department of Epidemiology, University of Michigan School of Public Health, 109 Observatory Street, Ann Arbor, MI 48109, USA
    Carcinogenesis 28:1794-9. 2007
    ..Variations in genetic mutations in pancreatic carcinoma between different geographical regions have not been studied extensively, especially in developing countries where pancreatic cancer is relatively rare...