Tomohiro Hakozaki

Summary

Affiliation: The Procter and Gamble Company
Country: USA

Publications

  1. ncbi request reprint Effective inhibition of melanosome transfer to keratinocytes by lectins and niacinamide is reversible
    Amanda Greatens
    Department of Dermatology, University of Cincinnati, Cincinnati, OH, USA
    Exp Dermatol 14:498-508. 2005
  2. doi request reprint A regulator of ubiquitin-proteasome activity, 2-hexyldecanol, suppresses melanin synthesis and the appearance of facial hyperpigmented spots
    T Hakozaki
    The Procter and Gamble Company, 8700 Mason Montgomery Road, Mason, OH, USA
    Br J Dermatol 169:39-44. 2013
  3. ncbi request reprint Visualization and characterization of UVB-induced reactive oxygen species in a human skin equivalent model
    Tomohiro Hakozaki
    Kobe Technical Center 7F, Procter and Gamble Japan K K, Naka 1 17, Koyo cho, Higashinada ku, Kobe 658 0032, Japan
    Arch Dermatol Res 300:S51-6. 2008
  4. ncbi request reprint The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer
    T Hakozaki
    Research and Development Department, Procter and Gamble Far East, Inc, Kobe Technical Center 7F, Naka 1 17, Koyo cho, Higashinada ku, Japan
    Br J Dermatol 147:20-31. 2002
  5. ncbi request reprint Ultrasound enhanced skin-lightening effect of vitamin C and niacinamide
    Tomohiro Hakozaki
    Department of Dermatology, School of Medicine, University of Tokushima, Tokushima, Japan
    Skin Res Technol 12:105-13. 2006
  6. doi request reprint Reduction in the appearance of facial hyperpigmentation by topical N-undecyl-10-enoyl-L-phenylalanine and its combination with niacinamide
    Donald L Bissett
    The Procter and Gamble Company, Cincinnati, OH, USA
    J Cosmet Dermatol 8:260-6. 2009
  7. ncbi request reprint Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine
    Donald L Bissett
    Procter and Gamble Company, Cincinnati, Ohio 45252, USA
    J Cosmet Dermatol 6:20-6. 2007
  8. ncbi request reprint Real-time chemiluminescent imaging and detection of reactive oxygen species generated in the UVB-exposed human skin equivalent model
    Hiroyuki Yasui
    Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Japan
    Biochem Biophys Res Commun 347:83-8. 2006
  9. ncbi request reprint Novel screening method for ultraviolet protection: combination of a human skin-equivalent model and 8-hydroxy-2'-deoxyguanosine
    Shinya Toyokuni
    Pathol Int 56:760-2. 2006
  10. ncbi request reprint Inhibition of inflammatory nitric oxide production and epidermis damages by Saccharomycopsis Ferment Filtrate
    Hsiou Hsin Tsai
    Department of Dermatology, Taipei Medical University Hospital, Taipei, Taiwan
    J Dermatol Sci 42:249-57. 2006

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Effective inhibition of melanosome transfer to keratinocytes by lectins and niacinamide is reversible
    Amanda Greatens
    Department of Dermatology, University of Cincinnati, Cincinnati, OH, USA
    Exp Dermatol 14:498-508. 2005
    ..These results suggest that lectins and niacinamide at concentrations that do not affect cell viability are reversible inhibitors of melanosome transfer...
  2. doi request reprint A regulator of ubiquitin-proteasome activity, 2-hexyldecanol, suppresses melanin synthesis and the appearance of facial hyperpigmented spots
    T Hakozaki
    The Procter and Gamble Company, 8700 Mason Montgomery Road, Mason, OH, USA
    Br J Dermatol 169:39-44. 2013
    ..2-Hexyldecanol has long been used in skin-care products, but has not previously been reported as an active ingredient for skin benefits...
  3. ncbi request reprint Visualization and characterization of UVB-induced reactive oxygen species in a human skin equivalent model
    Tomohiro Hakozaki
    Kobe Technical Center 7F, Procter and Gamble Japan K K, Naka 1 17, Koyo cho, Higashinada ku, Kobe 658 0032, Japan
    Arch Dermatol Res 300:S51-6. 2008
    ....
  4. ncbi request reprint The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer
    T Hakozaki
    Research and Development Department, Procter and Gamble Far East, Inc, Kobe Technical Center 7F, Naka 1 17, Koyo cho, Higashinada ku, Japan
    Br J Dermatol 147:20-31. 2002
    ..Cutaneous hyperpigmentation occurs in multiple conditions. In addition, many Asian women desire a lighter skin colour. Thus, there is a need for the development of skin lightening agents. Niacinamide is a possible candidate...
  5. ncbi request reprint Ultrasound enhanced skin-lightening effect of vitamin C and niacinamide
    Tomohiro Hakozaki
    Department of Dermatology, School of Medicine, University of Tokushima, Tokushima, Japan
    Skin Res Technol 12:105-13. 2006
    ..In this work, we investigate the effect of the use of high-frequency ultrasound together with coupling gel containing skin-lightening agents (ascorbyl glucoside and niacinamide) on facial hyperpigmentation in vivo in Japanese women...
  6. doi request reprint Reduction in the appearance of facial hyperpigmentation by topical N-undecyl-10-enoyl-L-phenylalanine and its combination with niacinamide
    Donald L Bissett
    The Procter and Gamble Company, Cincinnati, OH, USA
    J Cosmet Dermatol 8:260-6. 2009
    ..Since these two agents function by different mechanisms, we conducted two studies to determine if their combination is more effective than niacinamide alone in reducing facial hyperpigmentation...
  7. ncbi request reprint Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine
    Donald L Bissett
    Procter and Gamble Company, Cincinnati, Ohio 45252, USA
    J Cosmet Dermatol 6:20-6. 2007
    ....
  8. ncbi request reprint Real-time chemiluminescent imaging and detection of reactive oxygen species generated in the UVB-exposed human skin equivalent model
    Hiroyuki Yasui
    Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Japan
    Biochem Biophys Res Commun 347:83-8. 2006
    ....
  9. ncbi request reprint Novel screening method for ultraviolet protection: combination of a human skin-equivalent model and 8-hydroxy-2'-deoxyguanosine
    Shinya Toyokuni
    Pathol Int 56:760-2. 2006
  10. ncbi request reprint Inhibition of inflammatory nitric oxide production and epidermis damages by Saccharomycopsis Ferment Filtrate
    Hsiou Hsin Tsai
    Department of Dermatology, Taipei Medical University Hospital, Taipei, Taiwan
    J Dermatol Sci 42:249-57. 2006
    ..Yeast extracts have been shown to perform anti-inflammatory and cytoprotective activities. However, the effects of yeast extracts on lipopolysaccharide (LPS)-induced nitric oxide (NO) production and epidermal damages are still unclear...