Denis C Guttridge

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi request reprint Signaling pathways weigh in on decisions to make or break skeletal muscle
    Denis C Guttridge
    Division of Human Cancer Genetics, The Ohio State University, Columbus, Ohio, USA
    Curr Opin Clin Nutr Metab Care 7:443-50. 2004
  2. pmc IKK/NF-kappaB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis
    Nadine Bakkar
    Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    J Cell Biol 180:787-802. 2008
  3. pmc IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism
    Nadine Bakkar
    Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, The Ohio State University, Columbus, OH 43210, USA
    J Cell Biol 196:497-511. 2012
  4. pmc NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma
    Huating Wang
    Department of Molecular Virology, Human Cancer Genetics Program, The Ohio State University, Columbus, OH 43210, USA
    Cancer Cell 14:369-81. 2008
  5. pmc Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy
    Swarnali Acharyya
    Human Cancer Genetics Program and Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA
    J Clin Invest 117:889-901. 2007
  6. pmc NF-kappaB functions in stromal fibroblasts to regulate early postnatal muscle development
    Jason M Dahlman
    Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 285:5479-87. 2010
  7. pmc TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophy
    Swarnali Acharyya
    Human Cancer Genetics and Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 5:e12479. 2010
  8. doi request reprint The RelA/p65 subunit of NF-kappaB specifically regulates cyclin D1 protein stability: implications for cell cycle withdrawal and skeletal myogenesis
    Jason M Dahlman
    Human Cancer Genetics and the Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA
    J Cell Biochem 106:42-51. 2009
  9. pmc NF-kappaB regulation of YY1 inhibits skeletal myogenesis through transcriptional silencing of myofibrillar genes
    Huating Wang
    Human Cancer Genetics Program, The Ohio State University College of Medicine, Columbus, OH 43210, USA
    Mol Cell Biol 27:4374-87. 2007
  10. pmc miR-29 acts as a decoy in sarcomas to protect the tumor suppressor A20 mRNA from degradation by HuR
    M Y Balkhi
    Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, The Ohio State University, Columbus, OH 43210, USA
    Sci Signal 6:ra63. 2013

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Signaling pathways weigh in on decisions to make or break skeletal muscle
    Denis C Guttridge
    Division of Human Cancer Genetics, The Ohio State University, Columbus, Ohio, USA
    Curr Opin Clin Nutr Metab Care 7:443-50. 2004
    ..PI(3)K/Akt, myostatin and NF-kappaB represent three such pathways that will be the focus of this review...
  2. pmc IKK/NF-kappaB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis
    Nadine Bakkar
    Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    J Cell Biol 180:787-802. 2008
    ..Together, these data reveal a unique IKK/NF-kappaB signaling switch that functions to both inhibit differentiation and promote myotube homeostasis...
  3. pmc IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism
    Nadine Bakkar
    Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, The Ohio State University, Columbus, OH 43210, USA
    J Cell Biol 196:497-511. 2012
    ..Together, these data provide insight on PGC-1β regulation during skeletal myogenesis and reveal a unique function of alternative NF-κB signaling in promoting an oxidative metabolic phenotype...
  4. pmc NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma
    Huating Wang
    Department of Molecular Virology, Human Cancer Genetics Program, The Ohio State University, Columbus, OH 43210, USA
    Cancer Cell 14:369-81. 2008
    ..Together, these results identify a NF-kappaB-YY1-miR-29 regulatory circuit whose disruption may contribute to RMS...
  5. pmc Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy
    Swarnali Acharyya
    Human Cancer Genetics Program and Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA
    J Clin Invest 117:889-901. 2007
    ..Collectively, these results underscore the critical role of NF-kappaB in the progression of muscular dystrophy and suggest the IKK/NF-kappaB signaling pathway as a potential therapeutic target for DMD...
  6. pmc NF-kappaB functions in stromal fibroblasts to regulate early postnatal muscle development
    Jason M Dahlman
    Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 285:5479-87. 2010
    ....
  7. pmc TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophy
    Swarnali Acharyya
    Human Cancer Genetics and Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 5:e12479. 2010
    ..This regulation coincides with elevated levels of muscle derived TNFalpha that is also under IKKbeta and NF-kappaB control...
  8. doi request reprint The RelA/p65 subunit of NF-kappaB specifically regulates cyclin D1 protein stability: implications for cell cycle withdrawal and skeletal myogenesis
    Jason M Dahlman
    Human Cancer Genetics and the Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA
    J Cell Biochem 106:42-51. 2009
    ..Based on these findings we conclude that RelA/p65 functions as a specific regulator of cyclin D1 protein stability, necessary for proper cell cycle withdrawal during skeletal myogenesis...
  9. pmc NF-kappaB regulation of YY1 inhibits skeletal myogenesis through transcriptional silencing of myofibrillar genes
    Huating Wang
    Human Cancer Genetics Program, The Ohio State University College of Medicine, Columbus, OH 43210, USA
    Mol Cell Biol 27:4374-87. 2007
    ..Based on these results, we propose that NF-kappaB regulation of YY1 and transcriptional silencing of myofibrillar genes represent a new mechanism by which NF-kappaB functions in myoblasts to modulate skeletal muscle differentiation...
  10. pmc miR-29 acts as a decoy in sarcomas to protect the tumor suppressor A20 mRNA from degradation by HuR
    M Y Balkhi
    Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, The Ohio State University, Columbus, OH 43210, USA
    Sci Signal 6:ra63. 2013
    ..Together, the findings reveal a unique role of miR-29 and suggest that its absence may contribute to sarcoma tumorigenesis. ..
  11. pmc RelA/p65 functions to maintain cellular senescence by regulating genomic stability and DNA repair
    Jingxin Wang
    Human Cancer Genetics Program, The Ohio State University, Columbus, Ohio 43210, USA
    EMBO Rep 10:1272-8. 2009
    ..Altogether, our findings present a fresh perspective on the role of NF-kappaB as a tumour suppressor, which acts in pre-neoplastic cells to maintain cellular senescence by promoting DNA repair and genomic stability...
  12. doi request reprint Skeletal muscle diseases, inflammation, and NF-kappaB signaling: insights and opportunities for therapeutic intervention
    Jennifer M Peterson
    Department of Molecular Virology, Immunology, and Medical Genetics, Arthur G James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 23210, USA
    Int Rev Immunol 27:375-87. 2008
    ....
  13. pmc Cancer cachexia is regulated by selective targeting of skeletal muscle gene products
    Swarnali Acharyya
    Division of Human Cancer Genetics, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus 43210, USA
    J Clin Invest 114:370-8. 2004
    ..These results shed new light on cancer cachexia by revealing that wasting does not result from a general downregulation of muscle proteins but rather is highly selective as to which proteins are targeted during the wasting state...
  14. ncbi request reprint microRNAs: novel components in a muscle gene regulatory network
    Huating Wang
    Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics and The Arthur G James Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    Cell Cycle 8:1833-7. 2009
    ..Furthermore, their dysregulation and associated pathologies suggest that miRNA-based therapies may be effective in treating muscle-related disorders...
  15. doi request reprint NF-kappaB signaling: a tale of two pathways in skeletal myogenesis
    Nadine Bakkar
    Department of Molecular Virology, Immunology, and Medical Genetics, Arthur G James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Physiol Rev 90:495-511. 2010
    ..Additional knowledge of these signaling pathways in skeletal myogenesis should aid in the development of specific inhibitors that may be useful in treatments of muscle disorders...
  16. pmc RelA/p65 regulation of IkappaBbeta
    Erin Hertlein
    Human Cancer Genetics Program, The Ohio State University, Columbus, OH, USA
    Mol Cell Biol 25:4956-68. 2005
    ..Based on these findings, we propose that tight control of IkappaBbeta protein by p65 is necessary for the maintenance of cellular homeostasis...
  17. ncbi request reprint Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation
    Courtney Nicholas
    Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
    J Immunol 179:7121-7. 2007
    ..Collectively, these findings suggest a molecular mechanism by which apigenin suppresses inflammation and modulates the immune response in vivo...
  18. ncbi request reprint Cancer cachexia signaling pathways continue to emerge yet much still points to the proteasome
    Swarnali Acharyya
    Human Cancer Genetics, Department of Molecular Virology, Immunology and Medical Genetics, Integrated Biomedical Graduate Program, The Arthur G James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    Clin Cancer Res 13:1356-61. 2007
    ..Therefore, although the proteasome remains a preferred choice for therapy, the continually emerging upstream signaling molecules serve as additional promising therapeutic targets for the treatment of tumor-induced muscle wasting...
  19. ncbi request reprint ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions
    Anasuya Sarkar
    Davis Heart and Lung Research Institute, The Ohio State University, Columbus 43210, USA
    J Immunol 176:4979-86. 2006
    ..These data suggest that ASC may direct caspase-1 away from RIP2-mediated NF-kappaB activation, toward caspase-1-mediated processing of proIL-1beta by interfering with the RIP2 caspase-1 interaction...
  20. pmc Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia
    Shih Shih Chen
    Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 106:13433-8. 2009
    ..These results provide strong rationale for the development of strategies to target NF-kappaB components in CLL and potentially other B-cell malignancies...
  21. pmc Zinc modulates the innate immune response in vivo to polymicrobial sepsis through regulation of NF-kappaB
    Shengying Bao
    Dorothy M Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA
    Am J Physiol Lung Cell Mol Physiol 298:L744-54. 2010
    ..Zinc supplementation immediately before initiation of sepsis reversed these effects thereby supporting the plausibility of future studies that explore zinc supplementation strategies to prevent sepsis-mediated morbidity and mortality...
  22. pmc Microvesicles containing miRNAs promote muscle cell death in cancer cachexia via TLR7
    Wei A He
    Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, and the Arthur G James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210
    Proc Natl Acad Sci U S A 111:4525-9. 2014
    ..Together, these results describe a unique pathway by which tumor cells promote muscle loss, which might provide a great insight into elucidating the causes and treatment options of cancer cachexia. ..
  23. doi request reprint Reining in nuclear factor-kappaB in skeletal muscle disorders
    Jonathan Shintaku
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA
    Curr Opin Clin Nutr Metab Care 16:251-7. 2013
    ..Here, we review the evidence implicating specific NF-κB components in different disease pathologies and discuss therapies designed to target aberrant NF-κB signaling for the treatment of those pathologies...
  24. ncbi request reprint Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia
    Swarnali Acharyya
    Human Cancer Genetics Program, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Cell 8:421-32. 2005
    ..Based on these results, we propose that, similar to muscular dystrophy, DGC dysfunction plays a critical role in cancer-induced wasting...
  25. pmc A novel role for IkappaBzeta in the regulation of IFNgamma production
    RAQUEL M RAICES
    The Ohio State University, Davis Heart and Lung Research Institute, Columbus, Ohio, USA
    PLoS ONE 4:e6776. 2009
    ..Moreover, silencing of IkappaBzeta expression led to a specific decrease in IFNgamma production. Overall, our data suggests that IkappaBzeta positively regulates NFkappaB-mediated IFNgamma production in KG-1 cells...
  26. pmc Peptide-based inhibition of NF-κB rescues diaphragm muscle contractile dysfunction in a murine model of Duchenne muscular dystrophy
    Jennifer M Peterson
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA
    Mol Med 17:508-15. 2011
    ..Together, these results support the feasibility of using a mass-produced, water-soluble NBD peptide for clinical use...
  27. doi request reprint NF-κB signaling in skeletal muscle health and disease
    Jennifer M Peterson
    Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, Arthur G James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    Curr Top Dev Biol 96:85-119. 2011
    ..In this review, we summarize the NF-κB signaling pathway and provide a fresh perspective into the regulation and function of this transcription factor, underlying both the physiological and pathophysiological states of skeletal muscle...
  28. pmc Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis
    Ashley E Frakes
    Center for Gene Therapy, The Research Institute at Nationwide Children s Hospital, Columbus, OH 43205, USA Biomedical Sciences Graduate Program, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Neuron 81:1009-23. 2014
    ....
  29. doi request reprint Detection of NF-κB activity in skeletal muscle cells by electrophoretic mobility shift analysis
    Jason M Dahlman
    Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, Integrated Biomedical Sciences Graduate Program, The Ohio State University, Columbus, OH, USA
    Methods Mol Biol 798:505-16. 2012
    ..Here, we describe the methodology used to isolate the cytoplasmic and nuclear protein extracts from both cultured cells and tissues and utilize the nuclear protein fraction to assess NF-κB DNA-binding activity by EMSA analysis...
  30. pmc Improvement of cardiac contractile function by peptide-based inhibition of NF-κB in the utrophin/dystrophin-deficient murine model of muscular dystrophy
    Dawn A Delfin
    Department of Physiology and Cell Biology, Columbus, OH, USA
    J Transl Med 9:68. 2011
    ....
  31. pmc Metabolomic profiling reveals severe skeletal muscle group-specific perturbations of metabolism in aged FBN rats
    Sean M Garvey
    Abbott Nutrition R and D, 3300 Stelzer Road, Bldg RP4 2, Columbus, OH, 43219, USA
    Biogerontology 15:217-32. 2014
    ..Altogether, these data highlight skeletal muscle group-specific perturbations of glucose and lipid metabolism consistent with mitochondrial dysfunction in aged FBN rats. ..
  32. pmc Myeloid-derived suppressor cell inhibition of the IFN response in tumor-bearing mice
    Bethany L Mundy-Bosse
    Department of Integrated Biomedical Sciences, The Ohio State University, Columbus, OH, USA
    Cancer Res 71:5101-10. 2011
    ..These data suggest that nitric oxide produced by MDSC can lead to reduced IFN responsiveness in immune cells...
  33. pmc Prevention of upper aerodigestive tract cancer in zinc-deficient rodents: inefficacy of genetic or pharmacological disruption of COX-2
    Louise Y Y Fong
    Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Int J Cancer 122:978-89. 2008
    ..Thus, targeting only the COX-2 pathway in zinc-deficient animals did not prevent UADT carcinogenesis. Our data suggest zinc supplementation should be more thoroughly explored in human prevention clinical trials for UADT cancer...
  34. ncbi request reprint Tumor necrosis factor-regulated biphasic activation of NF-kappa B is required for cytokine-induced loss of skeletal muscle gene products
    Katherine J Ladner
    Division of Human Cancer Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus 43210, USA
    J Biol Chem 278:2294-303. 2003
    ..We propose that the biphasic activation of NF-kappaB in response to TNF may play a key regulatory role in skeletal muscle wasting associated with cachexia...
  35. ncbi request reprint Biomechanical signals suppress TAK1 activation to inhibit NF-kappaB transcriptional activation in fibrochondrocytes
    Shashi Madhavan
    Biomechanics and Tissue Engineering Laboratory, Section of Oral Biology, Ohio State University, Columbus 43210, USA
    J Immunol 179:6246-54. 2007
    ....
  36. ncbi request reprint NF-kappa B and I kappa B alpha are found in the mitochondria. Evidence for regulation of mitochondrial gene expression by NF-kappa B
    Patricia C Cogswell
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
    J Biol Chem 278:2963-8. 2003
    ..These data indicate that the NF-kappa B regulatory pathway exists in mitochondria and that NF-kappa B can negatively regulate mitochondrial mRNA expression...
  37. pmc Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis
    Zongbing You
    Laboratory of Molecular Signaling and Apoptosis, Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor 48109 1078, USA
    J Cell Biol 157:429-40. 2002
    ..These results elucidate the molecular mechanisms by which Wnt/beta-catenin inhibits apoptosis and provide new insight into Wnt signaling-mediated oncogenesis...