Research Topics
Genomes and Genes
| Denis C GuttridgeSummaryAffiliation: The Ohio State University Country: USA Publications
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Detail Information
Publications
Signaling pathways weigh in on decisions to make or break skeletal muscleDenis C Guttridge
Division of Human Cancer Genetics, The Ohio State University, Columbus, Ohio, USA
Curr Opin Clin Nutr Metab Care 7:443-50. 2004..PI(3)K/Akt, myostatin and NF-kappaB represent three such pathways that will be the focus of this review...
IKK/NF-kappaB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesisNadine Bakkar
Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
J Cell Biol 180:787-802. 2008..Together, these data reveal a unique IKK/NF-kappaB signaling switch that functions to both inhibit differentiation and promote myotube homeostasis...- IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolismNadine Bakkar
Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, The Ohio State University, Columbus, OH 43210, USA
J Cell Biol 196:497-511. 2012..Together, these data provide insight on PGC-1β regulation during skeletal myogenesis and reveal a unique function of alternative NF-κB signaling in promoting an oxidative metabolic phenotype... 
NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcomaHuating Wang
Department of Molecular Virology, Human Cancer Genetics Program, The Ohio State University, Columbus, OH 43210, USA
Cancer Cell 14:369-81. 2008..Together, these results identify a NF-kappaB-YY1-miR-29 regulatory circuit whose disruption may contribute to RMS...- Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophySwarnali Acharyya
Human Cancer Genetics Program and Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA
J Clin Invest 117:889-901. 2007..Collectively, these results underscore the critical role of NF-kappaB in the progression of muscular dystrophy and suggest the IKK/NF-kappaB signaling pathway as a potential therapeutic target for DMD... - TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophySwarnali Acharyya
Human Cancer Genetics and Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America
PLoS ONE 5:e12479. 2010..This regulation coincides with elevated levels of muscle derived TNFalpha that is also under IKKbeta and NF-kappaB control... - The RelA/p65 subunit of NF-kappaB specifically regulates cyclin D1 protein stability: implications for cell cycle withdrawal and skeletal myogenesisJason M Dahlman
Human Cancer Genetics and the Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA
J Cell Biochem 106:42-51. 2009..Based on these findings we conclude that RelA/p65 functions as a specific regulator of cyclin D1 protein stability, necessary for proper cell cycle withdrawal during skeletal myogenesis... - NF-kappaB functions in stromal fibroblasts to regulate early postnatal muscle developmentJason M Dahlman
Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, Ohio State University, Columbus, Ohio 43210, USA
J Biol Chem 285:5479-87. 2010.... - NF-kappaB regulation of YY1 inhibits skeletal myogenesis through transcriptional silencing of myofibrillar genesHuating Wang
Human Cancer Genetics Program, The Ohio State University College of Medicine, Columbus, OH 43210, USA
Mol Cell Biol 27:4374-87. 2007..Based on these results, we propose that NF-kappaB regulation of YY1 and transcriptional silencing of myofibrillar genes represent a new mechanism by which NF-kappaB functions in myoblasts to modulate skeletal muscle differentiation... - RelA/p65 functions to maintain cellular senescence by regulating genomic stability and DNA repairJingxin Wang
Human Cancer Genetics Program, The Ohio State University, Columbus, Ohio 43210, USA
EMBO Rep 10:1272-8. 2009..Altogether, our findings present a fresh perspective on the role of NF-kappaB as a tumour suppressor, which acts in pre-neoplastic cells to maintain cellular senescence by promoting DNA repair and genomic stability... - Cancer cachexia is regulated by selective targeting of skeletal muscle gene productsSwarnali Acharyya
Division of Human Cancer Genetics, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus 43210, USA
J Clin Invest 114:370-8. 2004..These results shed new light on cancer cachexia by revealing that wasting does not result from a general downregulation of muscle proteins but rather is highly selective as to which proteins are targeted during the wasting state... - Skeletal muscle diseases, inflammation, and NF-kappaB signaling: insights and opportunities for therapeutic interventionJennifer M Peterson
Department of Molecular Virology, Immunology, and Medical Genetics, Arthur G James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 23210, USA
Int Rev Immunol 27:375-87. 2008.... - microRNAs: novel components in a muscle gene regulatory networkHuating Wang
Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics and The Arthur G James Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
Cell Cycle 8:1833-7. 2009..Furthermore, their dysregulation and associated pathologies suggest that miRNA-based therapies may be effective in treating muscle-related disorders... - NF-kappaB signaling: a tale of two pathways in skeletal myogenesisNadine Bakkar
Department of Molecular Virology, Immunology, and Medical Genetics, Arthur G James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
Physiol Rev 90:495-511. 2010..Additional knowledge of these signaling pathways in skeletal myogenesis should aid in the development of specific inhibitors that may be useful in treatments of muscle disorders... - RelA/p65 regulation of IkappaBbetaErin Hertlein
Human Cancer Genetics Program, The Ohio State University, Columbus, OH, USA
Mol Cell Biol 25:4956-68. 2005..Based on these findings, we propose that tight control of IkappaBbeta protein by p65 is necessary for the maintenance of cellular homeostasis... - Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylationCourtney Nicholas
Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
J Immunol 179:7121-7. 2007..Collectively, these findings suggest a molecular mechanism by which apigenin suppresses inflammation and modulates the immune response in vivo... - Zinc modulates the innate immune response in vivo to polymicrobial sepsis through regulation of NF-kappaBShengying Bao
Dorothy M Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA
Am J Physiol Lung Cell Mol Physiol 298:L744-54. 2010..Zinc supplementation immediately before initiation of sepsis reversed these effects thereby supporting the plausibility of future studies that explore zinc supplementation strategies to prevent sepsis-mediated morbidity and mortality... - ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactionsAnasuya Sarkar
Davis Heart and Lung Research Institute, The Ohio State University, Columbus 43210, USA
J Immunol 176:4979-86. 2006..These data suggest that ASC may direct caspase-1 away from RIP2-mediated NF-kappaB activation, toward caspase-1-mediated processing of proIL-1beta by interfering with the RIP2 caspase-1 interaction... - Cancer cachexia signaling pathways continue to emerge yet much still points to the proteasomeSwarnali Acharyya
Human Cancer Genetics, Department of Molecular Virology, Immunology and Medical Genetics, Integrated Biomedical Graduate Program, The Arthur G James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
Clin Cancer Res 13:1356-61. 2007..Therefore, although the proteasome remains a preferred choice for therapy, the continually emerging upstream signaling molecules serve as additional promising therapeutic targets for the treatment of tumor-induced muscle wasting... - Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemiaShih Shih Chen
Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
Proc Natl Acad Sci U S A 106:13433-8. 2009..These results provide strong rationale for the development of strategies to target NF-kappaB components in CLL and potentially other B-cell malignancies... - A novel role for IkappaBzeta in the regulation of IFNgamma productionRAQUEL M RAICES
The Ohio State University, Davis Heart and Lung Research Institute, Columbus, Ohio, USA
PLoS ONE 4:e6776. 2009..Moreover, silencing of IkappaBzeta expression led to a specific decrease in IFNgamma production. Overall, our data suggests that IkappaBzeta positively regulates NFkappaB-mediated IFNgamma production in KG-1 cells... - Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexiaSwarnali Acharyya
Human Cancer Genetics Program, The Ohio State University, Columbus, Ohio 43210, USA
Cancer Cell 8:421-32. 2005..Based on these results, we propose that, similar to muscular dystrophy, DGC dysfunction plays a critical role in cancer-induced wasting... - Peptide-based inhibition of NF-κB rescues diaphragm muscle contractile dysfunction in a murine model of Duchenne muscular dystrophyJennifer M Peterson
Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio 43210, USA
Mol Med 17:508-15. 2011..Together, these results support the feasibility of using a mass-produced, water-soluble NBD peptide for clinical use... - NF-κB signaling in skeletal muscle health and diseaseJennifer M Peterson
Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, Arthur G James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
Curr Top Dev Biol 96:85-119. 2011..In this review, we summarize the NF-κB signaling pathway and provide a fresh perspective into the regulation and function of this transcription factor, underlying both the physiological and pathophysiological states of skeletal muscle... - Detection of NF-κB activity in skeletal muscle cells by electrophoretic mobility shift analysisJason M Dahlman
Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, Integrated Biomedical Sciences Graduate Program, The Ohio State University, Columbus, OH, USA
Methods Mol Biol 798:505-16. 2012..Here, we describe the methodology used to isolate the cytoplasmic and nuclear protein extracts from both cultured cells and tissues and utilize the nuclear protein fraction to assess NF-κB DNA-binding activity by EMSA analysis... - Improvement of cardiac contractile function by peptide-based inhibition of NF-κB in the utrophin/dystrophin-deficient murine model of muscular dystrophyDawn A Delfin
Department of Physiology and Cell Biology, Columbus, OH, USA
J Transl Med 9:68. 2011.... - Tumor necrosis factor-regulated biphasic activation of NF-kappa B is required for cytokine-induced loss of skeletal muscle gene productsKatherine J Ladner
Division of Human Cancer Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus 43210, USA
J Biol Chem 278:2294-303. 2003..We propose that the biphasic activation of NF-kappaB in response to TNF may play a key regulatory role in skeletal muscle wasting associated with cachexia... - Myeloid-derived suppressor cell inhibition of the IFN response in tumor-bearing miceBethany L Mundy-Bosse
Department of Integrated Biomedical Sciences, The Ohio State University, Columbus, OH, USA
Cancer Res 71:5101-10. 2011..These data suggest that nitric oxide produced by MDSC can lead to reduced IFN responsiveness in immune cells... - Prevention of upper aerodigestive tract cancer in zinc-deficient rodents: inefficacy of genetic or pharmacological disruption of COX-2Louise Y Y Fong
Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
Int J Cancer 122:978-89. 2008..Thus, targeting only the COX-2 pathway in zinc-deficient animals did not prevent UADT carcinogenesis. Our data suggest zinc supplementation should be more thoroughly explored in human prevention clinical trials for UADT cancer... - NF-kappa B and I kappa B alpha are found in the mitochondria. Evidence for regulation of mitochondrial gene expression by NF-kappa BPatricia C Cogswell
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
J Biol Chem 278:2963-8. 2003..These data indicate that the NF-kappa B regulatory pathway exists in mitochondria and that NF-kappa B can negatively regulate mitochondrial mRNA expression... - Biomechanical signals suppress TAK1 activation to inhibit NF-kappaB transcriptional activation in fibrochondrocytesShashi Madhavan
Biomechanics and Tissue Engineering Laboratory, Section of Oral Biology, Ohio State University, Columbus 43210, USA
J Immunol 179:6246-54. 2007.... 
Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosisZongbing You
Laboratory of Molecular Signaling and Apoptosis, Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor 48109-1078, USA
J Cell Biol 157:429-40. 2002..These results elucidate the molecular mechanisms by which Wnt/beta-catenin inhibits apoptosis and provide new insight into Wnt signaling-mediated oncogenesis...