Luca Guidotti

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Hepatitis B virus replication is cell cycle independent during liver regeneration in transgenic mice
    L G Guidotti
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 71:4804-8. 1997
  2. ncbi request reprint Immunobiology and pathogenesis of viral hepatitis
    Luca G Guidotti
    Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California 92037, USA
    Annu Rev Pathol 1:23-61. 2006
  3. pmc Interferon-regulated pathways that control hepatitis B virus replication in transgenic mice
    Luca G Guidotti
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 76:2617-21. 2002
  4. ncbi request reprint Noncytolytic control of viral infections by the innate and adaptive immune response
    L G Guidotti
    Department of Molecular and Experimental Medicine, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Annu Rev Immunol 19:65-91. 2001
  5. pmc Nitric oxide inhibits hepatitis B virus replication in the livers of transgenic mice
    L G Guidotti
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Exp Med 191:1247-52. 2000
  6. ncbi request reprint Cytokine-induced viral purging--role in viral pathogenesis
    L G Guidotti
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Opin Microbiol 2:388-91. 1999
  7. pmc Noncytopathic clearance of lymphocytic choriomeningitis virus from the hepatocyte
    L G Guidotti
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Exp Med 189:1555-64. 1999
  8. pmc Interleukin-18 inhibits hepatitis B virus replication in the livers of transgenic mice
    Kiminori Kimura
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 76:10702-7. 2002
  9. ncbi request reprint Activated intrahepatic antigen-presenting cells inhibit hepatitis B virus replication in the liver of transgenic mice
    Kiminori Kimura
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 169:5188-95. 2002
  10. pmc Platelets mediate cytotoxic T lymphocyte-induced liver damage
    Matteo Iannacone
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Med 11:1167-9. 2005

Research Grants

Collaborators

Detail Information

Publications24

  1. pmc Hepatitis B virus replication is cell cycle independent during liver regeneration in transgenic mice
    L G Guidotti
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 71:4804-8. 1997
    ..Despite massive hepatocellular turnover, this effect is independent of liver cell division, indicating that HBV replicates efficiently in resting and dividing hepatocytes...
  2. ncbi request reprint Immunobiology and pathogenesis of viral hepatitis
    Luca G Guidotti
    Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California 92037, USA
    Annu Rev Pathol 1:23-61. 2006
    ..Over long periods of time, recurrent immune-mediated liver damage contributes to the development of cirrhosis and hepatocellular carcinoma...
  3. pmc Interferon-regulated pathways that control hepatitis B virus replication in transgenic mice
    Luca G Guidotti
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 76:2617-21. 2002
    ..Finally, RNase L(-/-) transgenic mice were undistinguishable from controls under basal conditions and after poly(I-C) or IFN-gamma administration, suggesting that RNase L does not modulate HBV replication in this model...
  4. ncbi request reprint Noncytolytic control of viral infections by the innate and adaptive immune response
    L G Guidotti
    Department of Molecular and Experimental Medicine, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Annu Rev Immunol 19:65-91. 2001
    ..In keeping with these concepts, it is not surprising that a number of viruses encode proteins that have the potential to inhibit the antiviral activity of cytokines...
  5. pmc Nitric oxide inhibits hepatitis B virus replication in the livers of transgenic mice
    L G Guidotti
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Exp Med 191:1247-52. 2000
    ..Interestingly, LCMV replicated to higher levels in the liver of iNOS-deficient mice than control mice, indicating that NO controls LCMV replication in the liver, as well as HBV...
  6. ncbi request reprint Cytokine-induced viral purging--role in viral pathogenesis
    L G Guidotti
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Opin Microbiol 2:388-91. 1999
    ..e. viral purging). The relative sensitivity of viruses to such curative mechanisms depends not only on the virus but also on the capacity of the specific infected cell to produce the appropriate intracellular antiviral factors...
  7. pmc Noncytopathic clearance of lymphocytic choriomeningitis virus from the hepatocyte
    L G Guidotti
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Exp Med 189:1555-64. 1999
    ..Antiviral mechanisms like these may have evolved to maintain the functional integrity of vital organs in the face of massive infection...
  8. pmc Interleukin-18 inhibits hepatitis B virus replication in the livers of transgenic mice
    Kiminori Kimura
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 76:10702-7. 2002
    ..These results suggest that IL-18 has the potential to contribute to the control of HBV replication during self-limited infection and that it may have therapeutic value for the treatment of patients with chronic hepatitis...
  9. ncbi request reprint Activated intrahepatic antigen-presenting cells inhibit hepatitis B virus replication in the liver of transgenic mice
    Kiminori Kimura
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 169:5188-95. 2002
    ..These results provide insight into a hitherto unsuspected antiviral function of intrahepatic APCs, and they suggest that therapeutic activation of APCs may represent a new strategy for the treatment of chronic HBV infection...
  10. pmc Platelets mediate cytotoxic T lymphocyte-induced liver damage
    Matteo Iannacone
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Med 11:1167-9. 2005
    ..Thus, activated platelets contribute to CTL-mediated liver immunopathology independently of procoagulant function...
  11. pmc Searching for interferon-induced genes that inhibit hepatitis B virus replication in transgenic mouse hepatocytes
    Stefan F Wieland
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 77:1227-36. 2003
    ..We have already exploited this information by demonstrating that the antiviral activity of IFN-alpha/beta and IFN-gamma is proteasome dependent...
  12. pmc MMPs are required for recruitment of antigen-nonspecific mononuclear cells into the liver by CTLs
    Giovanni Sitia
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 113:1158-67. 2004
    ....
  13. pmc Depletion of neutrophils blocks the recruitment of antigen-nonspecific cells into the liver without affecting the antiviral activity of hepatitis B virus-specific cytotoxic T lymphocytes
    Giovanni Sitia
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:13717-22. 2002
    ..The notion that depletion of neutrophils is associated with maintenance of antiviral effects but diminished tissue damage may be significant for the development of immunotherapeutic approaches for the treatment of chronic HBV infection...
  14. pmc Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice
    Andrew I Su
    Department of Chemistry and Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:11181-6. 2002
    ..The genome-wide changes that are observed provide a detailed and comprehensive map of the initial priming stage of liver regeneration...
  15. pmc Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus
    Matteo Iannacone
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:629-34. 2008
    ....
  16. pmc Antiplatelet drug therapy moderates immune-mediated liver disease and inhibits viral clearance in mice infected with a replication-deficient adenovirus
    Matteo Iannacone
    Department of Molecular and Experimental Medicine, Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Clin Vaccine Immunol 14:1532-5. 2007
    ....
  17. pmc HBV pathogenesis in animal models: recent advances on the role of platelets
    Matteo Iannacone
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Hepatol 46:719-26. 2007
    ....
  18. ncbi request reprint The role of cytotoxic T cells and cytokines in the control of hepatitis B virus infection
    Luca G Guidotti
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Vaccine 20:A80-2. 2002
    ..These results provided insight into immunological and virological processes that may lead to the development of new therapeutic strategies to terminate chronic HBV infection...
  19. ncbi request reprint In vivo administration of lentiviral vectors triggers a type I interferon response that restricts hepatocyte gene transfer and promotes vector clearance
    Brian D Brown
    San Raffaele Telethon Institute for Gene Therapy, San Raffaele Scientific Institute, Milan, Italy
    Blood 109:2797-805. 2007
    ....
  20. ncbi request reprint Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice
    Giovanni Sitia
    San Raffaele Scientific Institute, Chromatin Dynamics Unit, Via Olgettina 58, Milan 20132, Italy
    J Leukoc Biol 81:100-7. 2007
    ....
  21. pmc Immune tolerance split between hepatitis B virus precore and core proteins
    Margaret Chen
    Vaccine Research Institute of San Diego, 3030 Bunker Hill St, Suite 300, San Diego, CA 92109, USA
    J Virol 79:3016-27. 2005
    ....
  22. pmc A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigen
    Margaret T Chen
    Karolinska Institute and Swedish Institute for Infectious Disease Control, 171 82 Solna, Sweden
    Proc Natl Acad Sci U S A 101:14913-8. 2004
    ..This HBeAg-mediated immune regulation may predispose to chronicity during perinatal infections and prevent severe liver injury during adult infections...
  23. ncbi request reprint Naive HIV/HCV-coinfected patients have higher intrahepatic pro-inflammatory cytokines than coinfected patients treated with antiretroviral therapy
    Giovanni Sitia
    Infectious Disease Department, San Raffaele Scientific Institute, Milan, Italy
    Antivir Ther 11:385-9. 2006
    ..Together, these results suggest that HIV infection may exacerbate the immune-mediated inflammatory response in the liver of patients chronically infected with HCV and antiretroviral therapy may prevent this effect...
  24. doi request reprint Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis
    Michele De Palma
    Angiogenesis and Tumor Targeting Research Unit, San Raffaele Institute, 20132 Milano, Italy
    Cancer Cell 14:299-311. 2008
    ..These results illustrate the therapeutic potential of gene- and cell-based IFN-alpha delivery and should allow the development of IFN treatments that more effectively treat cancer...

Research Grants13

  1. Regulation of HBV Replication by the Immune System
    Luca Guidotti; Fiscal Year: 2006
    ..The results of these experiments will provide insight into the basic immunological processes that may determine liver disease, viral clearance and viral persistence in the pathogenesis of HBV infection. ..
  2. REGULATION OF HBV REPLICATION BY OTHER HUMAN PATHOGENS
    Luca Guidotti; Fiscal Year: 2001
    ....
  3. Regulation of HBV Replication by the Immune System
    Luca G Guidotti; Fiscal Year: 2010
    ..models to elucidate the pathogenesis of HBV infection with the ultimate hope that this knowledge will lead to the development of new therapeutic strategies to terminate persistent infection and its attendant costs and complications ..