Shawn P Grogan

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis
    Shawn P Grogan
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Arthritis Res Ther 11:R85. 2009
  2. pmc Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways
    Shuhei Otsuki
    Department of Molecular and Experimental Medicine and Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:10202-7. 2010
  3. pmc Effects of perfusion and dynamic loading on human neocartilage formation in alginate hydrogels
    Shawn P Grogan
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA 92037, USA
    Tissue Eng Part A 18:1784-92. 2012
  4. pmc Tissue neogenesis and STRO-1 expression in immature and mature articular cartilage
    Shuhei Otsuki
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Orthop Res 28:96-102. 2010
  5. pmc Zone-specific gene expression patterns in articular cartilage
    Shawn P Grogan
    The Scripps Research Institute and Shiley Center for Orthopaedic Research and Education, Scripps Clinic, La Jolla, California, USA
    Arthritis Rheum 65:418-28. 2013
  6. pmc Digital micromirror device projection printing system for meniscus tissue engineering
    Shawn P Grogan
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, Suite 200, La Jolla, CA 92037, USA
    Acta Biomater 9:7218-26. 2013
  7. pmc Vimentin contributes to changes in chondrocyte stiffness in osteoarthritis
    Dominik R Haudenschild
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, La Jolla, California 92037, USA
    J Orthop Res 29:20-5. 2011
  8. pmc MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses
    Shigeru Miyaki
    Department of Molecular and Experimental Medicine, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Arthritis Rheum 60:2723-30. 2009
  9. pmc In situ tissue engineering using magnetically guided three-dimensional cell patterning
    Shawn P Grogan
    Shiley Center for Orthopaedic Research and Education, Scripps Clinic, La Jolla, CA 92037, USA
    Tissue Eng Part C Methods 18:496-506. 2012
  10. pmc Expression of novel extracellular sulfatases Sulf-1 and Sulf-2 in normal and osteoarthritic articular cartilage
    Shuhei Otsuki
    Division of Arthritis Research, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Arthritis Res Ther 10:R61. 2008

Collaborators

Detail Information

Publications12

  1. pmc Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis
    Shawn P Grogan
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Arthritis Res Ther 11:R85. 2009
    ....
  2. pmc Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways
    Shuhei Otsuki
    Department of Molecular and Experimental Medicine and Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:10202-7. 2010
    ..Approaches to correct abnormal Sulf expression have the potential to protect against cartilage degradation and promote cartilage repair in OA...
  3. pmc Effects of perfusion and dynamic loading on human neocartilage formation in alginate hydrogels
    Shawn P Grogan
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA 92037, USA
    Tissue Eng Part A 18:1784-92. 2012
    ..Optimal conditions, which permit appropriate anabolic and catabolic processes for accumulation of ECM and tissue remodeling for neocartilage development, specifically for humans, are needed...
  4. pmc Tissue neogenesis and STRO-1 expression in immature and mature articular cartilage
    Shuhei Otsuki
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Orthop Res 28:96-102. 2010
    ..In conclusion, these findings suggest that the high percentage of STRO-1+ cells in immature cartilage changes with joint maturation. STRO-1+ cells have the potential to form new cartilage spontaneously and after tissue injury...
  5. pmc Zone-specific gene expression patterns in articular cartilage
    Shawn P Grogan
    The Scripps Research Institute and Shiley Center for Orthopaedic Research and Education, Scripps Clinic, La Jolla, California, USA
    Arthritis Rheum 65:418-28. 2013
    ..To identify novel genes and pathways specific to the superficial zone (SZ), middle zone (MZ), and deep zone (DZ) of normal articular cartilage...
  6. pmc Digital micromirror device projection printing system for meniscus tissue engineering
    Shawn P Grogan
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, Suite 200, La Jolla, CA 92037, USA
    Acta Biomater 9:7218-26. 2013
    ..Prefabrication of GelMA scaffolds with architectures mimicking the meniscus collagen bundle organization shows promise for meniscal repair. Furthermore, the technique presented may be scaled up to repair larger defects...
  7. pmc Vimentin contributes to changes in chondrocyte stiffness in osteoarthritis
    Dominik R Haudenschild
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, 11025 North Torrey Pines Road, La Jolla, California 92037, USA
    J Orthop Res 29:20-5. 2011
    ..This 3D experimental system revealed contributions of vimentin to chondrocyte stiffness previously not apparent, and correlated changes in vimentin-based chondrocyte stiffness with osteoarthritis...
  8. pmc MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses
    Shigeru Miyaki
    Department of Molecular and Experimental Medicine, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Arthritis Rheum 60:2723-30. 2009
    ..The objectives of this study were to identify miRNA expressed in articular chondrocytes, to determine changes in osteoarthritic (OA) cartilage, and to address the function of miRNA-140 (miR-140)...
  9. pmc In situ tissue engineering using magnetically guided three-dimensional cell patterning
    Shawn P Grogan
    Shiley Center for Orthopaedic Research and Education, Scripps Clinic, La Jolla, CA 92037, USA
    Tissue Eng Part C Methods 18:496-506. 2012
    ..Taken together, this approach can be adapted for studying basic biological processes in vitro, for general tissue engineering approaches, and for producing organized repair tissues directly in situ...
  10. pmc Expression of novel extracellular sulfatases Sulf-1 and Sulf-2 in normal and osteoarthritic articular cartilage
    Shuhei Otsuki
    Division of Arthritis Research, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Arthritis Res Ther 10:R61. 2008
    ..The aim of this study was to analyze expression patterns of recently identified extracellular sulfatases Sulf-1 and Sulf-2 in articular cartilage and chondrocytes...
  11. pmc Repression of chondrogenesis through binding of notch signaling proteins HES-1 and HEY-1 to N-box domains in the COL2A1 enhancer site
    Shawn P Grogan
    Scripps Research Institute, La Jolla, California, USA
    Arthritis Rheum 58:2754-63. 2008
    ..Notch signaling is implicated in the repression of mesenchymal stem cell (MSC) chondrogenic differentiation. The purpose of this study was to examine the mechanism of this repression and how it is modulated to permit chondrogenesis...
  12. doi request reprint Osteoarthritis: detection, pathophysiology, and current/future treatment strategies
    Sujata Sovani
    Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA, USA
    Orthop Nurs 32:25-36; quiz 37-8. 2013
    ..Knowledge and understanding of OA and how this affects the individual patient form the basis for such an integrative approach to all-round patient care and disease management...