P Greengard

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi request reprint The neurobiology of slow synaptic transmission
    P Greengard
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 294:1024-30. 2001
  2. ncbi request reprint Phosphorylation of protein phosphatase inhibitor-1 by Cdk5
    J A Bibb
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021 6399, USA
    J Biol Chem 276:14490-7. 2001
  3. ncbi request reprint DARPP-32: regulator of the efficacy of dopaminergic neurotransmission
    A A Fienberg
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Science 281:838-42. 1998
  4. ncbi request reprint Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5
    J A Bibb
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 410:376-80. 2001
  5. ncbi request reprint Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1
    L C Hsieh-Wilson
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York 10021, USA
    Biochemistry 38:4365-73. 1999
  6. ncbi request reprint Drugs of abuse modulate the phosphorylation of ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in the basal ganglia
    G L Caporaso
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuropharmacology 39:1637-44. 2000
  7. pmc Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors
    F Liu
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 98:11062-8. 2001
  8. ncbi request reprint Opposing changes in phosphorylation of specific sites in synapsin I during Ca2+-dependent glutamate release in isolated nerve terminals
    J N Jovanovic
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 21:7944-53. 2001
  9. ncbi request reprint Regulation of phosphorylation of the GluR1 AMPA receptor in the neostriatum by dopamine and psychostimulants in vivo
    G L Snyder
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 20:4480-8. 2000
  10. ncbi request reprint ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteins
    I Dulubova
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York 10021, USA
    J Neurochem 77:229-38. 2001

Collaborators

Detail Information

Publications94

  1. ncbi request reprint The neurobiology of slow synaptic transmission
    P Greengard
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 294:1024-30. 2001
    ....
  2. ncbi request reprint Phosphorylation of protein phosphatase inhibitor-1 by Cdk5
    J A Bibb
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021 6399, USA
    J Biol Chem 276:14490-7. 2001
    ....
  3. ncbi request reprint DARPP-32: regulator of the efficacy of dopaminergic neurotransmission
    A A Fienberg
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Science 281:838-42. 1998
    ..The results show that DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission...
  4. ncbi request reprint Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5
    J A Bibb
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 410:376-80. 2001
    ..Our results suggest that changes in Cdk5 levels mediated by DeltaFosB, and resulting alterations in signalling involving D1 dopamine receptors, contribute to adaptive changes in the brain related to cocaine addiction...
  5. ncbi request reprint Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1
    L C Hsieh-Wilson
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York 10021, USA
    Biochemistry 38:4365-73. 1999
    ..These studies support the notion that spinophilin functions in vivo as a neuronal PP1 targeting subunit by directing the enzyme to postsynaptic densities and regulating its activity toward physiological substrates...
  6. ncbi request reprint Drugs of abuse modulate the phosphorylation of ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in the basal ganglia
    G L Caporaso
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuropharmacology 39:1637-44. 2000
    ..We speculate that ARPP-21 might mediate some of the physiologic effects of dopamine and certain drugs of abuse in the basal ganglia...
  7. pmc Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors
    F Liu
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 98:11062-8. 2001
    ..Together these results indicate that a CK1-Cdk5-DARPP-32 cascade may be involved in the regulation by mGluR agonists of Ca(2+) channels...
  8. ncbi request reprint Opposing changes in phosphorylation of specific sites in synapsin I during Ca2+-dependent glutamate release in isolated nerve terminals
    J N Jovanovic
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 21:7944-53. 2001
    ..These two opposing, rapid, Ca(2+)-dependent processes may play a crucial role in the modulation of synaptic vesicle trafficking within the presynaptic terminal...
  9. ncbi request reprint Regulation of phosphorylation of the GluR1 AMPA receptor in the neostriatum by dopamine and psychostimulants in vivo
    G L Snyder
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 20:4480-8. 2000
    ..These results identify DARPP-32 and AMPA-type glutamate receptors as likely essential cellular effectors for psychostimulant actions...
  10. ncbi request reprint ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteins
    I Dulubova
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York 10021, USA
    J Neurochem 77:229-38. 2001
    ..The conservation of this protein family through evolution suggests that it subserves an important cellular function that is regulated by PKA...
  11. ncbi request reprint Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase II
    J A Girault
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York 10021
    J Biol Chem 264:21748-59. 1989
    ..2-fold increase in the Vmax and a 1.4-fold increase in the apparent Km. Phosphorylation of DARPP-32 by casein kinase II in intact cells may therefore modulate its phosphorylation in response to increased levels of cAMP...
  12. ncbi request reprint Cocaine self-administration in mice is inversely related to phosphorylation at Thr34 (protein kinase A site) and Ser130 (kinase CK1 site) of DARPP-32
    Y Zhang
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 26:2645-51. 2006
    ..Thus, phosphorylation states of Thr34- and Ser130-DARPP-32 play important roles in modulating the reinforcing effects of cocaine...
  13. pmc Protein phosphatase 1 regulation by inhibitors and targeting subunits
    T Watanabe
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 98:3080-5. 2001
    ..More limited alterations in residues in beta12, beta13, and beta14 strands highlighted a key role for M290 and C291 in the interaction of PP1 with thiophospho-DARPP-32, but not inhibitor-2...
  14. pmc Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice
    J A Bibb
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 97:6809-14. 2000
    ..HD mice also show defects in dopamine-regulated ion channels and in the D(1) dopamine/DARPP-32 signaling cascade. These presymptomatic defects may contribute to HD pathology...
  15. ncbi request reprint Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons
    J A Bibb
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
    Nature 402:669-71. 1999
    ..Thus DARPP-32 is a bifunctional signal transduction molecule which, by distinct mechanisms, controls a serine/threonine kinase and a serine/threonine phosphatase...
  16. ncbi request reprint Regulation of synaptotagmin I phosphorylation by multiple protein kinases
    S Hilfiker
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York 10021, USA
    J Neurochem 73:921-32. 1999
    ..The results suggest the possibility that the phosphorylation of synaptotagmin I by CaMKII and PKC contributes to the mechanism(s) by which these two kinases regulate neurotransmitter release...
  17. ncbi request reprint Localization of cyclic GMP-dependent protein kinase in rat basal ganglia neurons
    S I Walaas
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021
    J Mol Neurosci 1:243-50. 1989
    ..The results indicate that cyclic GMP-regulated protein phosphorylation may play a role in the function of distinct basal ganglion neurons...
  18. pmc A third member of the synapsin gene family
    H T Kao
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 95:4667-72. 1998
    ..On the basis of this localization and the well established neurobiological roles of the synapsins, synapsin III represents a candidate gene for schizophrenia...
  19. ncbi request reprint A network of control mediated by regulator of calcium/calmodulin-dependent signaling
    S V Rakhilin
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021, USA
    Science 306:698-701. 2004
    ....
  20. ncbi request reprint Molecular evolution of the synapsin gene family
    H T Kao
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
    J Exp Zool 285:360-77. 1999
    ..This was accompanied by the emergence of an additional conserved domain, termed A. J. Exp. Zool. ( Mol. Dev. Evol. ) 285:360-377, 1999...
  21. ncbi request reprint ARPP-21, a cAMP-regulated phosphoprotein enriched in dopamine-innervated brain regions: tissue distribution and regulation of phosphorylation in rat brain
    J A Girault
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021
    Neuroscience 37:317-25. 1990
    ..The phosphorylation of ARPP-21 is likely to mediate some of the intracellular effects of neurotransmitters which stimulate adenylate cyclase in these regions, in particular dopamine and vasoactive intestinal peptide...
  22. ncbi request reprint Synapsins as mediators of BDNF-enhanced neurotransmitter release
    J N Jovanovic
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
    Nat Neurosci 3:323-9. 2000
    ..These results indicate a causal link of synapsin phosphorylation via BDNF, TrkB receptors and MAP kinase with downstream facilitation of neurotransmitter release...
  23. ncbi request reprint Characterization of transcripts from the synapsin III gene locus
    B Porton
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York 10021 6399, USA
    J Neurochem 73:2266-71. 1999
    ..This level of genome complexity is far greater than that described previously for the synapsin I and II genes and suggests that synapsin III may have functions distinct from those described for synapsins I and II...
  24. ncbi request reprint Phosphorylation of the cytoplasmic domain of Alzheimer's beta-amyloid precursor protein at Ser655 by a novel protein kinase
    T Isohara
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York 10021 6399, USA
    Biochem Biophys Res Commun 258:300-5. 1999
    ..The identification of a novel protein kinase that phosphorylates Ser655 will hopefully contribute to our understanding of the metabolism and/or function of APP in the pathogenesis of Alzheimer's disease (AD)...
  25. ncbi request reprint Regulation of neurabin I interaction with protein phosphatase 1 by phosphorylation
    T McAvoy
    Departments of Anesthesiology and Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Biochemistry 38:12943-9. 1999
    ..These findings identify a signaling mechanism involving the regulation of PP1 activity and localization mediated by the cAMP pathway...
  26. pmc Impairment of synaptic vesicle clustering and of synaptic transmission, and increased seizure propensity, in synapsin I-deficient mice
    L Li
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 92:9235-9. 1995
    ..These results provide strong support for the hypothesis that synapsin I plays a key role in the regulation of nerve terminal function in mature synapses...
  27. pmc Spinophilin regulates the formation and function of dendritic spines
    J Feng
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 97:9287-92. 2000
    ..In conclusion, spinophilin appears to be required for the regulation of the properties of dendritic spines...
  28. ncbi request reprint Novel target sites for estrogen action in the dorsal hippocampus: an examination of synaptic proteins
    W G Brake
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    Endocrinology 142:1284-9. 2001
    ..These results also suggest that RICC is a rapid and sensitive method for examining molecular changes in synaptic profiles in anatomically distinct brain regions...
  29. ncbi request reprint ARPP-21, a cyclic AMP-regulated phosphoprotein (Mr = 21,000) enriched in dopamine-innervated brain regions. Amino acid sequence of the site phosphorylated by cyclic AMP in intact cells and kinetic studies of its phosphorylation in vitro
    H C Hemmings
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York 10021
    J Biol Chem 264:7726-33. 1989
    ..g. dopamine and vasoactive intestinal peptide...
  30. ncbi request reprint Rat DARPP-32: cloning, sequencing, and characterization of the cDNA
    M E Ehrlich
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York 10021
    J Mol Neurosci 2:1-10. 1990
    ..Unilateral destruction of the nigrostriatal dopaminergic pathway by injection of 6-hydroxydopamine (6-OHDA) into the substantia nigra did not alter the striatal steady state levels of DARPP-32 mRNA...
  31. ncbi request reprint Synapsin dispersion and reclustering during synaptic activity
    P Chi
    Department of Biochemistry, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA
    Nat Neurosci 4:1187-93. 2001
    ..Thus synapsin acts as a phosphorylation-state-dependent regulator of synaptic vesicle mobilization, and hence, neurotransmitter release...
  32. pmc The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement
    S L Sabo
    Laboratory of Molecular and Cellular Neuroscience and the Zachary and Elizabeth M Fisher Center, The Rockefeller University, New York, New York 10021, USA
    J Cell Biol 153:1403-14. 2001
    ..These data are consistent with a role for FE65 and APP, possibly in a Mena-containing macromolecular complex, in regulation of actin-based motility...
  33. ncbi request reprint Neuron-specific expression of the synapsin II gene is directed by a specific core promoter and upstream regulatory elements
    L S Chin
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York 10021
    J Biol Chem 269:18507-13. 1994
    ....
  34. ncbi request reprint Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein
    S L Sabo
    Laboratory of Molecular and Cellular Neuroscience and Zachary and Elizabeth M Fisher Center, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 274:7952-7. 1999
    ....
  35. pmc D(2) dopamine receptors induce mitogen-activated protein kinase and cAMP response element-binding protein phosphorylation in neurons
    Z Yan
    Laboratory of Molecular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 96:11607-12. 1999
    ..Our results suggest that MAPK and CREB signaling cascades are involved in the regulation of gene expression and other long-term effects of D(2) receptor activation...
  36. pmc The cytoplasmic domain of Alzheimer's amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells
    M Oishi
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York, USA
    Mol Med 3:111-23. 1997
    ..The cytoplasmic domain of the Alzheimer's disease amyloid precursor protein (APP) is phosphorylated in vitro at Thr654 and Ser655, and both in vitro and in intact cells at Thr668 (numbering for APP695 isoform)...
  37. pmc Tonically active protein kinase A regulates neurotransmitter release at the squid giant synapse
    S Hilfiker
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    J Physiol 531:141-6. 2001
    ....
  38. ncbi request reprint A 127-kDa protein (UV-DDB) binds to the cytoplasmic domain of the Alzheimer's amyloid precursor protein
    T Watanabe
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York 10021, USA
    J Neurochem 72:549-56. 1999
    ....
  39. pmc Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor
    J D Buxbaum
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021
    Proc Natl Acad Sci U S A 89:10075-8. 1992
    ..Cholinergic agonists stimulated secretion in human glioma and neuroblastoma cells as well as in PC12 cells transfected with the M1 receptor, while interleukin 1 stimulated secretion in human endothelial and glioma cells...
  40. ncbi request reprint Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling
    L Gasparini
    Laboratory of Molecular and Cellular Neuroscience, Fisher Center for Research on Alzheimer Disease, and Laboratory for Mass Spectrometry, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 21:2561-70. 2001
    ..The results suggest cell biological and signal transduction mechanisms by which insulin modulates betaAPP and Abeta trafficking in neuronal cultures...
  41. ncbi request reprint Protein phosphatase-1 regulation in the induction of long-term potentiation: heterogeneous molecular mechanisms
    P B Allen
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    J Neurosci 20:3537-43. 2000
    ..Examination of the performance of I-1 mutants in spatial learning tests indicated that intact LTP at lateral perforant path-granule cell synapses is either redundant or is not involved in this form of learning...
  42. ncbi request reprint Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit
    P B Allen
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 273:4089-95. 1998
    ..The properties of PNUTS are consistent with its role as a targeting subunit for the regulation of nuclear PP1 function...
  43. ncbi request reprint Differential expression of protein phosphatase 1 isoforms in mammalian brain
    E F da Cruz e Silva
    Rockefeller University, New York, New York 10021, USA
    J Neurosci 15:3375-89. 1995
    ..PP1 beta appeared to be relatively less abundant in the same cells, as judged both by "in situ" hybridization and by the apparent absence of PP1 beta clones from the striatal cDNA libraries used...
  44. ncbi request reprint Synaptic vesicle phosphoproteins and regulation of synaptic function
    P Greengard
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021
    Science 259:780-5. 1993
    ..This article describes current understanding of the mechanism by which synapsin I modulates communication between nerve cells and reviews the properties and putative functions of other phosphoproteins associated with synaptic vesicles...
  45. ncbi request reprint ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. II. Molecular cloning and nucleotide sequence
    T Kurihara
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York 10021
    J Neurosci 9:3638-44. 1989
    ..There was a differential expression of these 2 mRNAs within the brain. Both ARPP-21 mRNAs were most abundant in the caudate nucleus, where the concentration of the protein is highly enriched...
  46. ncbi request reprint Distribution of DARPP-32 in the basal ganglia: an electron microscopic study
    C C Ouimet
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021
    J Neurocytol 19:39-52. 1990
    ..The presence of DARPP-32 in these striatal neurons and in their axon terminals suggests that DARPP-32 mediates part of the response of medium-size spiny neurons in the striatum to dopamine D-1 receptor activation...
  47. ncbi request reprint Purification and cDNA cloning of ARPP-16, a cAMP-regulated phosphoprotein enriched in basal ganglia, and of a related phosphoprotein, ARPP-19
    A Horiuchi
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York 10021
    J Biol Chem 265:9476-84. 1990
    ..The 5'-untranslated regions of the two clones were entirely different. The results suggest the possibility that ARPP-16 and ARPP-19 are produced by alternative transcription and splicing...
  48. ncbi request reprint Alzheimer amyloid protein precursor is localized in nerve terminal preparations to Rab5-containing vesicular organelles distinct from those implicated in the synaptic vesicle pathway
    A F Ikin
    Laboratory of Molecular and Cellular Neurosciences and Zachary and Elizabeth M Fisher Center, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 271:31783-6. 1996
    ..Thus, it appears that nerve terminal APP is contained predominantly in large vesicular organelles, distinct from synaptic vesicles and from the synaptic vesicle recycling pathway...
  49. pmc Characterization of the interaction between DARPP-32 and protein phosphatase 1 (PP-1): DARPP-32 peptides antagonize the interaction of PP-1 with binding proteins
    Y G Kwon
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 94:3536-41. 1997
    ....
  50. pmc Impairment of axonal development and of synaptogenesis in hippocampal neurons of synapsin I-deficient mice
    L S Chin
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 92:9230-4. 1995
    ..Furthermore, synapse formation was significantly delayed in these mutant neurons. These results indicate that synapsin I plays a role in regulation of axonogenesis and synaptogenesis...
  51. pmc Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein
    T Suzuki
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021 6399
    EMBO J 13:1114-22. 1994
    ..These findings suggest the possibility that phosphorylation-dependent events occurring during the cell cycle affect the metabolism of APP. Alterations in these events might play a role in the pathogenesis of Alzheimer's disease...
  52. ncbi request reprint Cloning of cDNA for DARPP-32, a dopamine- and cyclic AMP-regulated neuronal phosphoprotein
    T Kurihara
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York 10021
    J Neurosci 8:508-17. 1988
    ..8 and 1.65 kilobase in length. The high concentration of DARPP-32 mRNAs in the caudate nucleus is in agreement with the known distribution of this protein...
  53. pmc Amino acid sequences surrounding the cAMP-dependent and calcium/calmodulin-dependent phosphorylation sites in rat and bovine synapsin I
    A J Czernik
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021
    Proc Natl Acad Sci U S A 84:7518-22. 1987
    ..Thus, the sequences surrounding the four sites that are phosphorylated by calcium/calmodulin-dependent protein kinase II, namely sites 2 and 3 in rat and bovine synapsin I, exhibit a high degree of homology...
  54. ncbi request reprint Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices
    S Halpain
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York 10021
    Nature 343:369-72. 1990
    ....
  55. pmc Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides
    J P Greenfield
    Laboratory of Molecular and Cellular Neuroscience, and Fisher Center for Research on Alzheimer Disease, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 96:742-7. 1999
    ..The identification of the organelles in which distinct forms of Abeta are generated and from which they are secreted should facilitate the identification of the proteolytic enzymes responsible for their formation...
  56. pmc Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines
    P B Allen
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 94:9956-61. 1997
    ..g., neurotransmitter receptors, which mediate the regulation of synaptic function by PP1...
  57. pmc Regulation by cAMP and vasoactive intestinal peptide of phosphorylation of specific proteins in striatal cells in culture
    J A Girault
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021
    Proc Natl Acad Sci U S A 85:7790-4. 1988
    ..These phosphoproteins may therefore play a role in mediating some of the actions of vasoactive intestinal peptide in the caudate-putamen...
  58. ncbi request reprint Effects of chronic 'Binge' cocaine administration on plasma ACTH and corticosterone levels in mice deficient in DARPP-32
    Y Zhou
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, N Y, USA
    Neuroendocrinology 70:196-9. 1999
    ..The results indicate that DARPP-32 plays a role in mediating the stimulatory effects of cocaine on the HPA axis...
  59. ncbi request reprint The neurobiology of dopamine signaling
    P Greengard
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Biosci Rep 21:247-69. 2001
    ..The biochemistry of synaptic transmission, especially the neurobiology of dopamine signaling, is discussed...
  60. ncbi request reprint Cholinergic regulation of protein III phosphorylation in bovine adrenal chromaffin cells
    J W Haycock
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York 10021
    J Neurosci 8:3233-9. 1988
    ....
  61. ncbi request reprint Cloning of cDNAs encoding human synapsins IIa and IIb
    B Porton
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
    DNA Seq 10:49-54. 1999
    ..Human synapsins IIa and IIb conform to the previously described domain model of the synapsins, and the most conserved protein domains are A, C, and E...
  62. ncbi request reprint Localization of the synapsin II (SYN2) gene to human chromosome 3 and mouse chromosome 6
    L Li
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York 10021, USA
    Genomics 28:365-6. 1995
  63. ncbi request reprint A novel cyclin provides a link between dopamine and RNA processing
    A C Nairn
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021, USA
    Neuron 32:174-6. 2001
    ..Ania-6 may thus provide a link between dopamine and gene expression at the level of mRNA processing...
  64. ncbi request reprint Estradiol affects spinophilin protein differently in gonadectomized males and females
    S J Lee
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Box 165, 1230 York Avenue, New York, NY 10021, USA
    Neuroscience 127:983-8. 2004
    ..This suggests the possibility that E regulates spinophilin protein expression and or stability within dendrites via post-transcriptional mechanisms...
  65. ncbi request reprint Differential expression of ARPP-16 and ARPP-19, two highly related cAMP-regulated phosphoproteins, one of which is specifically associated with dopamine-innervated brain regions
    J A Girault
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York 10021
    J Neurosci 10:1124-33. 1990
    ..These 2 proteins provide a unique model for studying the specificity of signal transduction and gene expression in dopaminoceptive neurons...
  66. ncbi request reprint Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1
    J Goldberg
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
    Nature 376:745-53. 1995
    ..The fold of the catalytic domain is expected to be closely preserved in protein phosphatases 2A and 2B (calcineurin)...
  67. pmc Ca2+/calmodulin-dependent protein kinase II: identification of threonine-286 as the autophosphorylation site in the alpha subunit associated with the generation of Ca2+-independent activity
    G Thiel
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021
    Proc Natl Acad Sci U S A 85:6337-41. 1988
    ..The sequences obtained for two phosphopeptides derived from secondary chymotryptic digestion of CB-1 confirmed that Thr-286 was the phosphorylated residue...
  68. ncbi request reprint Dopamine D(1) receptor-induced gene transcription is modulated by DARPP-32
    P Svenningsson
    Departments of Physiology and Pharmacology Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Neurochem 75:248-57. 2000
    ..These results demonstrate an important involvement of DARPP-32 in dopamine receptor-mediated regulation of gene expression both in striatal neurons, which are enriched in DARPP-32, and in pallidal neurons, which do not contain DARPP-32...
  69. ncbi request reprint Phylogenetically conserved CK-II phosphorylation site of the murine homeodomain protein Hoxb-6
    A A Fienberg
    Department of Genetics, Yale University School of Medicine, Yale University, New Haven, Connecticut 06510, USA
    J Exp Zool 285:76-84. 1999
    ..The conservation of this site in several homeodomain proteins from various species is discussed...
  70. ncbi request reprint Phosphorylation of the cystic fibrosis transmembrane conductance regulator
    M R Picciotto
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York 10021
    J Biol Chem 267:12742-52. 1992
    ..Thus, regulation of CFTR is likely to occur through direct phosphorylation of the R-domain by protein kinases stimulated by different second messenger pathways...
  71. ncbi request reprint Characterization of rat ARPP-21 mRNA: sequence analysis, tissue distribution, and regulation
    M E Ehrlich
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021
    J Neurochem 57:1985-91. 1991
    ....
  72. pmc Distinct roles of synapsin I and synapsin II during neuronal development
    A Ferreira
    Department of Cell and Molecular Biology, Northwestern University, Chicago, IL 60611, USA
    Mol Med 4:22-8. 1998
    ..Remarkably, the deletion of both synapsins led to partial restoration of the wild phenotype. The results suggest that the synapsins play separate but coordinated developmental roles...
  73. ncbi request reprint Neuronal and behavioural abnormalities in striatal function in DARPP-32-mutant mice
    N Hiroi
    Laboratory of Molecular Psychiatry, Center for Genes and Behaviour, Yale University School of Medicine, New Haven, CT 06508, USA
    Eur J Neurosci 11:1114-8. 1999
    ..These data show that DARPP-32 is involved in regulating substance P expression in the striatonigral pathway, and in biochemical and behavioural plasticity with chronic administration of cocaine...
  74. ncbi request reprint Functional dopamine-1 receptors and DARPP-32 are expressed in human ovary and granulosa luteal cells in vitro
    A Mayerhofer
    Anatomisches Institut der Technischen Universität München, Germany
    J Clin Endocrinol Metab 84:257-64. 1999
    ..Taken together, the presence of DA and a functional DA receptor and DARPP-32 indicate that a novel, physiological regulatory pathway involving DA exists in the human ovary...
  75. ncbi request reprint Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5
    K Iijima
    Laboratory of Neurobiophysics, School of Pharmaceutical Sciences, The University of Tokyo, Japan
    J Neurochem 75:1085-91. 2000
    ..The expression of APP was unaffected in antisense-treated neurons. These results indicate that in neurons APP is phosphorylated by Cdk5, and that this may play a role in its localization...
  76. ncbi request reprint Cocaine-induced proliferation of dendritic spines in nucleus accumbens is dependent on the activity of cyclin-dependent kinase-5
    S D Norrholm
    Program in Neuroscience, Department of Psychology, The Florida State University, 251 Biomedical Research Facility, Tallahassee FL 32306, USA
    Neuroscience 116:19-22. 2003
    ..These data indicate that cyclin-dependent kinase-5 is involved in regulation of, as well as cocaine-induced changes in, dendritic spine density...
  77. pmc Molecular identification of human G-substrate, a possible downstream component of the cGMP-dependent protein kinase cascade in cerebellar Purkinje cells
    S Endo
    Laboratory for Learning and Memory, RIKEN, Brain Science Institute, Hirosawa 2 1, Wako, 351 0198, Japan
    Proc Natl Acad Sci U S A 96:2467-72. 1999
    ..However, purified G-substrate phosphorylated by cGMP-dependent protein kinase inhibited protein phosphatase 2A more effectively than protein phosphatase 1, suggesting a distinct role as a protein phosphatase inhibitor...
  78. ncbi request reprint Ovarian function and morphology after deletion of the DARPP-32 gene in mice
    A Mayerhofer
    Anatomisches Institut der Universität München, Munich, Germany
    Exp Clin Endocrinol Diabetes 112:451-7. 2004
    ..This implies that ovarian DARPP-32 is involved in follicular development, presumably by integrating effects of signaling molecules, which act together to ensure efficient follicular development...
  79. ncbi request reprint Distinct roles for spinophilin and neurabin in dopamine-mediated plasticity
    P B Allen
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Neuroscience 140:897-911. 2006
    ..These data establish a requirement for synaptic scaffolding in dopamine-mediated responses, and further indicate that spinophilin and neurabin play distinct roles in dopaminergic signal transduction and psychostimulant response...
  80. ncbi request reprint Role of adenosine A1 receptors in the modulation of dopamine D1 and adenosine A2A receptor signaling in the neostriatum
    K Yabuuchi
    Oita University Faculty of Medicine, Yufu, Oita 879 5593, Japan
    Neuroscience 141:19-25. 2006
    ..In conclusion, A(1) receptors play a major modulatory role in dopamine and adenosine receptor signaling...
  81. pmc Synaptic vesicle recycling in synapsin I knock-out mice
    T A Ryan
    Stanford University Medical School, California 94305, USA
    J Cell Biol 134:1219-27. 1996
    ....
  82. pmc Impaired conditioned taste aversion learning in spinophilin knockout mice
    C A Stafstrom-Davis
    Program in Neuroscience, Florida State University, Tallahassee, Florida 32306 4340 USA
    Learn Mem 8:272-8. 2001
    ..We conclude that spinophilin is a candidate molecule required for normal CTA learning...
  83. ncbi request reprint Dopamine and cAMP-regulated phosphoprotein 32 kDa controls both striatal long-term depression and long-term potentiation, opposing forms of synaptic plasticity
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Tor Vergata, Rome, Italy
    J Neurosci 20:8443-51. 2000
    ..These kinases appear to be stimulated by the activation of D1-like receptors in distinct neuronal populations...
  84. ncbi request reprint DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1
    H C Hemmings
    Nature 310:503-5. 1984
    ..Thus, the basal ganglia of mammalian brain contain a region-specific neuronal phosphoprotein that is a protein phosphatase inhibitor...
  85. ncbi request reprint DARPP-32, a dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Primary structure and homology with protein phosphatase inhibitor-1
    K R Williams
    J Biol Chem 261:1890-903. 1986
    ..These data suggest that these two protein phosphatase inhibitors may share a common structural basis for their inhibitory activity and may be related by a common ancestral gene...
  86. ncbi request reprint DARPP-32 knockout mice exhibit impaired reversal learning in a discriminated operant task
    C J Heyser
    Department of Psychology, Franklin and Marshall College, P O Box 3003, Lancaster, PA 17604, USA
    Brain Res 867:122-30. 2000
    ..These results provide evidence for a functional role of DARPP-32 in the mediation of processes underlying learning and memory...
  87. pmc Interaction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin I
    P S McPherson
    Department of Cell Biology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536
    Proc Natl Acad Sci U S A 91:6486-90. 1994
    ..These data suggest that Grb2, or other proteins containing SH3 domains, may play a role in the regulation of the exo/endocytotic cycle of synaptic vesicles and therefore of neurotransmitter release...
  88. ncbi request reprint Motivational effects of ethanol in DARPP-32 knock-out mice
    F O Risinger
    Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland, Oregon 97201 3098, USA
    J Neurosci 21:340-8. 2001
    ..2% w/v) was subsequently added to the ethanol mixture, and responding was examined at 0, 5, 10, and 20% ethanol concentrations. Ethanol responding increased in both genotypes, although WT mice showed higher rates at all concentrations...
  89. ncbi request reprint Synapsin controls both reserve and releasable synaptic vesicle pools during neuronal activity and short-term plasticity in Aplysia
    Y Humeau
    , Centre National de la Recherche Scientifique, IFR-37 des Neurosciences, , France
    J Neurosci 21:4195-206. 2001
    ....
  90. pmc Regulation of the phosphorylation of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa in vivo by dopamine D1, dopamine D2, and adenosine A2A receptors
    P Svenningsson
    Department of Physiology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 97:1856-60. 2000
    ..The results also underscore the fact that the adenosine system plays a role in the generation of responses to dopamine D(2) antagonists in vivo...
  91. ncbi request reprint Inhibition of mitochondrial complex II induces a long-term potentiation of NMDA-mediated synaptic excitation in the striatum requiring endogenous dopamine
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, , Rome 00133, Italy
    J Neurosci 21:5110-20. 2001
    ..Thus 3-NP-LTP might play a key role in the regional and cell type-specific neuronal death observed in HD...
  92. pmc Is myosin phosphatase regulated in vivo by inhibitor-1? Evidence from inhibitor-1 knockout mice
    A N Carr
    Department of Pharmacology and Cell Biophysics, University of Cincinnati, Cincinnati, OH 45267, USA
    J Physiol 534:357-66. 2001
    ..I-1 may play a role as a fine-tuning mechanism involved in regulating portal vein responsiveness to beta-adrenergic agonists...
  93. ncbi request reprint Requirement for DARPP-32 in progesterone-facilitated sexual receptivity in female rats and mice
    S K Mani
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 287:1053-6. 2000
    ..P also enhanced phosphorylation of DARPP-32 on threonine 34 in the hypothalamus of mice. DARPP-32 activation is thus an obligatory step in progestin receptor regulation of sexual receptivity in rats and mice...
  94. ncbi request reprint Phosphodiesterase 1B differentially modulates the effects of methamphetamine on locomotor activity and spatial learning through DARPP32-dependent pathways: evidence from PDE1B-DARPP32 double-knockout mice
    L A Ehrman
    Division of Developmental Biology, Division of Neurology, Cincinnati Children s Research Foundation and University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Genes Brain Behav 5:540-51. 2006
    ..Instead, the phenotype of double-KOs observed in these latter tasks may be mediated through independent pathways...