STRUAN GRANT

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. doi request reprint Classification of genetic profiles of Crohn's disease: a focus on the ATG16L1 gene
    Struan F A Grant
    The Center for Applied Genomics and Division of Human Genetics, The Abramson Research Center of the Joseph Stokes Jr Research Institute, Department of Pediatrics, The Children s Hospital of Philadelphia, PA 19104 4318, USA
    Expert Rev Mol Diagn 8:199-207. 2008
  2. doi request reprint Can the genetics of type 1 and type 2 diabetes shed light on the genetics of latent autoimmune diabetes in adults?
    Struan F A Grant
    Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Endocr Rev 31:183-93. 2010
  3. pmc Expression analyses of the genes harbored by the type 2 diabetes and pediatric BMI associated locus on 10q23
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, USA
    BMC Med Genet 13:89. 2012
  4. doi request reprint Lack of relationship between mitochondrial heteroplasmy or variation and childhood obesity
    S F A Grant
    Center for Applied Genomics, The Children s Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA
    Int J Obes (Lond) 36:80-3. 2012
  5. pmc The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    BMC Med Genet 11:96. 2010
  6. pmc Another tool in the genome-wide association study arsenal: population-based detection of somatic gene conversion
    Matthew A Deardorff
    Division of Human Genetics, The Children s Hospital of Philadelphia Research Institute, Philadelphia, PA, USA
    BMC Med 9:13. 2011
  7. pmc Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP
    Struan F A Grant
    Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 3:e1746. 2008
  8. doi request reprint A genome-wide association study identifies a locus for nonsyndromic cleft lip with or without cleft palate on 8q24
    Struan F A Grant
    Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    J Pediatr 155:909-13. 2009
  9. pmc Investigation of the locus near MC4R with childhood obesity in Americans of European and African ancestry
    Struan F A Grant
    Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 17:1461-5. 2009
  10. ncbi request reprint Recent development in pharmacogenomics: from candidate genes to genome-wide association studies
    Struan F A Grant
    Center for Applied Genomics, The Children s Hospital of Philadelphia, PA 19104 4318, USA
    Expert Rev Mol Diagn 7:371-93. 2007

Research Grants

Detail Information

Publications49

  1. doi request reprint Classification of genetic profiles of Crohn's disease: a focus on the ATG16L1 gene
    Struan F A Grant
    The Center for Applied Genomics and Division of Human Genetics, The Abramson Research Center of the Joseph Stokes Jr Research Institute, Department of Pediatrics, The Children s Hospital of Philadelphia, PA 19104 4318, USA
    Expert Rev Mol Diagn 8:199-207. 2008
    ....
  2. doi request reprint Can the genetics of type 1 and type 2 diabetes shed light on the genetics of latent autoimmune diabetes in adults?
    Struan F A Grant
    Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Endocr Rev 31:183-93. 2010
    ....
  3. pmc Expression analyses of the genes harbored by the type 2 diabetes and pediatric BMI associated locus on 10q23
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, USA
    BMC Med Genet 13:89. 2012
    ..This locus on 10q23 harbors three genes, encoding hematopoietically expressed homeobox (HHEX), insulin-degrading enzyme (IDE) and kinesin family member 11 (KIF11), respectively...
  4. doi request reprint Lack of relationship between mitochondrial heteroplasmy or variation and childhood obesity
    S F A Grant
    Center for Applied Genomics, The Children s Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA
    Int J Obes (Lond) 36:80-3. 2012
    ..As such, it is unlikely that common mitochondrial polymorphisms or heteroplasmy have a role in childhood obesity...
  5. pmc The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    BMC Med Genet 11:96. 2010
    ..Despite environmental influences, genetic factors are known to play an important role in stature determination. A number of genetic determinants of adult height have already been established through genome wide association studies...
  6. pmc Another tool in the genome-wide association study arsenal: population-based detection of somatic gene conversion
    Matthew A Deardorff
    Division of Human Genetics, The Children s Hospital of Philadelphia Research Institute, Philadelphia, PA, USA
    BMC Med 9:13. 2011
    ..Here, we describe how Ross's recent efforts to detect such occurrences could impact the field going forward...
  7. pmc Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP
    Struan F A Grant
    Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 3:e1746. 2008
    ..As such, variants in the FTO gene confer a similar magnitude of risk of obesity to children as to their adult counterparts and appear to have a global impact...
  8. doi request reprint A genome-wide association study identifies a locus for nonsyndromic cleft lip with or without cleft palate on 8q24
    Struan F A Grant
    Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    J Pediatr 155:909-13. 2009
    ..To identify, in a non-hypothesis manner, novel genetic factors associated with nonsyndromic cleft lip with or without cleft palate (NSCL/P)...
  9. pmc Investigation of the locus near MC4R with childhood obesity in Americans of European and African ancestry
    Struan F A Grant
    Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 17:1461-5. 2009
    ..As such, variants 3' to the MC4R locus present on the genotyping platform utilized confer a similar magnitude of risk of obesity in white children as to their adult white counterparts but this observation did not extend to AAs...
  10. ncbi request reprint Recent development in pharmacogenomics: from candidate genes to genome-wide association studies
    Struan F A Grant
    Center for Applied Genomics, The Children s Hospital of Philadelphia, PA 19104 4318, USA
    Expert Rev Mol Diagn 7:371-93. 2007
    ....
  11. pmc Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease
    Subra Kugathasan
    Department of Pediatrics, Children s Research Institute and Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Nat Genet 40:1211-5. 2008
    ..30 x 10(-8) and 6.95 x 10(-8), respectively; odds ratio (OR) = 0.74 for both) and 21q22 (rs2836878[A]; P = 6.01 x 10(-8); OR = 0.73), located close to the TNFRSF6B and PSMG1 genes, respectively...
  12. pmc Autism genome-wide copy number variation reveals ubiquitin and neuronal genes
    Joseph T Glessner
    Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Nature 459:569-73. 2009
    ....
  13. pmc High-resolution mapping and analysis of copy number variations in the human genome: a data resource for clinical and research applications
    Tamim H Shaikh
    Division of Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Genome Res 19:1682-90. 2009
    ..Together, this analysis and annotation provides a useful resource to assist with the assessment of CNVs in the contexts of human variation, disease susceptibility, and clinical molecular diagnostics...
  14. pmc Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects
    Kai Wang
    Center for Applied Genomics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Hum Mol Genet 19:2059-67. 2010
    ....
  15. pmc PennCNV: an integrated hidden Markov model designed for high-resolution copy number variation detection in whole-genome SNP genotyping data
    Kai Wang
    Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genome Res 17:1665-74. 2007
    ..3%. Our results demonstrate the feasibility of whole-genome fine-mapping of CNVs via high-density SNP genotyping...
  16. pmc Common genetic variants on 5p14.1 associate with autism spectrum disorders
    Kai Wang
    Center for Applied Genomics, Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Nature 459:528-33. 2009
    ..Our results implicate neuronal cell-adhesion molecules in the pathogenesis of ASDs, and represent, to our knowledge, the first demonstration of genome-wide significant association of common variants with susceptibility to ASDs...
  17. ncbi request reprint Association of variants of the interleukin-23 receptor gene with susceptibility to pediatric Crohn's disease
    Robert N Baldassano
    Division of Gastroenterology and Nutrition, Abramson Research Center, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, USA
    Clin Gastroenterol Hepatol 5:972-6. 2007
    ..We examined the effects of this and other previously reported SNPs at this locus with respect to CD in children...
  18. pmc ATOM: a powerful gene-based association test by combining optimally weighted markers
    Mingyao Li
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Bioinformatics 25:497-503. 2009
    ..One particularly challenging yet important question is how to best use all genetic information to test whether a gene or a region is associated with the trait of interest...
  19. pmc SNP array mapping of chromosome 20p deletions: genotypes, phenotypes, and copy number variation
    Binita M Kamath
    Division of Gastroenterology and Nutrition, Department of Pediatrics, The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Hum Mutat 30:371-8. 2009
    ..Deletions of the short arm of chromosome 20 are associated with relatively mild and limited clinical anomalies. The use of SNP arrays provides accurate high-resolution definition of genomic abnormalities...
  20. doi request reprint A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study
    Hakon Hakonarson
    Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, PA 19104 4318, USA
    Diabetes 57:1143-6. 2008
    ..03 x 10(-10)) and confirmed in two additional cohorts. Here we describe the results of testing, in these additional cohorts, 23 loci that were next in rank of statistical significance...
  21. pmc The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 17:2254-7. 2009
    ..We conclude that among 13 loci that have been reported to associate with adult BMI, at least nine also contribute to the determination of BMI in childhood as demonstrated by their associations in our pediatric cohort...
  22. pmc Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies
    Brendan J Keating
    The Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvannia, USA
    PLoS ONE 3:e3583. 2008
    ..These datasets will also facilitate more robust secondary analyses, such as explorations with alternative genetic models, epistasis and gene-environment interactions...
  23. pmc Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes
    Struan F A Grant
    Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 58:290-5. 2009
    ....
  24. doi request reprint Association of the TRAF1-C5 locus on chromosome 9 with juvenile idiopathic arthritis
    Edward M Behrens
    The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Arthritis Rheum 58:2206-7. 2008
  25. doi request reprint Mendelian randomization in the era of genomewide association studies
    Patrick M A Sleiman
    Center for Applied Genomics, The Children s Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA
    Clin Chem 56:723-8. 2010
    ..Randomized controlled trials are effective in dealing with the potential sources of error; however, their use is not always leveraged, for practical or ethical reasons...
  26. ncbi request reprint A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene
    Hakon Hakonarson
    Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Nature 448:591-4. 2007
    ..These results indicate that KIAA0350 might be involved in the pathogenesis of T1D and demonstrate the utility of the genome-wide association approach in the identification of previously unsuspected genetic determinants of complex traits...
  27. doi request reprint Variants of DENND1B associated with asthma in children
    Patrick M A Sleiman
    Center for Applied Genomics, Philadelphia, PA 19104 4318, USA
    N Engl J Med 362:36-44. 2010
    ..Asthma is a complex disease that has genetic and environmental causes. The genetic factors associated with susceptibility to asthma remain largely unknown...
  28. pmc Chromosome 6p22 locus associated with clinically aggressive neuroblastoma
    John M Maris
    Division of Oncology and the Center for Childhood Cancer Research, Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    N Engl J Med 358:2585-93. 2008
    ..Neuroblastoma is a malignant condition of the developing sympathetic nervous system that most commonly affects young children and is often lethal. Its cause is not known...
  29. doi request reprint Microarray technology and applications in the arena of genome-wide association
    Struan F A Grant
    The Center for Applied Genomics and Division of Human Genetics, The Abramson Research Center of the Joseph Stokes Jr Research Institute, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    Clin Chem 54:1116-24. 2008
    ..This has enabled large-scale genome-wide association (GWA) studies in complex diseases, such as diabetes, asthma, and inflammatory bowel disease, to be undertaken for the first time...
  30. pmc Modeling genetic inheritance of copy number variations
    Kai Wang
    Department of Genetics, Division of Human Genetics, Center for Applied Genomics, The Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucleic Acids Res 36:e138. 2008
    ..In conclusion, our method produces accurate CNV calls, gives probabilistic estimates of CNV transmission and builds a solid foundation for the development of linkage and association tests utilizing CNVs...
  31. doi request reprint Genome-wide association studies in type 1 diabetes, inflammatory bowel disease and other immune-mediated disorders
    Hakon Hakonarson
    The Center for Applied Genomics, The Abramson Research Center of the Joseph Stokes Jr Research Institute, The Children s Hospital of Philadelphia, PA 19104 4318, USA
    Semin Immunol 21:355-62. 2009
    ..The next steps are to identify the true causal variants underlying evidence of disease association and to leverage this information to improve diagnosis, prevention and cure of these diseases...
  32. ncbi request reprint Advances in whole genome sequencing technology
    Jianhua Zhao
    Children s Hospital of Philadelphia Research Institute, 34th and Civic Center Blvd, Philadelphia, PA 19104, USA
    Curr Pharm Biotechnol 12:293-305. 2011
    ..Thus, these technologies offer unprecedented opportunities to increase our understanding of the functions and dynamics of the human genome in the near future...
  33. pmc Large copy-number variations are enriched in cases with moderate to extreme obesity
    Kai Wang
    Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 59:2690-4. 2010
    ..We investigated whether large and rare copy-number variations (CNVs) differentiate moderate to extreme obesity from never-overweight control subjects...
  34. pmc Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight gene
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 58:2414-8. 2009
    ..In order to investigate whether type 2 diabetes risk-conferring alleles associate with low birth weight in our Caucasian childhood cohort, we examined the effects of 20 such loci on this trait...
  35. pmc Common variations in BARD1 influence susceptibility to high-risk neuroblastoma
    Mario Capasso
    Division of Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Nat Genet 41:718-23. 2009
    ..We also found significant association with known BARD1 nonsynonymous SNPs. These data show that common variation in BARD1 contributes to the etiology of the aggressive and most clinically relevant subset of human neuroblastoma...
  36. pmc Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 59:751-5. 2010
    ..Our goal was to investigate if any type 2 diabetes variants uncovered through genome-wide association studies (GWAS) impact BMI in childhood...
  37. pmc Strong synaptic transmission impact by copy number variations in schizophrenia
    Joseph T Glessner
    Center for Applied Genomics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:10584-9. 2010
    ..Our results suggest that novel variations involving the processes of synaptic transmission contribute to the genetic susceptibility of schizophrenia...
  38. pmc Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease
    Kai Wang
    Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Am J Hum Genet 84:399-405. 2009
    ..Our study suggests that examination beyond individual SNP hits, by focusing on genetic networks and pathways, is important to unleashing the true power of GWA studies...
  39. ncbi request reprint Genome-wide association studies in type 1 diabetes
    Struan F A Grant
    Center for Applied Genomics, 1216E Abramson Research Center, 3615 Civic Center Boulevard, Philadelphia, PA 19104 4318, USA
    Curr Diab Rep 9:157-63. 2009
    ..Combined with the well-established genes known for many years, 16 loci have now been uncovered to date as being robustly associated with the pathogenesis of this phenotype...
  40. pmc Common variants at 5q22 associate with pediatric eosinophilic esophagitis
    Marc E Rothenberg
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Nat Genet 42:289-91. 2010
    ..These data implicate the 5q22 locus in the pathogenesis of EoE and identify TSLP as the most likely candidate gene in the region...
  41. pmc Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2
    Inga Reynisdottir
    deCODE Genetics, Reykjavik, Iceland
    Am J Hum Genet 73:323-35. 2003
    ..Finally, we observed potential interactions between the 5q locus and two T2D susceptibility loci, previously mapped in other populations...
  42. pmc Linkage of osteoporosis to chromosome 20p12 and association to BMP2
    Unnur Styrkarsdottir
    deCODE Genetics, Reykjavik, Iceland
    PLoS Biol 1:E69. 2003
    ....
  43. ncbi request reprint The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke
    Anna Helgadottir
    deCODE Genetics, Sturlugata 8, Reykjavik, Iceland
    Nat Genet 36:233-9. 2004
    ..We conclude that variants of ALOX5AP are involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall...
  44. ncbi request reprint A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction
    Anna Helgadottir
    deCODE Genetics, Inc, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nat Genet 38:68-74. 2006
    ..Interactions with other genetic or environmental risk factors that are more common in African Americans are likely to account for the greater relative risk conferred by HapK in this group...
  45. ncbi request reprint Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
    Struan F A Grant
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 38:320-3. 2006
    ..It is thought to act through regulation of proglucagon gene expression in enteroendocrine cells via the Wnt signaling pathway...
  46. ncbi request reprint Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
    Agnar Helgason
    deCODE Genetics, 101 Reykjavik, Iceland
    Nat Genet 39:218-25. 2007
    ....
  47. pmc Association analysis of type 2 diabetes Loci in type 1 diabetes
    Hui Qi Qu
    Departments of Pediatrics and Human Genetics, McGill University, Montreal, Quebec, Canada
    Diabetes 57:1983-6. 2008
    ..To search for a possible association of type 1 diabetes with 10 validated type 2 diabetes loci, i.e., PPARG, KCNJ11, WFS1, HNF1B, IDE/HHEX, SLC30A8, CDKAL1, CDKN2A/B, IGF2BP2, and FTO/RPGRIP1L...
  48. pmc Association of the T300A non-synonymous variant of the ATG16L1 gene with susceptibility to paediatric Crohn's disease
    Robert N Baldassano
    Gut 56:1171-3. 2007
  49. pmc SNP genotyping on a genome-wide amplified DOP-PCR template
    Struan F A Grant
    LION bioscience AG, Im Neuenheimer Feld 515 517, 69120 Heidelberg, Germany
    Nucleic Acids Res 30:e125. 2002
    ..Adding carrier DNA to a final concentration of 10 ng/microl improved results. In conclusion, we have successfully used DOP-PCR to amplify our genomic DNA collection for subsequent SNP genotyping as a standard process...

Research Grants3

  1. Genome Wide Association Study for Childhood Obesity
    Struan F A Grant; Fiscal Year: 2010
    ..This project proposes to study genetic variants that influence the pathogenesis of childhood obesity in two large pediatric cohorts by conducting a genome-wide association study using a high density tag-SNP platform. ..
  2. Genome Wide Association Study for Childhood Obesity
    STRUAN GRANT; Fiscal Year: 2009
    ..This project proposes to study genetic variants that influence the pathogenesis of childhood obesity in two large pediatric cohorts by conducting a genome-wide association study using a high density tag-SNP platform. ..