Olga Y Gorlova

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy
    Olga Gorlova
    Department of Epidemiology, M D Anderson Cancer Center, Houston, Texas, USA
    PLoS Genet 7:e1002178. 2011
  2. pmc Derived SNP alleles are used more frequently than ancestral alleles as risk-associated variants in common human diseases
    Olga Y Gorlova
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 3721, USA
    J Bioinform Comput Biol 10:1241008. 2012
  3. ncbi DNA repair capacity and lung cancer risk in never smokers
    Olga Y Gorlova
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 17:1322-8. 2008
  4. ncbi Imprinting detection by extending a regression-based QTL analysis method
    Olga Y Gorlova
    Department of Epidemiology, MD Anderson Cancer Center, University of Texas, Unit 1340, 1155 Pressler Street, Houston, TX 77030, USA
    Hum Genet 122:159-74. 2007
  5. ncbi Aggregation of cancer among relatives of never-smoking lung cancer patients
    Olga Y Gorlova
    Department of Epidemiology, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 121:111-8. 2007
  6. ncbi Never smokers and lung cancer risk: a case-control study of epidemiological factors
    Olga Y Gorlova
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 118:1798-804. 2006
  7. ncbi Dietary patterns affect lung cancer risk in never smokers
    Olga Y Gorlova
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Nutr Cancer 63:842-9. 2011
  8. pmc Association of smoking with tumor size at diagnosis in non-small cell lung cancer
    Xing Chen
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Lung Cancer 74:378-83. 2011
  9. pmc Genome-wide association study reveals novel genetic determinants of DNA repair capacity in lung cancer
    Li E Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 73:256-64. 2013
  10. pmc Relative effects of mutability and selection on single nucleotide polymorphisms in transcribed regions of the human genome
    Ivan P Gorlov
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    BMC Genomics 9:292. 2008

Research Grants

Detail Information

Publications33

  1. pmc Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy
    Olga Gorlova
    Department of Epidemiology, M D Anderson Cancer Center, Houston, Texas, USA
    PLoS Genet 7:e1002178. 2011
    ..Within the HLA region, HLA-DQB1, HLA-DPA1/B1, and NOTCH4 associations with SSc are likely confined to specific auto-antibodies. These data emphasize the differential genetic components of subphenotypes of SSc...
  2. pmc Derived SNP alleles are used more frequently than ancestral alleles as risk-associated variants in common human diseases
    Olga Y Gorlova
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 3721, USA
    J Bioinform Comput Biol 10:1241008. 2012
    ..Alleles existing longer tend to show weaker linkage disequilibrium with neighboring alleles, including the causal alleles, and are less likely to tag a SNP-disease association...
  3. ncbi DNA repair capacity and lung cancer risk in never smokers
    Olga Y Gorlova
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 17:1322-8. 2008
    ..4 versus 67.7 years; P = 0.03)...
  4. ncbi Imprinting detection by extending a regression-based QTL analysis method
    Olga Y Gorlova
    Department of Epidemiology, MD Anderson Cancer Center, University of Texas, Unit 1340, 1155 Pressler Street, Houston, TX 77030, USA
    Hum Genet 122:159-74. 2007
    ..A parent-of-origin effect consistent with maternal imprinting was suggested at 99.67-111.26 Mb for body mass index, bioelectrical impedance analysis, waist circumference, and leptin concentration...
  5. ncbi Aggregation of cancer among relatives of never-smoking lung cancer patients
    Olga Y Gorlova
    Department of Epidemiology, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 121:111-8. 2007
    ..4, SD = 12.9) compared with control relatives (66.2, SD = 11.4; p = 0.07). Our analysis provides further evidence for the importance of genetic factors for lung cancer in never smokers...
  6. ncbi Never smokers and lung cancer risk: a case-control study of epidemiological factors
    Olga Y Gorlova
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 118:1798-804. 2006
    ..35-0.92]). In the multivariate analysis, exposure to ETS and dusts, and family history of cancer with onset before age 50 were significant risk factors, while a history of hay fever (occurring without asthma) was significantly protective...
  7. ncbi Dietary patterns affect lung cancer risk in never smokers
    Olga Y Gorlova
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Nutr Cancer 63:842-9. 2011
    ..This finding, if confirmed in a prospective study, has a clear preventive significance, by promoting interventions encouraging healthier diets...
  8. pmc Association of smoking with tumor size at diagnosis in non-small cell lung cancer
    Xing Chen
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Lung Cancer 74:378-83. 2011
    ..In the multivariate linear regression model, both rs1051730 and smoking were significant predictors for the size of squamous carcinomas. We conclude that smoking is positively associated with lung tumor size at the moment of diagnosis...
  9. pmc Genome-wide association study reveals novel genetic determinants of DNA repair capacity in lung cancer
    Li E Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 73:256-64. 2013
    ..In summary, we determined that DRC is an independent risk factor for lung cancer, and we defined several genetic loci contributing to DRC phenotype...
  10. pmc Relative effects of mutability and selection on single nucleotide polymorphisms in transcribed regions of the human genome
    Ivan P Gorlov
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    BMC Genomics 9:292. 2008
    ..The goal of this study was to estimate the relative effects of mutability and selection on SNP density in transcribed regions of human genes. It is important for prediction of the regions that harbor functional polymorphisms...
  11. pmc Variants in inflammation genes are implicated in risk of lung cancer in never smokers exposed to second-hand smoke
    Margaret R Spitz
    Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Discov 1:420-9. 2011
    ..These findings require further replication, followed by targeted resequencing, and functional validation...
  12. ncbi Interplay between mutagen sensitivity and epidemiological factors in modulatinglung cancer risk
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 120:2687-95. 2007
    ..This new integrative approach should facilitate identification of high-risk subgroups and has important implications in LC prevention...
  13. pmc Beyond comparing means: the usefulness of analyzing interindividual variation in gene expression for identifying genes associated with cancer development
    Ivan P Gorlov
    Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 3721, USA
    J Bioinform Comput Biol 10:1241013. 2012
    ..Our results suggest that analyzing IV in gene expression level is useful in identifying novel candidate genes associated with cancer development...
  14. pmc Initial medical attention on patients with early-stage non-small cell lung cancer
    Xing Chen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 7:e32644. 2012
    ..Understanding the reasons that caused initial detection of these patients is important for early diagnosis. However, these reasons are not well studied...
  15. pmc Associations between dietary intake of choline and betaine and lung cancer risk
    Jun Ying
    Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 8:e54561. 2013
    ..Our results suggest that choline and betaine intake, especially higher betaine intake, may be protective against lung cancer through mitigating the adverse effect of smoking...
  16. pmc Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms
    Ivan P Gorlov
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Hum Genet 82:100-12. 2008
    ..Our analysis suggests that including rare SNPs in genotyping platforms will advance identification of causal SNPs in case-control association studies, particularly as sample sizes increase...
  17. pmc A smoking-based carcinogenesis model for lung cancer risk prediction
    Millennia Foy
    Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Int J Cancer 129:1907-13. 2011
    ..The fitted model is validated against independent data from the control arm of a lung cancer chemoprevention trial, CARET, where it accurately predicted the number of lung cancer deaths observed...
  18. pmc Prioritizing genes associated with prostate cancer development
    Ivan P Gorlov
    Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    BMC Cancer 10:599. 2010
    ..Our working hypothesis was that combining meta-analyses on different but overlapping steps of prostate tumorigenesis will improve identification of genes associated with prostate cancer development...
  19. ncbi Missense mutations in cancer suppressor gene TP53 are colocalized with exonic splicing enhancers (ESEs)
    Ivan P Gorlov
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Box 189, 1515 Holcombe Boulevard, Houston 77030, USA
    Mutat Res 554:175-83. 2004
    ..These findings suggest that there is a limited number of missense mutations that influence ESE sites and our analysis provides further insight into the types of sites that harbor exonic enhancer elements...
  20. ncbi Genetic susceptibility for lung cancer: interactions with gender and smoking history and impact on early detection policies
    Olga Y Gorlova
    University of Texas M D Anderson Cancer Center, Houston, Tex, USA
    Hum Hered 56:139-45. 2003
    ....
  21. ncbi Predicting the oncogenicity of missense mutations reported in the International Agency for Cancer Research (IARC) mutation database on p53
    Ivan P Gorlov
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Hum Mutat 26:446-54. 2005
    ..We estimated the relative oncogenicity of all missense mutations reported in the IARC p53 mutation database, and constructed a profile of oncogenicity of the missense mutations along the DNA-binding region of p53...
  22. pmc Building a statistical model for predicting cancer genes
    Ivan P Gorlov
    Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    PLoS ONE 7:e49175. 2012
    ..We provide the list of the top 200 predicted PCa genes, which can be used as candidates for experimental validation. The model may be modified to predict genes for other cancer sites...
  23. pmc Adjusting a cancer mortality-prediction model for disease status-related eligibility criteria
    Millennia Foy
    Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 1825 Pressler St, Houston, TX 77030, USA
    BMC Med Res Methodol 11:64. 2011
    ....
  24. pmc IRF5 polymorphism predicts prognosis in patients with systemic sclerosis
    Roozbeh Sharif
    Division of Rheumatology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Ann Rheum Dis 71:1197-202. 2012
    ..The goal of this study was to investigate the impact of these gene variants on survival and severity of interstitial lung disease (ILD) in SSc...
  25. ncbi Genetic linkage and imprinting effects on body mass index in children and young adults
    Olga Y Gorlova
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Eur J Hum Genet 11:425-32. 2003
    ..1-q32 (maternal expression), 10p14-q11 (paternal expression), and 12p12-pter (paternal expression) in children, and 4q31-qter (paternal expression) and 8p (paternal expression) in adults...
  26. pmc Missense mutations in hMLH1 and hMSH2 are associated with exonic splicing enhancers
    Ivan P Gorlov
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Hum Genet 73:1157-61. 2003
    ..Similarly, pathogenic effects of >/=16% of missense mutations in the hMLH1 gene are ESE related. The colocalization of pathogenic missense mutations with ESE sites strongly suggests that their pathogenic effects are splicing related...
  27. pmc How to get the most from microarray data: advice from reverse genomics
    Ivan P Gorlov
    Department of Genitourinary Medical Oncology, Unit 1374, The University of Texas MD Anderson Cancer Center, 1155 Pressler Street, Houston, TX 77030 3721, USA
    BMC Genomics 15:223. 2014
    ..The goal of this study was to identify the best microarray data-derived predictor of known cancer associated genes...
  28. pmc Modeling the natural history and detection of lung cancer based on smoking behavior
    Xing Chen
    Department of Biomedical Engineering, Key Laboratory of Biomedical Engineering of Ministry of Education of China, Zhejiang University, Hangzhou, Zhejiang, China Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 9:e93430. 2014
    ..The model accurately predicted the gender distribution and median age of LC patients of diagnosis, and reasonably predicted the joint tumor size and disease stage distribution. ..
  29. pmc GWAS meets microarray: are the results of genome-wide association studies and gene-expression profiling consistent? Prostate cancer as an example
    Ivan P Gorlov
    Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    PLoS ONE 4:e6511. 2009
    ..It is not obvious whether there is a consistency between the candidate genes identified by GWAS (GWAS genes) and those identified by profiling gene expression (microarray genes)...
  30. pmc Modeling the mortality reduction due to computed tomography screening for lung cancer
    Millennia Foy
    Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA
    Cancer 117:2703-8. 2011
    ..In this study, the authors used data from a single-arm CT screening trial to estimate the mortality reduction using a modeling-based approach to construct a control comparison arm...
  31. pmc Candidate pathways and genes for prostate cancer: a meta-analysis of gene expression data
    Ivan P Gorlov
    Department of Genitourinary Medical Oncology, The University of Texas M, Anderson Cancer Center, Houston, TX, USA
    BMC Med Genomics 2:48. 2009
    ..Suppression of integrin expression driven by integrin-mediated cell death leads to increased cell proliferation and motility and increased tumor malignancy...
  32. pmc Possible genomic imprinting of three human obesity-related genetic loci
    Chuanhui Dong
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 6140, USA
    Am J Hum Genet 76:427-37. 2005
    ..79; multipoint LOD of 3.72 for BMI) in region 13q32, in the European American sample. The results suggest that parent-of-origin effects, perhaps including genomic imprinting, may play a role in human obesity...
  33. ncbi Re: "Cancer mortality among US men and women with asthma and hay fever"
    Matthew B Schabath
    Am J Epidemiol 163:394-5; author reply 395-6. 2006

Research Grants1

  1. A genomewide study of lung cancer in never smokers
    Olga Gorlova; Fiscal Year: 2010
    ..We will combine the available resources from the multiple sites to achieve the sample size sufficient for this study. The study will identify genetic architecture of the predisposition to the lung cancer in never smokers. ..