Ivan P Gorlov

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc Relative effects of mutability and selection on single nucleotide polymorphisms in transcribed regions of the human genome
    Ivan P Gorlov
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    BMC Genomics 9:292. 2008
  2. pmc Building a statistical model for predicting cancer genes
    Ivan P Gorlov
    Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    PLoS ONE 7:e49175. 2012
  3. pmc Beyond comparing means: the usefulness of analyzing interindividual variation in gene expression for identifying genes associated with cancer development
    Ivan P Gorlov
    Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 3721, USA
    J Bioinform Comput Biol 10:1241013. 2012
  4. pmc In silico functional profiling of individual prostate cancer tumors: many genes, few functions
    Ivan P Gorlov
    Department of Genitourinary Medical Oncology, Unit 1374, The University of Texas MD Anderson Cancer Center, 1155 Pressler Street, Houston, TX 77030 3721, USA
    Cancer Genomics Proteomics 9:109-14. 2012
  5. pmc Candidate pathways and genes for prostate cancer: a meta-analysis of gene expression data
    Ivan P Gorlov
    Department of Genitourinary Medical Oncology, The University of Texas M, Anderson Cancer Center, Houston, TX, USA
    BMC Med Genomics 2:48. 2009
  6. ncbi Strength of the purifying selection against different categories of the point mutations in the coding regions of the human genome
    Ivan P Gorlov
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Mol Genet 15:1143-50. 2006
  7. pmc Evolutionary evidence of the effect of rare variants on disease etiology
    I P Gorlov
    Department of Genitourinary Medical Oncology Department of Epidemiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Genet 79:199-206. 2011
  8. pmc Prioritizing genes associated with prostate cancer development
    Ivan P Gorlov
    Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    BMC Cancer 10:599. 2010
  9. pmc GWAS meets microarray: are the results of genome-wide association studies and gene-expression profiling consistent? Prostate cancer as an example
    Ivan P Gorlov
    Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    PLoS ONE 4:e6511. 2009
  10. pmc Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study
    Christopher I Amos
    Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 102:1199-205. 2010

Detail Information

Publications31

  1. pmc Relative effects of mutability and selection on single nucleotide polymorphisms in transcribed regions of the human genome
    Ivan P Gorlov
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    BMC Genomics 9:292. 2008
    ..The goal of this study was to estimate the relative effects of mutability and selection on SNP density in transcribed regions of human genes. It is important for prediction of the regions that harbor functional polymorphisms...
  2. pmc Building a statistical model for predicting cancer genes
    Ivan P Gorlov
    Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    PLoS ONE 7:e49175. 2012
    ..We provide the list of the top 200 predicted PCa genes, which can be used as candidates for experimental validation. The model may be modified to predict genes for other cancer sites...
  3. pmc Beyond comparing means: the usefulness of analyzing interindividual variation in gene expression for identifying genes associated with cancer development
    Ivan P Gorlov
    Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 3721, USA
    J Bioinform Comput Biol 10:1241013. 2012
    ..Our results suggest that analyzing IV in gene expression level is useful in identifying novel candidate genes associated with cancer development...
  4. pmc In silico functional profiling of individual prostate cancer tumors: many genes, few functions
    Ivan P Gorlov
    Department of Genitourinary Medical Oncology, Unit 1374, The University of Texas MD Anderson Cancer Center, 1155 Pressler Street, Houston, TX 77030 3721, USA
    Cancer Genomics Proteomics 9:109-14. 2012
    ..We hypothesized that analysis of these functions provides a better understanding of tumor biology than does actual identification of these genes...
  5. pmc Candidate pathways and genes for prostate cancer: a meta-analysis of gene expression data
    Ivan P Gorlov
    Department of Genitourinary Medical Oncology, The University of Texas M, Anderson Cancer Center, Houston, TX, USA
    BMC Med Genomics 2:48. 2009
    ..Suppression of integrin expression driven by integrin-mediated cell death leads to increased cell proliferation and motility and increased tumor malignancy...
  6. ncbi Strength of the purifying selection against different categories of the point mutations in the coding regions of the human genome
    Ivan P Gorlov
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Mol Genet 15:1143-50. 2006
    ....
  7. pmc Evolutionary evidence of the effect of rare variants on disease etiology
    I P Gorlov
    Department of Genitourinary Medical Oncology Department of Epidemiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Genet 79:199-206. 2011
    ..Further, targeting patients with a family history of the disease, an extreme phenotype, or early disease onset may facilitate the detection of risk-associated rare SNPs...
  8. pmc Prioritizing genes associated with prostate cancer development
    Ivan P Gorlov
    Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    BMC Cancer 10:599. 2010
    ..Our working hypothesis was that combining meta-analyses on different but overlapping steps of prostate tumorigenesis will improve identification of genes associated with prostate cancer development...
  9. pmc GWAS meets microarray: are the results of genome-wide association studies and gene-expression profiling consistent? Prostate cancer as an example
    Ivan P Gorlov
    Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    PLoS ONE 4:e6511. 2009
    ..It is not obvious whether there is a consistency between the candidate genes identified by GWAS (GWAS genes) and those identified by profiling gene expression (microarray genes)...
  10. pmc Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study
    Christopher I Amos
    Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 102:1199-205. 2010
    ..Thus, among African American persons, multiple loci in the region of chromosome 15q25.1 appear to be strongly associated with lung cancer risk...
  11. pmc Multistage analysis of variants in the inflammation pathway and lung cancer risk in smokers
    Margaret R Spitz
    Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 21:1213-21. 2012
    ..Tobacco-induced lung cancer is characterized by a deregulated inflammatory microenvironment. Variants in multiple genes in inflammation pathways may contribute to risk of lung cancer...
  12. pmc Novel genetic variants in the chromosome 5p15.33 region associate with lung cancer risk
    Mala Pande
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 32:1493-9. 2011
    ..Results of these analyses strongly suggest effects on risk from several loci in the TERT/CLPTM1L region...
  13. pmc ATM sequence variants associate with susceptibility to non-small cell lung cancer
    Hushan Yang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX
    Int J Cancer 121:2254-9. 2007
    ....
  14. pmc Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms
    Ivan P Gorlov
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Hum Genet 82:100-12. 2008
    ..Our analysis suggests that including rare SNPs in genotyping platforms will advance identification of causal SNPs in case-control association studies, particularly as sample sizes increase...
  15. pmc Derived SNP alleles are used more frequently than ancestral alleles as risk-associated variants in common human diseases
    Olga Y Gorlova
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 3721, USA
    J Bioinform Comput Biol 10:1241008. 2012
    ..Alleles existing longer tend to show weaker linkage disequilibrium with neighboring alleles, including the causal alleles, and are less likely to tag a SNP-disease association...
  16. ncbi Predicting the oncogenicity of missense mutations reported in the International Agency for Cancer Research (IARC) mutation database on p53
    Ivan P Gorlov
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Hum Mutat 26:446-54. 2005
    ..We estimated the relative oncogenicity of all missense mutations reported in the IARC p53 mutation database, and constructed a profile of oncogenicity of the missense mutations along the DNA-binding region of p53...
  17. pmc Variants in inflammation genes are implicated in risk of lung cancer in never smokers exposed to second-hand smoke
    Margaret R Spitz
    Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Discov 1:420-9. 2011
    ..These findings require further replication, followed by targeted resequencing, and functional validation...
  18. pmc Initial medical attention on patients with early-stage non-small cell lung cancer
    Xing Chen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 7:e32644. 2012
    ..Understanding the reasons that caused initial detection of these patients is important for early diagnosis. However, these reasons are not well studied...
  19. pmc Cell cycle-related genes as modifiers of age of onset of colorectal cancer in Lynch syndrome: a large-scale study in non-Hispanic white patients
    Jinyun Chen
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 34:299-306. 2013
    ..67, 95% CI = 3.16-6.92). The additional genetic markers identified may help in refining risk groups for more tailored screening and follow-up of non-Hispanic white patients with Lynch syndrome...
  20. pmc Association of smoking with tumor size at diagnosis in non-small cell lung cancer
    Xing Chen
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Lung Cancer 74:378-83. 2011
    ..In the multivariate linear regression model, both rs1051730 and smoking were significant predictors for the size of squamous carcinomas. We conclude that smoking is positively associated with lung tumor size at the moment of diagnosis...
  21. ncbi Missense mutations in cancer suppressor gene TP53 are colocalized with exonic splicing enhancers (ESEs)
    Ivan P Gorlov
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Box 189, 1515 Holcombe Boulevard, Houston 77030, USA
    Mutat Res 554:175-83. 2004
    ..These findings suggest that there is a limited number of missense mutations that influence ESE sites and our analysis provides further insight into the types of sites that harbor exonic enhancer elements...
  22. pmc Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1
    Christopher I Amos
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Genet 40:616-22. 2008
    ..Haplotype analysis was consistent with there being a single risk variant in this region. We conclude that variation in a region of 15q25.1 containing nicotinic acetylcholine receptors genes contributes to lung cancer risk...
  23. ncbi A method for isolating alternatively spliced isoforms: isolation of murine Pax6 isoforms
    Ivan P Gorlov
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Anal Biochem 308:401-4. 2002
  24. pmc Missense mutations in hMLH1 and hMSH2 are associated with exonic splicing enhancers
    Ivan P Gorlov
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Hum Genet 73:1157-61. 2003
    ..Similarly, pathogenic effects of >/=16% of missense mutations in the hMLH1 gene are ESE related. The colocalization of pathogenic missense mutations with ESE sites strongly suggests that their pathogenic effects are splicing related...
  25. ncbi Seizure 6-like (SEZ6L) gene and risk for lung cancer
    Ivan P Gorlov
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 67:8406-11. 2007
    ..In conclusion, the results of these studies representing 906 cases compared with 811 controls indicate a role of the SEZ6L Met430Ile polymorphic variant in increasing lung cancer risk...
  26. ncbi Housekeeping genes in prostate tumorigenesis
    Jinyoung Byun
    Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Int J Cancer 125:2603-8. 2009
    ..The results of these analyses suggest that during prostate tumorigenesis, there is a period when the tumor is under cellular stress and, therefore, may be the most vulnerable and responsive to treatment...
  27. pmc How to get the most from microarray data: advice from reverse genomics
    Ivan P Gorlov
    Department of Genitourinary Medical Oncology, Unit 1374, The University of Texas MD Anderson Cancer Center, 1155 Pressler Street, Houston, TX 77030 3721, USA
    BMC Genomics 15:223. 2014
    ..The goal of this study was to identify the best microarray data-derived predictor of known cancer associated genes...
  28. pmc Modified logistic regression models using gene coexpression and clinical features to predict prostate cancer progression
    Hongya Zhao
    Industrial Center, Shenzhen Polytechnic, Shenzhen, Guangdong 518055, China Department of Genitourinary Medical Oncology, Unit 1374, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Comput Math Methods Med 2013:917502. 2013
    ..Thus, we conclude that TSP selection is a useful tool for feature (and/or gene) selection to use in prognostic models and our model also provides an alternative for predicting prostate cancer progression. ..
  29. ncbi Polymorphisms of folate metabolic genes and susceptibility to bladder cancer: a case-control study
    Jie Lin
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Carcinogenesis 25:1639-47. 2004
    ..These results have important implications for cancer prevention in susceptible populations...
  30. ncbi PAX6, paired domain influences sequence recognition by the homeodomain
    Rajnikant Mishra
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Biol Chem 277:49488-94. 2002
    ..Functional analysis of the PD-less isoform of Pax6 as well as findings related to missense mutations in the PD suggest that the PD of PAX6 is required for HD function...
  31. ncbi Mutations of the GREAT gene cause cryptorchidism
    Ivan P Gorlov
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 11:2309-18. 2002
    ..This mutant receptor fails to respond to ligand stimulation, implicating the GREAT gene in the etiology in some cases of cryptorchidism in humans...

Research Grants3

  1. The Odd-Even Effect of Polymorphic CA repeats in the 5' Regulatory Region of the
    IVAN GORLOV; Fiscal Year: 2007
    ..The results obtained in this study will improve our understanding of how genetic polymorphisms in this key gene modulate breast cancer risk. [unreadable] [unreadable] [unreadable]..
  2. The Odd-Even Effect of Polymorphic CA repeats in the 5' Regulatory Region of the
    IVAN GORLOV; Fiscal Year: 2008
    ..The results obtained in this study will improve our understanding of how genetic polymorphisms in this key gene modulate breast cancer risk. [unreadable] [unreadable] [unreadable]..
  3. Tobacco Smoke Sensitive Genes and Genetic Susceptibility to Small-Cell Lung Cance
    IVAN GORLOV; Fiscal Year: 2008
    ..The proposed study will thus identify genes whose impaired expression by TSE causes SCLC. The identification of these genes will improve our ability not only to diagnose and treat SCLC early but also to prevent it. ..