RONALD M GLASER

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi request reprint Stress-related changes in proinflammatory cytokine production in wounds
    R Glaser
    Department of Medical Microbiology, The Institute for Behavioral Medicine Research, The Ohio State University, Columbus 43210, USA
    Arch Gen Psychiatry 56:450-6. 1999
  2. ncbi request reprint Stress-associated changes in the steady-state expression of latent Epstein-Barr virus: implications for chronic fatigue syndrome and cancer
    Ronald Glaser
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Medical Center, 333 W 10th Avenue, Columbus, OH 43210, USA
    Brain Behav Immun 19:91-103. 2005
  3. pmc Chronic stress and age-related increases in the proinflammatory cytokine IL-6
    Janice K Kiecolt-Glaser
    Department of Psychiatry, Ohio State University College of Medicine, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 100:9090-5. 2003
  4. ncbi request reprint EBV-encoded dUTPase induces immune dysregulation: Implications for the pathophysiology of EBV-associated disease
    Ronald Glaser
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Medical Center, 333 W 10th Avenue, Columbus, OH 43210, USA
    Virology 346:205-18. 2006
  5. ncbi request reprint Evidence for a shift in the Th-1 to Th-2 cytokine response associated with chronic stress and aging
    R Glaser
    Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Medical Center, 333 W 10th Ave, Columbus, OH 43210
    J Gerontol A Biol Sci Med Sci 56:M477-82. 2001
  6. ncbi request reprint Chronic stress modulates the immune response to a pneumococcal pneumonia vaccine
    R Glaser
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, USA
    Psychosom Med 62:804-7. 2000
  7. pmc Epstein-Barr virus-encoded dUTPase enhances proinflammatory cytokine production by macrophages in contact with endothelial cells: evidence for depression-induced atherosclerotic risk
    W James Waldman
    Department of Pathology, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Brain Behav Immun 22:215-23. 2008
  8. pmc Stress, inflammation, and yoga practice
    Janice K Kiecolt-Glaser
    Department of Psychiatry, Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, OH 43210, USA
    Psychosom Med 72:113-21. 2010
  9. pmc Depressive symptoms predict exaggerated inflammatory responses to an in vivo immune challenge among pregnant women
    Lisa M Christian
    Department of Psychiatry, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Brain Behav Immun 24:49-53. 2010
  10. pmc Depressive symptoms are associated with elevated serum proinflammatory cytokines among pregnant women
    Lisa M Christian
    Department of Psychiatry, The Ohio State University Medical Center, 1670 Upham Drive, Columbus, OH 43210, USA
    Brain Behav Immun 23:750-4. 2009

Detail Information

Publications47

  1. ncbi request reprint Stress-related changes in proinflammatory cytokine production in wounds
    R Glaser
    Department of Medical Microbiology, The Institute for Behavioral Medicine Research, The Ohio State University, Columbus 43210, USA
    Arch Gen Psychiatry 56:450-6. 1999
    ....
  2. ncbi request reprint Stress-associated changes in the steady-state expression of latent Epstein-Barr virus: implications for chronic fatigue syndrome and cancer
    Ronald Glaser
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Medical Center, 333 W 10th Avenue, Columbus, OH 43210, USA
    Brain Behav Immun 19:91-103. 2005
    ..The data also provide additional insight into the pathophysiology of EBV infection, inflammation, and cancer...
  3. pmc Chronic stress and age-related increases in the proinflammatory cytokine IL-6
    Janice K Kiecolt-Glaser
    Department of Psychiatry, Ohio State University College of Medicine, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 100:9090-5. 2003
    ..These data provide evidence of a key mechanism through which chronic stressors may accelerate risk of a host of age-related diseases by prematurely aging the immune response...
  4. ncbi request reprint EBV-encoded dUTPase induces immune dysregulation: Implications for the pathophysiology of EBV-associated disease
    Ronald Glaser
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Medical Center, 333 W 10th Avenue, Columbus, OH 43210, USA
    Virology 346:205-18. 2006
    ..The data support the hypothesis that at least one protein of the EBV early antigen complex can induce immune dysregulation and may be involved in the pathophysiology of EBV-associated disease...
  5. ncbi request reprint Evidence for a shift in the Th-1 to Th-2 cytokine response associated with chronic stress and aging
    R Glaser
    Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Medical Center, 333 W 10th Ave, Columbus, OH 43210
    J Gerontol A Biol Sci Med Sci 56:M477-82. 2001
    ..A number of studies have shown that the chronic stress of caring for persons with dementia can have significant immunological consequences as demonstrated by the down-regulation/dysregulation of the cellular immune response...
  6. ncbi request reprint Chronic stress modulates the immune response to a pneumococcal pneumonia vaccine
    R Glaser
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, USA
    Psychosom Med 62:804-7. 2000
    ..This study tested the hypothesis that stress can also significantly inhibit the IgG antibody response to a pneumococcal bacterial vaccine...
  7. pmc Epstein-Barr virus-encoded dUTPase enhances proinflammatory cytokine production by macrophages in contact with endothelial cells: evidence for depression-induced atherosclerotic risk
    W James Waldman
    Department of Pathology, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Brain Behav Immun 22:215-23. 2008
    ....
  8. pmc Stress, inflammation, and yoga practice
    Janice K Kiecolt-Glaser
    Department of Psychiatry, Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, OH 43210, USA
    Psychosom Med 72:113-21. 2010
    ..Stressors before each of the three conditions provided data on the extent to which yoga speeded an individual's physiological recovery...
  9. pmc Depressive symptoms predict exaggerated inflammatory responses to an in vivo immune challenge among pregnant women
    Lisa M Christian
    Department of Psychiatry, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Brain Behav Immun 24:49-53. 2010
    ..The current study was designed to test the hypothesis that depressive symptoms would predict an exaggerated proinflammatory response to an in vivo antigen challenge, influenza virus vaccination, among pregnant women...
  10. pmc Depressive symptoms are associated with elevated serum proinflammatory cytokines among pregnant women
    Lisa M Christian
    Department of Psychiatry, The Ohio State University Medical Center, 1670 Upham Drive, Columbus, OH 43210, USA
    Brain Behav Immun 23:750-4. 2009
    ..These data are consistent with the contention that depressive symptoms may contribute to negative perinatal outcomes via inflammatory pathways...
  11. ncbi request reprint Spousal support satisfaction as a modifier of physiological responses to marital conflict in younger and older couples
    Kathi L Heffner
    Department of Psychiatry, College of Medicine, Ohio State University, 200 Porter Hall, Athens, Ohio 45701, USA
    J Behav Med 27:233-54. 2004
    ..These relationships provide a window on mechanisms linking marriage and health for men and women across the life span...
  12. ncbi request reprint Epstein-Barr virus-encoded dUTPase modulates immune function and induces sickness behavior in mice
    David A Padgett
    Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Medical Center, Columbus, Ohio, USA
    J Med Virol 74:442-8. 2004
    ..These data suggest that individual viral proteins may play a role in the pathophysiology of EBV associated disease...
  13. ncbi request reprint Hostility and pain are related to inflammation in older adults
    Jennifer E Graham
    Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University College of Medicine, USA
    Brain Behav Immun 20:389-400. 2006
    ..Our results also shed light on inflammation as a mechanism underlying the effects of hostility on cardiovascular disease morbidity and mortality...
  14. ncbi request reprint Exercise accelerates wound healing among healthy older adults: a preliminary investigation
    Charles F Emery
    Departments of Psychology and Internal Medicine, 1885 Neil Avenue, The Ohio State University, Columbus, OH 43210, USA
    J Gerontol A Biol Sci Med Sci 60:1432-6. 2005
    ..This study evaluated the effect of a 3-month exercise program on wound healing, neuroendocrine function, and perceived stress among healthy older adults...
  15. ncbi request reprint Hostile marital interactions, proinflammatory cytokine production, and wound healing
    Janice K Kiecolt-Glaser
    Department of Psychiatry, Institute for Behavioral Medicine Research, Ohio State University College of Medicine, 1670 Upham Drive, Columbus, OH 43210, USA
    Arch Gen Psychiatry 62:1377-84. 2005
    ..In addition, depression and stress are associated with enhanced production of proinflammatory cytokines that influence a spectrum of conditions associated with aging...
  16. pmc Depressive symptoms, omega-6:omega-3 fatty acids, and inflammation in older adults
    Janice K Kiecolt-Glaser
    Department of Psychiatry, Ohio State University College of Medicine, 1670 Upham Drive, Columbus, OH 43210, USA
    Psychosom Med 69:217-24. 2007
    ..Dietary intakes of omega-3 (n-3) and omega-6 (n-6) PUFAs also influence inflammation; high n-6:n-3 ratios enhance proinflammatory cytokine production, although n-3 has anti-inflammatory properties...
  17. pmc Distress reduction from a psychological intervention contributes to improved health for cancer patients
    Barbara L Andersen
    Department of Psychology and Comprehensive Cancer Center, 1835 Neil Avenue, The Ohio State University, Columbus, OH 43210 1222, USA
    Brain Behav Immun 21:953-61. 2007
    ..A clinical trial tests whether a psychological intervention for cancer patients can do so, and also tests two routes to achieve better health: (a) reducing patients' Emotional Distress, and/or (b) enhancing their functional immunity...
  18. pmc Stress and wound healing
    Lisa M Christian
    Department of Molecular Virology, Immunology, and Medical Genetics, Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA
    Neuroimmunomodulation 13:337-46. 2006
    ..Moreover, specific physiological mechanisms are associated with certain types of interventions. In future research, an increased focus on mechanisms will help to more clearly elucidate pathways linking stress and healing processes...
  19. pmc Marital behavior, oxytocin, vasopressin, and wound healing
    Jean Philippe Gouin
    Department of Psychology, The Ohio State University, Columbus, OH 43210 1228, USA
    Psychoneuroendocrinology 35:1082-90. 2010
    ..These data confirm and extend prior evidence implicating oxytocin and vasopressin in couples' positive and negative communication behaviors, and also provide further evidence of their role in an important health outcome, wound healing...
  20. pmc Altered expression of circadian rhythm genes among individuals with a history of depression
    Jean Philippe Gouin
    Department of Psychology, The Ohio State University, USA
    J Affect Disord 126:161-6. 2010
    ..The interaction of several circadian clock genes generates these daily circadian rhythms...
  21. pmc The influence of anger expression on wound healing
    Jean Philippe Gouin
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    Brain Behav Immun 22:699-708. 2008
    ..This enhanced cortisol secretion was in turn related to longer time to heal. These findings suggest that the ability to regulate the expression of one's anger has a clinically relevant impact on wound healing...
  22. pmc Olfactory influences on mood and autonomic, endocrine, and immune function
    Janice K Kiecolt-Glaser
    Department of Psychiatry, The Ohio State University, 1670 Upham Drive, Columbus, OH 43210, USA
    Psychoneuroendocrinology 33:328-39. 2008
    ..Odors did not reliably alter IL-6 and IL-10 production, salivary cortisol, heart rate or blood pressure, skin barrier repair following tape stripping, or pain ratings following the cold pressor...
  23. pmc Attachment avoidance predicts inflammatory responses to marital conflict
    Jean Philippe Gouin
    Department of Psychology, The Ohio State University 43210, USA
    Brain Behav Immun 23:898-904. 2009
    ..In sum, these results suggest that attachment avoidance modulates marital behavior and stress-induced immune dysregulation...
  24. pmc How stress and anxiety can alter immediate and late phase skin test responses in allergic rhinitis
    Janice K Kiecolt-Glaser
    The Ohio State University College of Medicine, Department of Psychiatry, 1670 Upham Drive, Columbus, OH 43210, United States
    Psychoneuroendocrinology 34:670-80. 2009
    ..Greater anxiety was associated with more IL-6 production by Con A-stimulated leukocytes following the stressor compared to the control visit. The data suggest that stress and anxiety can enhance and prolong AR symptoms...
  25. ncbi request reprint Stress-induced immune dysregulation: implications for wound healing, infectious disease and cancer
    Jonathan P Godbout
    Institute for Behavioral Medicine Research, Ohio State University, Columbus, OH, USA
    J Neuroimmune Pharmacol 1:421-7. 2006
    ..This overview will discuss the evidence that psychological stress promotes immune dysfunction that negatively impacts human health...
  26. ncbi request reprint Stress-induced immune dysfunction: implications for health
    Ronald Glaser
    Department of Molecular Virology, Immunology and Medical Genetics, College of Medicine and Public Health and Institute for Behavioral Medical Research, Ohio State University, Columbus, OH 43210, USA
    Nat Rev Immunol 5:243-51. 2005
    ..PNI researchers have used animal and human models to learn how the immune system communicates bidirectionally with the central nervous and endocrine systems and how these interactions impact on health...
  27. ncbi request reprint Psychoneuroimmunology and psychosomatic medicine: back to the future
    Janice K Kiecolt-Glaser
    Department of Psychiatry, Ohio State University, Columbus, OH 43210, USA
    Psychosom Med 64:15-28. 2002
    ..This article speculates on future directions for psychoneuroimmunology research, after reviewing the history of the field...
  28. ncbi request reprint Human lymphocyte growth hormone stimulates interferon gamma production and is inhibited by cortisol and norepinephrine
    William B Malarkey
    Department of Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Neuroimmunol 123:180-7. 2002
    ..001), but not the TH2 cytokine, IL-10, in the supernatants of the cultured PBMLs. These studies suggest that L-GH plays a role in cellular immune function mediated via the TH-1 pathway...
  29. ncbi request reprint Psychoneuroimmunology: psychological influences on immune function and health
    Janice K Kiecolt-Glaser
    Department of Psychiatry and Institute for Behavioral Medicine Research, Ohio State University College of Medicine, Columbus 43210, USA
    J Consult Clin Psychol 70:537-47. 2002
    ....
  30. ncbi request reprint Depression and immune function: central pathways to morbidity and mortality
    Janice K Kiecolt-Glaser
    Department of Psychiatry, The Ohio State University College of Medicine, 1670 Upham Drive, Columbus, OH 43210, USA
    J Psychosom Res 53:873-6. 2002
    ..The increased morbidity and mortality associated with depression is substantial. In this paper, we review evidence suggesting that depression contributes to disease and death through immune dysregulation...
  31. pmc When fit indices and residuals are incompatible
    Michael W Browne
    Department of Psychology, The Ohio State University, Columbus, Ohio 43210 1222, USA
    Psychol Methods 7:403-21. 2002
    ..For this example, the fit indices indicate excellent fit. A theoretical explanation for this phenomenon is provided using relationships between unique variances and eigenvalues of the fitted correlation matrix...
  32. ncbi request reprint Love, marriage, and divorce: newlyweds' stress hormones foreshadow relationship changes
    Janice K Kiecolt-Glaser
    Department of Psychiatry, Ohio State University College of Medicine and Ohio State Institute for Behavioral Medicine Research, Columbus 43210, USA
    J Consult Clin Psychol 71:176-88. 2003
    ..Couples whose marriages were troubled at follow-up produced 34% more norepinephrine during conflict, 24% more norepinephrine during the daytime, and 17% more during nighttime hours at Time 1 than the untroubled...
  33. ncbi request reprint Stress-associated immunomodulation and its implications for responses to vaccination
    Eric V Yang
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University College of Medicine and Public Health, Columbus 43210, USA
    Expert Rev Vaccines 1:453-9. 2002
    ..In this review, we discuss human studies and animal models, which focus on psychological stress and its effects on the immune response to vaccination, emphasizing the implications of these effects on health...
  34. ncbi request reprint Emotions, morbidity, and mortality: new perspectives from psychoneuroimmunology
    Janice K Kiecolt-Glaser
    Department of Psychiatry The Ohio State University College of Medicine, 1670 Upham Drive, Columbus, Ohio 43210, USA
    Annu Rev Psychol 53:83-107. 2002
    ..Resources such as close personal relationships that diminish negative emotions enhance health in part through their positive impact on immune and endocrine regulation...
  35. ncbi request reprint Stress-associated immune dysregulation and its importance for human health: a personal history of psychoneuroimmunology
    Ronald Glaser
    Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Institute for Behavioral Medicine Research, The Ohio State University Medical Center, USA
    Brain Behav Immun 19:3-11. 2005
    ....
  36. ncbi request reprint Mild depressive symptoms are associated with amplified and prolonged inflammatory responses after influenza virus vaccination in older adults
    Ronald Glaser
    Departments of Molecular Virology, Immunology, and Medical Genetics, Institute for Behavioral Medicine Research, Columbus, OH 43210, USA
    Arch Gen Psychiatry 60:1009-14. 2003
    ..In this prospective community study, we assessed the relationship between depressive symptoms and changes in inflammatory response after an influenza virus vaccination...
  37. pmc Psychological, behavioral, and immune changes after a psychological intervention: a clinical trial
    Barbara L Andersen
    Department of Psychology, College of Medicine, The Ohio State University, Columbus, OH 43210 1222, USA
    J Clin Oncol 22:3570-80. 2004
    ..This randomized clinical trial tests the hypothesis that a psychological intervention can reduce emotional distress, improve health behaviors and dose-intensity, and enhance immune responses...
  38. ncbi request reprint Stress-induced immunomodulation and the implications for health
    Eric V Yang
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University Comprehensive Cancer Center, Institute for Behavioral Medicine Research, The Ohio State University Medical Center, Columbus 43210, USA
    Int Immunopharmacol 2:315-24. 2002
    ..In this review, we discuss human studies and animal models, which focuses on psychological stress emphasizing the implications of these effects on wound healing and infectious diseases...
  39. ncbi request reprint Stress-related modulation of matrix metalloproteinase expression
    Eric V Yang
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, 2175 Graves Hall, 333 W 10th Avenue, Columbus, OH 43210, USA
    J Neuroimmunol 133:144-50. 2002
    ..The data suggest that activation of the HPA and SAM axes, even in individuals within the normal range of depressive symptoms, could mediate MMP levels and wound healing in blister wounds...
  40. ncbi request reprint Wound site neutrophil transcriptome in response to psychological stress in young men
    Sashwati Roy
    Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Gene Expr 12:273-87. 2005
    ..Further effort to gain a more comprehensive understanding of the functional significance of such behavior-genome interaction is warranted...
  41. pmc Norepinephrine upregulates VEGF, IL-8, and IL-6 expression in human melanoma tumor cell lines: implications for stress-related enhancement of tumor progression
    Eric V Yang
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Brain Behav Immun 23:267-75. 2009
    ....
  42. ncbi request reprint Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cells
    Eric V Yang
    Department of Molecular Virology, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Cancer Res 66:10357-64. 2006
    ..The data suggest that catecholamine hormones produced by the sympathetic-adrenal medullary axis may affect NPC tumor progression, in part, through modulation of key angiogenic cytokines...
  43. ncbi request reprint How stress influences the immune response
    David A Padgett
    Department of Oral Biology, 3180 Postle Hall, Ohio State University, 305 W 12th Avenue, Columbus, OH 43210, USA
    Trends Immunol 24:444-8. 2003
  44. pmc VEGF is differentially regulated in multiple myeloma-derived cell lines by norepinephrine
    Eric V Yang
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Brain Behav Immun 22:318-23. 2008
    ..The data suggest that the ability of NE to regulate the expression of VEGF is not limited to solid epithelial tumors and suggests a possible regulatory role of catecholamine stress hormones in MM progression...
  45. ncbi request reprint Stress-induced immunomodulation: Implications for tumorigenesis
    Eric V Yang
    Department of Molecular Virology, Immunology, and Medical Genetics, Institute for Behavioral Medicine Research, The Ohio State University College of Medicine and Public Health, 2175, Graves Hall, 333 W 10th Avenue, Columbus 43210, USA
    Brain Behav Immun 17:S37-40. 2003
  46. doi request reprint Stress hormones and immune function
    Jeanette I Webster Marketon
    Institute for Behavioral Medicine Research, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Cell Immunol 252:16-26. 2008
    ..These data provide scientific evidence of the effects of stress on immune function and implications for health...
  47. ncbi request reprint Depressive symptoms and lymphocyte proliferation in older adults
    Lynanne McGuire
    Division of Health Psychology, Department of Psychiatry, Ohio State University College of Medicine, USA
    J Abnorm Psychol 111:192-7. 2002
    ..These findings extend the association between depression and immune function to community-dwelling older adults with chronic, mild depressive symptoms...

Research Grants6

  1. Stress, the Immune System and Basal Cell Carcinoma
    Ronald Glaser; Fiscal Year: 2006
    ..2) We will determine if the relationships between depressive symptoms and severe life stressors and tumor immunoreactivity are more pronounced among older adults. ..
  2. Stress, the Immune System and Basal Cell Carcinoma
    Ronald Glaser; Fiscal Year: 2007
    ..2) We will determine if the relationships between depressive symptoms and severe life stressors and tumor immunoreactivity are more pronounced among older adults. ..
  3. Stress, the Immune System and Basal Cell Carcinoma
    Ronald Glaser; Fiscal Year: 2006
    ..2) We will determine if the relationships between depressive symptoms and severe life stressors and tumor immunoreactivity are more pronounced among older adults. ..
  4. Stress, the Immune System and Basal Cell Carcinoma
    Ronald Glaser; Fiscal Year: 2007
    ..2) We will determine if the relationships between depressive symptoms and severe life stressors and tumor immunoreactivity are more pronounced among older adults. ..
  5. Stress effects on virus protein induced inflammation and sickness behavior
    Ronald Glaser; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: This multidisciplinary research grant will provide new information on how stress can have an impact on the pathophysiology on herpesvirus associated diseases. ..