Research Topics
Species | RONALD M GLASERSummaryAffiliation: The Ohio State University Country: USA Publications
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Detail Information
Publications
Stress-related changes in proinflammatory cytokine production in woundsR Glaser
Department of Medical Microbiology, The Institute for Behavioral Medicine Research, The Ohio State University, Columbus 43210, USA
Arch Gen Psychiatry 56:450-6. 1999....- Stress-associated changes in the steady-state expression of latent Epstein-Barr virus: implications for chronic fatigue syndrome and cancerRonald Glaser
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Medical Center, 333 W 10th Avenue, Columbus, OH 43210, USA
Brain Behav Immun 19:91-103. 2005..The data also provide additional insight into the pathophysiology of EBV infection, inflammation, and cancer... 
Chronic stress and age-related increases in the proinflammatory cytokine IL-6Janice K Kiecolt-Glaser
Department of Psychiatry, Ohio State University College of Medicine, Columbus, OH 43210, USA
Proc Natl Acad Sci U S A 100:9090-5. 2003..These data provide evidence of a key mechanism through which chronic stressors may accelerate risk of a host of age-related diseases by prematurely aging the immune response...- EBV-encoded dUTPase induces immune dysregulation: Implications for the pathophysiology of EBV-associated diseaseRonald Glaser
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Medical Center, 333 W 10th Avenue, Columbus, OH 43210, USA
Virology 346:205-18. 2006..The data support the hypothesis that at least one protein of the EBV early antigen complex can induce immune dysregulation and may be involved in the pathophysiology of EBV-associated disease... - Evidence for a shift in the Th-1 to Th-2 cytokine response associated with chronic stress and agingR Glaser
Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Medical Center, 333 W 10th Ave, Columbus, OH 43210
J Gerontol A Biol Sci Med Sci 56:M477-82. 2001..A number of studies have shown that the chronic stress of caring for persons with dementia can have significant immunological consequences as demonstrated by the down-regulation/dysregulation of the cellular immune response... - Chronic stress modulates the immune response to a pneumococcal pneumonia vaccineR Glaser
Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, USA
Psychosom Med 62:804-7. 2000..This study tested the hypothesis that stress can also significantly inhibit the IgG antibody response to a pneumococcal bacterial vaccine... - Epstein-Barr virus-encoded dUTPase enhances proinflammatory cytokine production by macrophages in contact with endothelial cells: evidence for depression-induced atherosclerotic riskW James Waldman
Department of Pathology, The Ohio State University Medical Center, Columbus, OH 43210, USA
Brain Behav Immun 22:215-23. 2008.... - Stress, inflammation, and yoga practiceJanice K Kiecolt-Glaser
Department of Psychiatry, Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, OH 43210, USA
Psychosom Med 72:113-21. 2010..Stressors before each of the three conditions provided data on the extent to which yoga speeded an individual's physiological recovery... - Depressive symptoms predict exaggerated inflammatory responses to an in vivo immune challenge among pregnant womenLisa M Christian
Department of Psychiatry, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
Brain Behav Immun 24:49-53. 2010..The current study was designed to test the hypothesis that depressive symptoms would predict an exaggerated proinflammatory response to an in vivo antigen challenge, influenza virus vaccination, among pregnant women... - Depressive symptoms are associated with elevated serum proinflammatory cytokines among pregnant womenLisa M Christian
Department of Psychiatry, The Ohio State University Medical Center, 1670 Upham Drive, Columbus, OH 43210, USA
Brain Behav Immun 23:750-4. 2009..These data are consistent with the contention that depressive symptoms may contribute to negative perinatal outcomes via inflammatory pathways... - Spousal support satisfaction as a modifier of physiological responses to marital conflict in younger and older couplesKathi L Heffner
Department of Psychiatry, College of Medicine, Ohio State University, 200 Porter Hall, Athens, Ohio 45701, USA
J Behav Med 27:233-54. 2004..These relationships provide a window on mechanisms linking marriage and health for men and women across the life span... - Epstein-Barr virus-encoded dUTPase modulates immune function and induces sickness behavior in miceDavid A Padgett
Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Medical Center, Columbus, Ohio, USA
J Med Virol 74:442-8. 2004..These data suggest that individual viral proteins may play a role in the pathophysiology of EBV associated disease... - Hostility and pain are related to inflammation in older adultsJennifer E Graham
Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University College of Medicine, USA
Brain Behav Immun 20:389-400. 2006..Our results also shed light on inflammation as a mechanism underlying the effects of hostility on cardiovascular disease morbidity and mortality... - Exercise accelerates wound healing among healthy older adults: a preliminary investigationCharles F Emery
Departments of Psychology and Internal Medicine, 1885 Neil Avenue, The Ohio State University, Columbus, OH 43210, USA
J Gerontol A Biol Sci Med Sci 60:1432-6. 2005..This study evaluated the effect of a 3-month exercise program on wound healing, neuroendocrine function, and perceived stress among healthy older adults... - Hostile marital interactions, proinflammatory cytokine production, and wound healingJanice K Kiecolt-Glaser
Department of Psychiatry, Institute for Behavioral Medicine Research, Ohio State University College of Medicine, 1670 Upham Drive, Columbus, OH 43210, USA
Arch Gen Psychiatry 62:1377-84. 2005..In addition, depression and stress are associated with enhanced production of proinflammatory cytokines that influence a spectrum of conditions associated with aging... - Depressive symptoms, omega-6:omega-3 fatty acids, and inflammation in older adultsJanice K Kiecolt-Glaser
Department of Psychiatry, Ohio State University College of Medicine, 1670 Upham Drive, Columbus, OH 43210, USA
Psychosom Med 69:217-24. 2007..Dietary intakes of omega-3 (n-3) and omega-6 (n-6) PUFAs also influence inflammation; high n-6:n-3 ratios enhance proinflammatory cytokine production, although n-3 has anti-inflammatory properties... - Distress reduction from a psychological intervention contributes to improved health for cancer patientsBarbara L Andersen
Department of Psychology and Comprehensive Cancer Center, 1835 Neil Avenue, The Ohio State University, Columbus, OH 43210 1222, USA
Brain Behav Immun 21:953-61. 2007..A clinical trial tests whether a psychological intervention for cancer patients can do so, and also tests two routes to achieve better health: (a) reducing patients' Emotional Distress, and/or (b) enhancing their functional immunity... - Stress and wound healingLisa M Christian
Department of Molecular Virology, Immunology, and Medical Genetics, Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA
Neuroimmunomodulation 13:337-46. 2006..Moreover, specific physiological mechanisms are associated with certain types of interventions. In future research, an increased focus on mechanisms will help to more clearly elucidate pathways linking stress and healing processes... - Marital behavior, oxytocin, vasopressin, and wound healingJean Philippe Gouin
Department of Psychology, The Ohio State University, Columbus, OH 43210 1228, USA
Psychoneuroendocrinology 35:1082-90. 2010..These data confirm and extend prior evidence implicating oxytocin and vasopressin in couples' positive and negative communication behaviors, and also provide further evidence of their role in an important health outcome, wound healing... - Altered expression of circadian rhythm genes among individuals with a history of depressionJean Philippe Gouin
Department of Psychology, The Ohio State University, USA
J Affect Disord 126:161-6. 2010..The interaction of several circadian clock genes generates these daily circadian rhythms... - The influence of anger expression on wound healingJean Philippe Gouin
Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
Brain Behav Immun 22:699-708. 2008..This enhanced cortisol secretion was in turn related to longer time to heal. These findings suggest that the ability to regulate the expression of one's anger has a clinically relevant impact on wound healing... - Olfactory influences on mood and autonomic, endocrine, and immune functionJanice K Kiecolt-Glaser
Department of Psychiatry, The Ohio State University, 1670 Upham Drive, Columbus, OH 43210, USA
Psychoneuroendocrinology 33:328-39. 2008..Odors did not reliably alter IL-6 and IL-10 production, salivary cortisol, heart rate or blood pressure, skin barrier repair following tape stripping, or pain ratings following the cold pressor... - Attachment avoidance predicts inflammatory responses to marital conflictJean Philippe Gouin
Department of Psychology, The Ohio State University 43210, USA
Brain Behav Immun 23:898-904. 2009..In sum, these results suggest that attachment avoidance modulates marital behavior and stress-induced immune dysregulation... - How stress and anxiety can alter immediate and late phase skin test responses in allergic rhinitisJanice K Kiecolt-Glaser
The Ohio State University College of Medicine, Department of Psychiatry, 1670 Upham Drive, Columbus, OH 43210, United States
Psychoneuroendocrinology 34:670-80. 2009..Greater anxiety was associated with more IL-6 production by Con A-stimulated leukocytes following the stressor compared to the control visit. The data suggest that stress and anxiety can enhance and prolong AR symptoms... - Stress-induced immune dysregulation: implications for wound healing, infectious disease and cancerJonathan P Godbout
Institute for Behavioral Medicine Research, Ohio State University, Columbus, OH, USA
J Neuroimmune Pharmacol 1:421-7. 2006..This overview will discuss the evidence that psychological stress promotes immune dysfunction that negatively impacts human health... - Stress-induced immune dysfunction: implications for healthRonald Glaser
Department of Molecular Virology, Immunology and Medical Genetics, College of Medicine and Public Health and Institute for Behavioral Medical Research, Ohio State University, Columbus, OH 43210, USA
Nat Rev Immunol 5:243-51. 2005..PNI researchers have used animal and human models to learn how the immune system communicates bidirectionally with the central nervous and endocrine systems and how these interactions impact on health... - Psychoneuroimmunology and psychosomatic medicine: back to the futureJanice K Kiecolt-Glaser
Department of Psychiatry, Ohio State University, Columbus, OH 43210, USA
Psychosom Med 64:15-28. 2002..This article speculates on future directions for psychoneuroimmunology research, after reviewing the history of the field... - Human lymphocyte growth hormone stimulates interferon gamma production and is inhibited by cortisol and norepinephrineWilliam B Malarkey
Department of Medicine, The Ohio State University, Columbus, OH 43210, USA
J Neuroimmunol 123:180-7. 2002..001), but not the TH2 cytokine, IL-10, in the supernatants of the cultured PBMLs. These studies suggest that L-GH plays a role in cellular immune function mediated via the TH-1 pathway... - Psychoneuroimmunology: psychological influences on immune function and healthJanice K Kiecolt-Glaser
Department of Psychiatry and Institute for Behavioral Medicine Research, Ohio State University College of Medicine, Columbus 43210, USA
J Consult Clin Psychol 70:537-47. 2002.... - Depression and immune function: central pathways to morbidity and mortalityJanice K Kiecolt-Glaser
Department of Psychiatry, The Ohio State University College of Medicine, 1670 Upham Drive, Columbus, OH 43210, USA
J Psychosom Res 53:873-6. 2002..The increased morbidity and mortality associated with depression is substantial. In this paper, we review evidence suggesting that depression contributes to disease and death through immune dysregulation... - When fit indices and residuals are incompatibleMichael W Browne
Department of Psychology, The Ohio State University, Columbus, Ohio 43210 1222, USA
Psychol Methods 7:403-21. 2002..For this example, the fit indices indicate excellent fit. A theoretical explanation for this phenomenon is provided using relationships between unique variances and eigenvalues of the fitted correlation matrix... - Love, marriage, and divorce: newlyweds' stress hormones foreshadow relationship changesJanice K Kiecolt-Glaser
Department of Psychiatry, Ohio State University College of Medicine and Ohio State Institute for Behavioral Medicine Research, Columbus 43210, USA
J Consult Clin Psychol 71:176-88. 2003..Couples whose marriages were troubled at follow-up produced 34% more norepinephrine during conflict, 24% more norepinephrine during the daytime, and 17% more during nighttime hours at Time 1 than the untroubled... - Stress-associated immunomodulation and its implications for responses to vaccinationEric V Yang
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University College of Medicine and Public Health, Columbus 43210, USA
Expert Rev Vaccines 1:453-9. 2002..In this review, we discuss human studies and animal models, which focus on psychological stress and its effects on the immune response to vaccination, emphasizing the implications of these effects on health... - Emotions, morbidity, and mortality: new perspectives from psychoneuroimmunologyJanice K Kiecolt-Glaser
Department of Psychiatry The Ohio State University College of Medicine, 1670 Upham Drive, Columbus, Ohio 43210, USA
Annu Rev Psychol 53:83-107. 2002..Resources such as close personal relationships that diminish negative emotions enhance health in part through their positive impact on immune and endocrine regulation... - Stress-associated immune dysregulation and its importance for human health: a personal history of psychoneuroimmunologyRonald Glaser
Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Institute for Behavioral Medicine Research, The Ohio State University Medical Center, USA
Brain Behav Immun 19:3-11. 2005.... - Mild depressive symptoms are associated with amplified and prolonged inflammatory responses after influenza virus vaccination in older adultsRonald Glaser
Departments of Molecular Virology, Immunology, and Medical Genetics, Institute for Behavioral Medicine Research, Columbus, OH 43210, USA
Arch Gen Psychiatry 60:1009-14. 2003..In this prospective community study, we assessed the relationship between depressive symptoms and changes in inflammatory response after an influenza virus vaccination... - Psychological, behavioral, and immune changes after a psychological intervention: a clinical trialBarbara L Andersen
Department of Psychology, College of Medicine, The Ohio State University, Columbus, OH 43210 1222, USA
J Clin Oncol 22:3570-80. 2004..This randomized clinical trial tests the hypothesis that a psychological intervention can reduce emotional distress, improve health behaviors and dose-intensity, and enhance immune responses... - Stress-induced immunomodulation and the implications for healthEric V Yang
Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University Comprehensive Cancer Center, Institute for Behavioral Medicine Research, The Ohio State University Medical Center, Columbus 43210, USA
Int Immunopharmacol 2:315-24. 2002..In this review, we discuss human studies and animal models, which focuses on psychological stress emphasizing the implications of these effects on wound healing and infectious diseases... - Stress-related modulation of matrix metalloproteinase expressionEric V Yang
Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, 2175 Graves Hall, 333 W 10th Avenue, Columbus, OH 43210, USA
J Neuroimmunol 133:144-50. 2002..The data suggest that activation of the HPA and SAM axes, even in individuals within the normal range of depressive symptoms, could mediate MMP levels and wound healing in blister wounds... - Wound site neutrophil transcriptome in response to psychological stress in young menSashwati Roy
Laboratory of Molecular Medicine, Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
Gene Expr 12:273-87. 2005..Further effort to gain a more comprehensive understanding of the functional significance of such behavior-genome interaction is warranted... - Norepinephrine upregulates VEGF, IL-8, and IL-6 expression in human melanoma tumor cell lines: implications for stress-related enhancement of tumor progressionEric V Yang
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Medical Center, Columbus, OH 43210, USA
Brain Behav Immun 23:267-75. 2009.... - Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cellsEric V Yang
Department of Molecular Virology, The Ohio State University Medical Center, Columbus, OH 43210, USA
Cancer Res 66:10357-64. 2006..The data suggest that catecholamine hormones produced by the sympathetic-adrenal medullary axis may affect NPC tumor progression, in part, through modulation of key angiogenic cytokines... - How stress influences the immune responseDavid A Padgett
Department of Oral Biology, 3180 Postle Hall, Ohio State University, 305 W. 12th Avenue, Columbus, OH 43210, USA
Trends Immunol 24:444-8. 2003 - VEGF is differentially regulated in multiple myeloma-derived cell lines by norepinephrineEric V Yang
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Medical Center, Columbus, OH 43210, USA
Brain Behav Immun 22:318-23. 2008..The data suggest that the ability of NE to regulate the expression of VEGF is not limited to solid epithelial tumors and suggests a possible regulatory role of catecholamine stress hormones in MM progression... - Stress-induced immunomodulation: Implications for tumorigenesisEric V Yang
Department of Molecular Virology, Immunology, and Medical Genetics, Institute for Behavioral Medicine Research, The Ohio State University College of Medicine and Public Health, 2175, Graves Hall, 333 W 10th Avenue, Columbus 43210, USA
Brain Behav Immun 17:S37-40. 2003 
Stress hormones and immune functionJeanette I Webster Marketon
Institute for Behavioral Medicine Research, The Ohio State University Medical Center, Columbus, OH 43210, USA
Cell Immunol 252:16-26. 2008..These data provide scientific evidence of the effects of stress on immune function and implications for health...- Depressive symptoms and lymphocyte proliferation in older adultsLynanne McGuire
Division of Health Psychology, Department of Psychiatry, Ohio State University College of Medicine, USA
J Abnorm Psychol 111:192-7. 2002..These findings extend the association between depression and immune function to community-dwelling older adults with chronic, mild depressive symptoms...
Research Grants
- Stress, the Immune System and Basal Cell CarcinomaRonald Glaser; Fiscal Year: 2007..2) We will determine if the relationships between depressive symptoms and severe life stressors and tumor immunoreactivity are more pronounced among older adults. ..
- Stress, the Immune System and Basal Cell CarcinomaRonald Glaser; Fiscal Year: 2007..2) We will determine if the relationships between depressive symptoms and severe life stressors and tumor immunoreactivity are more pronounced among older adults. ..
- Stress effects on virus protein induced inflammation and sickness behaviorRonald Glaser; Fiscal Year: 2010..PUBLIC HEALTH RELEVANCE: This multidisciplinary research grant will provide new information on how stress can have an impact on the pathophysiology on herpesvirus associated diseases. ..