Gary Ginsberg

Summary

Affiliation: The Connecticut Agricultural Experiment Station
Country: USA

Publications

  1. ncbi request reprint Assessing cancer risks from short-term exposures in children
    Gary L Ginsberg
    Connecticut Department of Public Health, Division of Environmental Epidemiology and Occupational Health, PO Box 340308, MS 11CHA, Hartford, CT 06134 0308, USA
    Risk Anal 23:19-34. 2003
  2. pmc Evaluation of the U.S. EPA/OSWER preliminary remediation goal for perchlorate in groundwater: focus on exposure to nursing infants
    Gary L Ginsberg
    Connecticut Department of Public Health, Hartford, Connecticut 06134, USA
    Environ Health Perspect 115:361-9. 2007
  3. ncbi request reprint Evaluation of child/adult pharmacokinetic differences from a database derived from the therapeutic drug literature
    Gary Ginsberg
    Connecticut Department of Public Health, P O Box 340308, Mail Stop 11CHA, Hartford, Connecticut 06134, USA
    Toxicol Sci 66:185-200. 2002
  4. doi request reprint Genetic polymorphism in paraoxonase 1 (PON1): Population distribution of PON1 activity
    Gary Ginsberg
    Connecticut Department of Public Health, Hartford, 06134, USA
    J Toxicol Environ Health B Crit Rev 12:473-507. 2009
  5. doi request reprint Genetic Polymorphism in Glutathione Transferases (GST): Population distribution of GSTM1, T1, and P1 conjugating activity
    Gary Ginsberg
    Connecticut Department of Public Health, Hartford 06134, USA
    J Toxicol Environ Health B Crit Rev 12:389-439. 2009
  6. doi request reprint The influence of genetic polymorphisms on population variability in six xenobiotic-metabolizing enzymes
    Gary Ginsberg
    Connecticut Department of Public Health, Hartford, 06134, USA
    J Toxicol Environ Health B Crit Rev 12:307-33. 2009
  7. pmc Does rapid metabolism ensure negligible risk from bisphenol A?
    Gary Ginsberg
    Connecticut Department of Public Health, Hartford, Connecticut, USA
    Environ Health Perspect 117:1639-43. 2009
  8. pmc Quantitative approach for incorporating methylmercury risks and omega-3 fatty acid benefits in developing species-specific fish consumption advice
    Gary L Ginsberg
    Connecticut Department of Public Health, Hartford, Connecticut 06134, USA
    Environ Health Perspect 117:267-75. 2009
  9. ncbi request reprint Modeling approaches for estimating the dosimetry of inhaled toxicants in children
    Gary L Ginsberg
    Connecticut Department of Public Health, Hartford, CT 06134, UAS
    J Toxicol Environ Health A 71:166-95. 2008
  10. pmc Pharmacokinetic and pharmacodynamic factors that can affect sensitivity to neurotoxic sequelae in elderly individuals
    Gary Ginsberg
    Connecticut Department of Public Health, Hartford, CT 06134, USA
    Environ Health Perspect 113:1243-9. 2005

Detail Information

Publications21

  1. ncbi request reprint Assessing cancer risks from short-term exposures in children
    Gary L Ginsberg
    Connecticut Department of Public Health, Division of Environmental Epidemiology and Occupational Health, PO Box 340308, MS 11CHA, Hartford, CT 06134 0308, USA
    Risk Anal 23:19-34. 2003
    ..This approach should be enhanced by early-life data specific to the particular carcinogen under analysis whenever possible...
  2. pmc Evaluation of the U.S. EPA/OSWER preliminary remediation goal for perchlorate in groundwater: focus on exposure to nursing infants
    Gary L Ginsberg
    Connecticut Department of Public Health, Hartford, Connecticut 06134, USA
    Environ Health Perspect 115:361-9. 2007
    ..This does not account for the greater exposure that is possible in nursing infants or for the relative source contribution (RSC), a factor normally used to lower the PRG due to nonwater exposures...
  3. ncbi request reprint Evaluation of child/adult pharmacokinetic differences from a database derived from the therapeutic drug literature
    Gary Ginsberg
    Connecticut Department of Public Health, P O Box 340308, Mail Stop 11CHA, Hartford, Connecticut 06134, USA
    Toxicol Sci 66:185-200. 2002
    ..g., enhanced discussion of uncertainties), semiquantitative (age group-specific adjustment factors), and quantitative (estimation of internal dosimetry in children via physiologically based PK modeling)...
  4. doi request reprint Genetic polymorphism in paraoxonase 1 (PON1): Population distribution of PON1 activity
    Gary Ginsberg
    Connecticut Department of Public Health, Hartford, 06134, USA
    J Toxicol Environ Health B Crit Rev 12:473-507. 2009
    ....
  5. doi request reprint Genetic Polymorphism in Glutathione Transferases (GST): Population distribution of GSTM1, T1, and P1 conjugating activity
    Gary Ginsberg
    Connecticut Department of Public Health, Hartford 06134, USA
    J Toxicol Environ Health B Crit Rev 12:389-439. 2009
    ..Ideally, such assessments would involve physiologically based toxicokinetic (PBTK) modeling to assess population variability in internal dose...
  6. doi request reprint The influence of genetic polymorphisms on population variability in six xenobiotic-metabolizing enzymes
    Gary Ginsberg
    Connecticut Department of Public Health, Hartford, 06134, USA
    J Toxicol Environ Health B Crit Rev 12:307-33. 2009
    ..This is best evaluated with the aid of physiologically based pharmacokinetic (PBPK) modeling. The population distribution of enzyme activity presented in this series of articles serves as inputs to such PBPK modeling analyses...
  7. pmc Does rapid metabolism ensure negligible risk from bisphenol A?
    Gary Ginsberg
    Connecticut Department of Public Health, Hartford, Connecticut, USA
    Environ Health Perspect 117:1639-43. 2009
    ..Bisphenol A (BPA) risks are being evaluated by many regulatory bodies because exposure is widespread and the potential exists for toxicity at low doses...
  8. pmc Quantitative approach for incorporating methylmercury risks and omega-3 fatty acid benefits in developing species-specific fish consumption advice
    Gary L Ginsberg
    Connecticut Department of Public Health, Hartford, Connecticut 06134, USA
    Environ Health Perspect 117:267-75. 2009
    ..One approach is to provide advice for individual species that highlights beneficial fish while cautioning against riskier fish...
  9. ncbi request reprint Modeling approaches for estimating the dosimetry of inhaled toxicants in children
    Gary L Ginsberg
    Connecticut Department of Public Health, Hartford, CT 06134, UAS
    J Toxicol Environ Health A 71:166-95. 2008
    ..A decision framework is discussed that considers these different approaches and modeling structures including assessment of parameter values, supporting data, reliability, and selection of dose metrics...
  10. pmc Pharmacokinetic and pharmacodynamic factors that can affect sensitivity to neurotoxic sequelae in elderly individuals
    Gary Ginsberg
    Connecticut Department of Public Health, Hartford, CT 06134, USA
    Environ Health Perspect 113:1243-9. 2005
    ..The many factors that affect elderly responses to neuroactive agents make environmental risk assessment for this age group a special concern and present a unique challenge...
  11. pmc The NAS perchlorate review: questions remain about the perchlorate RfD
    Gary Ginsberg
    Connecticut Department of Public Health, Hartford, Connecticut, USA
    Environ Health Perspect 113:1117-9. 2005
    ..We conclude that risk assessors should carefully evaluate whether the IRIS RfD is the most appropriate value for assessing perchlorate risk...
  12. ncbi request reprint Population distribution of aldehyde dehydrogenase-2 genetic polymorphism: implications for risk assessment
    Gary Ginsberg
    Connecticut Department of Public Health, Hartford, 06134, USA
    Regul Toxicol Pharmacol 36:297-309. 2002
    ..g., ethanol, toluene, ethylene glycol monomethyl ether)...
  13. ncbi request reprint Physiologically based pharmacokinetic (PBPK) modeling of caffeine and theophylline in neonates and adults: implications for assessing children's risks from environmental agents
    Gary Ginsberg
    Connecticut Department of Public Health, Hartford, Connecticut 06134, USA
    J Toxicol Environ Health A 67:297-329. 2004
    ..Neonatal PBPK models developed for these drugs may be adapted to other CYP1A2 substrates (e.g., arylamine toxicants). A stepwise approach for modeling environmental toxicants in children is proposed...
  14. ncbi request reprint Pediatric pharmacokinetic data: implications for environmental risk assessment for children
    Gary Ginsberg
    Connecticut Department of Public Health, Hartford, Connecticut 06134, USA
    Pediatrics 113:973-83. 2004
    ....
  15. ncbi request reprint Incorporating pharmacokinetic differences between children and adults in assessing children's risks to environmental toxicants
    Gary Ginsberg
    Connecticut Department of Public Health, Hartford, CT 06134, USA
    Toxicol Appl Pharmacol 198:164-83. 2004
    ..These models were calibrated with pharmacokinetic data in neonates and used to help understand key metabolic differences between neonates and adults across these two drugs...
  16. ncbi request reprint Review and analysis of inhalation dosimetry methods for application to children's risk assessment
    Gary L Ginsberg
    Connecticut Department of Public Health, Hartford, Connecticut 06134, USA
    J Toxicol Environ Health A 68:573-615. 2005
    ..These analyses support the approach of assuming twofold greater inhalation dose in children than adults, although there are cases in which this differential can be greater and others where it can be less...
  17. doi request reprint Human health risk assessment of synthetic turf fields based upon investigation of five fields in Connecticut
    Gary Ginsberg
    Connecticut Dept of Public Health, Hartford, Connecticut 06106, USA
    J Toxicol Environ Health A 74:1150-74. 2011
    ..S. Environmental Protection Agency (EPA), and Norway, which tested different kinds of fields and under a variety of weather conditions...
  18. doi request reprint Benzothiazole toxicity assessment in support of synthetic turf field human health risk assessment
    Gary Ginsberg
    Connecticut Dept of Public Health, Hartford, Connecticut 06106, USA
    J Toxicol Environ Health A 74:1175-83. 2011
    ..However, this is only a screening-level assessment, and research that better defines BZT potency is needed...
  19. pmc Incorporating children's toxicokinetics into a risk framework
    Gary Ginsberg
    Connecticut Department of Public Health, Hartford, Connecticut 06134, USA
    Environ Health Perspect 112:272-83. 2004
    ..This type of resource information is intended to help the assessor begin to address the issues raised in this paper...
  20. doi request reprint Genetic polymorphism in metabolism and host defense enzymes: implications for human health risk assessment
    Gary Ginsberg
    Connecticut Department of Public Health, Hartford, Connecticut 06106, USA
    Crit Rev Toxicol 40:575-619. 2010
    ..The current analysis is an important first step in bringing the highlighted polymorphisms into a physiologically based pharmacokinetic (PBPK) modeling framework...
  21. doi request reprint Synthetic turf field investigation in Connecticut
    Nancy J Simcox
    University of Connecticut Health Center, Farmington, Connecticut, USA
    J Toxicol Environ Health A 74:1133-49. 2011
    ..More research is needed to better understand air quality at indoor facilities. These field investigation data were incorporated into a separate human health risk assessment...