Research Topics
Genomes and GenesSpecies | Michael Z GilcreaseSummaryAffiliation: The University of Texas Country: USA Publications
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Publications
Integrin signaling in epithelial cellsMichael Z Gilcrease
Department of Pathology, MD Anderson Cancer Center, University of Texas, Houston, TX 77030, USA
Cancer Lett 247:1-25. 2007..This review highlights signal transduction functions of epithelial integrins, with particular emphasis on signaling pathways underlying some of the most important functions of epithelium...
Alpha6beta4 integrin crosslinking induces EGFR clustering and promotes EGF-mediated Rho activation in breast cancerMichael Z Gilcrease
Department of Pathology, The University of Texas M, d, Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, USA
J Exp Clin Cancer Res 28:67. 2009..EGFR is also overexpressed in the basal subtype of breast cancer, and crosstalk between alpha6beta4 integrin and EGFR appears to be important in tumor progression...
Even low-level HER2 expression may be associated with worse outcome in node-positive breast cancerMichael Z Gilcrease
Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Am J Surg Pathol 33:759-67. 2009....
Coexpression of alpha6beta4 integrin and guanine nucleotide exchange factor Net1 identifies node-positive breast cancer patients at high risk for distant metastasisMichael Z Gilcrease
Department of Pathology, Box 85 M D Anderson Cancer Center 1515 Holcombe Boulevard, Houston, TX 77030, USA
Cancer Epidemiol Biomarkers Prev 18:80-6. 2009..These findings suggest that coexpression of alpha6beta4 integrin and Net1 could be a useful biomarker for aggressive disease in node-positive breast cancer patients...
Histologic changes associated with false-negative sentinel lymph nodes after preoperative chemotherapy in patients with confirmed lymph node-positive breast cancer before treatmentAlexandra S Brown
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
Cancer 116:2878-83. 2010....
Beta4 integrin subunit gene expression correlates with tumor size and nuclear grade in early breast cancerLeslie K Diaz
Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Mod Pathol 18:1165-75. 2005....
CD44 expression is associated with increased survival in node-negative invasive breast carcinomaLeslie K Diaz
Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 11:3309-14. 2005..The purpose of this study was to evaluate the prognostic significance of CD44 isoforms in early-stage, lymph node-negative invasive breast carcinoma...
Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristicsBryan T Hennessy
Department of Gynecologic Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Cancer Res 69:4116-24. 2009..PIK3CA mutations, EMT, and stem cell-like characteristics likely contribute to the poor outcomes of MBC and suggest novel therapeutic targets...
Feasibility and accuracy of sentinel lymph node biopsy after preoperative chemotherapy in breast cancer patients with documented axillary metastasesJeannie Shen
Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Cancer 109:1255-63. 2007..The objective of this study was to determine the feasibility and accuracy of SLN biopsy after preoperative chemotherapy in patients with documented axillary metastases at presentation...
Pleomorphic ductal carcinoma of the breast: predictors of decreased overall survivalChristopher V Nguyen
Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, USA
Am J Surg Pathol 34:486-93. 2010..As the morphologic features of pleomorphic carcinoma can be seen in primary tumors from other sites, it is important to recognize this tumor as a rare variant of invasive breast carcinoma...
How many sentinel lymph nodes are enough during sentinel lymph node dissection for breast cancer?Min Yi
Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Cancer 113:30-7. 2008..The objective of this study was to determine how many SLNs need to be removed for accurate lymph node staging and which patient and tumor characteristics influence this number...
Pathological evaluation of axillary sentinel lymph nodes in breast cancerMichael Z Gilcrease
Division of Pathology and Laboratory Medicine, Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, USA
Methods Mol Med 120:113-25. 2006..Thorough histopathological evaluation of SLNs important for accurate assessment. In this chapter, we discuss the histopathological evaluation of SLNs...
Metaplastic sarcomatoid carcinoma of the breast with absent or minimal overt invasive carcinomatous component: a misnomerWilliam G Davis
Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA
Am J Surg Pathol 29:1456-63. 2005..In addition to systemic treatment, early aggressive local therapy is recommended, as these patients have a high rate of local relapse...
Adhesion-independent alpha6beta4 integrin clustering is mediated by phosphatidylinositol 3-kinaseMichael Z Gilcrease
Department of Pathology, M D Anderson Cancer Center, Houston, Texas, USA
Cancer Res 64:7395-8. 2004..A novel role for PI3K in alpha6beta4 integrin clustering is proposed...
Primary peritoneal serous carcinoma presenting as inflammatory breast cancerIbrahim Khalifeh
Department of Pathology, MD Anderson Cancer Center, Houston, Texas, USA
Breast J 15:176-81. 2009..To our knowledge, this is the first reported case of an extramammary primary malignancy that not only presented as inflammatory breast cancer but also was diagnosed and initially treated as such...
Chromogenic in situ hybridization for alpha6beta4 integrin in breast cancer: correlation with protein expressionLeslie K Diaz
Department of Pathology, MD Anderson Cancer Center, Houston, Texas 77030, USA
J Mol Diagn 6:10-5. 2004....
Matrix-producing carcinoma of the breast: an aggressive subtype of metaplastic carcinomaErinn Downs-Kelly
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Am J Surg Pathol 33:534-41. 2009..001) and decreased DRF survival (P=0.001). In summary, MPC is an aggressive subtype of metaplastic carcinoma with a worse clinical outcome than invasive ductal carcinoma...
Imaging differences in metaplastic and invasive ductal carcinomas of the breastWei Tse Yang
Department of Diagnostic Imaging, The University of Texas M D Anderson Cancer Center, PO Box 301439, Unit 1350, Houston, TX 77230, USA
AJR Am J Roentgenol 189:1288-93. 2007..The purpose of this study was to compare the imaging features of metaplastic breast carcinoma with those of invasive ductal carcinoma...
Do all mucocele-like lesions of the breast require surgery?Selin Carkaci
Department of Diagnostic Radiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
Clin Imaging 35:94-101. 2011....
Tumor cavitation in stage I non-small cell lung cancer: epidermal growth factor receptor expression and prediction of poor outcomeAmir Onn
Department of Thoracic/Head and Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Unit 57, Houston, TX 77030, USA
Radiology 237:342-7. 2005..01) and shorter overall survival time (P < .007). CONCLUSION: Patients who have stage I NSCLC with cavitary lesions have an adverse prognosis and are likely to have tumor EGFR overexpression...
Metastatic neuroendocrine tumour in the breast: a potential mimic of in-situ and invasive mammary carcinomaKyle D Perry
Division of Anatomic Pathology, Department of Pathology, Mayo Clinic, Rochester, MN, USA
Histopathology 59:619-30. 2011....
Jun activation domain binding protein 1 expression is associated with low p27(Kip1)levels in node-negative breast cancerFrancisco J Esteva
Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 9:5652-9. 2003....
Gross cystic disease fluid protein-15 and mammaglobin A expression determined by immunohistochemistry is of limited utility in triple-negative breast cancerLei Huo
Department of Pathology, The University of Texas MD Anderson Cancer Centre, 1515 Holcombe Blvd, Houston, TX 77030, USA
Histopathology 62:267-74. 2013..Data on their expression in triple-negative breast cancer (TNBC) are very limited. The aim of this study was to examine the expression of these markers in TNBC to determine their utility in pathological diagnosis...
Rosai-Dorfman disease confined to the breastJerzy J Morkowski
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Ann Diagn Pathol 14:81-7. 2010....
Imaging features of primary breast sarcomaTaletha B Smith
Department of Diagnostic Radiology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
AJR Am J Roentgenol 198:W386-93. 2012..This purpose of this study is to describe the imaging findings in patients who presented with a diagnosis of primary breast sarcoma...
A lymph node metastatic mouse model reveals alterations of metastasis-related gene expression in metastatic human oral carcinoma sublines selected from a poorly metastatic parental cell lineXin Zhang
Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA
Cancer 95:1663-72. 2002..The data suggest that certain alterations of metastasis-related gene expression favor invasion of oral SCC and that cell surface proteins may play major roles in the metastasis of oral SCC to the lymph nodes...
Phosphorylated galectin-3 mediates tumor necrosis factor-related apoptosis-inducing ligand signaling by regulating phosphatase and tensin homologue deleted on chromosome 10 in human breast carcinoma cellsNachman Mazurek
Department of Gastrointestinal Medicine and Nutrition, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Biol Chem 282:21337-48. 2007..These findings suggest a pivotal role for P-GAL3 in promoting TRAIL sensitivity through activation of a nonclassic apoptotic pathway and identify P-GAL3 as a novel regulator of PTEN...
Histologic localization of sentinel lymph node metastases in breast cancerLeslie K Diaz
Department of Pathology, M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Am J Surg Pathol 27:385-9. 2003..This information may be useful in determining the optimal method for evaluating axillary sentinel lymph node specimens from breast cancer patients...
Lipomatous variant of myofibroblastoma with epithelioid features: a rare and diagnostically challenging breast lesionMary M Wahbah
Unit 85, Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
Ann Diagn Pathol 15:454-8. 2011..We report a rare case of a lipomatous variant of myofibroblastoma with an epithelioid cell component and discuss the differential diagnosis and potential diagnostic pitfalls...
Fibroepithelial lesions of the breast with pleomorphic stromal giant cells: a clinicopathologic study of 4 cases and review of the literatureLei Huo
Department of Pathology and Laboratory Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
Ann Diagn Pathol 13:226-32. 2009..The clinicopathologic features of each case are discussed, and a review of the literature is provided...
Primary squamous cell carcinoma of the breast: predictors of locoregional recurrence and overall survivalAnupma Nayak
Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX
Am J Surg Pathol 37:867-73. 2013..The presence of at least focal keratinization, however, is associated with significantly improved OS...
Breast carcinoma with neuroendocrine differentiation and myocardial metastasesBryan T Hennessy
Department of Gynecologic Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
Clin Breast Cancer 7:892-4. 2007..Better understanding of the cellular origin and molecular pathogenesis of this relatively enigmatic rare disease is required...
Primary desmoid tumor (extraabdominal fibromatosis) of the breastBasak Erguvan-Dogan
Department of Diagnostic Radiology, Breast Imaging, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Unit 57, Houston, TX 77030, USA
AJR Am J Roentgenol 185:488-9. 2005
Sarcomatoid breast tumors have sarcomatoid behaviorMichael Z Gilcrease
Am J Surg Pathol 31:326-7; author reply 327. 2007
