Davide Gianni

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity
    Davide Gianni
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Sci Signal 2:ra54. 2009
  2. pmc Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation
    Davide Gianni
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Eur J Cell Biol 90:164-71. 2011
  3. pmc c-Src-mediated phosphorylation of NoxA1 and Tks4 induces the reactive oxygen species (ROS)-dependent formation of functional invadopodia in human colon cancer cells
    Davide Gianni
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Biol Cell 21:4287-98. 2010
  4. pmc Emerging evidence for the importance of phosphorylation in the regulation of NADPH oxidases
    Gary M Bokoch
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA
    Antioxid Redox Signal 11:2429-41. 2009
  5. pmc A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells
    Davide Gianni
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA
    ACS Chem Biol 5:981-93. 2010
  6. pmc The involvement of the tyrosine kinase c-Src in the regulation of reactive oxygen species generation mediated by NADPH oxidase-1
    Davide Gianni
    Departments of Immunology and Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Biol Cell 19:2984-94. 2008
  7. pmc Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism
    Yu Ya Kao
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 283:12736-46. 2008

Collaborators

Detail Information

Publications7

  1. pmc Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity
    Davide Gianni
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Sci Signal 2:ra54. 2009
    ..We propose that Tks organizers represent previously unrecognized members of an organizer superfamily that link Nox to localized ROS formation...
  2. pmc Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation
    Davide Gianni
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Eur J Cell Biol 90:164-71. 2011
    ..Taken together, these results clarify the molecular basis for the interaction between NoxA1 and the Tks proteins and may provide new insights into the pharmacological design of a more effective anti-metastatic strategy...
  3. pmc c-Src-mediated phosphorylation of NoxA1 and Tks4 induces the reactive oxygen species (ROS)-dependent formation of functional invadopodia in human colon cancer cells
    Davide Gianni
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Biol Cell 21:4287-98. 2010
    ..Taken together, these results elucidate the role of c-Src activity on the formation of invadopodia and may provide insight into the mechanisms of tumor formation in colon cancers...
  4. pmc Emerging evidence for the importance of phosphorylation in the regulation of NADPH oxidases
    Gary M Bokoch
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA
    Antioxid Redox Signal 11:2429-41. 2009
    ..We describe here the evidence for Nox regulation through the action of kinases, and speculate on how such regulatory mechanisms might contribute to the development of pathological disease states...
  5. pmc A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells
    Davide Gianni
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA
    ACS Chem Biol 5:981-93. 2010
    ..These results elucidate the relevance of Nox1-dependent ROS generation in mechanisms of cancer invasion and define ML171 as a useful Nox1 chemical probe and potential therapeutic agent for inhibition of cancer cell invasion...
  6. pmc The involvement of the tyrosine kinase c-Src in the regulation of reactive oxygen species generation mediated by NADPH oxidase-1
    Davide Gianni
    Departments of Immunology and Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Biol Cell 19:2984-94. 2008
    ..Together, these results establish c-Src as an important regulator of Nox1 activity, and they may provide insight into the mechanisms of tumor formation in colon cancers...
  7. pmc Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism
    Yu Ya Kao
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 283:12736-46. 2008
    ..Our data identify a functional Rac interaction site conserved in Rac-dependent Noxs and support a direct regulatory interaction of Rac GTPases to promote activation of these NADPH oxidases...