Olivier George

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Animal models of nicotine exposure: relevance to second-hand smoking, electronic cigarette use, and compulsive smoking
    Ami Cohen
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA
    Front Psychiatry 4:41. 2013
  2. pmc Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking
    Olivier George
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 109:18156-61. 2012
  3. pmc Allostasis and addiction: role of the dopamine and corticotropin-releasing factor systems
    Olivier George
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Physiol Behav 106:58-64. 2012
  4. pmc Varenicline blocks nicotine intake in rats with extended access to nicotine self-administration
    Olivier George
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 213:715-22. 2011
  5. pmc CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats
    Olivier George
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:17198-203. 2007
  6. pmc Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments
    Olivier George
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 33:2474-82. 2008
  7. pmc Exposure to chronic intermittent nicotine vapor induces nicotine dependence
    Olivier George
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Pharmacol Biochem Behav 96:104-7. 2010
  8. pmc Low brain allopregnanolone levels mediate flattened circadian activity associated with memory impairments in aged rats
    Olivier George
    Institut National de la Sante et de la Recherche Medical INSERM, Unite 862, Neurocenter Magendie, Physiopathology of Addiction Group, Bordeaux, France
    Biol Psychiatry 68:956-63. 2010
  9. pmc Individual differences in prefrontal cortex function and the transition from drug use to drug dependence
    Olivier George
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA 92037, USA
    Neurosci Biobehav Rev 35:232-47. 2010
  10. pmc Addiction as a stress surfeit disorder
    George F Koob
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA 92037, USA Electronic address
    Neuropharmacology 76:370-82. 2014

Collaborators

Detail Information

Publications24

  1. pmc Animal models of nicotine exposure: relevance to second-hand smoking, electronic cigarette use, and compulsive smoking
    Ami Cohen
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA
    Front Psychiatry 4:41. 2013
    ....
  2. pmc Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking
    Olivier George
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 109:18156-61. 2012
    ....
  3. pmc Allostasis and addiction: role of the dopamine and corticotropin-releasing factor systems
    Olivier George
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Physiol Behav 106:58-64. 2012
    ....
  4. pmc Varenicline blocks nicotine intake in rats with extended access to nicotine self-administration
    Olivier George
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 213:715-22. 2011
    ..Varenicline has not been tested on the increase in motivation to take nicotine in nicotine-dependent rats...
  5. pmc CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats
    Olivier George
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:17198-203. 2007
    ..Overactivation of the CRF-CRF(1) system may contribute to nicotine dependence and may represent a prominent target for investigating the vulnerability to tobacco addiction...
  6. pmc Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments
    Olivier George
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 33:2474-82. 2008
    ....
  7. pmc Exposure to chronic intermittent nicotine vapor induces nicotine dependence
    Olivier George
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Pharmacol Biochem Behav 96:104-7. 2010
    ....
  8. pmc Low brain allopregnanolone levels mediate flattened circadian activity associated with memory impairments in aged rats
    Olivier George
    Institut National de la Sante et de la Recherche Medical INSERM, Unite 862, Neurocenter Magendie, Physiopathology of Addiction Group, Bordeaux, France
    Biol Psychiatry 68:956-63. 2010
    ..However, the underlying mechanism of these alterations is unknown. Here, we demonstrate the role of alterations in brain steroid levels in age-related sleep-dependent memory impairment in rats...
  9. pmc Individual differences in prefrontal cortex function and the transition from drug use to drug dependence
    Olivier George
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA 92037, USA
    Neurosci Biobehav Rev 35:232-47. 2010
    ..A subhypothesis is that the different patterns of drug addiction and individual differences in the transition to addiction may emerge from differential vulnerability in one or more of the subcomponents...
  10. pmc Addiction as a stress surfeit disorder
    George F Koob
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA 92037, USA Electronic address
    Neuropharmacology 76:370-82. 2014
    ..This article is part of a Special Issue entitled 'NIDA 40th Anniversary Issue'...
  11. doi request reprint κ Opioid Receptors in the Nucleus Accumbens Shell Mediate Escalation of Methamphetamine Intake
    Timothy W Whitfield
    The Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037
    J Neurosci 35:4296-305. 2015
    ....
  12. pmc A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions
    Laura Orio
    Committee on Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 29:4846-57. 2009
    ..These results suggest that neuroadaptations in the endogenous cannabinoid system may be part of the neuroplasticity associated with the development of cocaine addiction...
  13. pmc Long-term antagonism of κ opioid receptors prevents escalation of and increased motivation for heroin intake
    Joel E Schlosburg
    Committee on Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037
    J Neurosci 33:19384-92. 2013
    ....
  14. pmc Robust escalation of nicotine intake with extended access to nicotine self-administration and intermittent periods of abstinence
    Ami Cohen
    Committee on Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 37:2153-60. 2012
    ....
  15. pmc Hippocampal neurogenesis protects against cocaine-primed relapse
    Olivier Deschaux
    Laboratoire de Neurobiologie et Psychotraumatologie, Universite de Nice Sophia Antipolis, Nice, France Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA
    Addict Biol 19:562-74. 2014
    ..Thus, newly born dentate gyrus neurons during withdrawal and extinction learning facilitate hippocampal networking that mediates extinction-induced inhibition of cocaine seeking and may play a key role in preventing relapse. ..
  16. ncbi request reprint Neurosteroids and cholinergic systems: implications for sleep and cognitive processes and potential role of age-related changes
    Olivier George
    INSERM, U588, Institut Francois Magendie, Universite de Bordeaux II, F 33077, Bordeaux, France
    Psychopharmacology (Berl) 186:402-13. 2006
    ..As these processes depend on the integrity of cholinergic systems, a specific effect of neurosteroids on these systems may account for their effects on sleep and memory...
  17. pmc Levels of neural progenitors in the hippocampus predict memory impairment and relapse to drug seeking as a function of excessive methamphetamine self-administration
    Patrick Recinto
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA
    Neuropsychopharmacology 37:1275-87. 2012
    ....
  18. pmc Extended access to nicotine leads to a CRF1 receptor dependent increase in anxiety-like behavior and hyperalgesia in rats
    Ami Cohen
    The Scripps Research Institute, La Jolla, CA, USA
    Addict Biol 20:56-68. 2015
    ....
  19. pmc Extended access nicotine self-administration with periodic deprivation increases immature neurons in the hippocampus
    Ami Cohen
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA, 92037, USA
    Psychopharmacology (Berl) 232:453-63. 2015
    ..However, recent studies have shown that limited access nicotine self-administration does not exhibit key features of nicotine dependence such as motivational withdrawal and increased motivation for nicotine after deprivation...
  20. pmc Anticipatory 50 kHz ultrasonic vocalizations are associated with escalated alcohol intake in dependent rats
    Cara L Buck
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, United States Department of Psychology, University of California, San Diego, La Jolla, CA, United States Electronic address
    Behav Brain Res 271:171-6. 2014
    ..These findings suggest that anticipatory 50kHz USVs may be an indicator of context-elicited negative reinforcement learning...
  21. pmc Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization
    Ami Cohen
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS ONE 9:e97216. 2014
    ....
  22. pmc Dopamine D1 and μ-opioid receptor antagonism blocks anticipatory 50 kHz ultrasonic vocalizations induced by palatable food cues in Wistar rats
    Cara L Buck
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA, 92037, USA
    Psychopharmacology (Berl) 231:929-37. 2014
    ..However, little is known about the predictability of USVs, subtypes of USVs involved, and underlying neurobiological mechanisms...
  23. pmc Neuropeptide YY(2)R blockade in the central amygdala reduces anxiety-like behavior but not alcohol drinking in alcohol-dependent rats
    Marsida Kallupi
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA
    Addict Biol 19:755-7. 2014
    ..The finding that Y2 R antagonism reduces anxiety-like behavior but not alcohol drinking suggests that these two effects may occur via different functions of the Y2 R (e.g. autoreceptor versus heteroceptor function). ..
  24. pmc Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats
    Vez Repunte-Canonigo
    Molecular and Cellular Neuroscience Department, La Jolla, CA 92037, USA
    Mol Neurodegener 9:26. 2014
    ....