James Gaynor

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. ncbi request reprint Neurodevelopmental outcomes in preschool survivors of the Fontan procedure
    J William Gaynor
    Division of Cardiac Surgery, The Children s Hospital of Philadelphia, Philadelphia, PA Electronic address
    J Thorac Cardiovasc Surg 147:1276-82; discussion 1282-1283.e5. 2014
  2. ncbi request reprint Postoperative electroencephalographic seizures are associated with deficits in executive function and social behaviors at 4 years of age following cardiac surgery in infancy
    J William Gaynor
    Division of Cardiothoracic Surgery, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 146:132-7. 2013
  3. pmc The relationship of postoperative electrographic seizures to neurodevelopmental outcome at 1 year of age after neonatal and infant cardiac surgery
    J William Gaynor
    Division of Cardiothoracic Surgery, The Cardiac Center at The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 131:181-9. 2006
  4. ncbi request reprint Haemodynamic changes during modified ultrafiltration immediately following the first stage of the Norwood reconstruction
    J William Gaynor
    Division of Cardiothoracic Surgery, The Cardiac Center at The Children s Hospital of Philadelphia, Philadelphia 19104, USA
    Cardiol Young 15:4-7. 2005
  5. ncbi request reprint Severe pulmonary insufficiency should be conservatively treated
    J William Gaynor
    Daniel M Tabas Endowed Chair in Pediatric Cardiothoracic Surgery, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, United States of America
    Cardiol Young 15:68-71. 2005
  6. pmc Increasing duration of deep hypothermic circulatory arrest is associated with an increased incidence of postoperative electroencephalographic seizures
    J William Gaynor
    Division of Cardiothoracic Surgery, The Cardiac Center at The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 130:1278-86. 2005
  7. pmc Apolipoprotein E genotype modifies the risk of behavior problems after infant cardiac surgery
    J William Gaynor
    Division of Cardiothoracic Surgery, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 124:241-50. 2009
  8. ncbi request reprint Invited commentary
    J William Gaynor
    Division of Cardiothoracic Surgery, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Ann Thorac Surg 81:967. 2006
  9. pmc Is cardiac diagnosis a predictor of neurodevelopmental outcome after cardiac surgery in infancy?
    J William Gaynor
    Division of Cardiothoracic Surgery, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 140:1230-7. 2010
  10. pmc Patient characteristics are important determinants of neurodevelopmental outcome at one year of age after neonatal and infant cardiac surgery
    J William Gaynor
    Division of Cardiothoracic Surgery, The Cardiac Center at The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 133:1344-53, 1353.e1-3. 2007

Detail Information

Publications88

  1. ncbi request reprint Neurodevelopmental outcomes in preschool survivors of the Fontan procedure
    J William Gaynor
    Division of Cardiac Surgery, The Children s Hospital of Philadelphia, Philadelphia, PA Electronic address
    J Thorac Cardiovasc Surg 147:1276-82; discussion 1282-1283.e5. 2014
    ....
  2. ncbi request reprint Postoperative electroencephalographic seizures are associated with deficits in executive function and social behaviors at 4 years of age following cardiac surgery in infancy
    J William Gaynor
    Division of Cardiothoracic Surgery, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 146:132-7. 2013
    ..The current study was undertaken to determine if testing in the preschool period would identify deficits that become apparent as children develop...
  3. pmc The relationship of postoperative electrographic seizures to neurodevelopmental outcome at 1 year of age after neonatal and infant cardiac surgery
    J William Gaynor
    Division of Cardiothoracic Surgery, The Cardiac Center at The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 131:181-9. 2006
    ..The occurrence of a seizure after the arterial switch operation is associated with a worse long-term neurodevelopmental outcome. The significance of seizures after neonatal and infant repair of other congenital heart defects is not known...
  4. ncbi request reprint Haemodynamic changes during modified ultrafiltration immediately following the first stage of the Norwood reconstruction
    J William Gaynor
    Division of Cardiothoracic Surgery, The Cardiac Center at The Children s Hospital of Philadelphia, Philadelphia 19104, USA
    Cardiol Young 15:4-7. 2005
    ..There has been concern, however, about the safety and efficacy of modified ultrafiltration after the first stage of Norwood reconstruction for palliation of neonates with hypoplasia of the left heart and its variants...
  5. ncbi request reprint Severe pulmonary insufficiency should be conservatively treated
    J William Gaynor
    Daniel M Tabas Endowed Chair in Pediatric Cardiothoracic Surgery, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, United States of America
    Cardiol Young 15:68-71. 2005
  6. pmc Increasing duration of deep hypothermic circulatory arrest is associated with an increased incidence of postoperative electroencephalographic seizures
    J William Gaynor
    Division of Cardiothoracic Surgery, The Cardiac Center at The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 130:1278-86. 2005
    ..The contemporary incidence of postoperative seizures after repair of cardiac defects such as hypoplastic left heart syndrome and other forms of single ventricle is not known...
  7. pmc Apolipoprotein E genotype modifies the risk of behavior problems after infant cardiac surgery
    J William Gaynor
    Division of Cardiothoracic Surgery, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 124:241-50. 2009
    ..The goal was to evaluate polymorphisms of the APOE gene as modifiers of neurobehavioral outcomes for preschool-aged children with congenital heart defects, after cardiac surgery...
  8. ncbi request reprint Invited commentary
    J William Gaynor
    Division of Cardiothoracic Surgery, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Ann Thorac Surg 81:967. 2006
  9. pmc Is cardiac diagnosis a predictor of neurodevelopmental outcome after cardiac surgery in infancy?
    J William Gaynor
    Division of Cardiothoracic Surgery, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 140:1230-7. 2010
    ..To determine whether a cardiac diagnosis is a predictor of neurodevelopmental outcomes after infant cardiac surgery...
  10. pmc Patient characteristics are important determinants of neurodevelopmental outcome at one year of age after neonatal and infant cardiac surgery
    J William Gaynor
    Division of Cardiothoracic Surgery, The Cardiac Center at The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 133:1344-53, 1353.e1-3. 2007
    ..There is increasing evidence that patient-specific factors are more important determinants of outcome...
  11. ncbi request reprint The effect of modified ultrafiltration on the postoperative course in patients with congenital heart disease
    J William Gaynor
    Division of Cardiothoracic Surgery, The Cardiac Center at The Children s Hospital of Philadelphia, PA 19104 4399, USA
    Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 6:128-39. 2003
    ..In the future, prospective randomized studies incorporating recent advances in the technology of cardiopulmonary bypass will be necessary to define the optimal utilization of ultrafiltration during and after cardiopulmonary bypass...
  12. ncbi request reprint Outcome following single-stage repair of coarctation with ventricular septal defect
    J W Gaynor
    Divisions of Pediatric Cardiothoracic Surgery and Pediatric Cardiology, The Cardiac Center, The Children s Hospital of Philadelphia, 34th Street and Civic Center Blvd, Suite 8527, Philadelphia, PA 19104, USA
    Eur J Cardiothorac Surg 18:62-7. 2000
    ..The current study was undertaken to determine outcome and need for reintervention following single-stage repair of coarctation and VSD at our institution...
  13. ncbi request reprint Risk factors for mortality after the Norwood procedure
    J William Gaynor
    Division of Cardiothoracic Surgery, The Cardiac Center at The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Suite 8527, Philadelphia, PA 19104, USA
    Eur J Cardiothorac Surg 22:82-9. 2002
    ..The current study was undertaken to evaluate our recent experience with the Norwood procedure and to evaluate potential predictors of operative and 1-year mortality...
  14. ncbi request reprint Congenital Heart Surgery Nomenclature and Database Project: end-stage lung disease
    J W Gaynor
    Division of Pediatric Cardiothoracic Surgery, The Cardiac Center at The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Ann Thorac Surg 69:S343-57. 2000
    ..A minimum database set is also presented, which will allow for data sharing and would lend itself to basic interpretation of trends. Outcome tables relating diagnoses, procedures, and various risk factors are presented...
  15. ncbi request reprint Outcome following tricuspid valve detachment for ventricular septal defects closure
    J W Gaynor
    Division of Pediatric Cardiothoracic Surgery, The Cardiac Center at The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, 19104, Philadelphia, PA, USA
    Eur J Cardiothorac Surg 19:279-82. 2001
    ....
  16. ncbi request reprint Apolipoprotein E genotype and neurodevelopmental sequelae of infant cardiac surgery
    J William Gaynor
    Division of Cardiothoracic Surgery, The Children s Hospital of Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 126:1736-45. 2003
    ..Polymorphisms of apolipoprotein E have been identified as a risk factor for worse neurologic recovery after central nervous system injury...
  17. ncbi request reprint Congenital Heart Surgery Nomenclature and Database Project: systemic venous anomalies
    J W Gaynor
    Division of Pediatric Cardiothoracic Surgery, Cardiac Center at The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Ann Thorac Surg 69:S70-6. 2000
    ..A minimum database set is also presented that will allow for data sharing and would lend itself to basic interpretation of trends. Outcome tables relating diagnoses, procedures, and various risk factors are presented...
  18. ncbi request reprint Congenital Heart Surgery Nomenclature and Database Project: update and proposed data harvest
    J William Gaynor
    Division of Pediatric Cardiothoracic Surgery, Cardiac Center at Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Ann Thorac Surg 73:1016-8. 2002
    ..The current report outlines modifications to the minimum dataset as well as the diagnoses and procedure short lists. Plans for the next STS National Congenital Heart Surgery Database harvest are also presented...
  19. doi request reprint Reintervention for arch obstruction after stage 1 reconstruction does not adversely affect survival or outcome at Fontan completion
    Jean A Ballweg
    Children s Hospital of Philadelphia, PA, USA
    J Thorac Cardiovasc Surg 140:545-9. 2010
    ..To determine the effect of reintervention for coarctation after stage 1 reconstruction for hypoplastic left heart syndrome and variants on survival, suitability for Fontan, and morbidity at Fontan...
  20. ncbi request reprint Staphylococcus aureus as a risk factor for bloodstream infection in children with postoperative mediastinitis
    Samir S Shah
    Center for Education and Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pediatr Infect Dis J 24:834-7. 2005
    ..4; 95% confidence interval, 1.4-29.3). Postoperative mediastinitis caused by S. aureus has a higher intrinsic risk of being complicated by BSI than mediastinitis caused by other pathogens...
  21. ncbi request reprint Efficacy of prophylactic epicardial pacing leads in children and young adults
    Mitchell I Cohen
    Division of Cardiology, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 78:197-202; discussion 202-3. 2004
    ..Prophylactic epicardial pacing leads, placed at the time of concomitant congenital heart surgery, may reduce a late thoracotomy or sternotomy. The efficacy of prophylactic epicardial leads in the pediatric population is unknown...
  22. ncbi request reprint Risk adjustment for surgical site infection after median sternotomy in children
    Jessica Kagen
    Division of Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, PA, 19104, USA
    Infect Control Hosp Epidemiol 28:398-405. 2007
    ....
  23. doi request reprint A contemporary comparison of the effect of shunt type in hypoplastic left heart syndrome on the hemodynamics and outcome at Fontan completion
    Jean A Ballweg
    Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Thorac Cardiovasc Surg 140:537-44. 2010
    ..This article compares the hemodynamics and perioperative course at the time of the Fontan completion and reports longer-term survival for this cohort...
  24. ncbi request reprint Postoperative mediastinitis in children: epidemiology, microbiology and risk factors for Gram-negative pathogens
    Caroline B Long
    Divisions of General Pediatrics, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Pediatr Infect Dis J 24:315-9. 2005
    ..Mediastinitis, although an infrequent complication of median sternotomy, represents a significant source of morbidity and mortality...
  25. ncbi request reprint Improving outcomes in functional single ventricle and total anomalous pulmonary venous connection
    Andrew J Lodge
    Division of Cardiothoracic Surgery, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 78:1688-95. 2004
    ..A review of our recent experience was undertaken to determine whether results in these patients are improving...
  26. ncbi request reprint Periventricular leukomalacia is common after neonatal cardiac surgery
    Kristin K Galli
    Division of Cardiothoracic Anesthesiology, The Cardiac Center, Children s Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 127:692-704. 2004
    ..The incidence of periventricular leukomalacia and the risk factors for development of periventricular leukomalacia after infant cardiac surgery are not known...
  27. ncbi request reprint Postoperative junctional ectopic tachycardia in children: incidence, risk factors, and treatment
    Timothy M Hoffman
    Division of Cardiology, The Cardiac Center at The Children s Hospital of Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 74:1607-11. 2002
    ..The purpose of this study was to determine perioperative risk factors for the development of JET...
  28. ncbi request reprint Neurodevelopmental outcomes following congenital heart surgery
    Jean A Ballweg
    The Cardiac Center at The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Pediatr Cardiol 28:126-33. 2007
    ..The purpose of this review is to examine these mechanisms as they relate to available outcome data...
  29. ncbi request reprint Effects of inspired hypoxic and hypercapnic gas mixtures on cerebral oxygen saturation in neonates with univentricular heart defects
    Chandra Ramamoorthy
    Department of Anesthesiology Critical Care Medicine, and Division of Cardiothoracic Surgery, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Anesthesiology 96:283-8. 2002
    ..This study examined the effect of these treatments on cerebral oxygen saturation and systemic hemodynamics...
  30. ncbi request reprint Risk factors for mediastinitis following median sternotomy in children
    Jessica Kagen
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatr Infect Dis J 26:613-8. 2007
    ..The objective of this study was to identify risk factors for mediastinitis in a cohort of children undergoing cardiothoracic surgery at a tertiary care children's hospital...
  31. ncbi request reprint Intermediate outcomes after the Fontan procedure in the current era
    Michael E Mitchell
    Department of Surgery, Division of Cardiothoracic Surgery, University of Louisville, Louisville, KY 40202, USA
    J Thorac Cardiovasc Surg 131:172-80. 2006
    ..This study was undertaken to investigate the intermediate outcomes after the Fontan operation in the current era...
  32. ncbi request reprint Cause and prevention of central nervous system injury in neonates undergoing cardiac surgery
    Troy E Dominguez
    Division of Cardiothoracic Surgery, The Cardiac Center at The Childre s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Semin Thorac Cardiovasc Surg 19:269-77. 2007
    ..Unfortunately, modifiable perioperative factors may explain less of the variability in long-term outcomes than do patient-specific factors...
  33. ncbi request reprint Hyperglycemia after infant cardiac surgery does not adversely impact neurodevelopmental outcome
    Jean A Ballweg
    Division of Pediatric Cardiology, The Cardiac Center at The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Ann Thorac Surg 84:2052-8. 2007
    ..Hyperglycemia has been associated with worse outcome after traumatic brain injury and cardiac surgery in adults. It is not known whether postoperative hyperglycemia results in worse neurodevelopmental outcome after infant cardiac surgery...
  34. ncbi request reprint Aortic morphometry and microcephaly in hypoplastic left heart syndrome
    Amanda J Shillingford
    Division of Cardiology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Cardiol Young 17:189-95. 2007
    ..Microcephaly was associated with a small ascending aorta, but not a small transverse aortic arch. Impairment of somatic growth may be an additional factor in the development of microcephaly in these neonates...
  35. doi request reprint Hypoplastic left heart syndrome: consensus and controversies in 2007
    Gil Wernovsky
    Division of Pediatric Cardiology, The Cardiac Centre at The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia 19104, United States of America
    Cardiol Young 17:75-86. 2007
    ....
  36. ncbi request reprint Risk factors for adverse outcomes after surgery on the systemic atrioventricular valve in 109 children
    Matthew J Gillespie
    Division of Cardiology, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Cardiol Young 16:35-42. 2006
  37. pmc Perioperative stroke in infants undergoing open heart operations for congenital heart disease
    Jodi Chen
    Division of Pediatric Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Ann Thorac Surg 88:823-9. 2009
    ....
  38. doi request reprint A case report of rapid progressive coarctation and severe middle aortic syndrome in an infant with Williams syndrome
    E Kevin Hall
    Division of Cardiology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Congenit Heart Dis 4:373-7. 2009
    ..We report the case of a newborn infant who had a rapidly progressing diffuse form of arteriopathy that required two surgeries and one percutaneous balloon dilation within the first 2 months of her life...
  39. doi request reprint Outcome of high-risk neonates with congenital complete heart block paced in the first 24 hours after birth
    Andrew C Glatz
    The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4399, USA
    J Thorac Cardiovasc Surg 136:767-73. 2008
    ..The purpose of this study is to assess outcomes of patients with congenital complete heart block who were paced in the first 24 hours after birth owing to the presence of known risk factors...
  40. ncbi request reprint Surrogate markers for neurological outcome in children after deep hypothermic circulatory arrest
    Scott D Markowitz
    Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Semin Cardiothorac Vasc Anesth 11:59-65. 2007
    ..This article summarizes the state of the art and an admission about how far we have yet to travel as we strive to make the neurodevelopmental outcomes of patients with CHD comparable to their healthy peers...
  41. doi request reprint Long-term noninvasive arrhythmia assessment after surgical repair of sinus venosus atrial septal defect
    Andrew C Glatz
    Department of Pediatrics, Division of Cardiology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Congenit Heart Dis 5:141-8. 2010
    ..Postoperative arrhythmias have not been comprehensively described. We sought to define the prevalence of late arrhythmias after surgical closure of the SVASD...
  42. doi request reprint Determinants of intensive care unit length of stay for infants undergoing cardiac surgery
    Matthew Gillespie
    Cardiology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Congenit Heart Dis 1:152-60. 2006
    ..The purpose of this study was to identify factors that influence postoperative intensive care unit length of stay (ICULOS) in infants less than 6 months of age undergoing congenital heart surgery...
  43. pmc Evaluation of myocardial ischemia after surgical repair of anomalous aortic origin of a coronary artery in a series of pediatric patients
    Julie A Brothers
    Division of Cardiology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Am Coll Cardiol 50:2078-82. 2007
    ..We sought to prospectively evaluate evidence of myocardial ischemia after surgical repair of anomalous aortic origin of a coronary artery with an interarterial course (AAOCA)...
  44. doi request reprint Anomalous aortic origin of a coronary artery with an interarterial course: should family screening be routine?
    Julie A Brothers
    Division of Cardiology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Am Coll Cardiol 51:2062-4. 2008
    ..We sought to present cases of familial occurrence of anomalous aortic origin of a coronary artery with an interarterial course (AAOCA) to determine if it would alter our current screening and management recommendations...
  45. pmc Genetic factors are important determinants of impaired growth after infant cardiac surgery
    Nancy Burnham
    Division of Cardiothoracic Surgery, Cardiac Center, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 140:144-9. 2010
    ..We sought to estimate the prevalence and identify the predictors of impaired growth after infant cardiac surgery...
  46. doi request reprint Ventricular assist device-associated anti-human leukocyte antigen antibody sensitization in pediatric patients bridged to heart transplantation
    Matthew J O'Connor
    Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4399, USA
    J Heart Lung Transplant 29:109-16. 2010
    ..The incidence and effects of VAD-associated anti-HLA sensitization have not been well studied in the pediatric population...
  47. ncbi request reprint Neurodevelopmental outcomes after staged palliation for hypoplastic left heart syndrome
    Sarah Tabbutt
    Department of Pediatrics, Division of Cardiology, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 121:476-83. 2008
    ..The goal was to determine the relative effects of underlying genetic factors and current management strategies on neurodevelopmental disabilities among one-year old survivors of palliation for hypoplastic left heart syndrome...
  48. ncbi request reprint Long-term noninvasive arrhythmia assessment after total anomalous pulmonary venous connection repair
    Ronn E Tanel
    Department of Pediatrics, The University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am Heart J 153:267-74. 2007
    ..However, there has been no comprehensive, long-term, electrophysiologic study of patients who have undergone repair of total anomalous pulmonary venous connection...
  49. ncbi request reprint Preoperative pulmonary venous obstruction affects long-term outcome for survivors of total anomalous pulmonary venous connection repair
    Paul M Kirshbom
    Division of Pediatric Cardiac Surgery, The Cardiac Center at The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Ann Thorac Surg 74:1616-20. 2002
    ..Early outcomes after repair of total anomalous pulmonary venous connection continue to improve; however, little information is available concerning long-term functional status and quality of life...
  50. ncbi request reprint Electrographic neonatal seizures after infant heart surgery
    Robert R Clancy
    Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19105, USA
    Epilepsia 46:84-90. 2005
    ....
  51. ncbi request reprint Preoperative cerebral blood flow is diminished in neonates with severe congenital heart defects
    Daniel J Licht
    Division of Neurology, Department of Pediatrics, The Children s Hospital of Philadelphia, Wood Building 6th Floor, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 128:841-9. 2004
    ..The hypothesis of this study is that preoperative cerebral blood flow is substantially diminished and might relate to preoperative neurologic conditions...
  52. ncbi request reprint Postpericardiotomy syndrome after permanent pacemaker implantation in children and young adults
    Ilana Zeltser
    Division of Cardiology, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Ann Thorac Surg 78:1684-7. 2004
    ..Postpericardiotomy syndrome (PPS) occurs in 10% to 50% of pediatric patients after cardiac surgery. The incidence and outcome of PPS after permanent pacemaker implantation in children is not described...
  53. ncbi request reprint Thoratec left ventricular assist device as a bridge to recovery in a child weighing 27 kilograms
    Peter Pastuszko
    Division of Cardiothoracic Surgery, Cardiac Center, Children s Hospital of Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 127:1203-4. 2004
  54. ncbi request reprint Pediatric pacemaker infections: twenty years of experience
    Mitchell I Cohen
    Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 124:821-7. 2002
    ..We sought to evaluate possible predictors of early and late pacemaker infections in children...
  55. ncbi request reprint A comparison of on-site and off-site patent ductus arteriosus ligation in premature infants
    Douglas S Gould
    Division of Cardiothoracic Anesthesia, Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Pediatrics 112:1298-301. 2003
    ..We retrospectively reviewed our experience...
  56. ncbi request reprint Surgical reinterventions following the Fontan procedure
    Matus Petko
    Division of Cardiothoracic Surgery, The Cardiac Center at The Children s Hospital of Philadelphia, 34th and Civic Center Boulevard, Suite 8527, Philadelphia, PA 19104, USA
    Eur J Cardiothorac Surg 24:255-9. 2003
    ..Short- and long-term outcomes have improved significantly, however, some patients require additional cardiac procedures following the Fontan operation. The outcomes for these reinterventions are not known...
  57. ncbi request reprint An MRI study of neurological injury before and after congenital heart surgery
    William T Mahle
    Department of Pediatrics, Division of Cardiology, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Penn, USA
    Circulation 106:I109-14. 2002
    ..To understand the impact of preoperative events and to characterize the evaluation of neurological injury, we performed serial magnetic resonance imaging (MRI) studies of the brain in a cohort of neonates undergoing open-heart surgery...
  58. ncbi request reprint Central nervous system outcomes in children with complex congenital heart disease
    Gil Wernovsky
    Division of Pediatric Cardiology, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Curr Opin Cardiol 20:94-9. 2005
    ....
  59. ncbi request reprint Predictors of outcome after the Fontan operation: is hypoplastic left heart syndrome still a risk factor?
    J William Gaynor
    Division of Pediatric Cardiothoracic Surgery, The Cardiac Center at The Children s Hospital of Philadelphia, PA, USA
    J Thorac Cardiovasc Surg 123:237-45. 2002
    ..This study was undertaken to evaluate factors contributing to a decrease in early mortality and morbidity after the Fontan procedure between January 1, 1992, and December 31, 1999...
  60. ncbi request reprint Intracardiac temperature monitoring in infants after cardiac surgery
    Sarah Tabbutt
    Department of Pediatrics, Division of Cardiology, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 131:614-20. 2006
    ....
  61. ncbi request reprint The registry of anomalous aortic origin of the coronary artery of the Congenital Heart Surgeons' Society
    Julie A Brothers
    The Division of Cardiology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, United States of America
    Cardiol Young 20:50-8. 2010
    ..In this report, we describe the creation and design of the Registry of Anomalous Aortic Origin of the Coronary Artery. Data from the registry will be published at a later date...
  62. ncbi request reprint Population pharmacokinetics of milrinone in neonates with hypoplastic left heart syndrome undergoing stage I reconstruction
    Athena F Zuppa
    Division of Clinical Pharmacology and Therapeutics, Department of Pediatrics, Abramson Research Center, Philadelphia, Pennsylvania 19104 4318, USA
    Anesth Analg 102:1062-9. 2006
    ..6 mL x kg(-1) x min(-1)) by postoperative day 4. In the postoperative setting of markedly impaired renal function, an infusion rate of 0.2 microg x kg(-1) x min(-1) should be considered...
  63. ncbi request reprint Parental decision-making in congenital heart disease
    K Sarah Hoehn
    Division of Critical Care Medicine, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cardiol Young 14:309-14. 2004
    ..To explore whether prenatal diagnosis of congenital heart disease is associated with lower levels of parental distress and greater satisfaction with decisions about cardiothoracic surgery when compared to postnatal diagnosis...
  64. doi request reprint Induction therapy with antithymocyte globulin before reperfusion
    Samuel B Goldfarb
    Division of Pulmonary Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Ann Thorac Surg 90:1110-4; discussion 1114-5. 2010
    ..The timing of induction is not universal. We hypothesize that early treatment with antilymphocyte globulin (ATG) prior to reperfusion of the first donor lung will decrease the incidence of ACR...
  65. ncbi request reprint Real-time 3-dimensional echocardiographic imaging of congenital heart disease using matrix-array technology: freehand real-time scanning adds instant morphologic details not well delineated by conventional 2-dimensional imaging
    Mohamed A Seliem
    Cardiac Center, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Soc Echocardiogr 19:121-9. 2006
    ....
  66. ncbi request reprint Mechanical support of the functionally single ventricle
    Chitra Ravishankar
    Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Pennsylvania 19104, USA
    Cardiol Young 16:55-60. 2006
  67. ncbi request reprint Use of extracorporeal membrane oxygenation in pediatric thoracic organ transplantation
    Paul M Kirshbom
    Department of Cardiothoracic Surgery, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 123:130-6. 2002
    ..The goal of this study was to examine the indications for initiation and outcomes after peritransplant use of extracorporeal membrane oxygenation...
  68. ncbi request reprint Late cardiopulmonary and musculoskeletal exercise performance after repair for total anomalous pulmonary venous connection during infancy
    Michael G McBride
    Division of Cardiology, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 133:1533-9. 2007
    ..We evaluated cardiopulmonary function at rest and during exercise in children after surgical repair for total anomalous pulmonary venous connection...
  69. doi request reprint Inattention, hyperactivity, and school performance in a population of school-age children with complex congenital heart disease
    Amanda J Shillingford
    Division of Cardiology, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Pediatrics 121:e759-67. 2008
    ....
  70. doi request reprint Assessment of parental decision-making in neonatal cardiac research: a pilot study
    Aruna T Nathan
    Department of Anesthesiology and Critical Care Medicine, University of Pennsylvania, Pennsylvania, USA
    J Med Ethics 36:106-10. 2010
    ..To assess parental permission for a neonate's research participation using the MacArthur competence assessment tool for clinical research (MacCAT-CR), specifically testing the components of understanding, appreciation, reasoning and choice...
  71. pmc J. Maxwell Chamberlain Memorial Paper for congenital heart surgery. Deep hypothermic circulatory arrest does not impair neurodevelopmental outcome in school-age children after infant cardiac surgery
    Stephanie Fuller
    Division of Cardiothoracic Surgery, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Ann Thorac Surg 90:1985-94; discussion 1994-5. 2010
    ..The purpose of this study was to assess deep hypothermic circulatory arrest (DHCA) as a modifier of neurodevelopmental (ND) outcomes in preschool children after cardiac surgery in infancy for repair of congenital heart defects (CHD)...
  72. doi request reprint Neuropsychological status in children after repair of acyanotic congenital heart disease
    Michael D Quartermain
    Divisions of Cardiology, Department of Anesthesia, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatrics 126:e351-9. 2010
    ..We sought to limit confounding variables and isolate potential independent effects of CPB by describing neuropsychological function in school-aged children after repair of acyanotic CHD...
  73. doi request reprint Anomalous aortic origin of a coronary artery with an interarterial course: understanding current management strategies in children and young adults
    Julie Brothers
    The Children s Hospital of Philadelphia, Cardiology, Philadelphia, PA, USA
    Pediatr Cardiol 30:911-21. 2009
    ..A multicenter registry would facilitate the development of evidence-based treatment and management guidelines for children and young adults with AAOCA...
  74. ncbi request reprint Neo-aortic root dilation and valve regurgitation up to 21 years after staged reconstruction for hypoplastic left heart syndrome
    Meryl S Cohen
    Department of Pediatrics, University of Pennsylvania School of Medicine, Cardiac Center at Children s Hospital of Philadelphia, 19104, USA
    J Am Coll Cardiol 42:533-40. 2003
    ..We sought to assess the prevalence and progression of neo-aortic root dilation and valvar regurgitation after staged reconstruction for hypoplastic left heart syndrome (HLHS)...
  75. ncbi request reprint Brain versus lung: hierarchy of feedback loops in single-ventricle patients with superior cavopulmonary connection
    Mark A Fogel
    Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Circulation 110:II147-52. 2004
    ..When the brain and lungs are connected exclusively in series, which feedback loop predominates is unknown. The circulation of the superior cavopulmonary connection (SCPC) provides a unique physiology to answer this question...
  76. ncbi request reprint Neurodevelopmental outcome after early repair of a ventricular septal defect with or without aortic arch obstruction
    Jonathan R Kaltman
    Division of Cardiology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 131:792-8. 2006
    ..The purpose of this study was to evaluate the neurodevelopmental outcome at 1 year of age of children who had surgical repair in infancy of a ventricular septal defect or a ventricular septal defect with aortic arch obstruction...
  77. ncbi request reprint Heart rate variability following neonatal heart surgery for complex congenital heart disease
    Jonathan R Kaltman
    Division of Cardiology, University of Pennsylvania School of Medicine, and The Cardiac Center at The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Pacing Clin Electrophysiol 29:471-8. 2006
    ..In addition, we assessed the hypothesis that single-ventricle physiology and surgical interruption of the great arteries negatively affects HRV...
  78. ncbi request reprint Early results of single-stage biventricular repair of severe aortic hypoplasia or atresia with ventricular septal defect and normal left ventricle
    Peter J Gruber
    Pediatric Cardiothoracic Surgery, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 132:260-3. 2006
    ..We considered whether primary biventricular repair was a safe alternative in all cases, even in the presence of interrupted aortic arch...
  79. ncbi request reprint Neo-aortic valvar function after the arterial switch
    Bradley S Marino
    Cardiac Center, Children s Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania School of Medicine, United States of America
    Cardiol Young 16:481-9. 2006
    ....
  80. ncbi request reprint Heterotaxy syndrome with functional single ventricle: does prenatal diagnosis improve survival?
    Meryl S Cohen
    Division of Cardiology, The Cardiac Center at The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Ann Thorac Surg 82:1629-36. 2006
    ..Prenatal identification of heterotaxy syndrome may improve long-term survival...
  81. ncbi request reprint Bloodstream infections after median sternotomy at a children's hospital
    Samir S Shah
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 133:435-40. 2007
    ..The objectives of this retrospective cohort study were to determine the incidence and to identify risk factors for postoperative bloodstream infections among children after median sternotomy in an urban tertiary care children's hospital...
  82. ncbi request reprint Outcomes after the stage I reconstruction comparing the right ventricular to pulmonary artery conduit with the modified Blalock Taussig shunt
    Sarah Tabbutt
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 80:1582-90; discussion 1590-1. 2005
    ..Recent reports advocate that a right ventricular to pulmonary artery (RV-PA) conduit improves outcome after the stage I reconstruction...
  83. ncbi request reprint A contemporary comparison of the effect of shunt type in hypoplastic left heart syndrome on the hemodynamics and outcome at stage 2 reconstruction
    Jean A Ballweg
    Department of Pediatrics, Division of Cardiology, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19119, USA
    J Thorac Cardiovasc Surg 134:297-303. 2007
    ..We compare the hemodynamics and perioperative course of shunt type in hypoplastic left heart syndrome at the time of stage 2 reconstruction and longer-term survival...
  84. ncbi request reprint Postoperative course in the cardiac intensive care unit following the first stage of Norwood reconstruction
    Gil Wernovsky
    Department of Pediatrics Division of Pediatric Cardiology, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cardiol Young 17:652-65. 2007
    ....
  85. doi request reprint Risk factors for interstage death after stage 1 reconstruction of hypoplastic left heart syndrome and variants
    David A Hehir
    Division of Cardiology, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Thorac Cardiovasc Surg 136:94-9, 99.e1-3. 2008
    ..The purpose of this study is to identify risk factors for interstage death and to describe the events leading to interstage death...
  86. pmc Brain maturation is delayed in infants with complex congenital heart defects
    Daniel J Licht
    Divison of Neurology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Thorac Cardiovasc Surg 137:529-36; discussion 536-7. 2009
    ..This study tests the hypothesis that congenital heart defects delay in utero structural brain development...
  87. ncbi request reprint Thromboelastography of patients after fontan compared with healthy children
    Leslie Raffini
    Division of Hematology, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104 4399, USA
    Pediatr Cardiol 30:771-6. 2009
    ..Further studies comparing the thromboelastography of Fontan patients with the thromboembolic complications of those without Fontan are needed to delineate these issues...
  88. ncbi request reprint Risk of seizures in survivors of newborn heart surgery using deep hypothermic circulatory arrest
    Robert R Clancy
    Division of Neurology and the Cardiac Center, Children s Hospital of Philadelphia, PA 19104, USA
    Pediatrics 111:592-601. 2003
    ....

Research Grants5

  1. APOE Genotype and Sequelae of Infant Cardiac Surgery
    James Gaynor; Fiscal Year: 2003
    ..We propose to evaluate this cohort at 4 years of age to test the hypothesis that APOE genotype predicts cognitive impairment, impaired attention and executive function, as well as impairment of fine motor and visual-motor skills. ..
  2. APOE Genotype and Sequelae of Infant Cardiac Surgery
    James Gaynor; Fiscal Year: 2004
    ..We propose to evaluate this cohort at 4 years of age to test the hypothesis that APOE genotype predicts cognitive impairment, impaired attention and executive function, as well as impairment of fine motor and visual-motor skills. ..
  3. APOE Genotype and Sequelae of Infant Cardiac Surgery
    James Gaynor; Fiscal Year: 2005
    ..We propose to evaluate this cohort at 4 years of age to test the hypothesis that APOE genotype predicts cognitive impairment, impaired attention and executive function, as well as impairment of fine motor and visual-motor skills. ..
  4. APOE Genotype and Sequelae of Infant Cardiac Surgery
    James Gaynor; Fiscal Year: 2006
    ..We propose to evaluate this cohort at 4 years of age to test the hypothesis that APOE genotype predicts cognitive impairment, impaired attention and executive function, as well as impairment of fine motor and visual-motor skills. ..
  5. APOE Genotype and Sequelae of Infant Cardiac Surgery
    James Gaynor; Fiscal Year: 2007
    ..We propose to evaluate this cohort at 4 years of age to test the hypothesis that APOE genotype predicts cognitive impairment, impaired attention and executive function, as well as impairment of fine motor and visual-motor skills. ..