Mikhail A Gavrilin

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi request reprint Site-directed mutagenesis of CCR2 identified amino acid residues in transmembrane helices 1, 2, and 7 important for MCP-1 binding and biological functions
    Mikhail A Gavrilin
    Davis Heart and Lung Reseach Institute, The Ohio State University, Columbus, OH 43210, USA
    Biochem Biophys Res Commun 327:533-40. 2005
  2. pmc Pyrin critical to macrophage IL-1beta response to Francisella challenge
    Mikhail A Gavrilin
    Division of Pulmonary Allergy Critical Care and Sleep Medicine, Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH 43210, USA
    J Immunol 182:7982-9. 2009
  3. pmc Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization
    Anwari Akhter
    Department of Microbial Infection and Immunity, Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA
    Immunity 37:35-47. 2012
  4. ncbi request reprint Monocyte mRNA phenotype and adverse outcomes from pediatric multiple organ dysfunction syndrome
    Mark W Hall
    Department of Pediatrics, Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA
    Pediatr Res 62:597-603. 2007
  5. pmc Inflammasome Priming by Lipopolysaccharide Is Dependent upon ERK Signaling and Proteasome Function
    Mohammed G Ghonime
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Dorothy M Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210
    J Immunol 192:3881-8. 2014
  6. pmc Activation of the pyrin inflammasome by intracellular Burkholderia cenocepacia
    Mikhail A Gavrilin
    Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Immunol 188:3469-77. 2012
  7. pmc Analysis of human bronchial epithelial cell proinflammatory response to Burkholderia cenocepacia infection: inability to secrete il-1β
    Devyn D Gillette
    Integrated Biomedical Graduate Program, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 288:3691-5. 2013
  8. pmc Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis
    Basant A Abdulrahman
    Center for Microbial Interface Biology, Department of Microbial Infection, Ohio State University, Columbus, OH, USA
    Autophagy 7:1359-70. 2011
  9. ncbi request reprint Pyrin levels in human monocytes and monocyte-derived macrophages regulate IL-1beta processing and release
    Sudarshan Seshadri
    Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH 43210, USA
    J Immunol 179:1274-81. 2007
  10. pmc Microarray analysis of human monocytes infected with Francisella tularensis identifies new targets of host response subversion
    Jonathan P Butchar
    Division of Pulmonary and Critical Care, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 3:e2924. 2008

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Site-directed mutagenesis of CCR2 identified amino acid residues in transmembrane helices 1, 2, and 7 important for MCP-1 binding and biological functions
    Mikhail A Gavrilin
    Davis Heart and Lung Reseach Institute, The Ohio State University, Columbus, OH 43210, USA
    Biochem Biophys Res Commun 327:533-40. 2005
    ..Our results show that induction of lamellipodia formation, but not Ca(2+) influx and adenylate cyclase inhibition, is necessary for chemotaxis...
  2. pmc Pyrin critical to macrophage IL-1beta response to Francisella challenge
    Mikhail A Gavrilin
    Division of Pulmonary Allergy Critical Care and Sleep Medicine, Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH 43210, USA
    J Immunol 182:7982-9. 2009
    ..novicida. In summary, intracellular pyrin levels positively regulate MDM IL-1beta responsiveness to Francisella challenge...
  3. pmc Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization
    Anwari Akhter
    Department of Microbial Infection and Immunity, Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA
    Immunity 37:35-47. 2012
    ..However, caspase-11 was dispensable for the fusion of lysosomes with phagosomes containing nonpathogenic bacteria, uncovering a fundamental difference in the trafficking of phagosomes according to their cargo...
  4. ncbi request reprint Monocyte mRNA phenotype and adverse outcomes from pediatric multiple organ dysfunction syndrome
    Mark W Hall
    Department of Pediatrics, Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA
    Pediatr Res 62:597-603. 2007
    ..02). These data suggest that adverse outcomes from pediatric MODS are associated with an anti-inflammatory monocyte mRNA phenotype. Future studies are warranted to explore mechanisms of immunodepression in pediatric critical illness...
  5. pmc Inflammasome Priming by Lipopolysaccharide Is Dependent upon ERK Signaling and Proteasome Function
    Mohammed G Ghonime
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Dorothy M Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210
    J Immunol 192:3881-8. 2014
    ....
  6. pmc Activation of the pyrin inflammasome by intracellular Burkholderia cenocepacia
    Mikhail A Gavrilin
    Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Immunol 188:3469-77. 2012
    ..cenocepacia, pyrin associates with caspase-1 and ASC forming an inflammasome that upregulates mononuclear cell IL-1β processing and release...
  7. pmc Analysis of human bronchial epithelial cell proinflammatory response to Burkholderia cenocepacia infection: inability to secrete il-1β
    Devyn D Gillette
    Integrated Biomedical Graduate Program, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 288:3691-5. 2013
    ..cenocepacia infection, suggesting that a deficiency in caspase-1 is responsible, at least in part, for the attenuated IL-1β secretion...
  8. pmc Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis
    Basant A Abdulrahman
    Center for Microbial Interface Biology, Department of Microbial Infection, Ohio State University, Columbus, OH, USA
    Autophagy 7:1359-70. 2011
    ..cepacia infection and ameliorate the associated inflammation. Therefore, autophagy is a novel target for new drug development for CF patients to control B. cepacia infection and accompanying inflammation...
  9. ncbi request reprint Pyrin levels in human monocytes and monocyte-derived macrophages regulate IL-1beta processing and release
    Sudarshan Seshadri
    Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH 43210, USA
    J Immunol 179:1274-81. 2007
    ..In conclusion, in the context of endotoxin-induced activation of mononuclear phagocytes, pyrin augments IL-1beta processing and release...
  10. pmc Microarray analysis of human monocytes infected with Francisella tularensis identifies new targets of host response subversion
    Jonathan P Butchar
    Division of Pulmonary and Critical Care, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 3:e2924. 2008
    ..This study identifies several new factors potentially important in host cell subversion by the virulent Type A F. tularensis that may serve as novel targets for drug discovery...
  11. ncbi request reprint Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation
    Courtney Nicholas
    Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
    J Immunol 179:7121-7. 2007
    ..Collectively, these findings suggest a molecular mechanism by which apigenin suppresses inflammation and modulates the immune response in vivo...
  12. pmc Inflammasome mRNA expression in human monocytes during early septic shock
    Ruairi J Fahy
    Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, The Ohio State University Medical Center, Columbus, Ohio, USA
    Am J Respir Crit Care Med 177:983-8. 2008
    ..Monocytes are central to the initiation of the inflammatory response in sepsis, with caspase-1 activation playing a key role. Monocyte deactivation during sepsis has been linked to poor outcomes...
  13. pmc Apoptosis-associated speck-like protein (ASC) controls Legionella pneumophila infection in human monocytes
    Dalia H Abdelaziz
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 286:3203-8. 2011
    ..pneumophila manipulates ASC levels to evade inflammasome activation and grow in human monocytes. By targeting ASC, L. pneumophila modulates the inflammasome, the apoptosome, and NF-κB pathway simultaneously...
  14. pmc Mycoplasma suppression of THP-1 Cell TLR responses is corrected with antibiotics
    Ekaterina Zakharova
    Division of Pulmonary Allergy Critical Care and Sleep Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 5:e9900. 2010
    ..Thus, routine screening of cell lines for mycoplasma is important for the maintenance of reliable experimental data and contaminated cell lines can be restored to their baseline function with antibiotic clearance of mycoplasma...
  15. pmc Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection
    Anwari Akhter
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, OH, USA
    PLoS Pathog 5:e1000361. 2009
    ..These results reveal a new mechanism for caspase-7 activation downstream of the Nlrc4 inflammasome and present a novel biological role for caspase-7 in host defense against an intracellular bacterium...
  16. pmc Macrophage pro-inflammatory response to Francisella novicida infection is regulated by SHIP
    Kishore V L Parsa
    The Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio, USA
    PLoS Pathog 2:e71. 2006
    ..A detailed analysis of phosphoinositide signaling may provide valuable clues for better understanding the pathogenesis of tularemia...
  17. pmc Tyrosine phosphatase inhibition induces an ASC-dependent pyroptosis
    Mohammed G Ghonime
    Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA
    Biochem Biophys Res Commun 425:384-9. 2012
    ..These data demonstrate that pyroptotic death is linked to tyrosine phosphatase activity providing novel targets for future pharmacologic interventions...
  18. pmc Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators of pulmonary sarcoidosis
    Elliott D Crouser
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, The Dorothy M Davis Heart and Lung Research Institute, Columbus, Ohio 43210 1252, USA
    Am J Respir Crit Care Med 179:929-38. 2009
    ..Little is known about the genetic regulation of granulomatous inflammation in sarcoidosis...
  19. pmc Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue
    Tiffany Hughes
    Integrated Biomedical Graduate Program, The Ohio State University, Columbus, OH 43210, USA
    Immunity 32:803-14. 2010
    ..Thus, cDC-derived IL-1beta preserves and expands IL-1R1(hi)IL-22(+)AHR(+) iNK cells, potentially influencing human mucosal innate immunity during infection...
  20. pmc Receptor interacting protein-2 plays a critical role in human lung epithelial cells survival in response to Fas-induced cell-death
    Mohd Akhlakur Rahman
    Dorothy M Davis Heart and Lung Research Institute, Department of Internal Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Wexner Medical Center, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 9:e92731. 2014
    ..Thus RIP2's CARD tyrosine phosphorylation may represent a new therapeutic target to promote the survival of human lung epithelial cells in disorders that lead to acute lung injury and ARDS. ..
  21. pmc Internalization and phagosome escape required for Francisella to induce human monocyte IL-1beta processing and release
    Mikhail A Gavrilin
    Davis Heart and Lung Research Institute, Department of Molecular Virology and Immunology and Medical Genetics, and Center for Microbial Interface Biology, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 103:141-6. 2006
    ..These findings demonstrate that Francisella organisms efficiently induce IL-1beta processing and release in fresh monocytes by means of a sensing system that requires the uptake of live bacteria capable of phagosome escape...
  22. pmc Francisella Recognition by Inflammasomes: Differences between Mice and Men
    Mikhail A Gavrilin
    Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Davis Heart and Lung Research Institute, The Center for Microbial Interface Biology, The Ohio State University Columbus, OH, USA
    Front Microbiol 2:11. 2011
    ..Specific attention is placed on functional differences between human and murine pyrin as an intracellular recognition molecule for Francisella...