Research Topics
Species | M J GardnerSummaryAffiliation: The Institute for Genomic Research Country: USA Publications
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Publications
Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14Malcolm J Gardner
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
Nature 419:531-4. 2002..We report here the nucleotide sequences of chromosomes 10, 11 and 14, and a re-analysis of the chromosome 2 sequence. These chromosomes represent about 35% of the 23-megabase P. falciparum genome...- The genome of the malaria parasiteM J Gardner
The Institute for Genomic Research, Rockville 20850, USA
Curr Opin Genet Dev 9:704-8. 1999..Even at this early stage of the project, analysis of the genome sequence has provided promising new leads for drug and vaccine development... - The malaria genome sequencing project: complete sequence of Plasmodium falciparum chromosome 2M J Gardner
Institute of Genomic Research, Naval Medical Research Center, Rockville, MD, USA
Parassitologia 41:69-75. 1999..Within 2-3 years, the sequence of almost all P. falciparum genes will have been determined, paving the way for genetic, biochemical, and immunological research aimed at developing new drugs and vaccines against malaria... - A status report on the sequencing and annotation of the P. falciparum genomeM J Gardner
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
Mol Biochem Parasitol 118:133-8. 2001..The consortium recently developed plans for the annotation and analysis of the complete genome sequence and its publication in 2002... - Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytesMalcolm J Gardner
Institute for Genomic Research TIGR, 9712 Medical Center Drive, Rockville, MD 20850, USA
Science 309:134-7. 2005..Several biosynthetic pathways are incomplete or absent, suggesting substantial metabolic dependence on the host cell. One protein family that may generate parasite antigenic diversity is not telomere-associated... - Genome sequence of the human malaria parasite Plasmodium falciparumMalcolm J Gardner
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
Nature 419:498-511. 2002..The genome sequence provides the foundation for future studies of this organism, and is being exploited in the search for new drugs and vaccines to fight malaria... - Comparative genomics of the neglected human malaria parasite Plasmodium vivaxJane M Carlton
The Institute for Genomic Research J Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
Nature 455:757-63. 2008..Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species... - The genome sequence of the malaria mosquito Anopheles gambiaeRobert A Holt
Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
Science 298:129-49. 2002..An expressed sequence tag analysis of genes regulated by blood feeding provided insights into the physiological adaptations of a hematophagous insect... - Interpolated Markov models for eukaryotic gene findingS L Salzberg
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
Genomics 59:24-31. 1999..With the rapid progress in sequencing the genome of P. falciparum, the availability of this new gene finder will greatly facilitate the annotation process... - Immune responses to Plasmodium vivax pre-erythrocytic stage antigens in naturally exposed Duffy-negative humans: a potential model for identification of liver-stage antigensRuobing Wang
The Institute for Genomic Research, Rockville, USA
Eur J Immunol 35:1859-68. 2005..These results suggest that differential immune responses observed in naturally exposed Fy(-) and Fy(+) individuals can be exploited to identify P. vivax stage-specific antigens... - AvGI, an index of genes transcribed in the salivary glands of the ixodid tick Amblyomma variegatumVishvanath Nene
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
Int J Parasitol 32:1447-56. 2002..The database may be accessed via the World Wide Web at http://www.tigr.org/tdb/tgi.shtml... - Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoeliiJane M Carlton
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
Nature 419:512-9. 2002..This is the first genome sequence of a model eukaryotic parasite, and it provides insight into the use of such systems in the modelling of Plasmodium biology and disease... - Purification of chromosomes from Plasmodium falciparumDaniel J Carucci
Malaria Program, Naval Medical Research Center, Silver Spring, MD, USA
Methods Mol Med 72:235-40. 2002 - Curation of the Plasmodium falciparum genomeAndrew E Berry
Pathogen Sequencing Unit, Wellcome Trust Sanger Institute, Hinxton Hall, Cambridge CB10 1SA, UK
Trends Parasitol 20:548-52. 2004..The recently initiated curation of the genome resource is a vital investment for maintaining and enhancing the use of this genomic information in the post-genomic era... - Analysis of the transcriptome of the protozoan Theileria parva using MPSS reveals that the majority of genes are transcriptionally active in the schizont stageRichard Bishop
The International Livestock Research Institute ILRI, PO Box 30709, Nairobi, Kenya
Nucleic Acids Res 33:5503-11. 2005..The data suggests a low level of baseline transcription from the majority of protein-coding genes... - Using the transcriptome to annotate the genome revisited: application of massively parallel signature sequencing (MPSS)Trushar Shah
International Livestock Research Institute, PO Box 30709, Nairobi, Kenya
Gene 366:104-8. 2006..parva that were absent from the genome of the closely related T. annulata had MPSS signatures. This study illustrates the utility of MPSS for improving annotation of small, gene-rich microbial eukaryotic genomes... - Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytesSimon P Graham
International Livestock Research Institute, Nairobi, Kenya
Proc Natl Acad Sci U S A 103:3286-91. 2006..These data provide a basis for developing a CTL-targeted anti-East Coast fever subunit vaccine. In addition, orthologs of these antigens may be vaccine targets for other apicomplexan parasites... - Assessment and improvement of the Plasmodium yoelii yoelii genome annotation through comparative analysisAshley Vaughan
Seattle Biomedical Research Institute, Seattle, WA 98109, USA
Bioinformatics 24:i383-9. 2008..Unfortunately, only preliminary gene models were annotated on the partially sequenced genome, mostly by in silico gene prediction, and there has been no major improvement of the annotation since 2002... - A proteomic view of the Plasmodium falciparum life cycleLaurence Florens
Department of Cell Biology, The Scripps Research Institute, SR-11, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Nature 419:520-6. 2002..The detection of chromosomal clusters encoding co-expressed proteins suggested a potential mechanism for controlling gene expression... - Functional characterization of the acyl carrier protein (PfACP) and beta-ketoacyl ACP synthase III (PfKASIII) from Plasmodium falciparumNorman C Waters
Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, MD 20910-5100, USA
Mol Biochem Parasitol 123:85-94. 2002..During the schizont stage of parasite development, there is a significant up-regulation of the mRNAs corresponding to these proteins, indicating an important metabolic requirement for fatty acids during this stage...