M J Gardner

Summary

Affiliation: The Institute for Genomic Research
Country: USA

Publications

  1. ncbi request reprint Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14
    Malcolm J Gardner
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 419:531-4. 2002
  2. ncbi request reprint The genome of the malaria parasite
    M J Gardner
    The Institute for Genomic Research, Rockville 20850, USA
    Curr Opin Genet Dev 9:704-8. 1999
  3. ncbi request reprint The malaria genome sequencing project: complete sequence of Plasmodium falciparum chromosome 2
    M J Gardner
    Institute of Genomic Research, Naval Medical Research Center, Rockville, MD, USA
    Parassitologia 41:69-75. 1999
  4. ncbi request reprint A status report on the sequencing and annotation of the P. falciparum genome
    M J Gardner
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Mol Biochem Parasitol 118:133-8. 2001
  5. ncbi request reprint Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes
    Malcolm J Gardner
    Institute for Genomic Research TIGR, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 309:134-7. 2005
  6. pmc Genome sequence of the human malaria parasite Plasmodium falciparum
    Malcolm J Gardner
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 419:498-511. 2002
  7. pmc Comparative genomics of the neglected human malaria parasite Plasmodium vivax
    Jane M Carlton
    The Institute for Genomic Research J Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
    Nature 455:757-63. 2008
  8. ncbi request reprint The genome sequence of the malaria mosquito Anopheles gambiae
    Robert A Holt
    Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
    Science 298:129-49. 2002
  9. ncbi request reprint Interpolated Markov models for eukaryotic gene finding
    S L Salzberg
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Genomics 59:24-31. 1999
  10. ncbi request reprint Immune responses to Plasmodium vivax pre-erythrocytic stage antigens in naturally exposed Duffy-negative humans: a potential model for identification of liver-stage antigens
    Ruobing Wang
    The Institute for Genomic Research, Rockville, USA
    Eur J Immunol 35:1859-68. 2005

Detail Information

Publications20

  1. ncbi request reprint Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14
    Malcolm J Gardner
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 419:531-4. 2002
    ..We report here the nucleotide sequences of chromosomes 10, 11 and 14, and a re-analysis of the chromosome 2 sequence. These chromosomes represent about 35% of the 23-megabase P. falciparum genome...
  2. ncbi request reprint The genome of the malaria parasite
    M J Gardner
    The Institute for Genomic Research, Rockville 20850, USA
    Curr Opin Genet Dev 9:704-8. 1999
    ..Even at this early stage of the project, analysis of the genome sequence has provided promising new leads for drug and vaccine development...
  3. ncbi request reprint The malaria genome sequencing project: complete sequence of Plasmodium falciparum chromosome 2
    M J Gardner
    Institute of Genomic Research, Naval Medical Research Center, Rockville, MD, USA
    Parassitologia 41:69-75. 1999
    ..Within 2-3 years, the sequence of almost all P. falciparum genes will have been determined, paving the way for genetic, biochemical, and immunological research aimed at developing new drugs and vaccines against malaria...
  4. ncbi request reprint A status report on the sequencing and annotation of the P. falciparum genome
    M J Gardner
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Mol Biochem Parasitol 118:133-8. 2001
    ..The consortium recently developed plans for the annotation and analysis of the complete genome sequence and its publication in 2002...
  5. ncbi request reprint Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes
    Malcolm J Gardner
    Institute for Genomic Research TIGR, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 309:134-7. 2005
    ..Several biosynthetic pathways are incomplete or absent, suggesting substantial metabolic dependence on the host cell. One protein family that may generate parasite antigenic diversity is not telomere-associated...
  6. pmc Genome sequence of the human malaria parasite Plasmodium falciparum
    Malcolm J Gardner
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 419:498-511. 2002
    ..The genome sequence provides the foundation for future studies of this organism, and is being exploited in the search for new drugs and vaccines to fight malaria...
  7. pmc Comparative genomics of the neglected human malaria parasite Plasmodium vivax
    Jane M Carlton
    The Institute for Genomic Research J Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
    Nature 455:757-63. 2008
    ..Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species...
  8. ncbi request reprint The genome sequence of the malaria mosquito Anopheles gambiae
    Robert A Holt
    Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
    Science 298:129-49. 2002
    ..An expressed sequence tag analysis of genes regulated by blood feeding provided insights into the physiological adaptations of a hematophagous insect...
  9. ncbi request reprint Interpolated Markov models for eukaryotic gene finding
    S L Salzberg
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Genomics 59:24-31. 1999
    ..With the rapid progress in sequencing the genome of P. falciparum, the availability of this new gene finder will greatly facilitate the annotation process...
  10. ncbi request reprint Immune responses to Plasmodium vivax pre-erythrocytic stage antigens in naturally exposed Duffy-negative humans: a potential model for identification of liver-stage antigens
    Ruobing Wang
    The Institute for Genomic Research, Rockville, USA
    Eur J Immunol 35:1859-68. 2005
    ..These results suggest that differential immune responses observed in naturally exposed Fy(-) and Fy(+) individuals can be exploited to identify P. vivax stage-specific antigens...
  11. ncbi request reprint AvGI, an index of genes transcribed in the salivary glands of the ixodid tick Amblyomma variegatum
    Vishvanath Nene
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Int J Parasitol 32:1447-56. 2002
    ..The database may be accessed via the World Wide Web at http://www.tigr.org/tdb/tgi.shtml...
  12. ncbi request reprint Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii
    Jane M Carlton
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 419:512-9. 2002
    ..This is the first genome sequence of a model eukaryotic parasite, and it provides insight into the use of such systems in the modelling of Plasmodium biology and disease...
  13. ncbi request reprint Purification of chromosomes from Plasmodium falciparum
    Daniel J Carucci
    Malaria Program, Naval Medical Research Center, Silver Spring, MD, USA
    Methods Mol Med 72:235-40. 2002
  14. ncbi request reprint Curation of the Plasmodium falciparum genome
    Andrew E Berry
    Pathogen Sequencing Unit, Wellcome Trust Sanger Institute, Hinxton Hall, Cambridge CB10 1SA, UK
    Trends Parasitol 20:548-52. 2004
    ..The recently initiated curation of the genome resource is a vital investment for maintaining and enhancing the use of this genomic information in the post-genomic era...
  15. pmc Analysis of the transcriptome of the protozoan Theileria parva using MPSS reveals that the majority of genes are transcriptionally active in the schizont stage
    Richard Bishop
    The International Livestock Research Institute ILRI, PO Box 30709, Nairobi, Kenya
    Nucleic Acids Res 33:5503-11. 2005
    ..The data suggests a low level of baseline transcription from the majority of protein-coding genes...
  16. ncbi request reprint Using the transcriptome to annotate the genome revisited: application of massively parallel signature sequencing (MPSS)
    Trushar Shah
    International Livestock Research Institute, PO Box 30709, Nairobi, Kenya
    Gene 366:104-8. 2006
    ..parva that were absent from the genome of the closely related T. annulata had MPSS signatures. This study illustrates the utility of MPSS for improving annotation of small, gene-rich microbial eukaryotic genomes...
  17. pmc Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes
    Simon P Graham
    International Livestock Research Institute, Nairobi, Kenya
    Proc Natl Acad Sci U S A 103:3286-91. 2006
    ..These data provide a basis for developing a CTL-targeted anti-East Coast fever subunit vaccine. In addition, orthologs of these antigens may be vaccine targets for other apicomplexan parasites...
  18. pmc Assessment and improvement of the Plasmodium yoelii yoelii genome annotation through comparative analysis
    Ashley Vaughan
    Seattle Biomedical Research Institute, Seattle, WA 98109, USA
    Bioinformatics 24:i383-9. 2008
    ..Unfortunately, only preliminary gene models were annotated on the partially sequenced genome, mostly by in silico gene prediction, and there has been no major improvement of the annotation since 2002...
  19. ncbi request reprint A proteomic view of the Plasmodium falciparum life cycle
    Laurence Florens
    Department of Cell Biology, The Scripps Research Institute, SR 11, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 419:520-6. 2002
    ..The detection of chromosomal clusters encoding co-expressed proteins suggested a potential mechanism for controlling gene expression...
  20. ncbi request reprint Functional characterization of the acyl carrier protein (PfACP) and beta-ketoacyl ACP synthase III (PfKASIII) from Plasmodium falciparum
    Norman C Waters
    Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, MD 20910 5100, USA
    Mol Biochem Parasitol 123:85-94. 2002
    ..During the schizont stage of parasite development, there is a significant up-regulation of the mRNAs corresponding to these proteins, indicating an important metabolic requirement for fatty acids during this stage...