Fred Gage

Summary

Affiliation: The Salk Institute
Country: USA

Publications

  1. ncbi request reprint Mammalian neural stem cells
    F H Gage
    The Salk Institute, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 287:1433-8. 2000
  2. ncbi request reprint A novel model for an older remodeler: the BAF swap in neurogenesis
    Stefan Aigner
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Neuron 55:171-3. 2007
  3. doi request reprint Transplantation in the future
    Fred H Gage
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA, USA
    Prog Brain Res 201:7-13. 2012
  4. doi request reprint Transplantation in the future
    Fred H Gage
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA, USA
    Prog Brain Res 200:7-13. 2012
  5. pmc Adult hippocampal neurogenesis and its role in Alzheimer's disease
    Yangling Mu
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Mol Neurodegener 6:85. 2011
  6. pmc Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice
    Brian Spencer
    Department of Neurosciences, University of California San Diego, La Jolla, California 92093, USA
    BMC Neurosci 9:109. 2008
  7. ncbi request reprint A small gem with great powers: geminin keeps neural progenitors thriving
    Stefan Aigner
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Dev Cell 9:171-2. 2005
  8. ncbi request reprint Molecular and cellular mechanisms contributing to the regulation, proliferation and differentiation of neural stem cells in the adult dentate gyrus
    Fred H Gage
    Laboratory of Genetics, Salk Institute of Biological Studies, La Jolla, CA 92037, USA
    Keio J Med 59:79-83. 2010
  9. ncbi request reprint Neural consequences of environmental enrichment
    H van Praag
    Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nat Rev Neurosci 1:191-8. 2000
  10. ncbi request reprint Neurogenesis in the adult brain
    Fred H Gage
    Laboratory of Genetics, The Salk Institute, La Jolla, California 92037, USA
    J Neurosci 22:612-3. 2002

Detail Information

Publications88

  1. ncbi request reprint Mammalian neural stem cells
    F H Gage
    The Salk Institute, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 287:1433-8. 2000
    ..quot; Before the full potential of neural stem cells can be realized, we need to learn what controls their proliferation, as well as the various pathways of differentiation available to their daughter cells...
  2. ncbi request reprint A novel model for an older remodeler: the BAF swap in neurogenesis
    Stefan Aigner
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Neuron 55:171-3. 2007
    ..In this issue of Neuron, Lessard et al. show that this process is regulated by specific cofactor exchanges within the SWI/SNF chromatin remodeling complex...
  3. doi request reprint Transplantation in the future
    Fred H Gage
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA, USA
    Prog Brain Res 201:7-13. 2012
    ..The convergence of advanced molecular and cellular methods together with improved methods of in vivo imaging adds to our optimism for significant advances in cellular transplantation in the near future...
  4. doi request reprint Transplantation in the future
    Fred H Gage
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA, USA
    Prog Brain Res 200:7-13. 2012
    ..The convergence of advanced molecular and cellular methods together with improved methods of in vivo imaging adds to our optimism for significant advances in cellular transplantation in the near future...
  5. pmc Adult hippocampal neurogenesis and its role in Alzheimer's disease
    Yangling Mu
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Mol Neurodegener 6:85. 2011
    ..Here we review recent findings on alterations of neurogenesis associated with pathogenesis of AD, and we discuss the potential of neurogenesis-based diagnostics and therapeutic strategies for AD...
  6. pmc Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice
    Brian Spencer
    Department of Neurosciences, University of California San Diego, La Jolla, California 92093, USA
    BMC Neurosci 9:109. 2008
    ..However the effects of long-term neprilysin gene transfer on other aspects of Abeta associated pathology have not been explored yet in APP transgenic mice...
  7. ncbi request reprint A small gem with great powers: geminin keeps neural progenitors thriving
    Stefan Aigner
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Dev Cell 9:171-2. 2005
    ..In a recent issue of Genes and Development, Seo and coworkers (2005a) show that geminin (Gem), a protein involved in cell cycle control, also regulates the transition from proliferating neural progenitors to differentiating neurons...
  8. ncbi request reprint Molecular and cellular mechanisms contributing to the regulation, proliferation and differentiation of neural stem cells in the adult dentate gyrus
    Fred H Gage
    Laboratory of Genetics, Salk Institute of Biological Studies, La Jolla, CA 92037, USA
    Keio J Med 59:79-83. 2010
    ....
  9. ncbi request reprint Neural consequences of environmental enrichment
    H van Praag
    Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nat Rev Neurosci 1:191-8. 2000
    ..We emphasize the behavioural and neurobiological consequences of specific elements of enrichment, especially exercise and learning...
  10. ncbi request reprint Neurogenesis in the adult brain
    Fred H Gage
    Laboratory of Genetics, The Salk Institute, La Jolla, California 92037, USA
    J Neurosci 22:612-3. 2002
  11. pmc Computational influence of adult neurogenesis on memory encoding
    James B Aimone
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Neuron 61:187-202. 2009
    ..Taken together, these results indicate that new granule cells may affect hippocampal function in several unique and previously unpredicted ways...
  12. ncbi request reprint The adult substantia nigra contains progenitor cells with neurogenic potential
    D Chichung Lie
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 22:6639-49. 2002
    ..This developmental potential of SN progenitor cells might be useful for future endogenous cell replacement strategies in Parkinson's disease...
  13. ncbi request reprint Brain, repair yourself
    Fred H Gage
    Laboratory of Genetics, Salk Institute for Biological Studies in San Diego, USA
    Sci Am 289:46-53. 2003
  14. pmc Directed differentiation of hippocampal stem/progenitor cells in the adult brain
    Sebastian Jessberger
    Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, California 92037, USA
    Nat Neurosci 11:888-93. 2008
    ..These data indicate that AHPs have substantial plasticity, which might have important implications for the potential use of endogenous AHPs in neurological disease...
  15. ncbi request reprint Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons
    Hong Jun Song
    Molecular Neurobiology Laboratory, Howard Hughes Medical Institute at the Salk Institute, 10010 N Torrey Pines Road, La Jolla, California 92037, USA
    Nat Neurosci 5:438-45. 2002
    ..These studies show that neural stem cells derived from adult tissues, like those derived from embryonic tissues, retain the potential to differentiate into functional neurons with essential properties of mature CNS neurons...
  16. ncbi request reprint Potential role for adult neurogenesis in the encoding of time in new memories
    James B Aimone
    Laboratory of Genetics, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Neurosci 9:723-7. 2006
    ..We discuss the possibility that one cognitive impact of this gradually changing population on hippocampal memory formation is the formation of the temporal clusters of long-term episodic memories seen in some human psychological studies...
  17. ncbi request reprint Endogenous neurogenesis replaces oligodendrocytes and astrocytes after primate spinal cord injury
    Hong Yang
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0626, USA
    J Neurosci 26:2157-66. 2006
    ..Thus, cell replacement is an extensive natural compensatory response to injury in the primate spinal cord that contributes to neural repair and is a potential target for therapeutic enhancement...
  18. pmc Retinoic acid is required early during adult neurogenesis in the dentate gyrus
    Sharoni Jacobs
    Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:3902-7. 2006
    ..Our results reveal RA as a crucial contributor to early stages of adult neurogenesis and survival in vivo...
  19. pmc Fate of endogenous stem/progenitor cells following spinal cord injury
    Laura L Horky
    The Salk Institute for Biological Studies, Laboratory of Genetics, La Jolla, California 92037, USA
    J Comp Neurol 498:525-38. 2006
    ....
  20. pmc In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus
    Hoonkyo Suh
    Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Stem Cell 1:515-28. 2007
    ..An asymmetric contribution of Sox2+ NSCs may play an important role in maintaining the constant size of the NSC pool and producing newly born neurons during adult neurogenesis...
  21. doi request reprint Multiple layers of molecular controls modulate self-renewal and neuronal lineage specification of embryonic stem cells
    Gene W Yeo
    Laboratory of Genetics, Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Hum Mol Genet 17:R67-75. 2008
    ..An integrative view of the different levels will hopefully provide much needed insight into understanding stem cell biology...
  22. pmc Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus
    Sebastian Jessberger
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California, USA
    PLoS Biol 6:e272. 2008
    ..The data presented here also suggest a mechanistic dissociation between accurate dendritic targeting and subsequent synapse formation...
  23. ncbi request reprint Expression and function of orphan nuclear receptor TLX in adult neural stem cells
    Yanhong Shi
    Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 427:78-83. 2004
    ..TLX can silence glia-specific expression of the astrocyte marker GFAP in neural stem cells, suggesting that transcriptional repression may be crucial in maintaining the undifferentiated state of these cells...
  24. ncbi request reprint Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition
    Alysson R Muotri
    Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 435:903-10. 2005
    ..Our data therefore indicate that neuronal genomes might not be static, but some might be mosaic because of de novo L1 retrotransposition events...
  25. ncbi request reprint Astroglia induce neurogenesis from adult neural stem cells
    Hongjun Song
    Molecular Neurobiology Laboratory, Howard Hughes Medical Institute at the Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 417:39-44. 2002
    ....
  26. ncbi request reprint Genetic influence on phenotypic differentiation in adult hippocampal neurogenesis
    Gerd Kempermann
    The Salk Institute for Biological Studies, Laboratory of Genetics, La Jolla, CA 92037, USA
    Brain Res Dev Brain Res 134:1-12. 2002
    ..At the present time it cannot be determined whether this regulation occurs by influencing cell fate decisions or by promoting selective survival...
  27. ncbi request reprint Functional and morphological effects of NG2 proteoglycan deletion on hippocampal neurogenesis
    Michaela Thallmair
    The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Exp Neurol 202:167-78. 2006
    ..These results suggest that the null mutation for NG2 does not influence adult hippocampal neurogenesis or hippocampal-dependent behavioral tasks...
  28. pmc Neurons born in the adult dentate gyrus form functional synapses with target cells
    Nicolas Toni
    Laboratory of Genetics, Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Neurosci 11:901-7. 2008
    ..Our structural and functional evidence indicates that axons of adult-born granule cells establish synapses with hilar interneurons, mossy cells and CA3 pyramidal cells and release glutamate as their main neurotransmitter...
  29. doi request reprint A role for adult TLX-positive neural stem cells in learning and behaviour
    Chun Li Zhang
    Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 451:1004-7. 2008
    ....
  30. ncbi request reprint Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus
    Chunmei Zhao
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 26:3-11. 2006
    ..Our study reveals the key morphological transitions of newborn granule neurons during their course of maturation...
  31. ncbi request reprint Differential properties of adult rat and mouse brain-derived neural stem/progenitor cells
    Jasodhara Ray
    The Salk Institute for Biological Studies, Laboratory of Genetics, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell Neurosci 31:560-73. 2006
    ..Thus, extrapolation of cell properties from one species to another based on studies of these cells should be made with caution...
  32. ncbi request reprint Experience-specific functional modification of the dentate gyrus through adult neurogenesis: a critical period during an immature stage
    Ayumu Tashiro
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 27:3252-9. 2007
    ..This experience-specific functional modification through adult neurogenesis could be a mechanism by which new neurons exert a long-term influence on the function of the dentate gyrus related to learning and memory...
  33. pmc A functional study of miR-124 in the developing neural tube
    Xinwei Cao
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 21:531-6. 2007
    ..Thus miR-124 appears to ensure that progenitor genes are post-transcriptionally inhibited in neurons...
  34. ncbi request reprint Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling
    Sebastian Jessberger
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 27:9400-7. 2007
    ....
  35. ncbi request reprint Noncoding RNAs in the mammalian central nervous system
    Xinwei Cao
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Annu Rev Neurosci 29:77-103. 2006
    ..Finally, we speculate why ncRNAs are well adapted to improving organism-environment interactions...
  36. ncbi request reprint Targeted expression of IGF-1 in the central nervous system fails to protect mice from experimental autoimmune encephalomyelitis
    Stephane Genoud
    Laboratory of Genetics, The Salk Institute, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
    J Neuroimmunol 168:40-5. 2005
    ..Thus, enhanced expression of IGF-1 in the CNS during inflammation does not have a significant effect on myelination. These data have important implications for the potential use of IGF-1 in the treatment of multiple sclerosis...
  37. doi request reprint Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus
    Helena Mira
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell Stem Cell 7:78-89. 2010
    ..BMPs are therefore required to balance NSC quiescence/proliferation and to prevent loss of the stem cell activity that supports continuous neurogenesis in the mature hippocampus...
  38. ncbi request reprint A small modulatory dsRNA specifies the fate of adult neural stem cells
    Tomoko Kuwabara
    Laboratory of Genetics, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 116:779-93. 2004
    ..The discovery of small modulatory dsRNAs (smRNAs) extends the important contribution of noncoding RNAs as key regulators of cell behavior at both transcriptional and posttranscriptional levels...
  39. ncbi request reprint Targeted retrograde gene delivery for neuronal protection
    Brian K Kaspar
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Mol Ther 5:50-6. 2002
    ..This approach may also facilitate experimental studies of defined neural circuits...
  40. ncbi request reprint Functional neurogenesis in the adult hippocampus
    Henriette van Praag
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 415:1030-4. 2002
    ..Our findings demonstrate that newly generated cells mature into functional neurons in the adult mammalian brain...
  41. ncbi request reprint Long-term production of choline acetyltransferase in the CNS after transplantation of fibroblasts modified with a regulatable vector
    Donald P Pizzo
    Department of Neurosciences, University of California San Diego, La Jolla, CA 92023, USA
    Brain Res Mol Brain Res 126:1-13. 2004
    ..Removal of DOX led to a derepression of ChAT activity within 2 days. These cells will be useful for ex vivo gene therapy of the cholinergic system...
  42. ncbi request reprint Neurogenesis in the adult brain: new strategies for central nervous system diseases
    D Chichung Lie
    Laboratory of Genetics, The Salk Institute, La Jolla, California 92037, USA
    Annu Rev Pharmacol Toxicol 44:399-421. 2004
    ..Here, we summarize our current understanding of the mechanisms controlling adult neurogenesis and discuss their implications for the development of new strategies for the treatment of neurodegenerative diseases...
  43. pmc Alternative splicing events identified in human embryonic stem cells and neural progenitors
    Gene W Yeo
    Crick Jacobs Center for Theoretical and Computational Biology, Salk Institute, La Jolla, California, USA
    PLoS Comput Biol 3:1951-67. 2007
    ..In summary, a new methodology for exon array analysis was introduced, leading to new insights into the complexity of AS in human embryonic stem cells and their transition to neural stem cells...
  44. ncbi request reprint Adult neurogenesis and neural stem cells of the central nervous system in mammals
    Philippe Taupin
    Laboratory of Genetics, The Salk Institute, La Jolla, California 92037 1099, USA
    J Neurosci Res 69:745-9. 2002
  45. doi request reprint Put them out to pasture? What are old granule cells good for, anyway...?
    James B Aimone
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Hippocampus 20:1124-5. 2010
    ..Here, we present several implications of this interesting theory for the function of both neurogenesis and the dentate gyrus...
  46. ncbi request reprint A synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells
    Masaki Warashina
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, SR202, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 45:591-3. 2006
  47. ncbi request reprint Acetylcholine-secreting cells improve age-induced memory deficits
    Heather Dickinson-Anson
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Mol Ther 8:51-61. 2003
    ..These results indicate that locally restricted supplementation of acetylcholine into the two major target regions of the cholinergic basal forebrain of aged impaired rats ameliorates some age-related cognitive deficits...
  48. ncbi request reprint Synapse formation on neurons born in the adult hippocampus
    Nicolas Toni
    Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, California 92037, USA
    Nat Neurosci 10:727-34. 2007
    ..The connectivity of new neurons continued to change until at least 2 months, long after the formation of the first dendritic protrusions...
  49. pmc YAP regulates neural progenitor cell number via the TEA domain transcription factor
    Xinwei Cao
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 22:3320-34. 2008
    ..Thus, the Hippo pathway plays critical roles in regulating neural progenitor cell number by affecting proliferation, fate choice, and cell survival...
  50. doi request reprint Mechanisms and functional implications of adult neurogenesis
    Chunmei Zhao
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell 132:645-60. 2008
    ..We further address the potential significance of adult neurogenesis in memory, depression, and neurodegenerative disorders such as Alzheimer's and Parkinson's disease...
  51. doi request reprint Hippocampus-dependent learning is associated with adult neurogenesis in MRL/MpJ mice
    Sandrine Thuret
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Hippocampus 19:658-69. 2009
    ..Together, these results suggest that adult neurogenesis is correlated with spatial learning and visual recognition learning, possibly by modulating morphological plasticity in the dentate gyrus...
  52. ncbi request reprint Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6
    Luc Vallières
    Laboratories of Neuronal Structure and Function, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 22:486-92. 2002
    ..These findings suggest that long-term exposure of the brain to proinflammatory mediators such as IL-6, as is seen in certain degenerative disorders and infections, can interfere with adult neurogenesis...
  53. ncbi request reprint Generation of neuronal variability and complexity
    Alysson R Muotri
    Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 441:1087-93. 2006
    ....
  54. pmc IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes
    Jenny Hsieh
    Laboratory of Genetics, The Salk Institute, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Cell Biol 164:111-22. 2004
    ..These data demonstrate the existence of a single molecule, IGF-I, that can influence the fate choice of multipotent adult neural progenitor cells to an oligodendroglial lineage...
  55. pmc Exercise enhances learning and hippocampal neurogenesis in aged mice
    Henriette van Praag
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 25:8680-5. 2005
    ..Thus, voluntary exercise ameliorates some of the deleterious morphological and behavioral consequences of aging...
  56. pmc Genetic and functional differences between multipotent neural and pluripotent embryonic stem cells
    Kevin A D'Amour
    Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:11866-72. 2003
    ..This direct comparison elucidates the molecular basis for the functional differences in pluripotent ESCs and multipotent NSCs...
  57. ncbi request reprint Neuroscience. Cellular interactions in the stem cell niche
    Andrew E Wurmser
    Laboratory of Genetics, Salk Institute, La Jolla, CA 92037, USA
    Science 304:1253-5. 2004
  58. pmc Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease
    John B Rose
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0624, USA
    J Neurosci 29:1115-25. 2009
    ..This function of NEP represents a unique example of a proteolytic enzyme with dual action, namely, degradation of Abeta as well as processing of NPY...
  59. pmc Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats
    Sebastian Jessberger
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Learn Mem 16:147-54. 2009
    ....
  60. pmc Development of functional human embryonic stem cell-derived neurons in mouse brain
    Alysson R Muotri
    Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:18644-8. 2005
    ..The model also has the potential to speed up the screening process for therapeutic drugs...
  61. ncbi request reprint Cell fusion-independent differentiation of neural stem cells to the endothelial lineage
    Andrew E Wurmser
    The Salk Institute, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 430:350-6. 2004
    ..We conclude that stem-cell plasticity is a true characteristic of NSCs and that the conversion of NSCs to unanticipated cell types can be accomplished without cell fusion...
  62. ncbi request reprint Spontaneous fusion and nonclonal growth of adult neural stem cells
    Sebastian Jessberger
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Stem Cells 25:871-4. 2007
    ..The nonclonal growth between distinct NSC populations strongly suggests the use of careful and precise culture conditions, such as single-cell assays, to characterize potency and growth of NSCs in vitro...
  63. ncbi request reprint Epigenetic control of neural stem cell fate
    Jenny Hsieh
    Laboratory of Genetics, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Curr Opin Genet Dev 14:461-9. 2004
    ..Extracellular signaling systems that control the growth and differentiation of neural stem cells act, at least in part, by interfacing with these diverse epigenetic mechanisms...
  64. ncbi request reprint Mouse erythrocyte tropomodulin in the brain reported by lacZ knocked-in downstream from the E1 promoter
    Weijuan Yao
    Department of Bioengineering and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Gene Expr Patterns 8:36-46. 2007
    ..Large neurons, e.g., mitral cells in olfactory bulb and mossy cells in hilus of the dentate gyrus are among those that expressed very high levels of E-Tmod in the CNS...
  65. pmc Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1
    Chun Li Zhang
    Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 20:1308-20. 2006
    ..Together, these results reveal a molecular strategy by which an orphan nuclear receptor can precisely orchestrate tissue-specific proliferation and differentiation programs to prevent retinal malformation and degeneration...
  66. ncbi request reprint Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model
    Brian K Kaspar
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Science 301:839-42. 2003
    ..We report that insulin-like growth factor 1 prolongs life and delays disease progression, even when delivered at the time of overt disease symptoms...
  67. pmc Adeno-associated virus effectively mediates conditional gene modification in the brain
    Brian K Kaspar
    Laboratory of Genetics, Molecular Neurobiology Laboratory, and Peptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:2320-5. 2002
    ..This approach will greatly facilitate the study of genetic modifications in the mouse brain...
  68. ncbi request reprint Maintenance of embryonic stem cell pluripotency by Nanog-mediated reversal of mesoderm specification
    Atsushi Suzuki
    Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Nat Clin Pract Cardiovasc Med 3:S114-22. 2006
    ..These findings uncover specific roles of leukemia inhibitory factor, Nanog, and bone morphogenetic protein in the self-renewal of ESCs and provide novel insights into the cellular bases of ESC pluripotency...
  69. ncbi request reprint Neuronal and glial cell biology
    Fred H Gage
    Curr Opin Neurobiol 15:497-9. 2005
  70. ncbi request reprint IGF-I has a direct proliferative effect in adult hippocampal progenitor cells
    Maria A I Aberg
    The Arvid Carlsson Institute for Neuroscience at the Institute of Clinical Neuroscience, Sahlgrenska University Hospital, Goteborg University, Bla straket 7, SE 413 45 Goteborg, Sweden
    Mol Cell Neurosci 24:23-40. 2003
    ..These results were confirmed with dominant-negative constructs for these pathways. Stimulation of differentiation was found at a low dose (1 ng/ml) of IGF-I, clonal analysis indicating an instructive component of IGF-I signaling...
  71. ncbi request reprint Neurogenesis and neuroadaptation
    David V Schaffer
    Department of Chemical Engineering and the Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720 1462, USA
    Neuromolecular Med 5:1-9. 2004
    ....
  72. pmc Novel neuronal phenotypes from neural progenitor cells
    Eleni A Markakis
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 24:2886-97. 2004
    ....
  73. ncbi request reprint Functional significance of adult neurogenesis
    Gerd Kempermann
    Max Delbruck Center for Molecular Medicine, Berlin Buch and Volkswagenstiftung Research Group at the Department of Experimental Neurology, Charite University Medicine Berlin, Berlin, Germany
    Curr Opin Neurobiol 14:186-91. 2004
    ..Nevertheless, the information that has been obtained and published so far provides ample evidence that neurons generated in the adult can function and even suggests how they might contribute to cognitive processes...
  74. pmc Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice
    Brian J Cummings
    Department of Physical Medicine and Rehabilitation, Reeve Irvine Research Center, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 102:14069-74. 2005
    ..Glial fibrillary acidic protein-positive astrocytic differentiation was rare, and hCNS-SCns did not appear to contribute to the scar. These data suggest that hCNS-SCns may possess therapeutic potential for CNS injury and disease...
  75. doi request reprint Experts provide insights into emerging field of brain and spine repair. Interview by Bridget M. Kuehn
    Fred H Gage
    JAMA 300:1013-4. 2008
  76. pmc Epigenetic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells
    Xuekun Li
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    J Biol Chem 283:27644-52. 2008
    ..These data indicate that intrinsic epigenetic mechanisms play critical roles in the regulation of adult NSPC functions...
  77. ncbi request reprint Integration of new neurons into functional neural networks
    Victor Ramirez-Amaya
    Arizona Research Laboratories Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson, Arizona 85724, USA
    J Neurosci 26:12237-41. 2006
    ....
  78. pmc An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus
    Ana C Pereira
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 104:5638-43. 2007
    ....
  79. ncbi request reprint Defining the NG2-expressing cell of the adult CNS
    Philip J Horner
    Department of Neurological Surgery, University of Washington, 325 Ninth Ave Box 359655, Seattle, WA 98104, USA
    J Neurocytol 31:469-80. 2002
    ..Future studies should elucidate the functional importance of NG2 in a variety of cell functions and shed light on the role NG2-expressing cells play in the intact and diseased CNS...
  80. ncbi request reprint Similar GABAergic inputs in dentate granule cells born during embryonic and adult neurogenesis
    Diego A Laplagne
    Laboratorio de Plasticidad Neuronal, Fundación Instituto Leloir 1405 Buenos Aires, Argentina
    Eur J Neurosci 25:2973-81. 2007
    ..Our results demonstrate that granule cells of different age, location and degree of excitability receive GABAergic inputs of equivalent functional characteristics...
  81. pmc Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons
    Richard D Smrt
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Neurobiol Dis 27:77-89. 2007
    ..Our studies suggest that MeCP2 plays a central role in neuronal maturation, which might be mediated through epigenetic control of expression pathways that are instrumental in both dendritic development and synaptogenesis...
  82. ncbi request reprint Neurogenic niche modulation by activated microglia: transforming growth factor beta increases neurogenesis in the adult dentate gyrus
    Daniela Battista
    Laboratory of Neuromodulation, Leloir Institute, CONICET UBA, University of Buenos Aires, 435 Av Patricias Argentinas, Buenos Aires 1405, Argentina
    Eur J Neurosci 23:83-93. 2006
    ..Importantly, we identified an anti-inflammatory cytokine, TGF-beta, with neurogenic potential in the adult brain...
  83. ncbi request reprint Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis
    Jason Brown
    Department of Neurology, University of Regensburg, 93053 Regensburg, Germany
    Eur J Neurosci 17:2042-6. 2003
    ..The discrepancy between the olfactory bulb and the dentate gyrus suggests that these living conditions trigger locally through an as yet unidentified mechanism specific to neurogenic signals in the dentate gyrus...
  84. ncbi request reprint Is neurogenesis reparative after status epilepticus?
    Jack M Parent
    Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 2200, USA
    Epilepsia 48:69-71. 2007
  85. ncbi request reprint Stem cells. Setting standards for human embryonic stem cells
    Ali H Brivanlou
    Rockefeller University, New York, NY 10021, USA
    Science 300:913-6. 2003
  86. ncbi request reprint Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo
    Karen Lai
    Department of Chemical Engineering and the Helen Wills Neuroscience Institute, 201 Gilman Hall, University of California, Berkeley, California 94720 1462, USA
    Nat Neurosci 6:21-7. 2003
    ..Finally, the pharmacological inhibitor of Shh signaling cyclopamine reduced hippocampal neural progenitor proliferation in vivo. This work identifies Shh as a regulator of adult hippocampal neural stem cells...
  87. ncbi request reprint Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment
    Gerd Kempermann
    Department of Neurology, Charite, Humboldt University, Berlin, Germany
    Ann Neurol 52:135-43. 2002
    ..Activity exerts not only an acute but also a sustained effect on brain plasticity...
  88. pmc Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation
    Basam Z Barkho
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, 87131, USA
    Stem Cells Dev 15:407-21. 2006
    ..The finding that cytokines and chemokines expressed by astrocytes could promote NSPC neuronal differentiation may help us to understand how injuries induce neurogenesis in adult brains...

Research Grants40

  1. Translational Research of AAV-IGF-1 Gene Therapy for ALS
    Fred Gage; Fiscal Year: 2006
    ..We aim to complete further efficacy studies as well safety and toxicity studies required for the submission of an Investigational New Drug Application (IND) for a clinical study of AAV-IGF-1 in adults with ALS. ..
  2. Gene Targeting and Regulation for Neurological Disease
    Fred Gage; Fiscal Year: 2006
    ..abstract_text> ..
  3. Function of Stem Cell-Derived Neurons in the Aging Brain
    Fred Gage; Fiscal Year: 2006
    ..abstract_text> ..
  4. smRNA-Mediated Regulation of Adult Neural Stem Cell Fate
    Fred Gage; Fiscal Year: 2007
    ..Specific Aim 4 continues the search for new smRNAs by taking advantage of the expertise in ribozyme technology developed by Kuwabara in Japan and applied at the Salk for this project. ..
  5. Functional Analysis of Adult Hippocampal Neurogenesis
    Fred H Gage; Fiscal Year: 2010
    ..The findings of this study will increase our understanding of the adult neurogenesis process which has been implicated in neurological conditions such as aging, depression, and schizophrenia. ..
  6. Role of Astrocyte-Derived Wnts in Adult Neurogenesis
    Fred Gage; Fiscal Year: 2009
    ..The studies may also ultimately help in the design of therapeutic approaches in CNS disorders that aim at the recruitment of endogenous NSCs for replacement of dying neurons. ..
  7. Cell Genesis in the Intact and Injured Substantia Nigra
    Fred Gage; Fiscal Year: 2005
    ..The suggested experiments will provide the groundwork for possible future strategies in which we will try to manipulate cell genesis in the adult SN in order to restore the function of the injured adult SN. ..
  8. CHARACTERIZATION & UTILIZATION OF ADULT PROGENITOR CELLS
    Fred Gage; Fiscal Year: 2001
    ..Finally in this aim we will inject FGF-2 chronically in the adult brain to induce proliferation and differentiation of the endogenous progenitor cells. ..
  9. Conference on Stem Cells: Origins, Fate and Functions
    Fred Gage; Fiscal Year: 2002
    ..Evaluation of the current application of stem cells for diagnosis and therapy should provide a measure of how much progress has been made and is needed. ..
  10. L1 Retrotransposon and Neural Diversity
    Fred H Gage; Fiscal Year: 2010
    ..The outcome of this study will increase our understanding of human diversity and behavior and may contain insights into the genesis of multiple neurological diseases. ..