Elaine Fuchs

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. request reprint
    Raghavan S, Vaezi A, Fuchs E. A role for alphabeta1 integrins in focal adhesion function and polarized cytoskeletal dynamics. Dev Cell. 2003;5:415-27 pubmed
    ..Without the ability to remodel their integrin-actin network efficiently, alphabeta1-deficient keratinocytes cannot respond dynamically to their environment and polarize movements. ..
  2. Blanpain C, Fuchs E. Stem cell plasticity. Plasticity of epithelial stem cells in tissue regeneration. Science. 2014;344:1242281 pubmed publisher
    ..We also discuss the implications of cellular plasticity for regenerative medicine and for cancer. ..
  3. Miao Y, Yang H, Levorse J, Yuan S, Polak L, Sribour M, et al. Adaptive Immune Resistance Emerges from Tumor-Initiating Stem Cells. Cell. 2019;: pubmed publisher
    ..Conversely, upon CTLA4- or TGF-β-blocking immunotherapies or Cd80 ablation, tSCs become vulnerable, diminishing tumor relapse after ACT treatment. Our findings place tSCs at the crux of how immune checkpoint pathways are activated. ..
  4. Fuchs E. Cédric Blanpain: ISSCR's outstanding young investigator for 2012. Cell Stem Cell. 2012;10:751-752 pubmed publisher
  5. Fuchs E. The impact of cell culture on stem cell research. Cell Stem Cell. 2012;10:640-641 pubmed publisher
    ..However, clinical applications utilizing cultured stem cells have existed for >30 years and can assist benchers and bedsiders in identifying and expediting promising avenues for future therapies. ..
  6. Naik S, Larsen S, Cowley C, Fuchs E. Two to Tango: Dialog between Immunity and Stem Cells in Health and Disease. Cell. 2018;175:908-920 pubmed publisher
    ..This fascinating crosstalk holds great promise for novel therapies in inflammatory diseases and regenerative medicine. ..
  7. Fuchs E. Skin stem cells: rising to the surface. J Cell Biol. 2008;180:273-84 pubmed publisher
    ..In this paper, I outline the basic lineages of the skin epithelia and review some of the major findings about mammalian skin epithelial stem cells that have emerged in the past five years. ..
  8. Fuchs E. Skin Stem Cells in Silence, Action, and Cancer. Stem Cell Reports. 2018;10:1432-1438 pubmed publisher
    ..Below, I focus on my laboratory's contributions to this fascinating field, to which so many friends and colleagues have made seminal discoveries equally deserving of this award. ..
  9. Zhang L, Stokes N, Polak L, Fuchs E. Specific microRNAs are preferentially expressed by skin stem cells to balance self-renewal and early lineage commitment. Cell Stem Cell. 2011;8:294-308 pubmed publisher
    ..We verify some of these miR-125b targets, and show that Blimp1 and VDR in particular can account for many tissue imbalances we see when miR-125b is deregulated. ..

More Information

Publications30

  1. Heller E, Fuchs E. Tissue patterning and cellular mechanics. J Cell Biol. 2015;211:219-31 pubmed publisher
    ..The regulation of tension within individual cells and across large groups of cells is a major driving force of tissue organization and the basis of all cell shape change and cell movement in development. ..
  2. Fuchs E. An unconventional route to becoming a cell biologist. Mol Biol Cell. 2015;26:3697-9 pubmed publisher
    ..I appreciate it deeply now, and on this meaningful occasion, I will sketch my rather circuitous road to cell biology. ..
  3. Adam R, Fuchs E. The Yin and Yang of Chromatin Dynamics In Stem Cell Fate Selection. Trends Genet. 2016;32:89-100 pubmed publisher
    ..Here, we explore the emerging role of chromatin modifiers and pioneer transcription factors in adult stem cell fate decisions and plasticity, which ensure that selective lineage choices are only made when environmentally cued. ..
  4. Lu C, Polak L, Keyes B, Fuchs E. Spatiotemporal antagonism in mesenchymal-epithelial signaling in sweat versus hair fate decision. Science. 2016;354: pubmed publisher
    ..In contrast, a shift from hair to gland fates is achieved in humans when a spike in BMP silences SHH during the final embryonic wave(s) of bud morphogenesis. ..
  5. Asare A, Levorse J, Fuchs E. Coupling organelle inheritance with mitosis to balance growth and differentiation. Science. 2017;355: pubmed publisher
    ..Together, our findings unveil a role for organelle inheritance in mitosis, spindle alignment, and the choice of daughter progenitors to differentiate or remain stem-like. ..
  6. Adam R, Yang H, Ge Y, Lien W, Wang P, Zhao Y, et al. Temporal Layering of Signaling Effectors Drives Chromatin Remodeling during Hair Follicle Stem Cell Lineage Progression. Cell Stem Cell. 2018;22:398-413.e7 pubmed publisher
    ..Barriers to progenitor plasticity increase when diverse, signal-sensitive transcription factors shape LEF1-regulated enhancer dynamics. ..
  7. Genander M, Cook P, Ramsköld D, Keyes B, Mertz A, Sandberg R, et al. BMP signaling and its pSMAD1/5 target genes differentially regulate hair follicle stem cell lineages. Cell Stem Cell. 2014;15:619-33 pubmed publisher
    ..Our study therefore illustrates the complex differential roles that a key signaling pathway can play in regulation of closely related stem/progenitor cells within the context of their overall niche. ..
  8. Ge Y, Gomez N, Adam R, Nikolova M, Yang H, Verma A, et al. Stem Cell Lineage Infidelity Drives Wound Repair and Cancer. Cell. 2017;169:636-650.e14 pubmed publisher
    ..In cancer, stress-responsive transcription factor levels rise, causing lineage commanders to reach excess. When lineage and stress factors collaborate, they activate oncogenic enhancers that distinguish cancers from wounds. ..
  9. Yang H, Adam R, Ge Y, Hua Z, Fuchs E. Epithelial-Mesenchymal Micro-niches Govern Stem Cell Lineage Choices. Cell. 2017;169:483-496.e13 pubmed publisher
  10. Ouspenskaia T, Matos I, Mertz A, Fiore V, Fuchs E. WNT-SHH Antagonism Specifies and Expands Stem Cells prior to Niche Formation. Cell. 2016;164:156-169 pubmed publisher
  11. Keyes B, Liu S, Asare A, Naik S, Levorse J, Polak L, et al. Impaired Epidermal to Dendritic T Cell Signaling Slows Wound Repair in Aged Skin. Cell. 2016;167:1323-1338.e14 pubmed publisher
    ..These findings underscore epithelial-immune crosstalk perturbations in general, and Skints in particular, as critical mediators in the age-related decline in wound-repair. ..
  12. Fuchs E. Epithelial Skin Biology: Three Decades of Developmental Biology, a Hundred Questions Answered and a Thousand New Ones to Address. Curr Top Dev Biol. 2016;116:357-74 pubmed publisher
    ..Finally, I tackle the relation between skin cancer and mutations that perturb the regulation of stem cells. ..
  13. Oshimori N, Oristian D, Fuchs E. TGF-β promotes heterogeneity and drug resistance in squamous cell carcinoma. Cell. 2015;160:963-976 pubmed publisher
    ..Together, these findings establish a surprising non-genetic paradigm for TGF-β signaling in fueling heterogeneity in SCC-SCs, tumor characteristics, and drug resistance. ..
  14. Ezratty E, Pasolli H, Fuchs E. A Presenilin-2-ARF4 trafficking axis modulates Notch signaling during epidermal differentiation. J Cell Biol. 2016;214:89-101 pubmed publisher
    ..Collectively, our findings raise the possibility that ARF4-dependent polarized exocytosis acts through the basal body-ciliary complex to spatially regulate Notch signaling during epidermal differentiation. ..
  15. Hsu Y, Li L, Fuchs E. Transit-amplifying cells orchestrate stem cell activity and tissue regeneration. Cell. 2014;157:935-49 pubmed publisher
    ..Our findings unveil TACs as transient but indispensable integrators of SC niche components and reveal an intriguing interdependency of primed and quiescent SC populations on tissue regeneration. ..
  16. Fuchs E, Horsley V. More than one way to skin . . . Genes Dev. 2008;22:976-85 pubmed publisher
    ..Understanding how these stem cells maintain normal homeostasis and wound repair in the skin is particularly important, as these mechanisms, when defective, lead to skin tissue diseases including cancers...
  17. Lay K, Kume T, Fuchs E. FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential. Proc Natl Acad Sci U S A. 2016;113:E1506-15 pubmed publisher
    ..Taken together, our findings suggest that HFSCs have restricted potential in vivo, which they conserve by coupling quiescence to adhesion-mediated niche maintenance, thereby achieving long-term tissue homeostasis. ..
  18. Kulukian A, Holland A, Vitre B, Naik S, Cleveland D, Fuchs E. Epidermal development, growth control, and homeostasis in the face of centrosome amplification. Proc Natl Acad Sci U S A. 2015;112:E6311-20 pubmed publisher
    ..Moreover, these abnormalities were insufficient to disrupt homeostasis and initiate or enhance tumorigenesis, underscoring the powerful surveillance mechanisms in the skin. ..
  19. Keyes B, Fuchs E. Stem cells: Aging and transcriptional fingerprints. J Cell Biol. 2018;217:79-92 pubmed publisher
    ..Finally, we examine transcriptional changes that have been documented in aged stem cell populations and discuss new questions and future directions that this collection of data has uncovered. ..
  20. Gonzales K, Fuchs E. Skin and Its Regenerative Powers: An Alliance between Stem Cells and Their Niche. Dev Cell. 2017;43:387-401 pubmed publisher
    ..This review focuses on the epithelial stem cells of skin, where they come from, where they reside, and how they function in normal homeostasis and wound repair. ..
  21. Fuchs E. Scratching the surface of skin development. Nature. 2007;445:834-42 pubmed
    ..Exciting recent developments have focused on how adult skin epithelia maintain populations of stem cells for use in the natural cycles of hair follicle regeneration and for re-epithelialization in response to wounding...