Research Topics
Genomes and Genes
| Elaine FuchsSummaryAffiliation: The Rockefeller University Country: USA Publications
| Collaborators
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Detail Information
Publications
A role for alphabeta1 integrins in focal adhesion function and polarized cytoskeletal dynamicsSrikala Raghavan
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA
Dev Cell 5:415-27. 2003..Without the ability to remodel their integrin-actin network efficiently, alphabeta1-deficient keratinocytes cannot respond dynamically to their environment and polarize movements...
NFATc1 balances quiescence and proliferation of skin stem cellsValerie Horsley
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
Cell 132:299-310. 2008..Our findings may explain why patients receiving cyclosporine A for immunosuppressive therapy display excessive hair growth, and unveil a functional role for calcium-NFATc1-CDK4 circuitry in governing stem cell quiescence...- A matter of life and death: self-renewal in stem cellsElaine Fuchs
Howard Hughes Medical Institute, Rockefeller University, Laboratory of Mammalian Cell Biology and Development, New York, New York 10065, USA
EMBO Rep 14:39-48. 2013..By doing so, we pinpoint important questions that still await answers... 
Cédric Blanpain: ISSCR's outstanding young investigator for 2012Elaine Fuchs
Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA
Cell Stem Cell 10:751-2. 2012....
Molecular dissection of mesenchymal-epithelial interactions in the hair follicleMichael Rendl
Howard Hughes Medical Institute, The Rockefeller University, New York, New York, United States of America
PLoS Biol 3:e331. 2005..Overall, our strategy illustrates how knowledge of the genes uniquely expressed by each cell type residing in a complex niche can reveal important new insights into the biology of the tissue and its associated disease states...- Specific microRNAs are preferentially expressed by skin stem cells to balance self-renewal and early lineage commitmentLiang Zhang
Howard Hughes Medical Institute and Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
Cell Stem Cell 8:294-308. 2011..We verify some of these miR-125b targets, and show that Blimp1 and VDR in particular can account for many tissue imbalances we see when miR-125b is deregulated... - The tortoise and the hair: slow-cycling cells in the stem cell raceElaine Fuchs
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
Cell 137:811-9. 2009..This Review explores the challenges that mammalian stem cells face in balancing the competing demands of proliferation and differentiation in tissues... - Socializing with the neighbors: stem cells and their nicheElaine Fuchs
Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
Cell 116:769-78. 2004..In this review, we examine adult stem cell niches and their impact on stem cell biology... - More than one way to skin . . Elaine Fuchs
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10065, USA
Genes Dev 22:976-85. 2008..Understanding how these stem cells maintain normal homeostasis and wound repair in the skin is particularly important, as these mechanisms, when defective, lead to skin tissue diseases including cancers... - Ferreting out stem cells from their nichesElaine Fuchs
Howard Hughes Medical Institute, Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10065, USA
Nat Cell Biol 13:513-8. 2011.... - Scratching the surface of skin developmentElaine Fuchs
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, 1230 York Avenue, Box 300, New York, New York 10021, USA
Nature 445:834-42. 2007..Exciting recent developments have focused on how adult skin epithelia maintain populations of stem cells for use in the natural cycles of hair follicle regeneration and for re-epithelialization in response to wounding... - Skin stem cells: rising to the surfaceElaine Fuchs
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
J Cell Biol 180:273-84. 2008..In this paper, I outline the basic lineages of the skin epithelia and review some of the major findings about mammalian skin epithelial stem cells that have emerged in the past five years... - AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermisXuan Wang
The Howard Hughes Medical Institute and Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
J Cell Biol 183:37-48. 2008.... - Lhx2 maintains stem cell character in hair folliclesHorace Rhee
Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, New York, NY 10021
Science 312:1946-9. 2006..Using gain- and loss-of-function studies, we uncovered a role for Lhx2 in maintaining the growth and undifferentiated properties of hair follicle progenitors... - Canonical notch signaling functions as a commitment switch in the epidermal lineageCedric Blanpain
Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
Genes Dev 20:3022-35. 2006.... - Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IAKrzysztof Kobielak
Howard Hughes Medical Institute and Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021 6399, USA
J Cell Biol 163:609-23. 2003.... - Blimp1 defines a progenitor population that governs cellular input to the sebaceous glandValerie Horsley
Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
Cell 126:597-609. 2006.... - Tcf3 and Tcf4 are essential for long-term homeostasis of skin epitheliaHoang Nguyen
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York, USA
Nat Genet 41:1068-75. 2009..We established roles for Tcf3 and Tcf4 in long-term maintenance and wound repair of both epidermis and hair follicles, suggesting that Tcf proteins have both Wnt-dependent and Wnt-independent roles in lineage determination... - A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesisColin Jamora
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York, USA
PLoS Biol 3:e11. 2005..This novel signaling pathway further weaves together the web of different morphogens and downstream transcriptional events that guide hair bud formation within the developing skin... - Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cellsElena Ezhkova
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
Cell 136:1122-35. 2009..They maintain their proliferative potential and globally repressing undesirable differentiation programs while selectively establishing a specific terminal differentiation program in a stepwise fashion... - Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epitheliaGeraldine Guasch
Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
Cancer Cell 12:313-27. 2007..Together, these mechanisms provide a molecular framework to account for many of the characteristics of TbetaRII-deficient invasive SQCCs... - Defining the epithelial stem cell niche in skinTudorita Tumbar
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, Rockefeller University, New York, NY 10021, USA
Science 303:359-63. 2004..Many of the >100 messenger RNAs preferentially expressed in the niche encode surface receptors and secreted proteins, enabling LRCs to signal and respond to their environment... - Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair folliclesDanelle Devenport
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
Nat Cell Biol 10:1257-68. 2008..Finally, we provide in vitro evidence that homotypic intracellular interactions of Celsr1 are required to recruit Vangl2 and Fzd6 to sites of cell-cell contact... - Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skinHaiying Zhang
Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA
Proc Natl Acad Sci U S A 108:2270-5. 2011..Finally, we identify Cyr61 as a target of YAP in MKs and demonstrate a requirement for TEA domain (TEAD) transcriptional factors to comediate YAP functions in MKs... - Governing epidermal homeostasis by coupling cell-cell adhesion to integrin and growth factor signaling, proliferation, and apoptosisGeulah Livshits
Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA
Proc Natl Acad Sci U S A 109:4886-91. 2012..The increased dependency of cells upon matrix interactions for their survival when cell-cell adhesions are destabilized has important implications for cancer progression and metastasis... - A role for the primary cilium in Notch signaling and epidermal differentiation during skin developmentEllen J Ezratty
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
Cell 145:1129-41. 2011..These findings unveil temporally and spatially distinct functions for primary cilia at the nexus of signaling, proliferation, and differentiation... - Links between signal transduction, transcription and adhesion in epithelial bud developmentColin Jamora
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10021, USA
Nature 422:317-22. 2003.... - AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermisXuan Wang
The Howard Hughes Medical Institute, Rockefeller University, New York, NY 10021, USA
J Cell Biol 172:409-21. 2006..These results provide insights into why elevated AP-2alpha levels are often associated with terminal differentiation and why tumor cells often display reduced AP-2alpha and elevated EGFR proteins... - Desmoplakin: an unexpected regulator of microtubule organization in the epidermisTerry Lechler
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA
J Cell Biol 176:147-54. 2007..Loss of DP prevents accumulation of cortical microtubules in vivo and in vitro. Our work uncovers a differentiation-specific rearrangement of the microtubule cytoskeleton in epidermis, and defines an essential role for DP in the process... - A skin microRNA promotes differentiation by repressing 'stemness'Rui Yi
Howard Hughes Medical Institute, The Rockefeller University, New York City, New York 10065, USA
Nature 452:225-9. 2008..Our findings suggest that miR-203 defines a molecular boundary between proliferative basal progenitors and terminally differentiating suprabasal cells, ensuring proper identity of neighbouring layers... - EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repairElena Ezhkova
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10065, USA
Genes Dev 25:485-98. 2011..Our findings reveal new insights into Polycomb-dependent tissue control, and provide a new twist to how different progenitors within one tissue respond to loss of H3K27me3... - Tcf3: a transcriptional regulator of axis induction in the early embryoBradley J Merrill
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA
Development 131:263-74. 2004..Taken together, these data reveal a unique requirement for Tcf3 repressor function in restricting induction of the anterior-posterior axis... - BMP signaling in dermal papilla cells is required for their hair follicle-inductive propertiesMichael Rendl
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10021, USA
Genes Dev 22:543-57. 2008.... - A two-step mechanism for stem cell activation during hair regenerationValentina Greco
Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA
Cell Stem Cell 4:155-69. 2009..Our findings suggest a model where HG cells fuel initial steps in hair regeneration, while the bulge is the engine maintaining the process... - Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAsRui Yi
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10021, USA
Nat Genet 38:356-62. 2006..Here we characterize miRNAs in skin, the existence of which was hitherto unappreciated, and demonstrate their differential expression and importance in the morphogenesis of epithelial tissues within this vital organ... - An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regenerationTing Chen
Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10065, USA
Nature 485:104-8. 2012..Our results validate the RNA interference screen and underscore its power in unearthing new molecules that govern stem cell self-renewal and tissue-regenerative potential... - Hair follicle stem cells are specified and function in early skin morphogenesisJonathan A Nowak
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
Cell Stem Cell 3:33-43. 2008..These findings establish the existence of early hair follicle SCs and reveal their physiological importance in tissue morphogenesis... - Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signalingKrzysztof Kobielak
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 104:10063-8. 2007..Conversely, sustained BMP signaling in the SC niche blocks activation and promotes premature hair follicle differentiation. Together, these studies reveal the importance of balancing BMP signaling in the SC niche... - Asymmetric cell divisions promote stratification and differentiation of mammalian skinTerry Lechler
Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
Nature 437:275-80. 2005..We further demonstrate that integrins and cadherins are essential for the apical localization of atypical protein kinase C, the Par3-LGN-Inscuteable complex and NuMA-dynactin to align the spindle... - Mammalian formin-1 participates in adherens junctions and polymerization of linear actin cablesAgnieszka Kobielak
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, 1230 York Avenue, Box 300, New York, NY 10021 6399, USA
Nat Cell Biol 6:21-30. 2004..These findings provide new insight into how alpha-catenin orchestrates actin dynamics during intercellular junction formation... - Loss of p120 catenin and links to mitotic alterations, inflammation, and skin cancerMirna Perez-Moreno
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
Proc Natl Acad Sci U S A 105:15399-404. 2008.... - Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell nicheCedric Blanpain
Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
Cell 118:635-48. 2004..These findings suggest that the niche microenvironment imposes intrinsic "stemness" features without restricting the establishment of epithelial polarity and changes in gene expression... - Identification of stem cell populations in sweat glands and ducts reveals roles in homeostasis and wound repairCatherine P Lu
Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
Cell 150:136-50. 2012..Our findings provide insight into glandular stem cells and a framework for the further study of sweat gland biology... - Mitotic internalization of planar cell polarity proteins preserves tissue polarityDanelle Devenport
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, 1230 York Avenue, Box 300, New York, New York 10065, USA
Nat Cell Biol 13:893-902. 2011..This underscores the physiological relevance and importance of this mechanism for regulating polarity during cell division... - p120-catenin mediates inflammatory responses in the skinMirna Perez-Moreno
Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
Cell 124:631-44. 2006..Although the underlying mechanism is likely complex, we show that p120 affects NFkB activation and immune homeostasis in part through regulation of Rho GTPases. These findings provide important new insights into p120 function... - Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamicsMarkus Schober
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA
J Cell Biol 176:667-80. 2007..We show that, together, these FAK-dependent activities are critical to control the turnover of focal adhesions, which is perturbed in the absence of FAK... - ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activityXiaoyang Wu
Howard Hughes Medical Institute and Laboratory of Mammalian Cell Biology and Development, Rockefeller University, New York, NY 10065, USA
Cell 135:137-48. 2008..Our findings provide insight into the functions of this important cytoskeletal crosslinking protein in regulating dynamic interactions between MTs and F-actin to sustain directional cell movement... - Actin cable dynamics and Rho/Rock orchestrate a polarized cytoskeletal architecture in the early steps of assembling a stratified epitheliumAlec Vaezi
Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
Dev Cell 3:367-81. 2002..This polarized cytoskeleton is dependent upon alpha-catenin, Rho, and Rock, and its regulation may be important for wound healing and/or stratification, where coordinated tissue movements are involved... - Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cellsWilliam E Lowry
Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
Genes Dev 19:1596-611. 2005..We also show that these changes precede subsequent Wnt signals that impact on the TA progeny to specify the differentiation lineages of the follicle... - Asymmetric cell divisions promote Notch-dependent epidermal differentiationScott E Williams
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10065, USA
Nature 470:353-8. 2011.... - DGCR8-dependent microRNA biogenesis is essential for skin developmentRui Yi
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, and Laboratory of RNA Molecular Biology, The Rockefeller University, New York, NY 10065, USA
Proc Natl Acad Sci U S A 106:498-502. 2009..Our results underscore a specific importance of microRNAs in controlling mammalian skin development... - Developmental roles for Srf, cortical cytoskeleton and cell shape in epidermal spindle orientationChen Luxenburg
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10065, USA
Nat Cell Biol 13:203-14. 2011..We provide a link between these features and Srf loss, and we show that the process is physiologically relevant in skin, as reflected by defects in spindle orientation, asymmetric cell divisions, stratification and differentiation... - GATA-3: an unexpected regulator of cell lineage determination in skinCharles K Kaufman
Howard Hughes Medical Institute and Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA
Genes Dev 17:2108-22. 2003..This newfound function for GATA-3 in skin development strengthens the parallels between the differentiation programs governing hair follicle and lymphocyte differentiation... - Stem cells in the skin: waste not, Wnt notLaura Alonso
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10021, USA
Genes Dev 17:1189-200. 2003 - Catenins: keeping cells from getting their signals crossedMirna Perez-Moreno
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10021, USA
Dev Cell 11:601-12. 2006..These findings reveal novel aspects of AJ function in normal tissues and offer insights into how changes in AJs and their associated proteins and cytoskeletal dynamics impact wound-repair and cancer... - Tcf3 governs stem cell features and represses cell fate determination in skinHoang Nguyen
Howard Hughes Medical Institute, Department of Mammalian Cell Biology and Development, The Rockefeller University, 1230 York Avenue, Box 300, New York, NY 10021, USA
Cell 127:171-83. 2006..These data suggest that in the absence of Wnt signals, Tcf3 may function in skin SCs to maintain an undifferentiated state and, through Wnt signaling, directs these cells along the hair lineage... - Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicleLaura Alonso
Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
J Cell Biol 170:559-70. 2005..Our results reveal a novel and important function for Sgk3 in controlling life and death in the hair follicle... - Mice cloned from skin cellsJinsong Li
Laboratory of Developmental Biology and Neurogenetics, The Rockefeller University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 104:2738-43. 2007..0% in females and 5.4% vs. 2.8% in males). Our findings reveal skin as a source of readily accessible stem cells, the nuclei of which can be reprogrammed to the pluripotent state by exposure to the cytoplasm of unfertilized oocytes... - Sticky business: orchestrating cellular signals at adherens junctionsMirna Perez-Moreno
Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
Cell 112:535-48. 2003..Deciphering the underlying mechanisms that govern these conserved cellular rearrangements is a prerequisite to understanding vertebrate morphogenesis... - Dissection of a complex enhancer element: maintenance of keratinocyte specificity but loss of differentiation specificityCharles K Kaufman
Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois 60637, USA
Mol Cell Biol 22:4293-308. 2002..Through mixing and matching of these modules, additional levels of specificity are obtained, indicating that both transcriptional repressors and activators govern the specificity... - Skin stem cells orchestrate directional migration by regulating microtubule-ACF7 connections through GSK3βXiaoyang Wu
The Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, Rockefeller University, New York, NY 10065, USA
Cell 144:341-52. 2011..Our findings provide insights into how this conserved spectraplakin integrates signaling, cytoskeletal dynamics, and polarized locomotion of somatic SCs... - Isolation and culture of epithelial stem cellsJonathan A Nowak
Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA
Methods Mol Biol 482:215-32. 2009..These techniques should be useful for directly evaluating stem cell function in normal mice and in mice with skin defects... - New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrityChristopher L Tinkle
Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA
Proc Natl Acad Sci U S A 105:15405-10. 2008..Finally, by comparing conditional loss-of-function studies of epidermal catenins and cadherins, we dissect cadherin-dependent and independent roles of adherens junction components in tissue physiology... - Genome-wide maps of histone modifications unwind in vivo chromatin states of the hair follicle lineageWen Hui Lien
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
Cell Stem Cell 9:219-32. 2011..Our findings explain how HF-SCs cycle through quiescent and activated states without losing stemness and define roles for PcG-mediated repression in governing a fate switch irreversibly... - Epithelial stem cells: turning over new leavesCedric Blanpain
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA
Cell 128:445-58. 2007..Understanding epithelial stem cell biology has major clinical implications for the diagnosis, prevention, and treatment of human diseases, as well as for regenerative medicine... - Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-β and integrin/focal adhesion kinase (FAK) signalingMarkus Schober
Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
Proc Natl Acad Sci U S A 108:10544-9. 2011..Overall, the coexistence and interconvertibility of CSCs with differing sensitivities to their microenvironment pose challenges and opportunities for SCC cancer therapies... - Coordinating cytoskeletal tracks to polarize cellular movementsAtsuko Kodama
Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
J Cell Biol 167:203-7. 2004..In the past few years, significant strides have been made in unraveling the intricacies that govern these intertwined cytoskeletal rearrangements... - Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryosSlobodan Beronja
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York, USA
Nat Med 16:821-7. 2010..Our study illustrates the strategy and its broad applicability for investigations of tissue morphogenesis, lineage specification and cancers... - Stem cells of the skin epitheliumLaura Alonso
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 100:11830-5. 2003..Skin epithelial stem cells represent a ripe target for research into the fundamental mechanisms underlying these important processes... - Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skinAgnieszka Kobielak
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 103:2322-7. 2006..We show that reductions in alpha-catenin, activation of NF-kappaB, and inflammation are common features of human squamous cell carcinomas of the skin... - Epidermal stem cells of the skinCedric Blanpain
Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
Annu Rev Cell Dev Biol 22:339-73. 2006..Finally, we speculate on how the deregulation of these pathways may lead to cancer formation... - Conditional targeting of E-cadherin in skin: insights into hyperproliferative and degenerative responsesChristopher L Tinkle
Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 101:552-7. 2004..These findings suggest that, if no compensatory mechanisms exist, E-cadherin loss may be incompatible with epithelial tissue survival, whereas partial compensation can result in alterations in differentiation and proliferation... - Cyfip1 is a putative invasion suppressor in epithelial cancersJose M Silva
Watson School Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
Cell 137:1047-61. 2009..Mechanistically, we have linked alterations in WAVE-regulated actin dynamics with impaired cell-cell adhesion and cell-ECM interactions. Thus, we propose Cyfip1 as an invasion suppressor gene... - A developmental conundrum: a stabilized form of beta-catenin lacking the transcriptional activation domain triggers features of hair cell fate in epidermal cells and epidermal cell fate in hair follicle cellsRamanuj DasGupta
Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
J Cell Biol 158:331-44. 2002..Finally, by varying the level of beta-catenin signaling during a cell fate program, the skin cell appears to be pliable, switching fates multiple times... - Finding one's niche in the skinElaine Fuchs
Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA
Cell Stem Cell 4:499-502. 2009..This review focuses on the elusive stem cell niche of the epidermis, long thought to reside within the basal layer that is sandwiched between the basement membrane and the suprabasal interface... - Mice in the world of stem cell biologyGeraldine Guasch
Howard Hughes Medical Institute, The Rockefeller University, Laboratory of Mammalian Cell Biology and Development, 1230 York Avenue Box 300, New York, New York 10021, USA
Nat Genet 37:1201-6. 2005..Here we highlight the importance of mice in stem cell biology and in bringing the world one step closer to seeing these cells brought to fruition in modern medicine... - Getting under the skin of epidermal morphogenesisElaine Fuchs
Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois 60637, USA
Nat Rev Genet 3:199-209. 2002..This explosion of knowledge paves the way for new discoveries into the genetic bases of human skin disorders and for developing new therapeutics... - ACF7: an essential integrator of microtubule dynamicsAtsuko Kodama
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA
Cell 115:343-54. 2003..Thus, spectraplakins are important for controlling microtubule dynamics and reinforcing links between microtubules and polarized F-actin, so that cellular polarization and coordinated cell movements can be sustained... - Basal cells are a multipotent progenitor capable of renewing the bronchial epitheliumKyung U Hong
Department of Environmental Medicine, University of Rochester, Rochester, New York, USA
Am J Pathol 164:577-88. 2004..We conclude that basal cells represent an alternative multipotent progenitor cell population of bronchial airways and that progenitor cell selection is dictated by the type of airway injury... - Intercellular adhesion, signalling and the cytoskeletonColin Jamora
Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA
Nat Cell Biol 4:E101-8. 2002..Recent studies suggest that their dual function may provide the means to integrate changes in morphology and gene expression during tissue and organ development... - Alpha-catenin: at the junction of intercellular adhesion and actin dynamicsAgnieszka Kobielak
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, Rockefeller University, 1230 York Avenue, Box 300, New York, New York 10021, USA
Nat Rev Mol Cell Biol 5:614-25. 2004..As the number of alpha-catenin-interacting partners increases, intriguing new connections imply even more complex regulatory functions for this protein... - A role for skin gammadelta T cells in wound repairJulie Jameson
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
Science 296:747-9. 2002..We propose that DETCs recognize antigen expressed by injured keratinocytes and produce factors that directly affect wound repair... - The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiationBaoan Li
Department of Biological Chemistry, University of California, Irvine, CA 92697, USA
Proc Natl Acad Sci U S A 99:6064-9. 2002.... - p63: revving up epithelial stem-cell potentialCedric Blanpain
Nat Cell Biol 9:731-3. 2007 - Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestineAndrea Haegebarth
University of Illinois College of Medicine, Department of Biochemistry and Molecular Genetics, M C 669, 900 S Ashland Ave, Chicago, IL 60607, USA
Mol Cell Biol 26:4949-57. 2006..PTK6 contributes to maintenance of tissue homeostasis through negative regulation of Akt in the small intestine and is associated with cell cycle exit and differentiation in normal intestinal epithelial cells... - Targeted disruption of the murine zyxin geneLaura M Hoffman
Huntsman Cancer Institute and Department of Biology, University of Utah, Salt Lake City 84112, USA
Mol Cell Biol 23:70-9. 2003.... - Cancer: More than skin deepDiana Bolotin
Nature 421:594-5. 2003 - The hair cycleLaura Alonso
Department of Medicine, Division of Endocrinology, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15261, USA
J Cell Sci 119:391-3. 2006 - In vivo differentiation potential of tracheal basal cells: evidence for multipotent and unipotent subpopulationsKyung U Hong
Dept. of Environmental and Occupational Health, Univ. of Pittsburgh, FORBL Rm. 314, 3343 Forbes Ave, Pittsburgh, PA 15260, USA
Am J Physiol Lung Cell Mol Physiol 286:L643-9. 2004..We conclude that basal cells have the capacity for restoration of a fully differentiated epithelium... - Molecular cloning and characterization of AP-2 epsilon, a fifth member of the AP-2 familyRamakumar Tummala
Department of Biochemistry, State University of New York at Buffalo, 3435 Main Street, 121 Farber Hall, Buffalo, NY 14214, USA
Gene 321:93-102. 2003..Our study establishes AP-2 epsilon as a novel member of the AP-2 family, and suggests that it may play an important role in skin biology... - Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5aGoncalo Castelo-Branco
Laboratory of Molecular Neurobiology, Medical Biochemistry, and Biophysics, Karolinska Institute, 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 100:12747-52. 2003..These findings indicate that Wnts are key regulators of proliferation and differentiation of DA precursors during VM neurogenesis and that different Wnts have specific and unique activity profiles... - BPAG1n4 is essential for retrograde axonal transport in sensory neuronsJia Jia Liu
Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305 5489, USA
J Cell Biol 163:223-9. 2003..We conclude that BPAG1n4 plays an essential role in retrograde axonal transport in sensory neurons. These findings might advance our understanding of pathogenesis of axonal degeneration and neuronal death... - Beta 1-integrins are required for hippocampal AMPA receptor-dependent synaptic transmission, synaptic plasticity, and working memoryChi Shing Chan
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 26:223-32. 2006..These observations suggest a new function of beta1-integrins as regulators of synaptic glutamate receptor function and working memory...