Elaine Fuchs

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi request reprint A role for alphabeta1 integrins in focal adhesion function and polarized cytoskeletal dynamics
    Srikala Raghavan
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA
    Dev Cell 5:415-27. 2003
  2. pmc NFATc1 balances quiescence and proliferation of skin stem cells
    Valerie Horsley
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Cell 132:299-310. 2008
  3. pmc Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle
    Laura Alonso
    Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    J Cell Biol 170:559-70. 2005
  4. pmc Mitotic internalization of planar cell polarity proteins preserves tissue polarity
    Danelle Devenport
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, 1230 York Avenue, Box 300, New York, New York 10065, USA
    Nat Cell Biol 13:893-902. 2011
  5. pmc Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles
    Danelle Devenport
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Nat Cell Biol 10:1257-68. 2008
  6. pmc Coordinating cytoskeletal tracks to polarize cellular movements
    Atsuko Kodama
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    J Cell Biol 167:203-7. 2004
  7. pmc Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA
    Krzysztof Kobielak
    Howard Hughes Medical Institute and Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021 6399, USA
    J Cell Biol 163:609-23. 2003
  8. ncbi request reprint Stem cell plasticity. Plasticity of epithelial stem cells in tissue regeneration
    Cedric Blanpain
    Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire IRIBHM, Universite Libre de Bruxelles, Brussels B 1070, Belgium Walloon Excellence in Life Sciences and Biotechnology WELBIO, Universite Libre de Bruxelles ULB, Brussels B 1070, Belgium
    Science 344:1242281. 2014
  9. pmc AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis
    Xuan Wang
    The Howard Hughes Medical Institute and Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    J Cell Biol 183:37-48. 2008
  10. pmc Asymmetric cell divisions promote Notch-dependent epidermal differentiation
    Scott E Williams
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10065, USA
    Nature 470:353-8. 2011

Collaborators

Detail Information

Publications101 found, 100 shown here

  1. ncbi request reprint A role for alphabeta1 integrins in focal adhesion function and polarized cytoskeletal dynamics
    Srikala Raghavan
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA
    Dev Cell 5:415-27. 2003
    ..Without the ability to remodel their integrin-actin network efficiently, alphabeta1-deficient keratinocytes cannot respond dynamically to their environment and polarize movements...
  2. pmc NFATc1 balances quiescence and proliferation of skin stem cells
    Valerie Horsley
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Cell 132:299-310. 2008
    ..Our findings may explain why patients receiving cyclosporine A for immunosuppressive therapy display excessive hair growth, and unveil a functional role for calcium-NFATc1-CDK4 circuitry in governing stem cell quiescence...
  3. pmc Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle
    Laura Alonso
    Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    J Cell Biol 170:559-70. 2005
    ..Our results reveal a novel and important function for Sgk3 in controlling life and death in the hair follicle...
  4. pmc Mitotic internalization of planar cell polarity proteins preserves tissue polarity
    Danelle Devenport
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, 1230 York Avenue, Box 300, New York, New York 10065, USA
    Nat Cell Biol 13:893-902. 2011
    ..This underscores the physiological relevance and importance of this mechanism for regulating polarity during cell division...
  5. pmc Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles
    Danelle Devenport
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Nat Cell Biol 10:1257-68. 2008
    ..Finally, we provide in vitro evidence that homotypic intracellular interactions of Celsr1 are required to recruit Vangl2 and Fzd6 to sites of cell-cell contact...
  6. pmc Coordinating cytoskeletal tracks to polarize cellular movements
    Atsuko Kodama
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    J Cell Biol 167:203-7. 2004
    ..In the past few years, significant strides have been made in unraveling the intricacies that govern these intertwined cytoskeletal rearrangements...
  7. pmc Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA
    Krzysztof Kobielak
    Howard Hughes Medical Institute and Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021 6399, USA
    J Cell Biol 163:609-23. 2003
    ....
  8. ncbi request reprint Stem cell plasticity. Plasticity of epithelial stem cells in tissue regeneration
    Cedric Blanpain
    Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire IRIBHM, Universite Libre de Bruxelles, Brussels B 1070, Belgium Walloon Excellence in Life Sciences and Biotechnology WELBIO, Universite Libre de Bruxelles ULB, Brussels B 1070, Belgium
    Science 344:1242281. 2014
    ..We also discuss the implications of cellular plasticity for regenerative medicine and for cancer. ..
  9. pmc AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis
    Xuan Wang
    The Howard Hughes Medical Institute and Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    J Cell Biol 183:37-48. 2008
    ....
  10. pmc Asymmetric cell divisions promote Notch-dependent epidermal differentiation
    Scott E Williams
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10065, USA
    Nature 470:353-8. 2011
    ....
  11. pmc Spindle orientation and epidermal morphogenesis
    Anita Kulukian
    Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA
    Philos Trans R Soc Lond B Biol Sci 368:20130016. 2013
    ..Here, we review how oriented divisions of progenitors contribute to the development and stratification of the epidermis. ..
  12. pmc A matter of life and death: self-renewal in stem cells
    Elaine Fuchs
    Howard Hughes Medical Institute, Rockefeller University, Laboratory of Mammalian Cell Biology and Development, New York, New York 10065, USA
    EMBO Rep 14:39-48. 2013
    ..By doing so, we pinpoint important questions that still await answers...
  13. doi request reprint Cédric Blanpain: ISSCR's outstanding young investigator for 2012
    Elaine Fuchs
    Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA
    Cell Stem Cell 10:751-2. 2012
    ....
  14. pmc Specific microRNAs are preferentially expressed by skin stem cells to balance self-renewal and early lineage commitment
    Liang Zhang
    Howard Hughes Medical Institute and Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Cell Stem Cell 8:294-308. 2011
    ..We verify some of these miR-125b targets, and show that Blimp1 and VDR in particular can account for many tissue imbalances we see when miR-125b is deregulated...
  15. pmc The tortoise and the hair: slow-cycling cells in the stem cell race
    Elaine Fuchs
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Cell 137:811-9. 2009
    ..This Review explores the challenges that mammalian stem cells face in balancing the competing demands of proliferation and differentiation in tissues...
  16. pmc Skin stem cells: rising to the surface
    Elaine Fuchs
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    J Cell Biol 180:273-84. 2008
    ..In this paper, I outline the basic lineages of the skin epithelia and review some of the major findings about mammalian skin epithelial stem cells that have emerged in the past five years...
  17. ncbi request reprint Socializing with the neighbors: stem cells and their niche
    Elaine Fuchs
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Cell 116:769-78. 2004
    ..In this review, we examine adult stem cell niches and their impact on stem cell biology...
  18. pmc More than one way to skin . .
    Elaine Fuchs
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10065, USA
    Genes Dev 22:976-85. 2008
    ..Understanding how these stem cells maintain normal homeostasis and wound repair in the skin is particularly important, as these mechanisms, when defective, lead to skin tissue diseases including cancers...
  19. pmc Scratching the surface of skin development
    Elaine Fuchs
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, 1230 York Avenue, Box 300, New York, New York 10021, USA
    Nature 445:834-42. 2007
    ..Exciting recent developments have focused on how adult skin epithelia maintain populations of stem cells for use in the natural cycles of hair follicle regeneration and for re-epithelialization in response to wounding...
  20. pmc Ferreting out stem cells from their niches
    Elaine Fuchs
    Howard Hughes Medical Institute, Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10065, USA
    Nat Cell Biol 13:513-8. 2011
    ....
  21. pmc Lhx2 maintains stem cell character in hair follicles
    Horace Rhee
    Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, New York, NY 10021
    Science 312:1946-9. 2006
    ..Using gain- and loss-of-function studies, we uncovered a role for Lhx2 in maintaining the growth and undifferentiated properties of hair follicle progenitors...
  22. pmc Canonical notch signaling functions as a commitment switch in the epidermal lineage
    Cedric Blanpain
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Genes Dev 20:3022-35. 2006
    ....
  23. pmc Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland
    Valerie Horsley
    Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Cell 126:597-609. 2006
    ....
  24. pmc Links between signal transduction, transcription and adhesion in epithelial bud development
    Colin Jamora
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10021, USA
    Nature 422:317-22. 2003
    ....
  25. pmc Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia
    Hoang Nguyen
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York, USA
    Nat Genet 41:1068-75. 2009
    ..We established roles for Tcf3 and Tcf4 in long-term maintenance and wound repair of both epidermis and hair follicles, suggesting that Tcf proteins have both Wnt-dependent and Wnt-independent roles in lineage determination...
  26. pmc A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesis
    Colin Jamora
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York, USA
    PLoS Biol 3:e11. 2005
    ..This novel signaling pathway further weaves together the web of different morphogens and downstream transcriptional events that guide hair bud formation within the developing skin...
  27. pmc AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis
    Xuan Wang
    The Howard Hughes Medical Institute, Rockefeller University, New York, NY 10021, USA
    J Cell Biol 172:409-21. 2006
    ..These results provide insights into why elevated AP-2alpha levels are often associated with terminal differentiation and why tumor cells often display reduced AP-2alpha and elevated EGFR proteins...
  28. pmc Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia
    Geraldine Guasch
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Cancer Cell 12:313-27. 2007
    ..Together, these mechanisms provide a molecular framework to account for many of the characteristics of TbetaRII-deficient invasive SQCCs...
  29. pmc Desmoplakin: an unexpected regulator of microtubule organization in the epidermis
    Terry Lechler
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA
    J Cell Biol 176:147-54. 2007
    ..Loss of DP prevents accumulation of cortical microtubules in vivo and in vitro. Our work uncovers a differentiation-specific rearrangement of the microtubule cytoskeleton in epidermis, and defines an essential role for DP in the process...
  30. pmc Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells
    Elena Ezhkova
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Cell 136:1122-35. 2009
    ..They maintain their proliferative potential and globally repressing undesirable differentiation programs while selectively establishing a specific terminal differentiation program in a stepwise fashion...
  31. pmc Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin
    Haiying Zhang
    Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 108:2270-5. 2011
    ..Finally, we identify Cyr61 as a target of YAP in MKs and demonstrate a requirement for TEA domain (TEAD) transcriptional factors to comediate YAP functions in MKs...
  32. pmc Defining the epithelial stem cell niche in skin
    Tudorita Tumbar
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, Rockefeller University, New York, NY 10021, USA
    Science 303:359-63. 2004
    ..Many of the >100 messenger RNAs preferentially expressed in the niche encode surface receptors and secreted proteins, enabling LRCs to signal and respond to their environment...
  33. ncbi request reprint Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs
    Rui Yi
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10021, USA
    Nat Genet 38:356-62. 2006
    ..Here we characterize miRNAs in skin, the existence of which was hitherto unappreciated, and demonstrate their differential expression and importance in the morphogenesis of epithelial tissues within this vital organ...
  34. doi request reprint A skin microRNA promotes differentiation by repressing 'stemness'
    Rui Yi
    Howard Hughes Medical Institute, The Rockefeller University, New York City, New York 10065, USA
    Nature 452:225-9. 2008
    ..Our findings suggest that miR-203 defines a molecular boundary between proliferative basal progenitors and terminally differentiating suprabasal cells, ensuring proper identity of neighbouring layers...
  35. pmc Molecular dissection of mesenchymal-epithelial interactions in the hair follicle
    Michael Rendl
    Howard Hughes Medical Institute, The Rockefeller University, New York, New York, United States of America
    PLoS Biol 3:e331. 2005
    ..Overall, our strategy illustrates how knowledge of the genes uniquely expressed by each cell type residing in a complex niche can reveal important new insights into the biology of the tissue and its associated disease states...
  36. pmc A role for the primary cilium in Notch signaling and epidermal differentiation during skin development
    Ellen J Ezratty
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Cell 145:1129-41. 2011
    ..These findings unveil temporally and spatially distinct functions for primary cilia at the nexus of signaling, proliferation, and differentiation...
  37. pmc Governing epidermal homeostasis by coupling cell-cell adhesion to integrin and growth factor signaling, proliferation, and apoptosis
    Geulah Livshits
    Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 109:4886-91. 2012
    ..The increased dependency of cells upon matrix interactions for their survival when cell-cell adhesions are destabilized has important implications for cancer progression and metastasis...
  38. ncbi request reprint Tcf3: a transcriptional regulator of axis induction in the early embryo
    Bradley J Merrill
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA
    Development 131:263-74. 2004
    ..Taken together, these data reveal a unique requirement for Tcf3 repressor function in restricting induction of the anterior-posterior axis...
  39. pmc Architectural niche organization by LHX2 is linked to hair follicle stem cell function
    Alicia R Folgueras
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Cell Stem Cell 13:314-27. 2013
    ..These findings suggest that niche organization underlies the requirement for LHX2 in hair follicle structure and function. ..
  40. pmc NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche
    Chiung Ying Chang
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10065, USA
    Nature 495:98-102. 2013
    ..Our findings reveal how melanocyte and hair follicle stem cell behaviours maintain reliance upon cooperative factors within the niche, and how this can be uncoupled in injury, stress and disease states...
  41. pmc EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair
    Elena Ezhkova
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10065, USA
    Genes Dev 25:485-98. 2011
    ..Our findings reveal new insights into Polycomb-dependent tissue control, and provide a new twist to how different progenitors within one tissue respond to loss of H3K27me3...
  42. pmc BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties
    Michael Rendl
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10021, USA
    Genes Dev 22:543-57. 2008
    ....
  43. pmc Mammalian formin-1 participates in adherens junctions and polymerization of linear actin cables
    Agnieszka Kobielak
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, 1230 York Avenue, Box 300, New York, NY 10021 6399, USA
    Nat Cell Biol 6:21-30. 2004
    ..These findings provide new insight into how alpha-catenin orchestrates actin dynamics during intercellular junction formation...
  44. pmc Asymmetric cell divisions promote stratification and differentiation of mammalian skin
    Terry Lechler
    Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
    Nature 437:275-80. 2005
    ..We further demonstrate that integrins and cadherins are essential for the apical localization of atypical protein kinase C, the Par3-LGN-Inscuteable complex and NuMA-dynactin to align the spindle...
  45. pmc A two-step mechanism for stem cell activation during hair regeneration
    Valentina Greco
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA
    Cell Stem Cell 4:155-69. 2009
    ..Our findings suggest a model where HG cells fuel initial steps in hair regeneration, while the bulge is the engine maintaining the process...
  46. pmc An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration
    Ting Chen
    Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10065, USA
    Nature 485:104-8. 2012
    ..Our results validate the RNA interference screen and underscore its power in unearthing new molecules that govern stem cell self-renewal and tissue-regenerative potential...
  47. pmc Hair follicle stem cells are specified and function in early skin morphogenesis
    Jonathan A Nowak
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Cell Stem Cell 3:33-43. 2008
    ..These findings establish the existence of early hair follicle SCs and reveal their physiological importance in tissue morphogenesis...
  48. ncbi request reprint Actin cable dynamics and Rho/Rock orchestrate a polarized cytoskeletal architecture in the early steps of assembling a stratified epithelium
    Alec Vaezi
    Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Dev Cell 3:367-81. 2002
    ..This polarized cytoskeleton is dependent upon alpha-catenin, Rho, and Rock, and its regulation may be important for wound healing and/or stratification, where coordinated tissue movements are involved...
  49. pmc Loss of p120 catenin and links to mitotic alterations, inflammation, and skin cancer
    Mirna Perez-Moreno
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 105:15399-404. 2008
    ....
  50. pmc Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling
    Krzysztof Kobielak
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:10063-8. 2007
    ..Conversely, sustained BMP signaling in the SC niche blocks activation and promotes premature hair follicle differentiation. Together, these studies reveal the importance of balancing BMP signaling in the SC niche...
  51. pmc GATA-3: an unexpected regulator of cell lineage determination in skin
    Charles K Kaufman
    Howard Hughes Medical Institute and Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA
    Genes Dev 17:2108-22. 2003
    ..This newfound function for GATA-3 in skin development strengthens the parallels between the differentiation programs governing hair follicle and lymphocyte differentiation...
  52. pmc RNAi screens in mice identify physiological regulators of oncogenic growth
    Slobodan Beronja
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10065, USA
    Nature 501:185-90. 2013
    ..By documenting some oncogenic growth regulators, we pave the way for future investigations of other hits and raise promise for unearthing new targets for cancer therapies. ..
  53. ncbi request reprint Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche
    Cedric Blanpain
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Cell 118:635-48. 2004
    ..These findings suggest that the niche microenvironment imposes intrinsic "stemness" features without restricting the establishment of epithelial polarity and changes in gene expression...
  54. ncbi request reprint SOX9: a stem cell transcriptional regulator of secreted niche signaling factors
    Meelis Kadaja
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10065, USA
    Genes Dev 28:328-41. 2014
    ..In addition, our studies expose a role for SCs in coordinating their own behavior in part through non-cell-autonomous signaling within the niche. ..
  55. pmc Nfatc1 orchestrates aging in hair follicle stem cells
    Brice E Keyes
    Laboratory of Mammalian Cell Biology and Development and Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065
    Proc Natl Acad Sci U S A 110:E4950-9. 2013
    ..Moreover, aged HFSCs display more youthful levels of hair regeneration when BMP and/or NFATc1 are inhibited. These results provide unique insights into how skin SCs age. ..
  56. pmc Identification of stem cell populations in sweat glands and ducts reveals roles in homeostasis and wound repair
    Catherine P Lu
    Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Cell 150:136-50. 2012
    ..Our findings provide insight into glandular stem cells and a framework for the further study of sweat gland biology...
  57. pmc ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity
    Xiaoyang Wu
    Howard Hughes Medical Institute and Laboratory of Mammalian Cell Biology and Development, Rockefeller University, New York, NY 10065, USA
    Cell 135:137-48. 2008
    ..Our findings provide insight into the functions of this important cytoskeletal crosslinking protein in regulating dynamic interactions between MTs and F-actin to sustain directional cell movement...
  58. pmc Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics
    Markus Schober
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA
    J Cell Biol 176:667-80. 2007
    ..We show that, together, these FAK-dependent activities are critical to control the turnover of focal adhesions, which is perturbed in the absence of FAK...
  59. pmc p120-catenin mediates inflammatory responses in the skin
    Mirna Perez-Moreno
    Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Cell 124:631-44. 2006
    ..Although the underlying mechanism is likely complex, we show that p120 affects NFkB activation and immune homeostasis in part through regulation of Rho GTPases. These findings provide important new insights into p120 function...
  60. ncbi request reprint Forces generated by cell intercalation tow epidermal sheets in Mammalian tissue morphogenesis
    Evan Heller
    Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA
    Dev Cell 28:617-32. 2014
    ..These studies uncover a mode of epithelial closure in which forces generated by cell intercalation are leveraged to tow the surrounding tissue. ..
  61. pmc DGCR8-dependent microRNA biogenesis is essential for skin development
    Rui Yi
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, and Laboratory of RNA Molecular Biology, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:498-502. 2009
    ..Our results underscore a specific importance of microRNAs in controlling mammalian skin development...
  62. pmc Developmental roles for Srf, cortical cytoskeleton and cell shape in epidermal spindle orientation
    Chen Luxenburg
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10065, USA
    Nat Cell Biol 13:203-14. 2011
    ..We provide a link between these features and Srf loss, and we show that the process is physiologically relevant in skin, as reflected by defects in spindle orientation, asymmetric cell divisions, stratification and differentiation...
  63. pmc Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells
    William E Lowry
    Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
    Genes Dev 19:1596-611. 2005
    ..We also show that these changes precede subsequent Wnt signals that impact on the TA progeny to specify the differentiation lineages of the follicle...
  64. pmc Skin stem cells orchestrate directional migration by regulating microtubule-ACF7 connections through GSK3β
    Xiaoyang Wu
    The Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, Rockefeller University, New York, NY 10065, USA
    Cell 144:341-52. 2011
    ..Our findings provide insights into how this conserved spectraplakin integrates signaling, cytoskeletal dynamics, and polarized locomotion of somatic SCs...
  65. ncbi request reprint Tcf3 governs stem cell features and represses cell fate determination in skin
    Hoang Nguyen
    Howard Hughes Medical Institute, Department of Mammalian Cell Biology and Development, The Rockefeller University, 1230 York Avenue, Box 300, New York, NY 10021, USA
    Cell 127:171-83. 2006
    ..These data suggest that in the absence of Wnt signals, Tcf3 may function in skin SCs to maintain an undifferentiated state and, through Wnt signaling, directs these cells along the hair lineage...
  66. pmc Catenins: keeping cells from getting their signals crossed
    Mirna Perez-Moreno
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10021, USA
    Dev Cell 11:601-12. 2006
    ..These findings reveal novel aspects of AJ function in normal tissues and offer insights into how changes in AJs and their associated proteins and cytoskeletal dynamics impact wound-repair and cancer...
  67. ncbi request reprint Stem cells in the skin: waste not, Wnt not
    Laura Alonso
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10021, USA
    Genes Dev 17:1189-200. 2003
  68. pmc Mice cloned from skin cells
    Jinsong Li
    Laboratory of Developmental Biology and Neurogenetics, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:2738-43. 2007
    ..0% in females and 5.4% vs. 2.8% in males). Our findings reveal skin as a source of readily accessible stem cells, the nuclei of which can be reprogrammed to the pluripotent state by exposure to the cytoplasm of unfertilized oocytes...
  69. ncbi request reprint Sticky business: orchestrating cellular signals at adherens junctions
    Mirna Perez-Moreno
    Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Cell 112:535-48. 2003
    ..Deciphering the underlying mechanisms that govern these conserved cellular rearrangements is a prerequisite to understanding vertebrate morphogenesis...
  70. pmc Dissection of a complex enhancer element: maintenance of keratinocyte specificity but loss of differentiation specificity
    Charles K Kaufman
    Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois 60637, USA
    Mol Cell Biol 22:4293-308. 2002
    ..Through mixing and matching of these modules, additional levels of specificity are obtained, indicating that both transcriptional repressors and activators govern the specificity...
  71. pmc Isolation and culture of epithelial stem cells
    Jonathan A Nowak
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA
    Methods Mol Biol 482:215-32. 2009
    ..These techniques should be useful for directly evaluating stem cell function in normal mice and in mice with skin defects...
  72. pmc New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity
    Christopher L Tinkle
    Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 105:15405-10. 2008
    ..Finally, by comparing conditional loss-of-function studies of epidermal catenins and cadherins, we dissect cadherin-dependent and independent roles of adherens junction components in tissue physiology...
  73. pmc Epithelial stem cells: turning over new leaves
    Cedric Blanpain
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA
    Cell 128:445-58. 2007
    ..Understanding epithelial stem cell biology has major clinical implications for the diagnosis, prevention, and treatment of human diseases, as well as for regenerative medicine...
  74. pmc Genome-wide maps of histone modifications unwind in vivo chromatin states of the hair follicle lineage
    Wen Hui Lien
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Cell Stem Cell 9:219-32. 2011
    ..Our findings explain how HF-SCs cycle through quiescent and activated states without losing stemness and define roles for PcG-mediated repression in governing a fate switch irreversibly...
  75. pmc Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-β and integrin/focal adhesion kinase (FAK) signaling
    Markus Schober
    Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 108:10544-9. 2011
    ..Overall, the coexistence and interconvertibility of CSCs with differing sensitivities to their microenvironment pose challenges and opportunities for SCC cancer therapies...
  76. pmc Stem cells of the skin epithelium
    Laura Alonso
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:11830-5. 2003
    ..Skin epithelial stem cells represent a ripe target for research into the fundamental mechanisms underlying these important processes...
  77. pmc Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos
    Slobodan Beronja
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York, USA
    Nat Med 16:821-7. 2010
    ..Our study illustrates the strategy and its broad applicability for investigations of tissue morphogenesis, lineage specification and cancers...
  78. pmc Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin
    Agnieszka Kobielak
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 103:2322-7. 2006
    ..We show that reductions in alpha-catenin, activation of NF-kappaB, and inflammation are common features of human squamous cell carcinomas of the skin...
  79. pmc Conditional targeting of E-cadherin in skin: insights into hyperproliferative and degenerative responses
    Christopher L Tinkle
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:552-7. 2004
    ..These findings suggest that, if no compensatory mechanisms exist, E-cadherin loss may be incompatible with epithelial tissue survival, whereas partial compensation can result in alterations in differentiation and proliferation...
  80. pmc Epidermal stem cells of the skin
    Cedric Blanpain
    Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
    Annu Rev Cell Dev Biol 22:339-73. 2006
    ..Finally, we speculate on how the deregulation of these pathways may lead to cancer formation...
  81. pmc Cyfip1 is a putative invasion suppressor in epithelial cancers
    Jose M Silva
    Watson School Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Cell 137:1047-61. 2009
    ..Mechanistically, we have linked alterations in WAVE-regulated actin dynamics with impaired cell-cell adhesion and cell-ECM interactions. Thus, we propose Cyfip1 as an invasion suppressor gene...
  82. pmc Finding one's niche in the skin
    Elaine Fuchs
    Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA
    Cell Stem Cell 4:499-502. 2009
    ..This review focuses on the elusive stem cell niche of the epidermis, long thought to reside within the basal layer that is sandwiched between the basement membrane and the suprabasal interface...
  83. pmc A developmental conundrum: a stabilized form of beta-catenin lacking the transcriptional activation domain triggers features of hair cell fate in epidermal cells and epidermal cell fate in hair follicle cells
    Ramanuj DasGupta
    Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    J Cell Biol 158:331-44. 2002
    ..Finally, by varying the level of beta-catenin signaling during a cell fate program, the skin cell appears to be pliable, switching fates multiple times...
  84. pmc Mice in the world of stem cell biology
    Geraldine Guasch
    Howard Hughes Medical Institute, The Rockefeller University, Laboratory of Mammalian Cell Biology and Development, 1230 York Avenue Box 300, New York, New York 10021, USA
    Nat Genet 37:1201-6. 2005
    ..Here we highlight the importance of mice in stem cell biology and in bringing the world one step closer to seeing these cells brought to fruition in modern medicine...
  85. ncbi request reprint Getting under the skin of epidermal morphogenesis
    Elaine Fuchs
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois 60637, USA
    Nat Rev Genet 3:199-209. 2002
    ..This explosion of knowledge paves the way for new discoveries into the genetic bases of human skin disorders and for developing new therapeutics...
  86. ncbi request reprint Intercellular adhesion, signalling and the cytoskeleton
    Colin Jamora
    Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA
    Nat Cell Biol 4:E101-8. 2002
    ..Recent studies suggest that their dual function may provide the means to integrate changes in morphology and gene expression during tissue and organ development...
  87. ncbi request reprint ACF7: an essential integrator of microtubule dynamics
    Atsuko Kodama
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA
    Cell 115:343-54. 2003
    ..Thus, spectraplakins are important for controlling microtubule dynamics and reinforcing links between microtubules and polarized F-actin, so that cellular polarization and coordinated cell movements can be sustained...
  88. pmc Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium
    Kyung U Hong
    Department of Environmental Medicine, University of Rochester, Rochester, New York, USA
    Am J Pathol 164:577-88. 2004
    ..We conclude that basal cells represent an alternative multipotent progenitor cell population of bronchial airways and that progenitor cell selection is dictated by the type of airway injury...
  89. pmc Alpha-catenin: at the junction of intercellular adhesion and actin dynamics
    Agnieszka Kobielak
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, Rockefeller University, 1230 York Avenue, Box 300, New York, New York 10021, USA
    Nat Rev Mol Cell Biol 5:614-25. 2004
    ..As the number of alpha-catenin-interacting partners increases, intriguing new connections imply even more complex regulatory functions for this protein...
  90. pmc Targeted disruption of the murine zyxin gene
    Laura M Hoffman
    Huntsman Cancer Institute and Department of Biology, University of Utah, Salt Lake City 84112, USA
    Mol Cell Biol 23:70-9. 2003
    ....
  91. pmc Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine
    Andrea Haegebarth
    University of Illinois College of Medicine, Department of Biochemistry and Molecular Genetics, M C 669, 900 S Ashland Ave, Chicago, IL 60607, USA
    Mol Cell Biol 26:4949-57. 2006
    ..PTK6 contributes to maintenance of tissue homeostasis through negative regulation of Akt in the small intestine and is associated with cell cycle exit and differentiation in normal intestinal epithelial cells...
  92. ncbi request reprint p63: revving up epithelial stem-cell potential
    Cedric Blanpain
    Nat Cell Biol 9:731-3. 2007
  93. ncbi request reprint In vivo differentiation potential of tracheal basal cells: evidence for multipotent and unipotent subpopulations
    Kyung U Hong
    Dept of Environmental and Occupational Health, Univ of Pittsburgh, FORBL Rm 314, 3343 Forbes Ave, Pittsburgh, PA 15260, USA
    Am J Physiol Lung Cell Mol Physiol 286:L643-9. 2004
    ..We conclude that basal cells have the capacity for restoration of a fully differentiated epithelium...
  94. ncbi request reprint A role for skin gammadelta T cells in wound repair
    Julie Jameson
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Science 296:747-9. 2002
    ..We propose that DETCs recognize antigen expressed by injured keratinocytes and produce factors that directly affect wound repair...
  95. pmc The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation
    Baoan Li
    Department of Biological Chemistry, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 99:6064-9. 2002
    ....
  96. ncbi request reprint The hair cycle
    Laura Alonso
    Department of Medicine, Division of Endocrinology, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    J Cell Sci 119:391-3. 2006
  97. ncbi request reprint Cancer: More than skin deep
    Diana Bolotin
    Nature 421:594-5. 2003
  98. pmc Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a
    Goncalo Castelo-Branco
    Laboratory of Molecular Neurobiology, Medical Biochemistry, and Biophysics, Karolinska Institute, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 100:12747-52. 2003
    ..These findings indicate that Wnts are key regulators of proliferation and differentiation of DA precursors during VM neurogenesis and that different Wnts have specific and unique activity profiles...
  99. pmc BPAG1n4 is essential for retrograde axonal transport in sensory neurons
    Jia Jia Liu
    Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305 5489, USA
    J Cell Biol 163:223-9. 2003
    ..We conclude that BPAG1n4 plays an essential role in retrograde axonal transport in sensory neurons. These findings might advance our understanding of pathogenesis of axonal degeneration and neuronal death...
  100. pmc Beta 1-integrins are required for hippocampal AMPA receptor-dependent synaptic transmission, synaptic plasticity, and working memory
    Chi Shing Chan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 26:223-32. 2006
    ..These observations suggest a new function of beta1-integrins as regulators of synaptic glutamate receptor function and working memory...
  101. ncbi request reprint Molecular cloning and characterization of AP-2 epsilon, a fifth member of the AP-2 family
    Ramakumar Tummala
    Department of Biochemistry, State University of New York at Buffalo, 3435 Main Street, 121 Farber Hall, Buffalo, NY 14214, USA
    Gene 321:93-102. 2003
    ..Our study establishes AP-2 epsilon as a novel member of the AP-2 family, and suggests that it may play an important role in skin biology...