Guo Fu

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc The role of protein kinase cη in T cell biology
    Guo Fu
    Department of Immunology and Microbial Science, The Scripps Research Institute La Jolla, CA, USA
    Front Immunol 3:177. 2012
  2. pmc Protein kinase C η is required for T cell activation and homeostatic proliferation
    Guo Fu
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Sci Signal 4:ra84. 2011
  3. pmc Multiplexed labeling of samples with cell tracking dyes facilitates rapid and accurate internally controlled calcium flux measurement by flow cytometry
    Guo Fu
    Department of Immunology and Microbial Science, IMM1, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Immunol Methods 350:194-9. 2009
  4. doi request reprint Themis sets the signal threshold for positive and negative selection in T-cell development
    Guo Fu
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 504:441-5. 2013
  5. pmc Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling
    Guo Fu
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA
    Nat Immunol 10:848-56. 2009
  6. pmc Divergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets
    Xiangli Li
    Department of Medicine, UCSD, La Jolla, California 92093 0663, USA
    J Clin Invest 122:963-73. 2012
  7. pmc Visualizing intermolecular interactions in T cells
    Nicholas R J Gascoigne
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Top Microbiol Immunol 334:31-46. 2009

Collaborators

Detail Information

Publications7

  1. pmc The role of protein kinase cη in T cell biology
    Guo Fu
    Department of Immunology and Microbial Science, The Scripps Research Institute La Jolla, CA, USA
    Front Immunol 3:177. 2012
    ..In this review, we will cover the topics mentioned above as well as provide some perspectives for further investigations regarding PKCη...
  2. pmc Protein kinase C η is required for T cell activation and homeostatic proliferation
    Guo Fu
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Sci Signal 4:ra84. 2011
    ..Together, these data suggest that PKCη shares some redundant roles with PKCθ in T cell biology and also performs nonredundant functions that are required for T cell homeostasis and activation...
  3. pmc Multiplexed labeling of samples with cell tracking dyes facilitates rapid and accurate internally controlled calcium flux measurement by flow cytometry
    Guo Fu
    Department of Immunology and Microbial Science, IMM1, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Immunol Methods 350:194-9. 2009
    ..This facilitates more rapid and accurate measurement of calcium flux and also dramatically reduces the cost and effort required for this type of assay...
  4. doi request reprint Themis sets the signal threshold for positive and negative selection in T-cell development
    Guo Fu
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 504:441-5. 2013
    ..By dampening mild TCR signals Themis increases the affinity threshold for activation, enabling positive selection of T cells with a naive phenotype in response to low-affinity self-antigens. ..
  5. pmc Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling
    Guo Fu
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA
    Nat Immunol 10:848-56. 2009
    ..In support of the idea that Themis is involved in TCR signaling, this protein was phosphorylated quickly after TCR stimulation and was needed for optimal TCR-driven calcium mobilization and activation of the kinase Erk...
  6. pmc Divergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets
    Xiangli Li
    Department of Medicine, UCSD, La Jolla, California 92093 0663, USA
    J Clin Invest 122:963-73. 2012
    ....
  7. pmc Visualizing intermolecular interactions in T cells
    Nicholas R J Gascoigne
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Top Microbiol Immunol 334:31-46. 2009
    ..This chapter reviews data on how these coreceptors are recruited to the immunological synapse, and how they interact when the T cell is stimulated by different ligands...