Guo Fu

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc The role of protein kinase cη in T cell biology
    Guo Fu
    Department of Immunology and Microbial Science, The Scripps Research Institute La Jolla, CA, USA
    Front Immunol 3:177. 2012
  2. pmc Protein kinase C η is required for T cell activation and homeostatic proliferation
    Guo Fu
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Sci Signal 4:ra84. 2011
  3. pmc Multiplexed labeling of samples with cell tracking dyes facilitates rapid and accurate internally controlled calcium flux measurement by flow cytometry
    Guo Fu
    Department of Immunology and Microbial Science, IMM1, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Immunol Methods 350:194-9. 2009
  4. pmc Themis sets the signal threshold for positive and negative selection in T-cell development
    Guo Fu
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 504:441-5. 2013
  5. pmc Fine-tuning T cell receptor signaling to control T cell development
    Guo Fu
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Trends Immunol 35:311-8. 2014
  6. pmc Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling
    Guo Fu
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA
    Nat Immunol 10:848-56. 2009
  7. pmc Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor
    Javier Casas
    1 Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 5 Science Drive 2, Singapore 117545, Singapore 2 Department of Immunology and Microbial Sciences, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California 92037, USA
    Nat Commun 5:5624. 2014
  8. pmc Allelic exclusion of TCR α-chains upon severe restriction of Vα repertoire
    Vasily Rybakin
    Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117545, Singapore Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States of America
    PLoS ONE 9:e114320. 2014
  9. pmc Divergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets
    Xiangli Li
    Department of Medicine, UCSD, La Jolla, California 92093 0663, USA
    J Clin Invest 122:963-73. 2012
  10. pmc Visualizing intermolecular interactions in T cells
    Nicholas R J Gascoigne
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Top Microbiol Immunol 334:31-46. 2009

Collaborators

Detail Information

Publications10

  1. pmc The role of protein kinase cη in T cell biology
    Guo Fu
    Department of Immunology and Microbial Science, The Scripps Research Institute La Jolla, CA, USA
    Front Immunol 3:177. 2012
    ..In this review, we will cover the topics mentioned above as well as provide some perspectives for further investigations regarding PKCη...
  2. pmc Protein kinase C η is required for T cell activation and homeostatic proliferation
    Guo Fu
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Sci Signal 4:ra84. 2011
    ..Together, these data suggest that PKCη shares some redundant roles with PKCθ in T cell biology and also performs nonredundant functions that are required for T cell homeostasis and activation...
  3. pmc Multiplexed labeling of samples with cell tracking dyes facilitates rapid and accurate internally controlled calcium flux measurement by flow cytometry
    Guo Fu
    Department of Immunology and Microbial Science, IMM1, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Immunol Methods 350:194-9. 2009
    ..This facilitates more rapid and accurate measurement of calcium flux and also dramatically reduces the cost and effort required for this type of assay...
  4. pmc Themis sets the signal threshold for positive and negative selection in T-cell development
    Guo Fu
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 504:441-5. 2013
    ..By dampening mild TCR signals Themis increases the affinity threshold for activation, enabling positive selection of T cells with a naive phenotype in response to low-affinity self-antigens. ..
  5. pmc Fine-tuning T cell receptor signaling to control T cell development
    Guo Fu
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Trends Immunol 35:311-8. 2014
    ..This allows them to govern thymocyte positive selection. Here, we summarize recent findings on these molecules and suggest new concepts of TCR positive-selection signaling. ..
  6. pmc Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling
    Guo Fu
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA
    Nat Immunol 10:848-56. 2009
    ..In support of the idea that Themis is involved in TCR signaling, this protein was phosphorylated quickly after TCR stimulation and was needed for optimal TCR-driven calcium mobilization and activation of the kinase Erk...
  7. pmc Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor
    Javier Casas
    1 Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 5 Science Drive 2, Singapore 117545, Singapore 2 Department of Immunology and Microbial Sciences, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California 92037, USA
    Nat Commun 5:5624. 2014
    ..Later (several minutes) CD3ζ-CD8 interactions require CD8-MHC binding. Lck can be found free or bound to the coreceptor. This work indicates that the initial TCR-triggering event is induced by free Lck. ..
  8. pmc Allelic exclusion of TCR α-chains upon severe restriction of Vα repertoire
    Vasily Rybakin
    Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117545, Singapore Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States of America
    PLoS ONE 9:e114320. 2014
    ..Because of the dominance of Vα3.2 expression over Vα2 expressed from the miniloci, the peripheral T cell population was predominantly CD8+ cells. ..
  9. pmc Divergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets
    Xiangli Li
    Department of Medicine, UCSD, La Jolla, California 92093 0663, USA
    J Clin Invest 122:963-73. 2012
    ....
  10. pmc Visualizing intermolecular interactions in T cells
    Nicholas R J Gascoigne
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Top Microbiol Immunol 334:31-46. 2009
    ..This chapter reviews data on how these coreceptors are recruited to the immunological synapse, and how they interact when the T cell is stimulated by different ligands...