Steven M Frisch

Summary

Affiliation: The Burnham Institute
Country: USA

Publications

  1. ncbi request reprint Adenovirus-5 E1A: paradox and paradigm
    Steven M Frisch
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Mol Cell Biol 3:441-52. 2002
  2. ncbi request reprint Anoikis mechanisms
    S M Frisch
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Cell Biol 13:555-62. 2001
  3. ncbi request reprint Evidence for a function of death-receptor-related, death-domain-containing proteins in anoikis
    S M Frisch
    The Burnham Institute 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Curr Biol 9:1047-9. 1999
  4. ncbi request reprint Blockade of tumor necrosis factor-induced Bid cleavage by caspase-resistant Rb
    Xiaodong Huang
    Division of Biological Sciences, Department of Medicine, University of California, San Diego, La Jolla, California 92093 0820, USA
    J Biol Chem 282:29401-13. 2007
  5. ncbi request reprint E1A as a tumor suppressor gene: commentary re S. Madhusudan et al. A multicenter Phase I gene therapy clinical trial involving intraperitoneal administration of E1A-lipid complex in patients with recurrent epithelial ovarian cancer overexpressing HER-2/ne
    Steven M Frisch
    The Burnham Institute, La Jolla, California 92037, USA
    Clin Cancer Res 10:2905-7. 2004
  6. pmc Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis
    Robert A Screaton
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:5211-6. 2003
  7. ncbi request reprint Caspase-8 interacts with the p85 subunit of phosphatidylinositol 3-kinase to regulate cell adhesion and motility
    Jamie Senft
    Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506, USA
    Cancer Res 67:11505-9. 2007
  8. ncbi request reprint Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions
    Brooke Helfer
    Mary Babb Randolph Cancer Center and Department of Biochemistry, West Virginia University, Morgantown, West Virginia 26506, USA
    Cancer Res 66:4273-8. 2006
  9. ncbi request reprint Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP
    Qinghong Zhang
    Vollum Institute, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97239, USA
    Cell 115:177-86. 2003
  10. pmc C-terminal-binding protein corepresses epithelial and proapoptotic gene expression programs
    Madeleine Grooteclaes
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:4568-73. 2003

Collaborators

  • Jean Y Wang
  • Owen Sansom
  • Brooke Helfer
  • Qinghong Zhang
  • Xiaodong Huang
  • Jamie Senft
  • Richard H Goodman
  • Robert A Screaton
  • Jeffrey Hildebrand
  • Madeleine Grooteclaes
  • Anja Masselli
  • Yong Jiang
  • Irina C Hunton
  • Kristiina Vuori
  • Daniel C Flynn
  • Darren Finlay
  • Angel Cipres
  • David Wallach
  • Tae Bong Kang
  • Jill M Lahti
  • Bernard C Boswell
  • Andrea Dorfleutner
  • Quinn Deveraux
  • Catherine B Millar
  • Adrian Bird
  • Yasuhiro Yoshimatsu
  • Alan R Clarke
  • Kathryn Maddison
  • Stephan Kiessling

Detail Information

Publications11

  1. ncbi request reprint Adenovirus-5 E1A: paradox and paradigm
    Steven M Frisch
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Mol Cell Biol 3:441-52. 2002
    ..These discoveries have provided a tool with which to study the regulation of fundamental cellular processes...
  2. ncbi request reprint Anoikis mechanisms
    S M Frisch
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Cell Biol 13:555-62. 2001
    ..The central problem of anoikis is to understand how integrin-mediated cell adhesion signals control the apoptotic machinery. In particular, the initiation of the caspase cascade in anoikis remains to be explained...
  3. ncbi request reprint Evidence for a function of death-receptor-related, death-domain-containing proteins in anoikis
    S M Frisch
    The Burnham Institute 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Curr Biol 9:1047-9. 1999
    ..These findings indicate a role for death receptors or proteins with related death domains in triggering anoikis...
  4. ncbi request reprint Blockade of tumor necrosis factor-induced Bid cleavage by caspase-resistant Rb
    Xiaodong Huang
    Division of Biological Sciences, Department of Medicine, University of California, San Diego, La Jolla, California 92093 0820, USA
    J Biol Chem 282:29401-13. 2007
    ..These results suggest that Rb cleavage is required for Bid cleavage in TNF-induced type-2 apoptosis, and this requirement can be supplanted by the inhibition of V-ATPase...
  5. ncbi request reprint E1A as a tumor suppressor gene: commentary re S. Madhusudan et al. A multicenter Phase I gene therapy clinical trial involving intraperitoneal administration of E1A-lipid complex in patients with recurrent epithelial ovarian cancer overexpressing HER-2/ne
    Steven M Frisch
    The Burnham Institute, La Jolla, California 92037, USA
    Clin Cancer Res 10:2905-7. 2004
  6. pmc Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis
    Robert A Screaton
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:5211-6. 2003
    ..The nuclear localization of FADD and its interaction with a genome surveillance/DNA repair protein that can regulate apoptosis suggests a novel function of FADD distinct from direct participation in death receptor signaling complexes...
  7. ncbi request reprint Caspase-8 interacts with the p85 subunit of phosphatidylinositol 3-kinase to regulate cell adhesion and motility
    Jamie Senft
    Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506, USA
    Cancer Res 67:11505-9. 2007
    ..These results suggest that caspase-8 phosphorylation converts it from a proapoptotic factor to a cell motility factor that, through tyrosine-380, interacts with p85, an established cell migration component...
  8. ncbi request reprint Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions
    Brooke Helfer
    Mary Babb Randolph Cancer Center and Department of Biochemistry, West Virginia University, Morgantown, West Virginia 26506, USA
    Cancer Res 66:4273-8. 2006
    ..This represents a novel nonapoptotic function of caspase-8 acting at the intersection of the caspase-8 and calpain proteolytic pathways to coordinate cell death versus cell motility signaling...
  9. ncbi request reprint Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP
    Qinghong Zhang
    Vollum Institute, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97239, USA
    Cell 115:177-86. 2003
    ..Finally, reduction in CtBP levels, either by genetic knockout or siRNA, promoted apoptosis in p53-deficient cells. These findings provide a pathway for UV-induced apoptosis in cells lacking p53...
  10. pmc C-terminal-binding protein corepresses epithelial and proapoptotic gene expression programs
    Madeleine Grooteclaes
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:4568-73. 2003
    ..The results presented herein establish two functional roles of CtBP: to corepress epithelial genes, thus permitting epithelial-to-mesenchymal transitions, and to modulate the cellular threshold for apoptotic responses...
  11. doi request reprint Caspase-8: fly or die
    Steven M Frisch
    West Virginia University, Mary Babb Randolph Cancer Center, Morgantown, West Virginia, USA
    Cancer Res 68:4491-3. 2008
    ..Here, I survey the findings of these studies and discuss potential mechanisms and ramifications for cancer prognosis and therapy...