Research Topics
Genomes and Genes | Jeffrey S FriedmanSummaryAffiliation: The Scripps Research Institute Country: USA Publications
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Publications
Increasing T-cell age reduces effector activity but preserves proliferative capacity in a murine allogeneic major histocompatibility complex-mismatched bone marrow transplant modelJeff S Friedman
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
Biol Blood Marrow Transplant 10:448-60. 2004..We suggest that the lack of effector activity demonstrated by old T cells in vivo is a reflection of a cell-autonomous defect downstream of signals required for antigen-driven proliferation...
SOD2 deficient erythroid cells up-regulate transferrin receptor and down-regulate mitochondrial biogenesis and metabolismFlorent M Martin
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of America
PLoS ONE 6:e16894. 2011..SA is primarily an acquired, clonal marrow disorder occurring in individuals over 60 years of age with uncertain etiology...- SOD2-deficiency anemia: protein oxidation and altered protein expression reveal targets of damage, stress response, and antioxidant responsivenessJeffrey S Friedman
The Scripps Research Institute, Department of Molecular and Experimental Medicine, MEM131, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
Blood 104:2565-73. 2004.... - SOD2-deficiency sideroblastic anemia and red blood cell oxidative stressFlorent M Martin
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
Antioxid Redox Signal 8:1217-25. 2006.... - Constitutive NADPH oxidase 4 activity resides in the composition of the B-loop and the penultimate C terminusKatharina von Löhneysen
Scripps Research Institute, Department of Molecular and Experimental Medicine, La Jolla, California 92037, USA
J Biol Chem 287:8737-45. 2012..These results indicate that accessibility for a Nox4-specific peptide inhibitor might be difficult to achieve in vivo... - The familial Parkinson's disease gene DJ-1 (PARK7) is expressed in red cells and plays a role in protection against oxidative damageXiuling Xu
Department of Molecular and Experimental Medicine, The Scripps Research Institute La Jolla, California 92037, USA
Blood Cells Mol Dis 45:227-32. 2010..These results indicate that DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress... - A method for rapid mouse siderocyte enrichmentFlorent M Martin
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, 92037, USA
Exp Hematol 33:1493-9. 2005..We have developed a simple and specific method to purify iron-overloaded red blood cells using magnetic affinity columns. Here we describe this method and characterize purified Sod2-deficient siderocytes... - Assessment of the red cell proteome of young patients with unexplained hemolytic anemia by two-dimensional differential in-gel electrophoresis (DIGE)Katharina von Löhneysen
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of America
PLoS ONE 7:e34237. 2012.... 
Erythropoietin, GDF15, IL6, hepcidin and testosterone levels in a large cohort of elderly individuals with anaemia of known and unknown causeJill Waalen
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
Eur J Haematol 87:107-16. 2011..Our data indicate that an impaired EPO response, in the absence of evidence for iron restriction or inflammation, is characteristic of AUE...- A novel approach for in vivo measurement of mouse red cell redox statusXiuling Xu
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
Blood 118:3694-7. 2011..Thus, roGFP2 transgenic mice are a new and versatile tool that can be used to probe how RBC redox status responds in the context of drug therapy, physiologic stressors and pathologic states... - Structural insights into Nox4 and Nox2: motifs involved in function and cellular localizationKatharina von Löhneysen
Department of Immunology and Microbial Science, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Mol Cell Biol 30:961-75. 2010..In contrast, Nox4 released H(2)O(2) and promoted cell migration. Our work provides insights into Nox structure, regulation, and ROS output that will aid inhibitor design... - Ticking fast or ticking slow, through Shc must you go?Florent M Martin
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
Sci Aging Knowledge Environ 2004:pe32. 2004..A full understanding of how interactions between p53 and p66(shc) affect longevity will require the production of animals with mutations in the genes encoding both proteins...
Research Grants
- Hemolytic Anemia: Biochemical, Molecular and Proteomic DiagnosticsJeffrey Friedman; Fiscal Year: 2009..We are pursuing these studies to try to find the cause of this disorder for the large group of patients for whom we can currently provide no specific diagnosis. ..
- Anemia in the Elderly: PathogenesisJeffrey S Friedman; Fiscal Year: 2010..If such differences also occur among controls they could account for the broad normal variation in hemoglobin levels. ..
- Anemia in the Elderly: PathogenesisJeffrey Friedman; Fiscal Year: 2009..If such differences also occur among controls they could account for the broad normal variation in hemoglobin levels. ..
- DIGE Package: Variable Mode Imager and Spot PickerJeffrey Friedman; Fiscal Year: 2007....
- Pathogenesis and Therapy of Sideroblastic AnemiaJeffrey Friedman; Fiscal Year: 2007....
- Pathogenesis and Therapy of Sideroblastic AnemiaJeffrey Friedman; Fiscal Year: 2003..abstract_text> ..
- Hemolytic Anemia: Biochemical, Molecular and Proteomic DiagnosticsJeffrey S Friedman; Fiscal Year: 2010..We are pursuing these studies to try to find the cause of this disorder for the large group of patients for whom we can currently provide no specific diagnosis. ..