Jeffrey S Friedman

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi request reprint Increasing T-cell age reduces effector activity but preserves proliferative capacity in a murine allogeneic major histocompatibility complex-mismatched bone marrow transplant model
    Jeff S Friedman
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Biol Blood Marrow Transplant 10:448-60. 2004
  2. pmc SOD2 deficient erythroid cells up-regulate transferrin receptor and down-regulate mitochondrial biogenesis and metabolism
    Florent M Martin
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS ONE 6:e16894. 2011
  3. pmc Assessment of the red cell proteome of young patients with unexplained hemolytic anemia by two-dimensional differential in-gel electrophoresis (DIGE)
    Katharina von Löhneysen
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS ONE 7:e34237. 2012
  4. ncbi request reprint SOD2-deficiency anemia: protein oxidation and altered protein expression reveal targets of damage, stress response, and antioxidant responsiveness
    Jeffrey S Friedman
    The Scripps Research Institute, Department of Molecular and Experimental Medicine, MEM131, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 104:2565-73. 2004
  5. ncbi request reprint SOD2-deficiency sideroblastic anemia and red blood cell oxidative stress
    Florent M Martin
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Antioxid Redox Signal 8:1217-25. 2006
  6. pmc The familial Parkinson's disease gene DJ-1 (PARK7) is expressed in red cells and plays a role in protection against oxidative damage
    Xiuling Xu
    Department of Molecular and Experimental Medicine, The Scripps Research Institute La Jolla, California 92037, USA
    Blood Cells Mol Dis 45:227-32. 2010
  7. pmc Constitutive NADPH oxidase 4 activity resides in the composition of the B-loop and the penultimate C terminus
    Katharina von Löhneysen
    Scripps Research Institute, Department of Molecular and Experimental Medicine, La Jolla, California 92037, USA
    J Biol Chem 287:8737-45. 2012
  8. ncbi request reprint A method for rapid mouse siderocyte enrichment
    Florent M Martin
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, 92037, USA
    Exp Hematol 33:1493-9. 2005
  9. pmc A novel approach for in vivo measurement of mouse red cell redox status
    Xiuling Xu
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
    Blood 118:3694-7. 2011
  10. doi request reprint Erythropoietin, GDF15, IL6, hepcidin and testosterone levels in a large cohort of elderly individuals with anaemia of known and unknown cause
    Jill Waalen
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Eur J Haematol 87:107-16. 2011

Research Grants

  1. Hemolytic Anemia: Biochemical, Molecular and Proteomic Diagnostics
    Jeffrey Friedman; Fiscal Year: 2009
  2. Anemia in the Elderly: Pathogenesis
    Jeffrey S Friedman; Fiscal Year: 2010
  3. Pathogenesis and Therapy of Sideroblastic Anemia
    Jeffrey Friedman; Fiscal Year: 2007
  4. Anemia in the Elderly: Pathogenesis
    Jeffrey Friedman; Fiscal Year: 2009
  5. DIGE Package: Variable Mode Imager and Spot Picker
    Jeffrey Friedman; Fiscal Year: 2007
  6. Pathogenesis and Therapy of Sideroblastic Anemia
    Jeffrey Friedman; Fiscal Year: 2003
  7. Hemolytic Anemia: Biochemical, Molecular and Proteomic Diagnostics
    Jeffrey S Friedman; Fiscal Year: 2010

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Increasing T-cell age reduces effector activity but preserves proliferative capacity in a murine allogeneic major histocompatibility complex-mismatched bone marrow transplant model
    Jeff S Friedman
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Biol Blood Marrow Transplant 10:448-60. 2004
    ..We suggest that the lack of effector activity demonstrated by old T cells in vivo is a reflection of a cell-autonomous defect downstream of signals required for antigen-driven proliferation...
  2. pmc SOD2 deficient erythroid cells up-regulate transferrin receptor and down-regulate mitochondrial biogenesis and metabolism
    Florent M Martin
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS ONE 6:e16894. 2011
    ..SA is primarily an acquired, clonal marrow disorder occurring in individuals over 60 years of age with uncertain etiology...
  3. pmc Assessment of the red cell proteome of young patients with unexplained hemolytic anemia by two-dimensional differential in-gel electrophoresis (DIGE)
    Katharina von Löhneysen
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS ONE 7:e34237. 2012
    ....
  4. ncbi request reprint SOD2-deficiency anemia: protein oxidation and altered protein expression reveal targets of damage, stress response, and antioxidant responsiveness
    Jeffrey S Friedman
    The Scripps Research Institute, Department of Molecular and Experimental Medicine, MEM131, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 104:2565-73. 2004
    ....
  5. ncbi request reprint SOD2-deficiency sideroblastic anemia and red blood cell oxidative stress
    Florent M Martin
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Antioxid Redox Signal 8:1217-25. 2006
    ....
  6. pmc The familial Parkinson's disease gene DJ-1 (PARK7) is expressed in red cells and plays a role in protection against oxidative damage
    Xiuling Xu
    Department of Molecular and Experimental Medicine, The Scripps Research Institute La Jolla, California 92037, USA
    Blood Cells Mol Dis 45:227-32. 2010
    ..These results indicate that DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress...
  7. pmc Constitutive NADPH oxidase 4 activity resides in the composition of the B-loop and the penultimate C terminus
    Katharina von Löhneysen
    Scripps Research Institute, Department of Molecular and Experimental Medicine, La Jolla, California 92037, USA
    J Biol Chem 287:8737-45. 2012
    ..These results indicate that accessibility for a Nox4-specific peptide inhibitor might be difficult to achieve in vivo...
  8. ncbi request reprint A method for rapid mouse siderocyte enrichment
    Florent M Martin
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, 92037, USA
    Exp Hematol 33:1493-9. 2005
    ..We have developed a simple and specific method to purify iron-overloaded red blood cells using magnetic affinity columns. Here we describe this method and characterize purified Sod2-deficient siderocytes...
  9. pmc A novel approach for in vivo measurement of mouse red cell redox status
    Xiuling Xu
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
    Blood 118:3694-7. 2011
    ..Thus, roGFP2 transgenic mice are a new and versatile tool that can be used to probe how RBC redox status responds in the context of drug therapy, physiologic stressors and pathologic states...
  10. doi request reprint Erythropoietin, GDF15, IL6, hepcidin and testosterone levels in a large cohort of elderly individuals with anaemia of known and unknown cause
    Jill Waalen
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Eur J Haematol 87:107-16. 2011
    ..Our data indicate that an impaired EPO response, in the absence of evidence for iron restriction or inflammation, is characteristic of AUE...
  11. pmc Structural insights into Nox4 and Nox2: motifs involved in function and cellular localization
    Katharina von Löhneysen
    Department of Immunology and Microbial Science, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Mol Cell Biol 30:961-75. 2010
    ..In contrast, Nox4 released H(2)O(2) and promoted cell migration. Our work provides insights into Nox structure, regulation, and ROS output that will aid inhibitor design...
  12. ncbi request reprint Ticking fast or ticking slow, through Shc must you go?
    Florent M Martin
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Sci Aging Knowledge Environ 2004:pe32. 2004
    ..A full understanding of how interactions between p53 and p66(shc) affect longevity will require the production of animals with mutations in the genes encoding both proteins...

Research Grants13

  1. Hemolytic Anemia: Biochemical, Molecular and Proteomic Diagnostics
    Jeffrey Friedman; Fiscal Year: 2009
    ..We are pursuing these studies to try to find the cause of this disorder for the large group of patients for whom we can currently provide no specific diagnosis. ..
  2. Anemia in the Elderly: Pathogenesis
    Jeffrey S Friedman; Fiscal Year: 2010
    ..If such differences also occur among controls they could account for the broad normal variation in hemoglobin levels. ..
  3. Pathogenesis and Therapy of Sideroblastic Anemia
    Jeffrey Friedman; Fiscal Year: 2007
    ....
  4. Anemia in the Elderly: Pathogenesis
    Jeffrey Friedman; Fiscal Year: 2009
    ..If such differences also occur among controls they could account for the broad normal variation in hemoglobin levels. ..
  5. DIGE Package: Variable Mode Imager and Spot Picker
    Jeffrey Friedman; Fiscal Year: 2007
    ....
  6. Pathogenesis and Therapy of Sideroblastic Anemia
    Jeffrey Friedman; Fiscal Year: 2003
    ..abstract_text> ..
  7. Hemolytic Anemia: Biochemical, Molecular and Proteomic Diagnostics
    Jeffrey S Friedman; Fiscal Year: 2010
    ..We are pursuing these studies to try to find the cause of this disorder for the large group of patients for whom we can currently provide no specific diagnosis. ..