Jeffrey M Friedman

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi request reprint Leptin and the regulation of body weigh
    Jeffrey M Friedman
    Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Keio J Med 60:1-9. 2011
  2. ncbi request reprint A war on obesity, not the obese
    Jeffrey M Friedman
    Howard Hughes Medical Institute, The Rockefeller University, 1230 New York Avenue, New York, NY 10021 USA
    Science 299:856-8. 2003
  3. ncbi request reprint Late-onset leanness in mice with targeted ablation of melanin concentrating hormone neurons
    Tamar Alon
    Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 26:389-97. 2006
  4. pmc Identification of neuronal subpopulations that project from hypothalamus to both liver and adipose tissue polysynaptically
    Sarah Stanley
    Laboratory of Molecular Genetics, Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 107:7024-9. 2010
  5. ncbi request reprint Rapid rewiring of arcuate nucleus feeding circuits by leptin
    Shirly Pinto
    Laboratory of Molecular Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 304:110-5. 2004
  6. pmc Cellular program controlling the recovery of adipose tissue mass: An in vivo imaging approach
    Kivanc Birsoy
    Laboratory of Molecular Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 105:12985-90. 2008
  7. pmc Systematic haplotype analysis resolves a complex plasma plant sterol locus on the Micronesian Island of Kosrae
    Eimear E Kenny
    Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:13886-91. 2009
  8. ncbi request reprint Topographic mapping of VMH --> arcuate nucleus microcircuits and their reorganization by fasting
    Scott M Sternson
    Howard Hughes Medical Institute and Laboratory of Molecular Genetics, The Rockefeller University, 1230 York Ave, New York, New York 10021, USA
    Nat Neurosci 8:1356-63. 2005
  9. pmc Whole population, genome-wide mapping of hidden relatedness
    Alexander Gusev
    Department of Computer Science, Columbia University, New York, New York 10027, USA
    Genome Res 19:318-26. 2009
  10. pmc Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae
    Jennifer K Lowe
    The Rockefeller University, New York, New York, USA
    PLoS Genet 5:e1000365. 2009

Detail Information

Publications62

  1. ncbi request reprint Leptin and the regulation of body weigh
    Jeffrey M Friedman
    Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Keio J Med 60:1-9. 2011
    ..Finally, this research has established that there is a powerful biological basis for obesity, a fact that is (correctly) changing public perception about the pathogenesis of this medical condition...
  2. ncbi request reprint A war on obesity, not the obese
    Jeffrey M Friedman
    Howard Hughes Medical Institute, The Rockefeller University, 1230 New York Avenue, New York, NY 10021 USA
    Science 299:856-8. 2003
    ..In their efforts to lose weight, obese individuals may be fighting a powerful set of evolutionary forces honed in an environment drastically different from that of today...
  3. ncbi request reprint Late-onset leanness in mice with targeted ablation of melanin concentrating hormone neurons
    Tamar Alon
    Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 26:389-97. 2006
    ..This has implications for the pathogenesis of acquired changes of body weight and might be considered in clinical settings characterized by substantial weight changes later in life...
  4. pmc Identification of neuronal subpopulations that project from hypothalamus to both liver and adipose tissue polysynaptically
    Sarah Stanley
    Laboratory of Molecular Genetics, Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 107:7024-9. 2010
    ..The delineation of this circuitry will facilitate a functional analysis of the possible role of these potential command-like neurons to modulate autonomic outflow and coordinate metabolic responses in liver and adipose tissue...
  5. ncbi request reprint Rapid rewiring of arcuate nucleus feeding circuits by leptin
    Shirly Pinto
    Laboratory of Molecular Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 304:110-5. 2004
    ..These data suggest that leptin-mediated plasticity in the ob/ob hypothalamus may underlie some of the hormone's behavioral effects...
  6. pmc Cellular program controlling the recovery of adipose tissue mass: An in vivo imaging approach
    Kivanc Birsoy
    Laboratory of Molecular Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 105:12985-90. 2008
    ....
  7. pmc Systematic haplotype analysis resolves a complex plasma plant sterol locus on the Micronesian Island of Kosrae
    Eimear E Kenny
    Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:13886-91. 2009
    ..These findings exemplify the power of haplotype analysis for mapping mutations in isolated populations and specifically for dissecting effects of multiple variants of the same locus...
  8. ncbi request reprint Topographic mapping of VMH --> arcuate nucleus microcircuits and their reorganization by fasting
    Scott M Sternson
    Howard Hughes Medical Institute and Laboratory of Molecular Genetics, The Rockefeller University, 1230 York Ave, New York, New York 10021, USA
    Nat Neurosci 8:1356-63. 2005
    ..These data identify a new molecularly defined circuit that is dynamically regulated by nutritional state in a manner consistent with the known role of the VMH as a satiety center...
  9. pmc Whole population, genome-wide mapping of hidden relatedness
    Alexander Gusev
    Department of Computer Science, Columbia University, New York, New York 10027, USA
    Genome Res 19:318-26. 2009
    ..This finding is supported by concordance of detected deletions with other evidence from independent databases and statistical analyses of fluorescence intensity not used by GERMLINE...
  10. pmc Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae
    Jennifer K Lowe
    The Rockefeller University, New York, New York, USA
    PLoS Genet 5:e1000365. 2009
    ..Finally, we show that a majority of common variants discovered in Caucasians have indistinguishable effect sizes on Kosrae, despite the major differences in population genetics and environment...
  11. pmc Site and mechanism of leptin action in a rodent form of congenital lipodystrophy
    Esra Asilmaz
    Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021, USA
    J Clin Invest 113:414-24. 2004
    ..Intracerebroventricular leptin improves glucose homeostasis by improving insulin signal transduction in liver, but in this case the effect appears to be independent of SCD-1...
  12. pmc PET imaging of leptin biodistribution and metabolism in rodents and primates
    Giovanni Ceccarini
    Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA
    Cell Metab 10:148-59. 2009
    ....
  13. pmc DASH: a method for identical-by-descent haplotype mapping uncovers association with recent variation
    Alexander Gusev
    Department of Computer Science, Columbia University, New York, NY 10027, USA
    Am J Hum Genet 88:706-17. 2011
    ..We have replicated one of these loci in an independent European cohort and identified putative structural changes in low-pass whole-genome sequence of the cluster carriers...
  14. doi request reprint Antidiabetic effects of IGFBP2, a leptin-regulated gene
    Kristina Hedbacker
    Rockefeller University, New York, NY 10065, USA
    Cell Metab 11:11-22. 2010
    ..These results show that IGFBP2 can regulate glucose metabolism, a finding with potential implications for the pathogenesis and treatment of diabetes...
  15. pmc Linkage analysis of quantitative traits for obesity, diabetes, hypertension, and dyslipidemia on the island of Kosrae, Federated States of Micronesia
    Dvora Shmulewitz
    Department of Biostatistics, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:3502-9. 2006
    ..These results also lay the foundation for whole genome scans with dense sets of SNPs aimed to identifying causal genes...
  16. ncbi request reprint Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms
    Zhu Chen
    Laboratory of Molecular Genetics, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Cell Metab 1:93-106. 2005
    ..These data indicate that Krox20 is necessary for adipogenesis and that, when overexpressed, Krox20 potently stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms...
  17. doi request reprint Molecular profiling of activated neurons by phosphorylated ribosome capture
    Zachary A Knight
    Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Cell 151:1126-37. 2012
    ..These studies identify elements of the neural circuit that controls food intake and illustrate how the activity-dependent capture of cell-type-specific transcripts can elucidate the functional organization of a complex tissue...
  18. pmc Increased power of mixed models facilitates association mapping of 10 loci for metabolic traits in an isolated population
    Eimear E Kenny
    Department of Computer Science, Columbia University, 505 Computer Science Building, 1214 Amsterdam Ave Mailcode 0401, New York, NY 10027 7003, USA
    Hum Mol Genet 20:827-39. 2011
    ..Finally, we report a novel associations for height (rs17629022, P< 2.1 × 10⁻⁸)...
  19. ncbi request reprint Induction of leptin receptor expression in the liver by leptin and food deprivation
    Paul Cohen
    Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 280:10034-9. 2005
    ..Membrane-bound Ob-R is then shed into the circulation as SLR. Our study thus reveals an unexpected role of the liver in modulating total circulating leptin levels and possibly its biological activity...
  20. pmc Insulin regulates leptin secretion from 3T3-L1 adipocytes by a PI 3 kinase independent mechanism
    Anja Zeigerer
    Department of Molecular Genetics, The Rockefeller University, New York, NY 10021, USA
    Exp Cell Res 314:2249-56. 2008
    ..These studies show that insulin can stimulate leptin release via a PI3K independent mechanism and provide a cellular system for studying the effect of insulin and potentially other mediators on leptin secretion...
  21. pmc Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13
    Ralph Burkhardt
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY 10065, USA
    Arterioscler Thromb Vasc Biol 28:2078-84. 2008
    ..Background- Variation in LDL-cholesterol (LDL-C) among individuals is a complex genetic trait involving multiple genes and gene-environment interactions...
  22. ncbi request reprint Use of laser-capture microdissection for the identification of marker genes for the ventromedial hypothalamic nucleus
    Jeremy P Segal
    The Rockefeller University, New York, New York 10021, USA
    J Neurosci 25:4181-8. 2005
    ..These results also demonstrate the utility of laser-capture microdissection coupled with microarray technology to identify nucleus-specific transcriptional networks...
  23. ncbi request reprint Leptin and the control of metabolism: role for stearoyl-CoA desaturase-1 (SCD-1)
    Paul Cohen
    Laboratory of Molecular Genetics, The Rockefeller University, New York, NY 10021, USA
    J Nutr 134:2455S-2463S. 2004
    ..Data indicate that pharmacologic manipulation of SCD-1 may be of benefit in the treatment of obesity, diabetes, hepatic steatosis, and other components of the Metabolic Syndrome...
  24. ncbi request reprint Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob/ob mice
    Aaron G Roseberry
    Laboratory of Molecular Genetics, The Rockefeller University, 1230 York Avenue, Box 305, New York, NY 10021, USA
    Neuron 41:711-22. 2004
    ..These data reveal an intricate and asymmetric interplay between NPY and POMC neurons in the hypothalamus and have important implications for the delineation of the neural circuits that regulate feeding behavior...
  25. ncbi request reprint Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity
    Kevin J Cheung
    Laboratory of Molecular Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Cell Metab 5:115-28. 2007
    ..Our results identify XOR as a potential therapeutic target for metabolic abnormalities beyond hyperuricemia...
  26. ncbi request reprint Stearoyl-CoA desaturase-1 and the metabolic syndrome
    Paul Cohen
    Laboratory of Molecular Genetics, The Rockefeller University, New York, NY 10021, USA
    Curr Drug Targets Immune Endocr Metabol Disord 3:271-80. 2003
    ..These findings indicate that pharmacologic manipulation of SCD-1 may be of benefit in the treatment of obesity, diabetes, hepatic steatosis, and other components of the Metabolic Syndrome...
  27. pmc Transgenic mice expressing green fluorescent protein under the control of the corticotropin-releasing hormone promoter
    Tamar Alon
    Laboratory of Molecular Genetics and Howard Hughes Medical Institute, Rockefeller University, New York, New York 10065, USA
    Endocrinology 150:5626-32. 2009
    ..We anticipate that this transgenic model will lend itself as a highly tractable tool for the investigation of CRH expression and function in discrete brain regions...
  28. doi request reprint Identification of white adipocyte progenitor cells in vivo
    Matthew S Rodeheffer
    Laboratory of Molecular Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Cell 135:240-9. 2008
    ..This report provides the identification of an undifferentiated adipocyte precursor subpopulation resident within the adipose tissue stroma that is capable of proliferating and differentiating into an adipose depot in vivo...
  29. pmc Hyperleptinemia is required for the development of leptin resistance
    Zachary A Knight
    Howard Hughes Medical Institute, Laboratory of Molecular Genetics, The Rockefeller University, New York, New York, United States of America
    PLoS ONE 5:e11376. 2010
    ..The data also suggest that hyperleptinemia itself can contribute to leptin resistance by downregulating cellular response to leptin as has been shown for other hormones...
  30. ncbi request reprint Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes
    Christian Wolfrum
    Laboratory of Metabolic Diseases, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 432:1027-32. 2004
    ..Pharmacological intervention to inhibit phosphorylation of Foxa2 may be an effective treatment for type 2 diabetes...
  31. pmc Contrasting effects of leptin on food anticipatory and total locomotor activity
    Ana C Ribeiro
    Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, New York, United States of America
    PLoS ONE 6:e23364. 2011
    ..Leptin, acting in the central nervous system and at physiologic levels, produces early increases in locomotor activity before substantial weight loss. In contrast, leptin suppresses augmented food anticipatory activity in obob mice...
  32. pmc Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity
    Makoto Ishii
    Laboratory of Molecular Genetics, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:10540-5. 2003
    ..These data suggest a potential role for GPR7 and its endogenous ligands, neuropeptide B and neuropeptide W, in regulating energy homeostasis independent of leptin and melanocortin signaling in a sexually dimorphic manner...
  33. pmc Developmental role for endocannabinoid signaling in regulating glucose metabolism and growth
    Zhiying Li
    Rockefeller University, New York, New York, USA
    Diabetes 62:2359-67. 2013
    ..The data also suggest a developmental role for Cnr1 to promote growth, regulate the GH/IGF-I axis, and improve β-cell function and glucose homeostasis in the setting of leptin deficiency. ..
  34. pmc Radio-wave heating of iron oxide nanoparticles can regulate plasma glucose in mice
    Sarah A Stanley
    Laboratory of Molecular Genetics, Rockefeller University, New York, NY 10065, USA
    Science 336:604-8. 2012
    ..We further show that cells can be engineered to synthesize genetically encoded ferritin nanoparticles and inducibly release insulin. These approaches provide a platform for using nanotechnology to activate cells...
  35. pmc Molecular annotation of integrative feeding neural circuits
    Cristian A Perez
    Laboratory of Molecular Genetics, Rockefeller University, New York, NY 10065, USA
    Cell Metab 13:222-32. 2011
    ..These markers now provide a means for functional studies of specific neuronal populations in feeding or other complex behaviors...
  36. ncbi request reprint Modern science versus the stigma of obesity
    Jeffrey M Friedman
    Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Med 10:563-9. 2004
  37. ncbi request reprint Evaluating potential for whole-genome studies in Kosrae, an isolated population in Micronesia
    Penelope E Bonnen
    Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Genet 38:214-7. 2006
    ..The long-range LD around common alleles and limited diversity result in improved efficiency in genetic studies in this population and augments the power to detect association of 'hidden SNPs'...
  38. ncbi request reprint Cytokine-induced patterns of gene expression in skeletal muscle tissue
    Tamar Alon
    Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 278:32324-34. 2003
    ....
  39. pmc Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans
    Wolfgang Liedtke
    Laboratory of Molecular Genetics, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:14531-6. 2003
    ..These results provide evidence that TRPV4 can function as a component of an osmotic/mechanical sensor in vivo...
  40. pmc Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis
    Kivanc Birsoy
    Laboratory of Molecular Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Development 138:4709-19. 2011
    ....
  41. ncbi request reprint Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss
    Paul Cohen
    Laboratory of Molecular Genetics, Center for Studies in Physics and Biology, Rogosin Institute, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 297:240-3. 2002
    ..These findings suggest that down-regulation of SCD-1 is an important component of leptin's metabolic actions...
  42. pmc Leptin at 14 y of age: an ongoing story
    Jeffrey M Friedman
    Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, Campus Box 305, New York, NY 10065, USA
    Am J Clin Nutr 89:973S-979S. 2009
    ..When fat mass increases, leptin concentrations increase, which suppresses appetite until weight is lost. This system maintains homeostatic control of adipose tissue mass...
  43. ncbi request reprint The function of leptin in nutrition, weight, and physiology
    Jeffrey M Friedman
    Rockefeller University, New York, New York 10021 6399, USA
    Nutr Rev 60:S1-14; discussion S68-84, 85-7. 2002
    ..Further studies of leptin, its receptor, and the molecular components of this system are likely to have a major impact on our understanding of obesity and the interplay between nutrition and physiology...
  44. pmc Abnormal osmotic regulation in trpv4-/- mice
    Wolfgang Liedtke
    Laboratory of Molecular Genetics and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:13698-703. 2003
    ..These data indicate that TRPV4 is necessary for the normal response to changes in osmotic pressure and functions as an osmotic sensor in the CNS...
  45. ncbi request reprint Phytosterolemia on the island of Kosrae: founder effect for a novel ABCG8 mutation results in high carrier rate and increased plasma plant sterol levels
    Ephraim Sehayek
    Laboratories of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY, USA
    J Lipid Res 45:1608-13. 2004
    ..The latter finding suggests that heterozygosity for a mutated ABCG8 allele results in a modest increase in dietary cholesterol absorption and a decrease in cholesterol biosynthesis...
  46. doi request reprint Site-specific (18)F-labeling of the protein hormone leptin using a general two-step ligation procedure
    Robert R Flavell
    Laboratory of Synthetic Protein Chemistry, Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10065, USA
    J Am Chem Soc 130:9106-12. 2008
    ..These protocols will allow for the routine production of site-specifically (18)F radiolabeled leptin, as well as other proteins, for use in PET imaging in systems from mouse to man...
  47. ncbi request reprint Krüppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1
    Dan Li
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 280:26941-52. 2005
    ....
  48. ncbi request reprint Candidate genes involved in cardiovascular risk factors by a family-based association study on the island of Kosrae, Federated States of Micronesia
    Zhihua Han
    Starr Center Human Genetics, Rockefeller University, New York, New York 10021, USA
    Am J Med Genet 110:234-42. 2002
    ..We further confirmed the connection between the apo AII gene and Tg level by a nonparametric linkage analysis. We therefore conclude that many of these candidate genes may play a significant role in susceptibility to heart disease...
  49. ncbi request reprint Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter
    Hongyan Liu
    Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 23:7143-54. 2003
    ..The transgenic mouse line should be useful for future studies on the role of melanocortin signaling in regulating feeding behavior and autonomic homeostasis...
  50. ncbi request reprint Serotonin reciprocally regulates melanocortin neurons to modulate food intake
    Lora K Heisler
    Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, Cambridge, CB2 2QQ, United Kingdom
    Neuron 51:239-49. 2006
    ....
  51. pmc A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2
    Anna Coppola
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell Metab 5:21-33. 2007
    ..These results reveal a physiological role for a thyroid-hormone-regulated mitochondrial uncoupling in hypothalamic neuronal networks...
  52. ncbi request reprint Regulation of T cell-mediated hepatic inflammation by adiponectin and leptin
    Joseph A Sennello
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Endocrinology 146:2157-64. 2005
    ..In conclusion, although leptin increases susceptibility to hepatotoxicity by regulating cytokine production and T cell activation, adiponectin protects hepatocytes from TNF alpha-induced death...
  53. pmc Acute leptin deficiency, leptin resistance, and the physiologic response to leptin withdrawal
    Jason M Montez
    Chromocell Corporation, 675 US Highway One, North Brunswick, NJ 08902 USA
    Proc Natl Acad Sci U S A 102:2537-42. 2005
    ....
  54. pmc Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity
    James M Ntambi
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 99:11482-6. 2002
    ..These observations suggest that a consequence of SCD1 deficiency is an activation of lipid oxidation in addition to reduced triglyceride synthesis and storage...
  55. ncbi request reprint Identification of cathepsin K as a novel marker of adiposity in white adipose tissue
    Chiara Chiellini
    Department of Endocrinology and Metabolism, University of Pisa, Ospedale di Cisanello, Pisa, Italy
    J Cell Physiol 195:309-21. 2003
    ..In conclusion, the WAT of obese db/db mice exhibits a different expression profile from that of the wt mice, and cathepsin K can be considered a novel marker of obesity and a target for the inhibition of adipose mass growth...
  56. ncbi request reprint The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
    Michael A Cowley
    The Vollum Institute, Oregon Health and Science University, Portland, OR 97201, USA
    Neuron 37:649-61. 2003
    ..We propose that at these sites, release of ghrelin may stimulate the release of orexigenic peptides and neurotransmitters, thus representing a novel regulatory circuit controlling energy homeostasis...
  57. ncbi request reprint Obesity modulates the expression of haptoglobin in the white adipose tissue via TNFalpha
    Chiara Chiellini
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Cell Physiol 190:251-8. 2002
    ..These results demonstrate that haptoglobin expression in WAT is increased in obesity in rodents and TNFalpha is an important signal for this regulation...
  58. ncbi request reprint Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 278:33904-11. 2003
    ..The current studies identify a novel heart-specific SCD isoform that demonstrates tissue-specific regulation by leptin and dietary factors...
  59. pmc Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver
    Pawel Dobrzyn
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 101:6409-14. 2004
    ..001) thereby stimulating the oxidation of mitochondrial palmitoyl-CoA. Our results identify AMPK as a mediator of increased fatty acid oxidation in liver of SCD1-deficient mice...
  60. ncbi request reprint Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle
    Agnieszka Dobrzyn
    Dept of Biochemistry, Univ of Wisconsin, 433 Babcock Dr, Madison, WI 53706, USA
    Am J Physiol Endocrinol Metab 288:E599-607. 2005
    ..Taken together, these results indicate that SCD1 deficiency reduces ceramide synthesis by decreasing SPT expression and increasing the rate of beta-oxidation in oxidative muscles...
  61. ncbi request reprint Neuropeptide Y Y1 receptor mRNA in rodent brain: distribution and colocalization with melanocortin-4 receptor
    Toshiro Kishi
    Department of Neurology, Beth Israel Deaconess Medical Center, and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 482:217-43. 2005
    ..These observations are consistent with the proposed roles of the central NPY/Y1-R system in energy homeostasis...
  62. pmc Characterization of a novel binding partner of the melanocortin-4 receptor: attractin-like protein
    Andrea M Haqq
    Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Biochem J 376:595-605. 2003
    ....