J M Friedman

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi request reprint Leptin and the regulation of body weight in mammals
    J M Friedman
    Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
    Nature 395:763-70. 1998
  2. ncbi request reprint Microdissection and microcloning of mid-chromosome 4: genetic mapping of 41 microdissection clones
    N Bahary
    Laboratory of Molecular Genetics, Rockefeller University, New York, New York 10021
    Genomics 16:113-22. 1993
  3. pmc Abnormal regulation of the leptin gene in the pathogenesis of obesity
    E Ioffe
    Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 95:11852-7. 1998
  4. ncbi request reprint Positional cloning of the mouse obese gene and its human homologue
    Y Zhang
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
    Nature 372:425-32. 1994
  5. pmc Selective deletion of leptin receptor in neurons leads to obesity
    P Cohen
    Laboratory of Molecular Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    J Clin Invest 108:1113-21. 2001
  6. ncbi request reprint Distinct transcriptional profiles of adipogenesis in vivo and in vitro
    A Soukas
    Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 276:34167-74. 2001
  7. ncbi request reprint Microdissection of proximal mouse chromosome 6: identification of RFLPs tightly linked to the ob mutation
    N Bahary
    Laboratory of Molecular Genetics, Rockefeller University, New York, New York 10021
    Mamm Genome 4:511-5. 1993
  8. ncbi request reprint Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice
    C Vaisse
    Laboratory of Metabolic Diseases, Rockefeller University, New York, New York 10021, USA
    Nat Genet 14:95-7. 1996
  9. ncbi request reprint Absence of soluble leptin receptor in plasma from dbPas/dbPas and other db/db mice
    C Li
    Howard Hughes Medical Institute, New York, New York 10021, USA
    J Biol Chem 273:10078-82. 1998
  10. ncbi request reprint Virus-assisted mapping of neural inputs to a feeding center in the hypothalamus
    J DeFalco
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Science 291:2608-13. 2001

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Leptin and the regulation of body weight in mammals
    J M Friedman
    Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
    Nature 395:763-70. 1998
    ..Leptin also signals nutritional status to several other physiological systems and modulates their function. Here we review the role of leptin in the control of body weight and its relevance to the pathogenesis of obesity...
  2. ncbi request reprint Microdissection and microcloning of mid-chromosome 4: genetic mapping of 41 microdissection clones
    N Bahary
    Laboratory of Molecular Genetics, Rockefeller University, New York, New York 10021
    Genomics 16:113-22. 1993
    ....
  3. pmc Abnormal regulation of the leptin gene in the pathogenesis of obesity
    E Ioffe
    Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 95:11852-7. 1998
    ..In aggregate these data suggest that dysregulation of leptin gene can result in obesity with relatively normal levels of leptin and that this form of obesity is responsive to leptin treatment...
  4. ncbi request reprint Positional cloning of the mouse obese gene and its human homologue
    Y Zhang
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
    Nature 372:425-32. 1994
    ..The ob gene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot...
  5. pmc Selective deletion of leptin receptor in neurons leads to obesity
    P Cohen
    Laboratory of Molecular Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    J Clin Invest 108:1113-21. 2001
    ..In summary, these data suggest that the brain is a direct target for the weight-reducing and neuroendocrine effects of leptin and that the liver abnormalities of db/db mice are secondary to defective leptin signaling in the brain...
  6. ncbi request reprint Distinct transcriptional profiles of adipogenesis in vivo and in vitro
    A Soukas
    Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 276:34167-74. 2001
    ..This gene expression survey now sets the stage for further studies to dissect the molecular differences between in vivo and in vitro adipocytes...
  7. ncbi request reprint Microdissection of proximal mouse chromosome 6: identification of RFLPs tightly linked to the ob mutation
    N Bahary
    Laboratory of Molecular Genetics, Rockefeller University, New York, New York 10021
    Mamm Genome 4:511-5. 1993
    ..Recombinants were then typed for D6Rck13. D6Rck13 was nonrecombinant among all the progency of both crosses corresponding to 831 meioses. This probe will be of use as an entry point for physical mapping of the ob mutation...
  8. ncbi request reprint Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice
    C Vaisse
    Laboratory of Metabolic Diseases, Rockefeller University, New York, New York 10021, USA
    Nat Genet 14:95-7. 1996
    ..This is the first in vivo demonstration of leptin signal transduction...
  9. ncbi request reprint Absence of soluble leptin receptor in plasma from dbPas/dbPas and other db/db mice
    C Li
    Howard Hughes Medical Institute, New York, New York 10021, USA
    J Biol Chem 273:10078-82. 1998
    ..This mutation introduces a premature stop codon into the protein at amino acid 281. The absence of Ob-R in db3J/db3J and dbPas/dbPas mice confirm the identify of the 120-kDa plasma protein as Ob-Re...
  10. ncbi request reprint Virus-assisted mapping of neural inputs to a feeding center in the hypothalamus
    J DeFalco
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Science 291:2608-13. 2001
    ..These data suggest that higher cortical centers modulate leptin signaling in the hypothalamus. This method of neural tracing may prove useful in studies of other complex neural circuits...
  11. ncbi request reprint Weight-reducing effects of the plasma protein encoded by the obese gene
    J L Halaas
    Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockfeller University, New York, NY 10021, USA
    Science 269:543-6. 1995
    ..2 to 0.7 percent. These data suggest that the OB protein serves an endocrine function to regulate body fat stores...
  12. pmc Leptin-specific patterns of gene expression in white adipose tissue
    A Soukas
    Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021, USA
    Genes Dev 14:963-80. 2000
    ..Future studies of the molecular basis for the apparent coordinate regulation of the other clusters of leptin-regulated genes may reveal additional mechanisms by which leptin exerts its weight-reducing effects...
  13. ncbi request reprint Abnormal splicing of the leptin receptor in diabetic mice
    G H Lee
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
    Nature 379:632-5. 1996
    ..This suggests that the weight-reducing effects of leptin may be mediated by signal transduction through a leptin receptor in the hypothalamus...
  14. ncbi request reprint The molecular basis of the obese mutation in ob2J mice
    B C Moon
    Department of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
    Genomics 42:152-6. 1997
    ..This leads to the production of chimeric RNAs in which the ob first exon is spliced to sequences in the ETn insertion. As a consequence mature ob RNA is not synthesized, and leptin, the encoded protein, is not produced...
  15. ncbi request reprint Leptin receptor mutations in 129 db3J/db3J mice and NIH facp/facp rats
    G Lee
    Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, Box 305, New York, NY 10021, USA
    Mamm Genome 8:445-7. 1997
  16. pmc Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
    H Fei
    Laboratory of Molecular Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 94:7001-5. 1997
    ..The obesity in GTG-treated mice is likely to be caused by ablation of Ob-Rb-expressing neurons, which results in leptin resistance...
  17. pmc Molecular mapping of the mouse db mutation
    N Bahary
    Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021
    Proc Natl Acad Sci U S A 87:8642-6. 1990
    ....
  18. pmc Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus
    M Maffei
    Laboratory of Molecular Genetics, Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 92:6957-60. 1995
    ..The molecules that regulate expression level of the ob gene in adipocytes probably are important in determining body weight, as are the molecules that mediate the effects of ob at its site of action...
  19. ncbi request reprint Level of expression and chromosome mapping of the mouse cholecystokinin gene: implications for murine models of genetic obesity
    J M Friedman
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
    Genomics 5:463-9. 1989
    ....
  20. ncbi request reprint Molecular mapping of obesity genes
    J M Friedman
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
    Mamm Genome 1:130-44. 1991
    ....
  21. pmc Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
    J L Halaas
    Laboratory of Molecular Genetics, The Rockefeller University, 1230 York Avenue, New York, NY, 10021, USA
    Proc Natl Acad Sci U S A 94:8878-83. 1997
    ..In NZO mice, leptin resistance may be the result of decreased transport of leptin into the cerebrospinal fluid, whereas in Ay mice, leptin resistance probably results from defects downstream of the leptin receptor in the hypothalamus...
  22. pmc Microsatellite marker content mapping of 12 candidate genes for obesity: assembly of seven obesity screening panels for automated genotyping
    J D Winick
    Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021 USA
    Genome Res 8:985-94. 1998
    ..These resources will be of use in studies to identify the genetic factors responsible for human obesity. [Figures are available at http://www.genome.org]..
  23. pmc Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction
    C Li
    Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY, USA
    Proc Natl Acad Sci U S A 96:9677-82. 1999
    ..The method used in this report can in principle be used to isolate additional components of the leptin, or other, signal transduction pathway...
  24. ncbi request reprint Epidemiology and factor analysis of obesity, type II diabetes, hypertension, and dyslipidemia (syndrome X) on the Island of Kosrae, Federated States of Micronesia
    D Shmulewitz
    Laboratory of Molecular Genetics, Rockefeller University, New York, NY 10021, USA
    Hum Hered 51:8-19. 2001
    ..To further understand the pathogenesis of syndrome X, a comprehensive epidemiological study was undertaken on the Pacific Island of Kosrae, Federated States of Micronesia (FSM)...
  25. ncbi request reprint Identification of microsatellite markers linked to the human leptin receptor gene on chromosome 1
    J D Winick
    Laboratory of Molecular Genetics, The Rockefeller University, 1230 York Avenue, New York, New York, 10021, USA
    Genomics 36:221-2. 1996
  26. ncbi request reprint The mouse Cebp gene encoding a DNA-binding protein is polymorphic and is located on chromosome 7
    K G Xanthopoulos
    Rockefeller University, New York, NY 10021
    Cytogenet Cell Genet 50:174-5. 1989
    ....
  27. pmc Regulation of N-myc gene expression: use of an adenovirus vector to demonstrate posttranscriptional control
    L E Babiss
    Laboratory of Molecular Cell Biology, Rockefeller University, New York, New York 10021 6399
    Mol Cell Biol 10:6700-8. 1990
    ..Finally, we further localized these sequences to a 600-bp fragment of the third exon by introducing various subclones of this sequence downstream of the E1A promoter in both viral and plasmid vectors...
  28. pmc Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipase
    P H Weinstock
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 94:10261-6. 1997
    ..These findings reveal marked alterations in AT metabolism that occur during LPL deficiency and provide strong evidence for a role of AT LPL in one type of genetic obesity...
  29. pmc Low-pass genome-wide sequencing and variant inference using identity-by-descent in an isolated human population
    A Gusev
    Department of Computer Science, Columbia University, New York, New York 10027, USA
    Genetics 190:679-89. 2012
    ..6% and 97.3%, respectively. This study presents whole-genome analysis of a homogenous isolate population with emphasis on optimal rare variant inference...
  30. pmc Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor
    W Liedtke
    Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021, USA
    Cell 103:525-35. 2000
    ..The channel also occurs in other neurosensory cells, including inner-ear hair cells, sensory neurons, and Merkel cells...
  31. ncbi request reprint Molecular mapping of the mouse ob mutation
    J M Friedman
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
    Genomics 11:1054-62. 1991
    ..The homologs of markers that flank ob map to human chromosome 7q, suggesting that if there is a human homologue of ob, it maps to 7q31...
  32. ncbi request reprint Acute intravenous leptin infusion increases glucose turnover but not skeletal muscle glucose uptake in ob/ob mice
    R Burcelin
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Diabetes 48:1264-9. 1999
    ..Insulin resistance of skeletal muscle and WAT, while not affected by acute leptin treatment, could also be corrected in the long term and account for some of leptin's antidiabetic effects...
  33. ncbi request reprint The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7
    E D Green
    Diagnostic Development Branch, National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 5:5-12. 1995
    ....
  34. ncbi request reprint Expression of ob gene in adipose cells. Regulation by insulin
    P Leroy
    Centre de Biochimie UMR 134 CNRS, Universite de Nice Sophia Antipolis, Faculte des Sciences, Nice, France
    J Biol Chem 271:2365-8. 1996
    ..The level of secreted Ob protein is also regulated by insulin. These results indicate that the ob gene is expressed in mature fat cells only and support the possibility that insulin is an important regulator of ob gene expression...
  35. pmc Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation
    J C Yoon
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 20:5343-9. 2000
    ..Alterations in nutrition and leptin administration are found to modulate the PGAR expression in vivo. Taken together, these data suggest a possible role for PGAR in the regulation of systemic lipid metabolism or glucose homeostasis...
  36. pmc Molecular genetics of the brown (b)-locus region of mouse chromosome 4. I. Origin and molecular mapping of radiation- and chemical-induced lethal brown deletions
    E M Rinchik
    Biology Division, Oak Ridge National Laboratory, Tennessee 37831 8077
    Genetics 137:845-54. 1994
    ..The resulting deletion map provides a framework on which to build future molecular-genetic and biological analyses of this region of mouse chromosome 4...