Research Topics
Genomes and Genes
| J M FriedmanSummaryAffiliation: The Rockefeller University Country: USA Publications
| Collaborators
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Detail Information
Publications
Leptin and the regulation of body weight in mammalsJ M Friedman
Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
Nature 395:763-70. 1998..Leptin also signals nutritional status to several other physiological systems and modulates their function. Here we review the role of leptin in the control of body weight and its relevance to the pathogenesis of obesity...- Microdissection and microcloning of mid-chromosome 4: genetic mapping of 41 microdissection clonesN Bahary
Laboratory of Molecular Genetics, Rockefeller University, New York, New York 10021
Genomics 16:113-22. 1993.... 
Abnormal regulation of the leptin gene in the pathogenesis of obesityE Ioffe
Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 95:11852-7. 1998..In aggregate these data suggest that dysregulation of leptin gene can result in obesity with relatively normal levels of leptin and that this form of obesity is responsive to leptin treatment...- Positional cloning of the mouse obese gene and its human homologueY Zhang
Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
Nature 372:425-32. 1994..The ob gene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot... - Selective deletion of leptin receptor in neurons leads to obesityP Cohen
Laboratory of Molecular Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
J Clin Invest 108:1113-21. 2001..In summary, these data suggest that the brain is a direct target for the weight-reducing and neuroendocrine effects of leptin and that the liver abnormalities of db/db mice are secondary to defective leptin signaling in the brain... - Distinct transcriptional profiles of adipogenesis in vivo and in vitroA Soukas
Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021, USA
J Biol Chem 276:34167-74. 2001..This gene expression survey now sets the stage for further studies to dissect the molecular differences between in vivo and in vitro adipocytes... - Microdissection of proximal mouse chromosome 6: identification of RFLPs tightly linked to the ob mutationN Bahary
Laboratory of Molecular Genetics, Rockefeller University, New York, New York 10021
Mamm Genome 4:511-5. 1993..Recombinants were then typed for D6Rck13. D6Rck13 was nonrecombinant among all the progency of both crosses corresponding to 831 meioses. This probe will be of use as an entry point for physical mapping of the ob mutation... - Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db miceC Vaisse
Laboratory of Metabolic Diseases, Rockefeller University, New York, New York 10021, USA
Nat Genet 14:95-7. 1996..This is the first in vivo demonstration of leptin signal transduction... - Absence of soluble leptin receptor in plasma from dbPas/dbPas and other db/db miceC Li
Howard Hughes Medical Institute, New York, New York 10021, USA
J Biol Chem 273:10078-82. 1998..This mutation introduces a premature stop codon into the protein at amino acid 281. The absence of Ob-R in db3J/db3J and dbPas/dbPas mice confirm the identify of the 120-kDa plasma protein as Ob-Re... - Virus-assisted mapping of neural inputs to a feeding center in the hypothalamusJ DeFalco
Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
Science 291:2608-13. 2001..These data suggest that higher cortical centers modulate leptin signaling in the hypothalamus. This method of neural tracing may prove useful in studies of other complex neural circuits... - Weight-reducing effects of the plasma protein encoded by the obese geneJ L Halaas
Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockfeller University, New York, NY 10021, USA
Science 269:543-6. 1995..2 to 0.7 percent. These data suggest that the OB protein serves an endocrine function to regulate body fat stores... - Leptin-specific patterns of gene expression in white adipose tissueA Soukas
Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021, USA
Genes Dev 14:963-80. 2000..Future studies of the molecular basis for the apparent coordinate regulation of the other clusters of leptin-regulated genes may reveal additional mechanisms by which leptin exerts its weight-reducing effects... - Abnormal splicing of the leptin receptor in diabetic miceG H Lee
Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
Nature 379:632-5. 1996..This suggests that the weight-reducing effects of leptin may be mediated by signal transduction through a leptin receptor in the hypothalamus... - The molecular basis of the obese mutation in ob2J miceB C Moon
Department of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
Genomics 42:152-6. 1997..This leads to the production of chimeric RNAs in which the ob first exon is spliced to sequences in the ETn insertion. As a consequence mature ob RNA is not synthesized, and leptin, the encoded protein, is not produced... - Leptin receptor mutations in 129 db3J/db3J mice and NIH facp/facp ratsG Lee
Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, Box 305, New York, NY 10021, USA
Mamm Genome 8:445-7. 1997 - Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissuesH Fei
Laboratory of Molecular Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 94:7001-5. 1997..The obesity in GTG-treated mice is likely to be caused by ablation of Ob-Rb-expressing neurons, which results in leptin resistance... - Molecular mapping of the mouse db mutationN Bahary
Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021
Proc Natl Acad Sci U S A 87:8642-6. 1990.... - Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locusM Maffei
Laboratory of Molecular Genetics, Rockefeller University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 92:6957-60. 1995..The molecules that regulate expression level of the ob gene in adipocytes probably are important in determining body weight, as are the molecules that mediate the effects of ob at its site of action... - Level of expression and chromosome mapping of the mouse cholecystokinin gene: implications for murine models of genetic obesityJ M Friedman
Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
Genomics 5:463-9. 1989.... - Molecular mapping of obesity genesJ M Friedman
Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
Mamm Genome 1:130-44. 1991.... - Physiological response to long-term peripheral and central leptin infusion in lean and obese miceJ L Halaas
Laboratory of Molecular Genetics, The Rockefeller University, 1230 York Avenue, New York, NY, 10021, USA
Proc Natl Acad Sci U S A 94:8878-83. 1997..In NZO mice, leptin resistance may be the result of decreased transport of leptin into the cerebrospinal fluid, whereas in Ay mice, leptin resistance probably results from defects downstream of the leptin receptor in the hypothalamus... - Microsatellite marker content mapping of 12 candidate genes for obesity: assembly of seven obesity screening panels for automated genotypingJ D Winick
Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021 USA
Genome Res 8:985-94. 1998..These resources will be of use in studies to identify the genetic factors responsible for human obesity. [Figures are available at http://www.genome.org].. - Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transductionC Li
Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY, USA
Proc Natl Acad Sci U S A 96:9677-82. 1999..The method used in this report can in principle be used to isolate additional components of the leptin, or other, signal transduction pathway... - Epidemiology and factor analysis of obesity, type II diabetes, hypertension, and dyslipidemia (syndrome X) on the Island of Kosrae, Federated States of MicronesiaD Shmulewitz
Laboratory of Molecular Genetics, Rockefeller University, New York, NY 10021, USA
Hum Hered 51:8-19. 2001..To further understand the pathogenesis of syndrome X, a comprehensive epidemiological study was undertaken on the Pacific Island of Kosrae, Federated States of Micronesia (FSM)... - Identification of microsatellite markers linked to the human leptin receptor gene on chromosome 1J D Winick
Laboratory of Molecular Genetics, The Rockefeller University, 1230 York Avenue, New York, New York, 10021, USA
Genomics 36:221-2. 1996 - The mouse Cebp gene encoding a DNA-binding protein is polymorphic and is located on chromosome 7K G Xanthopoulos
Rockefeller University, New York, NY 10021
Cytogenet Cell Genet 50:174-5. 1989.... - Regulation of N-myc gene expression: use of an adenovirus vector to demonstrate posttranscriptional controlL E Babiss
Laboratory of Molecular Cell Biology, Rockefeller University, New York, New York 10021 6399
Mol Cell Biol 10:6700-8. 1990..Finally, we further localized these sequences to a 600-bp fragment of the third exon by introducing various subclones of this sequence downstream of the E1A promoter in both viral and plasmid vectors... - Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipaseP H Weinstock
Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 94:10261-6. 1997..These findings reveal marked alterations in AT metabolism that occur during LPL deficiency and provide strong evidence for a role of AT LPL in one type of genetic obesity... - Low-pass genome-wide sequencing and variant inference using identity-by-descent in an isolated human populationA Gusev
Department of Computer Science, Columbia University, New York, New York 10027, USA
Genetics 190:679-89. 2012..6% and 97.3%, respectively. This study presents whole-genome analysis of a homogenous isolate population with emphasis on optimal rare variant inference... - Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptorW Liedtke
Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021, USA
Cell 103:525-35. 2000..The channel also occurs in other neurosensory cells, including inner-ear hair cells, sensory neurons, and Merkel cells... - Molecular mapping of the mouse ob mutationJ M Friedman
Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
Genomics 11:1054-62. 1991..The homologs of markers that flank ob map to human chromosome 7q, suggesting that if there is a human homologue of ob, it maps to 7q31... - Acute intravenous leptin infusion increases glucose turnover but not skeletal muscle glucose uptake in ob/ob miceR Burcelin
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Diabetes 48:1264-9. 1999..Insulin resistance of skeletal muscle and WAT, while not affected by acute leptin treatment, could also be corrected in the long term and account for some of leptin's antidiabetic effects... - The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7E D Green
Diagnostic Development Branch, National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892, USA
Genome Res 5:5-12. 1995.... - Expression of ob gene in adipose cells. Regulation by insulinP Leroy
Centre de Biochimie UMR 134 CNRS, Universite de Nice Sophia Antipolis, Faculte des Sciences, Nice, France
J Biol Chem 271:2365-8. 1996..The level of secreted Ob protein is also regulated by insulin. These results indicate that the ob gene is expressed in mature fat cells only and support the possibility that insulin is an important regulator of ob gene expression... - Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiationJ C Yoon
Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Cell Biol 20:5343-9. 2000..Alterations in nutrition and leptin administration are found to modulate the PGAR expression in vivo. Taken together, these data suggest a possible role for PGAR in the regulation of systemic lipid metabolism or glucose homeostasis... - Molecular genetics of the brown (b)-locus region of mouse chromosome 4. I. Origin and molecular mapping of radiation- and chemical-induced lethal brown deletionsE M Rinchik
Biology Division, Oak Ridge National Laboratory, Tennessee 37831 8077
Genetics 137:845-54. 1994..The resulting deletion map provides a framework on which to build future molecular-genetic and biological analyses of this region of mouse chromosome 4...