Martin Friedlander

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Astrocyte pVHL and HIF-α isoforms are required for embryonic-to-adult vascular transition in the eye
    Toshihide Kurihara
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 195:689-701. 2011
  2. pmc Differential macrophage polarization promotes tissue remodeling and repair in a model of ischemic retinopathy
    Valentina Marchetti
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA, USA
    Sci Rep 1:76. 2011
  3. ncbi request reprint Combination angiostatic therapies: targeting multiple angiogenic pathways
    Martin Friedlander
    Department of Cell Biology, Scripps Research Institute and Retina Services, Division of Ophthalmology, Scripps Clinic, La Jolla, California, USA
    Retina 29:S27-9. 2009
  4. pmc Fibrosis and diseases of the eye
    Martin Friedlander
    Department of Cell Biology, The Scripps Research Institute, and Division of Ophthalmology, Scripps Clinic, La Jolla, CA 92037, USA
    J Clin Invest 117:576-86. 2007
  5. ncbi request reprint Progenitor cells and retinal angiogenesis
    Martin Friedlander
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92014, USA
    Angiogenesis 10:89-101. 2007
  6. pmc Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina
    Alexander Weidemann
    Division of Biology, University of California, San Diego, La Jolla, California 92093, USA
    Glia 58:1177-85. 2010
  7. pmc A human aminoacyl-tRNA synthetase as a regulator of angiogenesis
    Keisuke Wakasugi
    The Skaggs Institute for Chemical Biology and Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:173-7. 2002
  8. pmc Maintaining retinal astrocytes normalizes revascularization and prevents vascular pathology associated with oxygen-induced retinopathy
    Michael I Dorrell
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Glia 58:43-54. 2010
  9. pmc Myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy
    Matthew R Ritter
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Clin Invest 116:3266-76. 2006
  10. ncbi request reprint T2-TrpRS inhibits preretinal neovascularization and enhances physiological vascular regrowth in OIR as assessed by a new method of quantification
    Eyal Banin
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Invest Ophthalmol Vis Sci 47:2125-34. 2006

Research Grants

  1. INTEGRINS AND OCULAR ANGIOGENESIS
    Martin Friedlander; Fiscal Year: 2010
  2. INTEGRINS AND OCULAR ANGIOGENESIS
    Martin Friedlander; Fiscal Year: 2007
  3. Fragments of TrpRS to Treat Neovascular Eye Diseases
    Martin Friedlander; Fiscal Year: 2006
  4. INTEGRINS AND OCULAR ANGIOGENESIS
    Martin Friedlander; Fiscal Year: 2000
  5. INTEGRINS AND OCULAR ANGIOGENESIS
    Martin Friedlander; Fiscal Year: 1999
  6. INTEGRINS AND OCULAR ANGIOGENESIS
    Martin Friedlander; Fiscal Year: 2009
  7. CORE GRANT FOR VISION RESEARCH
    Martin Friedlander; Fiscal Year: 2005
  8. INTEGRINS AND OCULAR ANGIOGENESIS
    Martin Friedlander; Fiscal Year: 2003
  9. INTEGRINS AND OCULAR ANGIOGENESIS
    Martin Friedlander; Fiscal Year: 2001
  10. INTEGRINS AND OCULAR ANGIOGENESIS
    Martin Friedlander; Fiscal Year: 2007

Collaborators

Detail Information

Publications43

  1. pmc Astrocyte pVHL and HIF-α isoforms are required for embryonic-to-adult vascular transition in the eye
    Toshihide Kurihara
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 195:689-701. 2011
    ..The phenotype observed in Vhl mutants strongly resembles human persistent hyperplastic primary vitreous cases and may provide insights into vascular remodeling mechanisms in other systems...
  2. pmc Differential macrophage polarization promotes tissue remodeling and repair in a model of ischemic retinopathy
    Valentina Marchetti
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA, USA
    Sci Rep 1:76. 2011
    ..This leads to stabilization of the ischemia-injured retinal vasculature by modulating the inflammatory response, reducing oxidative stress and apoptosis and promoting tissue repair...
  3. ncbi request reprint Combination angiostatic therapies: targeting multiple angiogenic pathways
    Martin Friedlander
    Department of Cell Biology, Scripps Research Institute and Retina Services, Division of Ophthalmology, Scripps Clinic, La Jolla, California, USA
    Retina 29:S27-9. 2009
    ..For the prevention of new blood vessel formation in neovascular eye diseases like age-related macular degeneration, the experimental evidence supports combination therapies that inhibit more than one molecular pathway...
  4. pmc Fibrosis and diseases of the eye
    Martin Friedlander
    Department of Cell Biology, The Scripps Research Institute, and Division of Ophthalmology, Scripps Clinic, La Jolla, CA 92037, USA
    J Clin Invest 117:576-86. 2007
    ..The recent development of progenitor and/or stem cell technologies holds promise for the treatment of currently incurable ocular diseases...
  5. ncbi request reprint Progenitor cells and retinal angiogenesis
    Martin Friedlander
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92014, USA
    Angiogenesis 10:89-101. 2007
    ..Such a therapeutic approach would obviate the need to employ destructive treatment modalities and would facilitate vascularization of ischemic and otherwise damaged retinal tissue...
  6. pmc Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina
    Alexander Weidemann
    Division of Biology, University of California, San Diego, La Jolla, California 92093, USA
    Glia 58:1177-85. 2010
    ..Thus, we demonstrate that astrocytes in the retina have highly divergent roles during developmental, physiological angiogenesis, and ischemia-driven, pathological neovascularization...
  7. pmc A human aminoacyl-tRNA synthetase as a regulator of angiogenesis
    Keisuke Wakasugi
    The Skaggs Institute for Chemical Biology and Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:173-7. 2002
    ..The full-length enzyme is inactive in the same assays. Thus, protein synthesis may be linked to the regulation of angiogenesis by a natural fragment of TrpRS...
  8. pmc Maintaining retinal astrocytes normalizes revascularization and prevents vascular pathology associated with oxygen-induced retinopathy
    Michael I Dorrell
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Glia 58:43-54. 2010
    ..Methods developed to target and protect glial cells may provide a novel strategy by which normalized revascularization can be promoted and the consequences of abnormal NV in retinal vascular diseases can be prevented...
  9. pmc Myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy
    Matthew R Ritter
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Clin Invest 116:3266-76. 2006
    ..These findings suggest what we believe to be a novel therapeutic approach for the treatment of ischemic retinopathies that promotes vascular repair rather than destruction...
  10. ncbi request reprint T2-TrpRS inhibits preretinal neovascularization and enhances physiological vascular regrowth in OIR as assessed by a new method of quantification
    Eyal Banin
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Invest Ophthalmol Vis Sci 47:2125-34. 2006
    ..The effects of T2-TrpRS on pathologic neovascularization were tested and compared with a potent VEGF antagonist using the mouse model of oxygen-induced retinopathy (OIR)...
  11. ncbi request reprint Role of protease activated receptor 1 and 2 signaling in hypoxia-induced angiogenesis
    Hannele Uusitalo-Jarvinen
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Arterioscler Thromb Vasc Biol 27:1456-62. 2007
    ..The TF-VIIa complex also directly cleaves PAR2 and promotes angiogenesis in vitro in TF cytoplasmic domain-deleted (TF(deltaCT)) mice. Here we address the effect of PAR1 and PAR2 deficiency on angiogenesis in vivo...
  12. ncbi request reprint Adult bone marrow-derived stem cells use R-cadherin to target sites of neovascularization in the developing retina
    Michael I Dorrell
    Departmentof Cell BIology, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 103:3420-7. 2004
    ..Thus, R-cadherin antagonists may be useful in the treatment of neovascular diseases in which circulating HSCs contribute to abnormal angiogenesis...
  13. ncbi request reprint Three-dimensional in vivo imaging of the mouse intraocular vasculature during development and disease
    Matthew R Ritter
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Invest Ophthalmol Vis Sci 46:3021-6. 2005
    ....
  14. pmc Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress
    Michael I Dorrell
    Department of Cell Biology, Scripps Center for Mass Spectrometry, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 119:611-23. 2009
    ....
  15. doi request reprint Chapter 6. Ocular models of angiogenesis
    Edith Aguilar
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA
    Methods Enzymol 444:115-58. 2008
    ..This chapter will outline several protocols used to study ocular angiogenesis, put the protocols into brief historical context, and describe some of the questions for which these protocols are commonly used...
  16. pmc Rescue of retinal degeneration by intravitreally injected adult bone marrow-derived lineage-negative hematopoietic stem cells
    Atsushi Otani
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 114:765-74. 2004
    ....
  17. ncbi request reprint Retinal vascular development is mediated by endothelial filopodia, a preexisting astrocytic template and specific R-cadherin adhesion
    Michael I Dorrell
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Invest Ophthalmol Vis Sci 43:3500-10. 2002
    ..Since most diseases that cause catastrophic loss of vision do so as a result of abnormal ocular angiogenesis, a better understanding of events regulating normal retinal vascular growth may provide insight into pathologic angiogenesis...
  18. pmc Generation of retinal pigment epithelial cells from small molecules and OCT4 reprogrammed human induced pluripotent stem cells
    Tim U Krohne
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Stem Cells Transl Med 1:96-109. 2012
    ....
  19. ncbi request reprint Bone marrow-derived stem cells target retinal astrocytes and can promote or inhibit retinal angiogenesis
    Atsushi Otani
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA
    Nat Med 8:1004-10. 2002
    ..Selective targeting with Lin(-) HSC may be a useful therapeutic approach for the treatment of many ocular diseases...
  20. pmc Targeted deletion of Vegfa in adult mice induces vision loss
    Toshihide Kurihara
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 122:4213-7. 2012
    ..Targeting factors upstream of VEGF, such as HIFs, may be therapeutically advantageous compared with more potent and selective VEGF antagonists, which may have more off-target inhibitory trophic effects...
  21. pmc Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits
    Lea Scheppke
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 118:2337-46. 2008
    ....
  22. pmc Combination angiostatic therapy completely inhibits ocular and tumor angiogenesis
    Michael I Dorrell
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:967-72. 2007
    ....
  23. pmc Myeloid cells in infantile hemangioma
    Matthew R Ritter
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Am J Pathol 168:621-8. 2006
    ..We report the results of experiments using myeloid markers (CD83, CD32, CD14, CD15) that unexpectedly co-labeled hemangioma endothelial cells, providing new evidence that these cells are distinct from normal endothelium...
  24. pmc Stemming vision loss with stem cells
    Valentina Marchetti
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA
    J Clin Invest 120:3012-21. 2010
    ....
  25. pmc A fragment of human TrpRS as a potent antagonist of ocular angiogenesis
    Atsushi Otani
    Department of Cell Biology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:178-83. 2002
    ..These results suggest that fragments of TrpRS, as naturally occurring and potentially nonimmunogenic anti-angiogenics, can be used for the treatment of neovascular eye diseases...
  26. pmc A homing mechanism for bone marrow-derived progenitor cell recruitment to the neovasculature
    Hui Jin
    Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California 92093 0819, USA
    J Clin Invest 116:652-62. 2006
    ..These studies describe an adhesion event that facilitates the homing of progenitor cells to the neovasculature...
  27. ncbi request reprint Global gene expression analysis of the developing postnatal mouse retina
    Michael I Dorrell
    Departments of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Invest Ophthalmol Vis Sci 45:1009-19. 2004
    ..In the current study, the gene expression profiles of thousands of genes in the developing postnatal mouse retina were analyzed and compared in a large-scale, unbiased microarray gene expression analysis...
  28. ncbi request reprint Regulation of angiogenesis by tissue factor cytoplasmic domain signaling
    Mattias Belting
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Med 10:502-9. 2004
    ..Targeting the TF-VIIa signaling pathway may thus enhance the efficacy of angiostatic treatments for cancer and neovascular eye diseases...
  29. ncbi request reprint Endothelial proliferation in diabetic retinal microaneurysms
    Edith Aguilar
    Scripps Research Institute, La Jolla, CA 92037, USA
    Arch Ophthalmol 121:740-1. 2003
  30. ncbi request reprint Identifying potential regulators of infantile hemangioma progression through large-scale expression analysis: a possible role for the immune system and indoleamine 2,3 dioxygenase (IDO) during involution
    Matthew R Ritter
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Lymphat Res Biol 1:291-9. 2003
    ..We also demonstrate that proliferating hemangiomas express indoleamine 2,3 dioxygenase (IDO) and discuss a possible mechanism that accounts for the often slow regression of these lesions...
  31. pmc Using flow cytometry to compare the dynamics of photoreceptor outer segment phagocytosis in iPS-derived RPE cells
    Peter D Westenskow
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA
    Invest Ophthalmol Vis Sci 53:6282-90. 2012
    ..One important and required function is that the iPS-RPE phagocytose photoreceptor outer segments (POS)...
  32. ncbi request reprint Ocular neovascularization: basic mechanisms and therapeutic advances
    Michael Dorrell
    Department of Cell Biology, The Scripps Research Institute, Department of Ophthalmology, Scripps Clinic, La Jolla, California 92014, USA
    Surv Ophthalmol 52:S3-19. 2007
    ..We will describe compounds currently in pre-clinical development stages as well as the results of clinical trials involving the use of these drugs as treatments for ocular neovascularization...
  33. ncbi request reprint Pathogenesis of infantile haemangioma: new molecular and cellular insights
    Matthew R Ritter
    The Scripps Research Institute, Department of Cell Biology, La Jolla, CA, USA
    Expert Rev Mol Med 9:1-19. 2007
    ..While no single hypothesis seems to describe all features of infantile haemangioma, continued research seeks to integrate these ideas, create a better understanding of these important tumours and bring new treatments to the clinic...
  34. pmc Insulin-like growth factor 2 and potential regulators of hemangioma growth and involution identified by large-scale expression analysis
    Matthew R Ritter
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:7455-60. 2002
    ..These studies identify potential regulators of hemangioma growth and involution and provide a foundation on which to build further mechanistic investigations into angiogenesis, using hemangiomas as a model...
  35. ncbi request reprint Mechanisms of endothelial cell guidance and vascular patterning in the developing mouse retina
    Michael I Dorrell
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd MB216, La Jolla, CA 92037, USA
    Prog Retin Eye Res 25:277-95. 2006
    ....
  36. ncbi request reprint Recent progress in our understanding of the pathogenesis of infantile hemangiomas
    Sheila Fallon Friedlander
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA
    Lymphat Res Biol 3:219-25. 2005
  37. ncbi request reprint In vivo transduction of photoreceptors or ciliary body by intravitreal injection of pseudotyped adenoviral vectors
    Dan J Von Seggern
    Department of Immunology The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Ther 7:27-34. 2003
    ..These studies demonstrate cell type-selective gene delivery in vivo with retargeted Ads, provide information about the cellular tropisms of several Ad serotypes, and should lead to improved strategies for preserving vision...
  38. ncbi request reprint Hypoxia-inducible factor (HIF)/vascular endothelial growth factor (VEGF) signaling in the retina
    Toshihide Kurihara
    Department of Cell and Molecular Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd La Jolla, 92014, San Diego, CA, USA
    Adv Exp Med Biol 801:275-81. 2014
    ..Here we discuss recent findings from our lab and others that define roles of the HIF-VEGF axis in the retina. ..
  39. ncbi request reprint Utilizing stem cell-derived RPE cells as a therapeutic intervention for age-related macular degeneration
    Peter D Westenskow
    Department of Cell Biology, The Scripps Research Institute, MB 216, 10550 N Torrey Pines Rd, 92014, La Jolla, CA, USA
    Adv Exp Med Biol 801:323-9. 2014
    ..We will also discuss some of the prevailing concerns and challenges associated with this technique...
  40. ncbi request reprint Retinal vascular regeneration
    Atsushi Otani
    Kyoto University, Japan
    Semin Ophthalmol 20:43-50. 2005
    ..Nonetheless, potential toxicities and unregulated cell growth will need to be carefully evaluated before this approach is brought to the clinics...
  41. ncbi request reprint Loss of p53 compensates for alpha v-integrin function in retinal neovascularization
    Staffan Stromblad
    Department of Microbiology, Pathology, and Immunology, Karolinska Institutet, 141 86 Huddinge, Sweden
    J Biol Chem 277:13371-4. 2002
    ..In conclusion, we demonstrate for the first time an in vivo intracellular mechanism for compensation of integrin function and that p53 and alpha(v)-integrins act in concert during retinal neovascularization...
  42. pmc The National Eye Institute Visual Function Questionnaire in the Macular Telangiectasia (MacTel) Project
    Traci E Clemons
    The EMMES Corporation, Rockville, Maryland 20850 1707, USA
    Invest Ophthalmol Vis Sci 49:4340-6. 2008
    ....
  43. ncbi request reprint Mouse model of subretinal neovascularization with choroidal anastomosis
    John R Heckenlively
    Jules Stein Eye Institute, UCLA School of Medicine, University of California at Los Angeles, 100 Stein Plaza, Los Angeles, CA 90095, USA
    Retina 23:518-22. 2003
    ..To characterize the phenotype and report a reliable genetic model of retinal angiogenesis and subretinal neovascularization in the mouse...

Research Grants22

  1. INTEGRINS AND OCULAR ANGIOGENESIS
    Martin Friedlander; Fiscal Year: 2010
    ..These studies will provide insights into mechanisms of angiogenesis that will be useful for the prevention and treatment of neovascular eye diseases. ..
  2. INTEGRINS AND OCULAR ANGIOGENESIS
    Martin Friedlander; Fiscal Year: 2007
    ..These studies will provide insights into mechanisms of angiogenesis that will be useful for the prevention and treatment of neovascular eye diseases. ..
  3. Fragments of TrpRS to Treat Neovascular Eye Diseases
    Martin Friedlander; Fiscal Year: 2006
    ..abstract_text> ..
  4. INTEGRINS AND OCULAR ANGIOGENESIS
    Martin Friedlander; Fiscal Year: 2000
    ..Such an approach will provide a rational basis for the development of therapeutics useful in inhibiting ocular angiogenesis. ..
  5. INTEGRINS AND OCULAR ANGIOGENESIS
    Martin Friedlander; Fiscal Year: 1999
    ..Such an approach will provide a rational basis for the development of therapeutics useful in inhibiting ocular angiogenesis. ..
  6. INTEGRINS AND OCULAR ANGIOGENESIS
    Martin Friedlander; Fiscal Year: 2009
    ..These studies will provide insights into mechanisms of angiogenesis that will be useful for the prevention and treatment of neovascular eye diseases. ..
  7. CORE GRANT FOR VISION RESEARCH
    Martin Friedlander; Fiscal Year: 2005
    ..abstract_text> ..
  8. INTEGRINS AND OCULAR ANGIOGENESIS
    Martin Friedlander; Fiscal Year: 2003
    ..Such an approach will provide a rational basis for the development of therapeutics useful in inhibiting ocular angiogenesis. ..
  9. INTEGRINS AND OCULAR ANGIOGENESIS
    Martin Friedlander; Fiscal Year: 2001
    ..Such an approach will provide a rational basis for the development of therapeutics useful in inhibiting ocular angiogenesis. ..
  10. INTEGRINS AND OCULAR ANGIOGENESIS
    Martin Friedlander; Fiscal Year: 2007
    ..These studies will provide insights into mechanisms of angiogenesis that will be useful for the prevention and treatment of neovascular eye diseases. ..
  11. INTEGRINS AND OCULAR ANGIOGENESIS
    Martin Friedlander; Fiscal Year: 2009
    ..These studies will provide insights into mechanisms of angiogenesis that will be useful for the prevention and treatment of neovascular eye diseases. ..
  12. INTEGRINS AND OCULAR ANGIOGENESIS
    Martin Friedlander; Fiscal Year: 2006
    ..These studies will provide insights into mechanisms of angiogenesis that will be useful for the prevention and treatment of neovascular eye diseases. ..
  13. INTEGRINS AND OCULAR ANGIOGENESIS
    Martin Friedlander; Fiscal Year: 2005
    ..These studies will provide insights into mechanisms of angiogenesis that will be useful for the prevention and treatment of neovascular eye diseases. ..
  14. INTEGRINS AND OCULAR ANGIOGENESIS
    Martin Friedlander; Fiscal Year: 2004
    ..Such an approach will provide a rational basis for the development of therapeutics useful in inhibiting ocular angiogenesis. ..
  15. INTEGRINS AND OCULAR ANGIOGENESIS
    Martin Friedlander; Fiscal Year: 2002
    ..Such an approach will provide a rational basis for the development of therapeutics useful in inhibiting ocular angiogenesis. ..
  16. INTEGRINS AND OCULAR ANGIOGENESIS
    Martin Friedlander; Fiscal Year: 2000
    ..Such an approach will provide a rational basis for the development of therapeutics useful in inhibiting ocular angiogenesis. ..
  17. Adult Stem Cells for Therapy of Visual Disorders
    Martin Friedlander; Fiscal Year: 2007
    ..If successful, these studies will lead to a novel therapeutic paradigm for currently untreatable vascular and degenerative diseases of the retina. ..