Hudson Freeze

Summary

Affiliation: The Burnham Institute
Country: USA

Publications

  1. ncbi request reprint Balancing N-linked glycosylation to avoid disease
    H H Freeze
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochimie 83:791-9. 2001
  2. ncbi request reprint Altered glycan structures: the molecular basis of congenital disorders of glycosylation
    Hudson H Freeze
    The Burnham Institute, Glycobiology and Carbohydrate Chemistry Program, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Struct Biol 15:490-8. 2005
  3. pmc Metabolic manipulation of glycosylation disorders in humans and animal models
    Hudson H Freeze
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Semin Cell Dev Biol 21:655-62. 2010
  4. ncbi request reprint Congenital Disorders of Glycosylation: CDG-I, CDG-II, and beyond
    Hudson H Freeze
    Glycobiology and Carbohydrate Chemistry Program, Burnham Institute for Medical Research, 10901 N Torrey Pines Rd, La Jolla, CA, 92037, USA
    Curr Mol Med 7:389-96. 2007
  5. ncbi request reprint Genetic defects in the human glycome
    Hudson H Freeze
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Genet 7:537-51. 2006
  6. ncbi request reprint Human disorders in N-glycosylation and animal models
    Hudson H Freeze
    Glycobiology and Carbohydrate Chemistry Program, The Burnham Institute, La Jolla, CA 92037, USA
    Biochim Biophys Acta 1573:388-93. 2002
  7. pmc Sweet solution: sugars to the rescue
    Hudson H Freeze
    The Burnham Institute, La Jolla Cancer Research Center, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Cell Biol 158:615-6. 2002
  8. ncbi request reprint Congenital disorders of glycosylation and the pediatric liver
    H H Freeze
    Glycobiology and Carbohydrate Chemistry Program, The Burnham Institute, La Jolla, California 92037, USA
    Semin Liver Dis 21:501-15. 2001
  9. ncbi request reprint N -Glycans on the receptor for advanced glycation end products influence amphoterin binding and neurite outgrowth
    Geetha Srikrishna
    The Burnham Institute, La Jolla, California 92037, USA
    J Neurochem 80:998-1008. 2002
  10. pmc Towards a therapy for phosphomannomutase 2 deficiency, the defect in CDG-Ia patients
    Hudson H Freeze
    Sanford Children s Health Research Center, Burnham Institute for Medical Research, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Biochim Biophys Acta 1792:835-40. 2009

Research Grants

  1. Carbohydrate Deficient Glycoprotein Syndromes: Models and Therapy
    Hudson H Freeze; Fiscal Year: 2010
  2. CARBOHYDRATE DEFICIENT GLYCOPROTEIN SYNDROMES
    Hudson Freeze; Fiscal Year: 2003
  3. Novel Approaches to Mend Deficient Glycosylation
    Hudson Freeze; Fiscal Year: 2005
  4. Basis of Post-Fontan Protein Losing Enteropathy
    Hudson Freeze; Fiscal Year: 2006
  5. Novel Carboxylated Glycans in Cell Adhesion
    Hudson Freeze; Fiscal Year: 2006
  6. CARBOHYDRATE DEFICIENT GLYCOPROTEIN SYNDROMES
    Hudson Freeze; Fiscal Year: 2007
  7. Factors Determining Protein Losing Enteropathy
    Hudson H Freeze; Fiscal Year: 2010
  8. Human Glycosylation Disorders 2003
    Hudson Freeze; Fiscal Year: 2004
  9. MANNOSE IN MAMMALIAN GLYCOPROTEIN SYNTHESIS
    Hudson Freeze; Fiscal Year: 2001
  10. Novel Carboxylated N-Glycans that Mediate Inflammation
    Hudson Freeze; Fiscal Year: 2003

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Balancing N-linked glycosylation to avoid disease
    H H Freeze
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biochimie 83:791-9. 2001
    ..By assessing the occurrence of a series of N-glycosylation-compromising alleles in multi-genic diseases, it may be possible to determine whether impaired glycosylation is a risk factor or a major determinant underlying their pathology...
  2. ncbi request reprint Altered glycan structures: the molecular basis of congenital disorders of glycosylation
    Hudson H Freeze
    The Burnham Institute, Glycobiology and Carbohydrate Chemistry Program, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Struct Biol 15:490-8. 2005
    ..Although most of the deficiencies observed in CDG patients are only partial, the severity of the clinical manifestations signifies the relevance of protein N-glycosylation and shows the importance of defined glycan structures...
  3. pmc Metabolic manipulation of glycosylation disorders in humans and animal models
    Hudson H Freeze
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Semin Cell Dev Biol 21:655-62. 2010
    ..This metabolic perspective may help explain some of these observations and guide the development of other vertebrate models of glycosylation disorders that can respond to dietary manipulation...
  4. ncbi request reprint Congenital Disorders of Glycosylation: CDG-I, CDG-II, and beyond
    Hudson H Freeze
    Glycobiology and Carbohydrate Chemistry Program, Burnham Institute for Medical Research, 10901 N Torrey Pines Rd, La Jolla, CA, 92037, USA
    Curr Mol Med 7:389-96. 2007
    ..This surprising finding makes identifying their defects more challenging, but the defects and associated clinical manifestations of these patients suggest that the N-glycosylation pathway has some secrets left to share...
  5. ncbi request reprint Genetic defects in the human glycome
    Hudson H Freeze
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Genet 7:537-51. 2006
    ..As more glycosylation disorders and patients with these disorders are identified, the functions of the glycome are starting to be revealed...
  6. ncbi request reprint Human disorders in N-glycosylation and animal models
    Hudson H Freeze
    Glycobiology and Carbohydrate Chemistry Program, The Burnham Institute, La Jolla, CA 92037, USA
    Biochim Biophys Acta 1573:388-93. 2002
    ..Investigators designing model systems to study human glycosylation disorders may want to construct strains with several heterozygous hypomorphic alleles in rate-limiting steps in the glycosylation pathway...
  7. pmc Sweet solution: sugars to the rescue
    Hudson H Freeze
    The Burnham Institute, La Jolla Cancer Research Center, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Cell Biol 158:615-6. 2002
    ..2002, this issue) use one to rescue designer mice unable to make GDP-Fucose. Dietary fucose enters a salvage pathway and spares the mice. Sound simple? Not so. Unknown genetic factors determine life or death...
  8. ncbi request reprint Congenital disorders of glycosylation and the pediatric liver
    H H Freeze
    Glycobiology and Carbohydrate Chemistry Program, The Burnham Institute, La Jolla, California 92037, USA
    Semin Liver Dis 21:501-15. 2001
    ....
  9. ncbi request reprint N -Glycans on the receptor for advanced glycation end products influence amphoterin binding and neurite outgrowth
    Geetha Srikrishna
    The Burnham Institute, La Jolla, California 92037, USA
    J Neurochem 80:998-1008. 2002
    ..These results indicate that carboxylated N -glycans on RAGE play an important functional role in amphoterin-RAGE-mediated signalling...
  10. pmc Towards a therapy for phosphomannomutase 2 deficiency, the defect in CDG-Ia patients
    Hudson H Freeze
    Sanford Children s Health Research Center, Burnham Institute for Medical Research, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Biochim Biophys Acta 1792:835-40. 2009
    ..Glycosylation-deficient cell and animal models are needed to determine which individual or combined approaches improve glycosylation and may be suitable for preclinical evaluation...
  11. ncbi request reprint Intracranial hemorrhage as the initial manifestation of a congenital disorder of glycosylation
    Ronald D Cohn
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins Hospital, Children s Center, Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 1008, Baltimore, Maryland 21205, USA
    Pediatrics 118:e514-21. 2006
    ..Intracranial hemorrhage in a term neonate without a potential precipitating factor represents yet another clinical feature that should raise the suspicion for a congenital disorder of glycosylation...
  12. ncbi request reprint Carboxylated glycans mediate colitis through activation of NF-kappa B
    Geetha Srikrishna
    Glycobiology Program, The Burnham Institute, La Jolla, CA 92037, USA
    J Immunol 175:5412-22. 2005
    ..It specifically blocked activation of NF-kappaB p65 in lamina propria cells of colitic mice and in activated macrophages. These results indicate that carboxylate-glycan-dependent pathways contribute to the early onset of colitis...
  13. ncbi request reprint Ablation of mouse phosphomannose isomerase (Mpi) causes mannose 6-phosphate accumulation, toxicity, and embryonic lethality
    Charles DeRossi
    Glycobiology and Carbohydrate Chemistry Program, Burnham Institute for Medical Research, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Biol Chem 281:5916-27. 2006
    ..5 Mpi(-/-) embryos where Man-6-P increased more than 10 times, and ATP decreased by 50% compared with Mpi(+/+) littermates. Because Mpi ablation is embryonic lethal, a murine CDG-Ib model will require hypomorphic Mpi alleles...
  14. ncbi request reprint Novel perspectives on glycosylation and human disease
    Hudson H Freeze
    Curr Mol Med 7:387. 2007
  15. pmc Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development
    Kylie T Greig
    Division of Molecular Medicine, The Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
    Mol Cell Biol 27:5849-59. 2007
    ....
  16. ncbi request reprint Mutation of the COG complex subunit gene COG7 causes a lethal congenital disorder
    Xiaohua Wu
    The Burnham Institute, 10901 N Torrey Pines Road, La Jolla, California 92037, USA
    Nat Med 10:518-23. 2004
    ..These cases represent a new type of CDG in which the molecular defect lies in a protein that affects the trafficking and function of the glycosylation machinery...
  17. ncbi request reprint Cryptogenic liver disease in four children: a novel congenital disorder of glycosylation
    Claudia Mandato
    Department of Pediatrics, University of Naples Federico II, Italy
    Pediatr Res 59:293-8. 2006
    ..Clinicians are encouraged to test such patients for abnormal Tf glycosylation by ESI-MS...
  18. ncbi request reprint COG8 deficiency causes new congenital disorder of glycosylation type IIh
    Christian Kranz
    Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Hum Mol Genet 16:731-41. 2007
    ..Lentiviral-mediated complementation with normal COG8 corrected mislocalization of other COG proteins, normalized sialylation and restored normal BFA-induced Golgi disruption. We propose to call this new disorder CDG-IIh or CDG-II/COG8...
  19. ncbi request reprint Deficiency of UDP-GlcNAc:Dolichol Phosphate N-Acetylglucosamine-1 Phosphate Transferase (DPAGT1) causes a novel congenital disorder of Glycosylation Type Ij
    Xiaohua Wu
    The Burnham Institute, La Jolla, California, USA
    Hum Mutat 22:144-50. 2003
    ..Thus, we conclude that the DPAGT1 gene defects are responsible for the CDG symptoms in this patient. Hum Mutat 22:144-150, 2003...
  20. ncbi request reprint New disorders in carbohydrate metabolism: congenital disorders of glycosylation and their impact on the endocrine system
    Bradley S Miller
    Division of Pediatric Endocrinology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, USA
    Rev Endocr Metab Disord 4:103-13. 2003
  21. pmc RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis
    Olga Turovskaya
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA
    Carcinogenesis 29:2035-43. 2008
    ..These findings show that RAGE, carboxylated glycans and S100A8/A9 play essential roles in tumor-stromal interactions, leading to inflammation-associated colon carcinogenesis...
  22. pmc Molecular and clinical characterization of a Moroccan Cog7 deficient patient
    Bobby G Ng
    Department of Glycobiology and Carbohydrate Chemistry, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Mol Genet Metab 91:201-4. 2007
    ..The mutation disrupted the hetero-octomeric COG complex and altered both N- and O-linked glycosylation. Here we present clinical and biochemical data from a second family with the same mutation...
  23. ncbi request reprint Expanding spectrum of congenital disorder of glycosylation Ig (CDG-Ig): sibs with a unique skeletal dysplasia, hypogammaglobulinemia, cardiomyopathy, genital malformations, and early lethality
    Christian Kranz
    Burnham Institute for Medical Research, La Jolla, California, USA
    Am J Med Genet A 143:1371-8. 2007
    ..Congenital disorders of glycosylation should be considered for children with undiagnosed multi-system disease including neurodevelopmental delay, skeletal dysplasia, immune deficiency, male genital hypoplasia, and cardiomyopathy...
  24. doi request reprint The relative contribution of mannose salvage pathways to glycosylation in PMI-deficient mouse embryonic fibroblast cells
    Naonobu Fujita
    Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Japan
    FEBS J 275:788-98. 2008
    ..From these data, we conclude that PMI-null cells can salvage mannose from both endogenous and external glycoconjugates via lysosomal and nonlysosomal degradation pathways...
  25. ncbi request reprint CDG-Id in two siblings with partially different phenotypes
    Christian Kranz
    Glycobiology and Carbohydrate Chemistry Program, The Burnham Institute for Medical Research, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Am J Med Genet A 143:1414-20. 2007
    ..The defect is corrected by introduction of a normal ALG3 cDNA. CDG should be ruled out in all patients with severe seizures and failure to thrive. (c) 2007 Wiley-Liss, Inc...
  26. ncbi request reprint Cloning and characterization of glucose transporter 11, a novel sugar transporter that is alternatively spliced in various tissues
    Xiaohua Wu
    The Burnham Institute, La Jolla, CA 92037, USA
    Mol Genet Metab 76:37-45. 2002
    ..Furthermore, a liposome reconstitution functional assay showed that GLUT11-L has glucose transport activity...
  27. doi request reprint Endoglycosidase and glycoamidase release of N-linked oligosaccharides
    Hudson H Freeze
    The Burnham Institute, La Jolla, California, USA
    Curr Protoc Protein Sci . 2006
    ..These changes can be used to indicate when a protein has passed a particular subcellular location. This unit details some of the methods used to track a protein as it traffics from the ER to the Golgi toward its final location...
  28. pmc Inhibition of N-linked glycosylation disrupts receptor tyrosine kinase signaling in tumor cells
    Joseph N Contessa
    Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA
    Cancer Res 68:3803-9. 2008
    ..This study provides evidence that enzymatic steps regulating N-linked glycosylation are novel targets for developing approaches to sensitize tumor cells to cytotoxic therapies...
  29. pmc Heparan sulfate and syndecan-1 are essential in maintaining murine and human intestinal epithelial barrier function
    Lars Bode
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Clin Invest 118:229-38. 2008
    ..We demonstrate here that non-anticoagulant 2,3-de-O-sulfated heparin could prevent intestinal protein leakage in syndecan-deficient mice, suggesting that this may be a safe and effective therapy for PLE patients...
  30. ncbi request reprint Essentials of glycosylation
    Erik A Eklund
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Semin Pediatr Neurol 12:134-43. 2005
  31. pmc The congenital disorders of glycosylation: a multifaceted group of syndromes
    Erik A Eklund
    Department of Cell and Molecular Biology, Lund University, Lund, Sweden
    NeuroRx 3:254-63. 2006
    ..In this review we will discuss the individual syndromes, with focus on their neuronal involvement, available and possible treatments, and future directions...
  32. ncbi request reprint Molecular cloning, gene organization, and expression of mouse Mpi encoding phosphomannose isomerase
    Joseph A Davis
    Glycobiology Program, The Burnham Institute, 10901 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Glycobiology 12:435-42. 2002
    ....
  33. ncbi request reprint Clinical and molecular features of congenital disorder of glycosylation in patients with type 1 sialotransferrin pattern and diverse ethnic origins
    Gregory M Enns
    Division of Medical Genetics, Department of Pediatrics, Stanford University, Palo Alto, California 94305, USA
    J Pediatr 141:695-700. 2002
    ..To increase awareness of congenital disorders of glycosylation (CDG), we report the features of patients with a variety of clinical presentations ranging from mild hypotonia and strabismus to severe neurologic impairment...
  34. ncbi request reprint GLUT14, a duplicon of GLUT3, is specifically expressed in testis as alternative splice forms
    Xiaohua Wu
    The Burnham Institute, La Jolla, California 92037, USA
    Genomics 80:553-7. 2002
    ..Interestingly, the ortholog of GLUT14 is not found in mice. The multiple duplications of GLUT genes suggest that the GLUT family probably emerged by gene duplications and mutations during evolution in different lineages...
  35. ncbi request reprint Affinity capture and elution/electrospray ionization mass spectrometry assay of phosphomannomutase and phosphomannose isomerase for the multiplex analysis of congenital disorders of glycosylation types Ia and Ib
    Yijun Li
    Department of Chemistry, University of Washington, Seattle, Washington 98195, USA
    Anal Chem 75:42-8. 2003
    ..The affinity purification procedure is fully automated, and the mass spectrometric analysis is multiplexed in a fashion that is suitable for high-throughput applications...
  36. ncbi request reprint Identification of a frequent variant in ALG6, the cause of Congenital Disorder of Glycosylation-Ic
    Vibeke Westphal
    The Burnham Institute, 10901 N Torrey Pines Rd, La Jolla, California 92037, USA
    Hum Mutat 22:420-1. 2003
    ..Thus, it is unclear whether c.391T>C causes CDG-Ic or contributes to the symptoms. Genotyping additional patients with CDG-like symptoms will be required to resolve this issue...
  37. ncbi request reprint Testing for congenital disorders of glycosylation by HPLC measurement of serum transferrin glycoforms
    Anders Helander
    Department of Clinical Neuroscience, Karolinska Institutet and University Hospital, Stockholm, Sweden
    Clin Chem 50:954-8. 2004
  38. ncbi request reprint Molecular and clinical description of the first US patients with congenital disorder of glycosylation Ig
    Erik A Eklund
    The Burnham Institute, Glycobiology and Carbohydrate Chemistry Program, La Jolla, CA 92037, USA
    Mol Genet Metab 84:25-31. 2005
    ..We therefore conclude that a combination of developmental delay, low IgG, and genital hypoplasia should prompt CDG testing...
  39. ncbi request reprint Congenital disorder of glycosylation id presenting with hyperinsulinemic hypoglycemia and islet cell hyperplasia
    Liangwu Sun
    The Burnham Institute, Program for Glycobiology and Carbohydrate Chemistry, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    J Clin Endocrinol Metab 90:4371-5. 2005
    ..Inborn errors in protein glycosylation, such as the congenital disorders of glycosylation (CDGs), generate multifaceted syndromes that impair many organ systems. We here report the diagnosis of the third known patient with CDG-Id...
  40. ncbi request reprint Novel carboxylated N-glycans contain oligosaccharide-linked glutamic acid
    Geetha Srikrishna
    Glycobiology Program, The Burnham Institute, La Jolla, CA, USA
    Biochem Biophys Res Commun 332:1020-7. 2005
    ..These results demonstrate that mammalian cells synthesize complex-type N-glycans with glutamate linked to their antennae, further expanding their potential for covalent or ionic interactions...
  41. ncbi request reprint Clinical and molecular characterization of the first adult congenital disorder of glycosylation (CDG) type Ic patient
    Liangwu Sun
    The Burnham Institute, La Jolla, CA 92037, USA
    Am J Med Genet A 137:22-6. 2005
    ..However, even in adulthood, this patient shows normal magnetic resonance imaging of the brain...
  42. ncbi request reprint Hydrophobic Man-1-P derivatives correct abnormal glycosylation in Type I congenital disorder of glycosylation fibroblasts
    Erik A Eklund
    The Burnham Institute, La Jolla, CA 92037, USA
    Glycobiology 15:1084-93. 2005
    ..These results validate the general concept of using pro-Man-1-P substrates as potential therapeutics for CDG-I patients...
  43. ncbi request reprint Congenital disorder of glycosylation Ic due to a de novo deletion and an hALG-6 mutation
    Erik A Eklund
    Glycobiology and Carbohydrate Chemistry Program, The Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Biochem Biophys Res Commun 339:755-60. 2006
    ..2p32.3)] and found no structural abnormalities in the father, suggesting a de novo event. Our findings extend the causes of CDG to larger DNA deletions and identify the first Japanese CDG-Ic mutation...
  44. ncbi request reprint Clinical and biochemical characterization of a patient with congenital disorder of glycosylation (CDG) IIx
    Yoshiaki Miura
    Burnham Institute, Program for Glycobiology and Carbohydrate Chemistry, La Jolla, Calif 92037, USA
    J Pediatr 147:851-3. 2005
    ..Transferrin analysis showed only hyposialylation, but analysis of total serum N-glycans indicated loss of additional sugars, arguing that the latter generates a more informative picture to search for the primary defect...
  45. ncbi request reprint Heparan sulfate plays a central role in a dynamic in vitro model of protein-losing enteropathy
    Lars Bode
    Burnham Institute for Medical Research, Glycobiology and Carbohydrate Chemistry Program, La Jolla, California 92037, USA
    J Biol Chem 281:7809-15. 2006
    ..Soluble heparin fully compensated for HS loss, providing a reasonable explanation for patient favorable response to heparin therapy...
  46. ncbi request reprint A frequent mild mutation in ALG6 may exacerbate the clinical severity of patients with congenital disorder of glycosylation Ia (CDG-Ia) caused by phosphomannomutase deficiency
    Vibeke Westphal
    The Burnham Institute, Glycobiology Program, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Hum Mol Genet 11:599-604. 2002
    ..We speculate that this type of variant may be implicated in other multi-factorial disorders that involve N-glycosylation...

Research Grants30

  1. Carbohydrate Deficient Glycoprotein Syndromes: Models and Therapy
    Hudson H Freeze; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: We will study the first mouse model of a rare human genetic disorder in protein glycosylation, offer a likely therapy, and apply the model/therapy to treat other human glycosylation disorders. ..
  2. CARBOHYDRATE DEFICIENT GLYCOPROTEIN SYNDROMES
    Hudson Freeze; Fiscal Year: 2003
    ..Analysis of glycosylation-deficient patients will broaden our understanding ob both glycobiology and its immediate application to human glycosylation diseases. ..
  3. Novel Approaches to Mend Deficient Glycosylation
    Hudson Freeze; Fiscal Year: 2005
    ....
  4. Basis of Post-Fontan Protein Losing Enteropathy
    Hudson Freeze; Fiscal Year: 2006
    ..The results could provide a fundamental understanding of how PLE develops, identify Fontan patients genetically at risk for developing PLE, and provide insights to new therapeutics for this enigmatic rare disease. ..
  5. Novel Carboxylated Glycans in Cell Adhesion
    Hudson Freeze; Fiscal Year: 2006
    ....
  6. CARBOHYDRATE DEFICIENT GLYCOPROTEIN SYNDROMES
    Hudson Freeze; Fiscal Year: 2007
    ..In the long run, we want to understand their physiological and molecular basis of new disorders and provide underpinnings for patient therapy. ..
  7. Factors Determining Protein Losing Enteropathy
    Hudson H Freeze; Fiscal Year: 2010
    ..We propose to make a mouse model of PLE and test a novel therapy developed in our laboratory. Our long-range goal is to identify at-risk patients and provide a therapy for them. ..
  8. Human Glycosylation Disorders 2003
    Hudson Freeze; Fiscal Year: 2004
    ..Since this meeting immediately precedes the annual meeting of the Society for Glycobiology, it will increase the chances of recruiting glycobiologists to explore the various types of human glycosylation disorders. ..
  9. MANNOSE IN MAMMALIAN GLYCOPROTEIN SYNTHESIS
    Hudson Freeze; Fiscal Year: 2001
    ..In some cases, mannose may be a therapeutic dietary supplement. A mannose supplementation trial for CDGS patients is now underway. ..
  10. Novel Carboxylated N-Glycans that Mediate Inflammation
    Hudson Freeze; Fiscal Year: 2003
    ..The impact of solving these structures could be quite substantial. However, in the past, we have had difficulty establishing this structure, and therein lies the risk in this project and why it responds to PA-97-049. ..