Wendy Frankel


Affiliation: The Ohio State University
Country: USA


  1. Genutis L, Tomsic J, Bundschuh R, Brock P, Williams M, Roychowdhury S, et al. Microsatellite Instability Occurs in a Subset of Follicular Thyroid Cancers. Thyroid. 2019;: pubmed publisher
    ..5%, and MSI is either entirely absent or rare in other histology subtypes of thyroid carcinoma. These findings highlight the importance of testing for MSI in follicular thyroid cancer. . ..
  2. Chen W, Frankel W. A practical guide to biomarkers for the evaluation of colorectal cancer. Mod Pathol. 2019;: pubmed publisher
    ..This review will discuss the biomarkers commonly encountered in the clinical evaluation of CRC, and practical issues regarding MSI screening, reporting, interpretation, molecular test indication, and specimen requirements. ..
  3. Yilmaz A, Mohamed N, Patterson K, Tang Y, Shilo K, Villalona Calero M, et al. Clinical and metabolic parameters in non-small cell lung carcinoma and colorectal cancer patients with and without KRAS mutations. Int J Environ Res Public Health. 2014;11:8645-60 pubmed publisher
    ..CRC patients carrying transition mutations are older than those carrying transversions, suggesting that age may determine the type of KRAS mutation in CRC patients. ..
  4. Yilmaz A, Mohamed N, Patterson K, Tang Y, Shilo K, Villalona Calero M, et al. Increased NQO1 but not c-MET and survivin expression in non-small cell lung carcinoma with KRAS mutations. Int J Environ Res Public Health. 2014;11:9491-502 pubmed publisher
  5. Pearlman R, Markow M, Knight D, Chen W, Arnold C, Pritchard C, et al. Two-stain immunohistochemical screening for Lynch syndrome in colorectal cancer may fail to detect mismatch repair deficiency. Mod Pathol. 2018;31:1891-1900 pubmed publisher
    ..Accordingly, we recommend the four-stain method be used for optimal Lynch syndrome screening detection. ..
  6. Hemminger J, Pearlman R, Haraldsdottir S, Knight D, Jonasson J, Pritchard C, et al. Histology of colorectal adenocarcinoma with double somatic mismatch-repair mutations is indistinguishable from those caused by Lynch syndrome. Hum Pathol. 2018;78:125-130 pubmed publisher
  7. Haraldsdottir S, Roth R, Pearlman R, Hampel H, Arnold C, Frankel W. Mismatch repair deficiency concordance between primary colorectal cancer and corresponding metastasis. Fam Cancer. 2016;15:253-60 pubmed publisher
    ..In 14 cases, time lapsed [median 16.5 months; quartile (Q)1 8.0; Q3 25; range 3-69] from the primary resection until metastatic resection. Metastatic tissue can be used to screen for Lynch syndrome and dMMR. ..
  8. Jin M, Frankel W. Lymph Node Metastasis in Colorectal Cancer. Surg Oncol Clin N Am. 2018;27:401-412 pubmed publisher
    ..Updates from the most recent AJCC 8th edition are included. ..
  9. Jin M, Zhou X, Yearsley M, Frankel W. Liver Metastases of Neuroendocrine Tumors Rarely Show Overlapping Immunoprofile with Hepatocellular Carcinomas. Endocr Pathol. 2016;27:253-8 pubmed publisher
    ..Rare CCs focally express HepPar1 and GPC3. Utilizing a limited staining panel can efficiently distinguish HCCs, NETs, and CCs and help avoid diagnostic pitfalls on small biopsies. ..

More Information


  1. Roth R, Haraldsdottir S, Hampel H, Arnold C, Frankel W. Discordant Mismatch Repair Protein Immunoreactivity in Lynch Syndrome-Associated Neoplasms: ?A Recommendation for Screening Synchronous/Metachronous Neoplasms. Am J Clin Pathol. 2016;146:50-6 pubmed publisher
    ..Accordingly, our findings support the recommendation to perform LS screening in all primary, synchronous, and metachronous intestinal and endometrial cancers if a previous tumor screened intact. ..
  2. Katz M, Ou F, Herman J, Ahmad S, Wolpin B, Marsh R, et al. Alliance for clinical trials in oncology (ALLIANCE) trial A021501: preoperative extended chemotherapy vs. chemotherapy plus hypofractionated radiation therapy for borderline resectable adenocarcinoma of the head of the pancreas. BMC Cancer. 2017;17:505 pubmed publisher
    ..ClinicalTrials.gov : NCT02839343 , registered July 14, 2016. ..
  3. request reprint
    Frankel W. Update on pancreatic endocrine tumors. Arch Pathol Lab Med. 2006;130:963-6 pubmed
    ..Resection remains the mainstay of surgical treatment. It is important to be aware that unusual morphologic variants of pancreatic endocrine tumors are common, and immunohistochemical stains can help avoid misdiagnosis...
  4. Chen W, Swanson B, Frankel W. Molecular genetics of microsatellite-unstable colorectal cancer for pathologists. Diagn Pathol. 2017;12:24 pubmed publisher
    ..This review summarizes the major pathogenesis pathways of dMMR CRCs, their clinicopathologic features, and practical screening suggestions. In addition, we include frequently asked questions for MMR immunohistochemistry interpretation. ..
  5. Markow M, Chen W, Frankel W. Immunohistochemical Pitfalls: Common Mistakes in the Evaluation of Lynch Syndrome. Surg Pathol Clin. 2017;10:977-1007 pubmed publisher
    ..Immunohistochemistry is one of the most widely used screening tools for identifying patients with Lynch syndrome. ..