Wolfgang Fischle

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi request reprint In nucleo enzymatic assays for the identification and characterization of histone modifying activities
    Wolfgang Fischle
    Laboratory of Chromatin Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Methods 36:362-7. 2005
  2. ncbi request reprint Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation
    Wolfgang Fischle
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA
    Nature 438:1116-22. 2005
  3. doi request reprint Role of histone modifications in defining chromatin structure and function
    Kathy A Gelato
    Laboratory of Chromatin Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D 37077 Gottingen, Germany
    Biol Chem 389:353-63. 2008
  4. pmc Specificity of the chromodomain Y chromosome family of chromodomains for lysine-methylated ARK(S/T) motifs
    Wolfgang Fischle
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia 22908 0733, USA
    J Biol Chem 283:19626-35. 2008
  5. ncbi request reprint Dynamic regulation of effector protein binding to histone modifications: the biology of HP1 switching
    Holger L Dormann
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York, USA
    Cell Cycle 5:2842-51. 2006
  6. ncbi request reprint Beyond the double helix: writing and reading the histone code
    Yanming Wang
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA
    Novartis Found Symp 259:3-17; discussion 17-21, 163-9. 2004
  7. ncbi request reprint Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger
    Haitao Li
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Cell 28:677-91. 2007
  8. ncbi request reprint Binary switches and modification cassettes in histone biology and beyond
    Wolfgang Fischle
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA
    Nature 425:475-9. 2003
  9. pmc A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis
    Xiao Jian Sun
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10065, USA
    Nature 500:93-7. 2013
  10. doi request reprint Roles of the Clr4 methyltransferase complex in nucleation, spreading and maintenance of heterochromatin
    Ke Zhang
    Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Struct Mol Biol 15:381-8. 2008

Collaborators

Detail Information

Publications21

  1. ncbi request reprint In nucleo enzymatic assays for the identification and characterization of histone modifying activities
    Wolfgang Fischle
    Laboratory of Chromatin Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Methods 36:362-7. 2005
    ..Simple methods for the analysis of histone modifications using these assays are discussed...
  2. ncbi request reprint Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation
    Wolfgang Fischle
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA
    Nature 438:1116-22. 2005
    ..These findings establish a regulatory mechanism of protein-protein interactions, through a combinatorial readout of two adjacent post-translational modifications: a stable methylation and a dynamic phosphorylation mark...
  3. doi request reprint Role of histone modifications in defining chromatin structure and function
    Kathy A Gelato
    Laboratory of Chromatin Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D 37077 Gottingen, Germany
    Biol Chem 389:353-63. 2008
    ..We review the properties of various chromatin elements and the apparent links of histone modifications with chromatin organization and functional output...
  4. pmc Specificity of the chromodomain Y chromosome family of chromodomains for lysine-methylated ARK(S/T) motifs
    Wolfgang Fischle
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia 22908 0733, USA
    J Biol Chem 283:19626-35. 2008
    ..Our studies underscore the significance of subtle sequence differences in a conserved signaling module for diverse epigenetic regulatory pathways...
  5. ncbi request reprint Dynamic regulation of effector protein binding to histone modifications: the biology of HP1 switching
    Holger L Dormann
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York, USA
    Cell Cycle 5:2842-51. 2006
    ....
  6. ncbi request reprint Beyond the double helix: writing and reading the histone code
    Yanming Wang
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA
    Novartis Found Symp 259:3-17; discussion 17-21, 163-9. 2004
    ..As this modification is not found during mitotic chromosome condensation, these findings suggest the intriguing possibility that a unique 'death' mark exists for chromatin condensation during apoptosis...
  7. ncbi request reprint Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger
    Haitao Li
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Cell 28:677-91. 2007
    ....
  8. ncbi request reprint Binary switches and modification cassettes in histone biology and beyond
    Wolfgang Fischle
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA
    Nature 425:475-9. 2003
    ..Our ideas might also apply to non-histone proteins and are open to direct experimental examination...
  9. pmc A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis
    Xiao Jian Sun
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10065, USA
    Nature 500:93-7. 2013
    ..These results reveal new mechanisms of action of AML1-ETO, and provide a potential therapeutic target in t(8;21)-positive acute myeloid leukaemia. ..
  10. doi request reprint Roles of the Clr4 methyltransferase complex in nucleation, spreading and maintenance of heterochromatin
    Ke Zhang
    Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Struct Mol Biol 15:381-8. 2008
    ..Our analyses delineate sequential steps for the assembly of heterochromatic domains and suggest that the ability of Clr4 to both 'write' and 'read' H3K9me facilitates heterochromatin maintenance through successive cell divisions...
  11. pmc Modulation of 14-3-3 interaction with phosphorylated histone H3 by combinatorial modification patterns
    Stefan Winter
    Max F Perutz Laboratories, Medical University of Vienna, Vienna Biocenter, Vienna, Austria
    Cell Cycle 7:1336-42. 2008
    ..Here we discuss the binding of 14-3-3 proteins to histone H3 in detail and putative biological implications of these interactions...
  12. pmc 14-3-3 proteins recognize a histone code at histone H3 and are required for transcriptional activation
    Stefan Winter
    Max F Perutz Laboratories, Vienna Biocenter, Medical University of Vienna, Vienna, Austria
    EMBO J 27:88-99. 2008
    ..Finally, siRNA-mediated loss of 14-3-3 proteins abolishes the transcriptional activation of HDAC1. Together our data indicate that 14-3-3 proteins are crucial mediators of histone phosphoacetylation signals...
  13. pmc A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities
    Tetyana Klymenko
    Gene Expression Programme, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Genes Dev 20:1110-22. 2006
    ..We propose that PRE-tethered PhoRC selectively interacts with methylated histones in the chromatin flanking PREs to maintain a Polycomb-repressed chromatin state...
  14. ncbi request reprint The nucleation and maintenance of heterochromatin by a histone deacetylase in fission yeast
    Takatomi Yamada
    Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell 20:173-85. 2005
    ....
  15. ncbi request reprint Assays for the determination of structure and dynamics of the interaction of the chromodomain with histone peptides
    Steven A Jacobs
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville 22908, USA
    Methods Enzymol 376:131-48. 2004
  16. pmc Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains
    Wolfgang Fischle
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia 22908 0733, USA
    Genes Dev 17:1870-81. 2003
    ..The Pc chromodomain distinguishes its methylation target on the H3 tail via an extended recognition groove that binds five additional residues preceding the ARKS motif...
  17. ncbi request reprint Histone and chromatin cross-talk
    Wolfgang Fischle
    Department of Biochemistry and Molecular Genetics, University of Virginia, Health Sciences Center, 1300 Jefferson Park Avenue, Charlottesville, VA 22908 0733, USA
    Curr Opin Cell Biol 15:172-83. 2003
    ..Different layers of cross-talk between several components of this complex regulatory system are emerging, and these epigenetic circuits are the focus of this review...
  18. pmc Control of cytomegalovirus lytic gene expression by histone acetylation
    Jane C Murphy
    Department of Medicine, University of Cambridge, Cambridge CB2 2QQ, UK
    EMBO J 21:1112-20. 2002
    ....
  19. pmc Structural and functional analyses of methyl-lysine binding by the malignant brain tumour repeat protein Sex comb on midleg
    Clemens Grimm
    European Molecular Biology Laboratory, Grenoble Outstation, 6 rue Jules Horowitz, 38042 Grenoble, France
    EMBO Rep 8:1031-7. 2007
    ..Functional analyses in Drosophila show that the MBT domain of Scm and its methyl-lysine-binding activity are required for repression of Hox genes...
  20. ncbi request reprint HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis
    Franck Dequiedt
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, San Francisco 94141, USA
    Immunity 18:687-98. 2003
    ..Inhibition of HDAC7 expression by RNA interference causes increased apoptosis in response to TCR activation. These observations define HDAC7 as a regulator of Nur77 and apoptosis in developing thymocytes...
  21. ncbi request reprint Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR
    Wolfgang Fischle
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, San Francisco, CA 94141, USA
    Mol Cell 9:45-57. 2002
    ..These observations indicate that class II HDACs regulate transcription by bridging the enzymatically active SMRT/N-CoR-HDAC3 complex and select transcription factors independently of any intrinsic HDAC activity...