Vincent Fischetti

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi request reprint Bacteriophage lytic enzymes: novel anti-infectives
    Vincent A Fischetti
    Laboratory of Bacterial Pathogenesis, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Trends Microbiol 13:491-6. 2005
  2. ncbi request reprint In vivo acquisition of prophage in Streptococcus pyogenes
    Vincent A Fischetti
    Laboratory of Bacterial Pathogenesis and Immunology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Trends Microbiol 15:297-300. 2007
  3. pmc PEGylating a bacteriophage endolysin inhibits its bactericidal activity
    Grégory Resch
    Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    AMB Express 1:29. 2011
  4. pmc Synergism between a novel chimeric lysin and oxacillin protects against infection by methicillin-resistant Staphylococcus aureus
    Anu Daniel
    The Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, 1230 York Ave, Box 172, New York, NY 10065, USA
    Antimicrob Agents Chemother 54:1603-12. 2010
  5. pmc Bacteriophage endolysins: a novel anti-infective to control Gram-positive pathogens
    Vincent A Fischetti
    Laboratory of Bacterial Pathogenesis, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Int J Med Microbiol 300:357-62. 2010
  6. pmc Bacteriophage lysins as effective antibacterials
    Vincent A Fischetti
    Laboratory of Bacterial Pathogenesis, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Curr Opin Microbiol 11:393-400. 2008
  7. ncbi request reprint Reinventing phage therapy: are the parts greater than the sum?
    Vincent A Fischetti
    Laboratory of Bacterial Pathogenesis and Immunology, Rockefeller University, New York, New York 10021, USA
    Nat Biotechnol 24:1508-11. 2006
  8. ncbi request reprint A bacteriolytic agent that detects and kills Bacillus anthracis
    Raymond Schuch
    Laboratory of Bacteriql Pathogenesis and Immunology, The Rockefeller University, New York, New York 10021, USA
    Nature 418:884-9. 2002
  9. pmc Identification of a broadly active phage lytic enzyme with lethal activity against antibiotic-resistant Enterococcus faecalis and Enterococcus faecium
    Pauline Yoong
    Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    J Bacteriol 186:4808-12. 2004
  10. ncbi request reprint A novel secreted endoglycosidase from Enterococcus faecalis with activity on human immunoglobulin G and ribonuclease B
    Mattias Collin
    Laboratory of Bacterial Pathogenesis, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 279:22558-70. 2004

Research Grants

  1. Pathogen-specific drug targets for weaponized bacteria
    Vincent Fischetti; Fiscal Year: 2007
  2. Isolaton of new phage enzymes to kill B. anthracis
    Vincent Fischetti; Fiscal Year: 2007
  3. PROPERTIES OF STREPTOCOCCAL M PROTEIN
    Vincent Fischetti; Fiscal Year: 2009
  4. PROPERTIES OF STREPTOCOCCAL M PROTEIN
    Vincent A Fischetti; Fiscal Year: 2010
  5. PROPERTIES OF STREPTOCOCCAL M-PROTEIN
    Vincent Fischetti; Fiscal Year: 1980
  6. Isolation of new phage enzymes to kill B. anthracis
    Vincent A Fischetti; Fiscal Year: 2010

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Bacteriophage lytic enzymes: novel anti-infectives
    Vincent A Fischetti
    Laboratory of Bacterial Pathogenesis, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Trends Microbiol 13:491-6. 2005
    ..Thus, lysins could be an effective anti-infective in an age of mounting antibiotic resistance...
  2. ncbi request reprint In vivo acquisition of prophage in Streptococcus pyogenes
    Vincent A Fischetti
    Laboratory of Bacterial Pathogenesis and Immunology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Trends Microbiol 15:297-300. 2007
    ..This suggests that, through evolution, phage have devised a system whereby progeny phage are induced and transferred to host streptococci at a site where host organisms are more prevalent...
  3. pmc PEGylating a bacteriophage endolysin inhibits its bactericidal activity
    Grégory Resch
    Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    AMB Express 1:29. 2011
    ..As most endolysins exhibit a similar modular structure, we believe that our work emphasizes the inability to improve the in vivo half-life of this class of enzybiotics using a cysteine-specific PEGylation strategy...
  4. pmc Synergism between a novel chimeric lysin and oxacillin protects against infection by methicillin-resistant Staphylococcus aureus
    Anu Daniel
    The Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, 1230 York Ave, Box 172, New York, NY 10065, USA
    Antimicrob Agents Chemother 54:1603-12. 2010
    ..aureus infections and would allow for the reinstatement of antibiotics shelved because of mounting resistance...
  5. pmc Bacteriophage endolysins: a novel anti-infective to control Gram-positive pathogens
    Vincent A Fischetti
    Laboratory of Bacterial Pathogenesis, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Int J Med Microbiol 300:357-62. 2010
    ..Here we review the current literature showing the effectiveness of these enzymes in controlling a variety of infections...
  6. pmc Bacteriophage lysins as effective antibacterials
    Vincent A Fischetti
    Laboratory of Bacterial Pathogenesis, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Curr Opin Microbiol 11:393-400. 2008
    ..Thus, lysins may be a much needed anti-infective in an age of mounting antibiotic resistance...
  7. ncbi request reprint Reinventing phage therapy: are the parts greater than the sum?
    Vincent A Fischetti
    Laboratory of Bacterial Pathogenesis and Immunology, Rockefeller University, New York, New York 10021, USA
    Nat Biotechnol 24:1508-11. 2006
    ..Although whole phage continue to generate interest as an alternative to antibiotics, focus is shifting to the use of purified phage components as antibacterial agents...
  8. ncbi request reprint A bacteriolytic agent that detects and kills Bacillus anthracis
    Raymond Schuch
    Laboratory of Bacteriql Pathogenesis and Immunology, The Rockefeller University, New York, New York 10021, USA
    Nature 418:884-9. 2002
    ..The lytic specificity of PlyG was also exploited as part of a rapid method for the identification of B. anthracis. We conclude that PlyG is a tool for the treatment and detection of B. anthracis...
  9. pmc Identification of a broadly active phage lytic enzyme with lethal activity against antibiotic-resistant Enterococcus faecalis and Enterococcus faecium
    Pauline Yoong
    Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    J Bacteriol 186:4808-12. 2004
    ..faecalis and E. faecium (including vancomycin-resistant strains), as well as other human pathogens. We propose its development and use as an alternative therapeutic tool...
  10. ncbi request reprint A novel secreted endoglycosidase from Enterococcus faecalis with activity on human immunoglobulin G and ribonuclease B
    Mattias Collin
    Laboratory of Bacterial Pathogenesis, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 279:22558-70. 2004
    ..faecalis, EndoE, which by two distinct activities hydrolyzes the glycans on RNase B and IgG. Both activities could be important for the molecular pathogenesis and persistence of E. faecalis during human infections...
  11. pmc The career of Maclyn McCarty
    Emil C Gotschlich
    Laboratory of Bacterial Pathogenesis and Immunology, Rockefeller University, New York, NY 10021, USA
    J Exp Med 201:1699-707. 2005
    ..But McCarty's scientific career was long and fruitful, and his contributions to science were vast. This retrospective offers a look at some of Mac's other notable scientific achievements...
  12. pmc PlyPH, a bacteriolytic enzyme with a broad pH range of activity and lytic action against Bacillus anthracis
    Pauline Yoong
    Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    J Bacteriol 188:2711-4. 2006
    ..PlyPH remains active between pH 4 and 10.5, and a single dose rescued a significant percentage of mice infected intraperitoneally with an attenuated B. anthracis strain. We propose PlyPH as a novel therapeutic agent...
  13. pmc Detailed genomic analysis of the Wbeta and gamma phages infecting Bacillus anthracis: implications for evolution of environmental fitness and antibiotic resistance
    Raymond Schuch
    Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Bacteriol 188:3037-51. 2006
    ..anthracis life cycle. Initial findings suggest that lysogeny of B. anthracis promotes ecological adaptation, rather than virulence, as with other gram-positive pathogens...
  14. pmc PlyC: a multimeric bacteriophage lysin
    Daniel Nelson
    Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 103:10765-70. 2006
    ..Similar to no other proteins in sequence databases, PlyC defines a previously uncharacterized structural family of cell-wall hydrolases...
  15. pmc M.SpyI, a DNA methyltransferase encoded on a mefA chimeric element, modifies the genome of Streptococcus pyogenes
    Chad W Euler
    Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, Box 172, 1230 York Avenue, New York, NY 10021, USA
    J Bacteriol 189:1044-54. 2007
    ..The presence of the SpyI R-M cassette in Phi10394.4 could impart a selective advantage to host strain survival and may provide another explanation for the observed increase in macrolide-resistant streptococci...
  16. pmc Sortase A localizes to distinct foci on the Streptococcus pyogenes membrane
    Assaf Raz
    Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 105:18549-54. 2008
    ..The ability to study cytoplasmic and membrane antigens using deconvolution immunofluorescence microscopy will facilitate further study of cellular processes in S. pyogenes...
  17. doi request reprint A genetic screen to identify bacteriophage lysins
    Raymond Schuch
    Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, NY, USA
    Methods Mol Biol 502:307-19. 2009
    ....
  18. pmc The in vitro interaction of Streptococcus pyogenes with human pharyngeal cells induces a phage-encoded extracellular DNase
    Thomas B Broudy
    Department of Bacterial Pathogenesis and Immunology, Rockefeller University, New York, New York 10021, USA
    Infect Immun 70:2805-11. 2002
    ..Finally, we speculate on the induction of phage-encoded DNase (Spd1) enhancing the fitness of both bacteria and phage...
  19. pmc A novel chimeric lysin shows superiority to mupirocin for skin decolonization of methicillin-resistant and -sensitive Staphylococcus aureus strains
    Mina Pastagia
    Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, NY 10065, USA
    Antimicrob Agents Chemother 55:738-44. 2011
    ..Our results showed no inhibition of ClyS activity at various antibody titers. These data demonstrate the potential of developing ClyS as a novel class of topical antimicrobial agents specific to staphylococcus...
  20. pmc Genomic sequence of C1, the first streptococcal phage
    Daniel Nelson
    Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, New York 10021, USA
    J Bacteriol 185:3325-32. 2003
    ..Likewise, comparative genomics revealed no close evolutionary matches, suggesting that the C(1) bacteriophage is a unique member of the Podoviridae...
  21. pmc Lytic enzyme discovery through multigenomic sequence analysis in Clostridium perfringens
    Jonathan E Schmitz
    Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, NY 10065, USA
    Appl Microbiol Biotechnol 89:1783-95. 2011
    ..Overall, PlyCM shows potential for development as an enzybiotic agent, demonstrating how expanding genomic databases can serve as rich pools for biotechnologically relevant proteins...
  22. pmc Identifying active phage lysins through functional viral metagenomics
    Jonathan E Schmitz
    Rockefeller University, Laboratory of Bacterial Pathogenesis and Immunology, 1230 York Ave, Box 172, New York, NY 10065, USA
    Appl Environ Microbiol 76:7181-7. 2010
    ..Overall, this study represents one of the first functional screens of a viral metagenomic population, and it provides a general approach for characterizing lysins from uncultured phage...
  23. pmc Phage lytic enzyme Cpl-1 as a novel antimicrobial for pneumococcal bacteremia
    Jutta M Loeffler
    Laboratory of Bacterial Pathogenesis, The Rockefeller University, New York, New York 10021, USA
    Infect Immun 71:6199-204. 2003
    ..Bacteriophage enzymes are unusual but extremely effective antimicrobials and represent a new weapon against infections with resistant bacteria...
  24. pmc The secret life of the anthrax agent Bacillus anthracis: bacteriophage-mediated ecological adaptations
    Raymond Schuch
    The Rockefeller University, New York, NY, USA
    PLoS ONE 4:e6532. 2009
    ..The results here demonstrate that during its environmental phase, bacteriophages provide B. anthracis with alternatives to sporulation that involve the activation of soil-survival and endosymbiotic capabilities...
  25. ncbi request reprint Novel method to control pathogenic bacteria on human mucous membranes
    Vincent A Fischetti
    The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Ann N Y Acad Sci 987:207-14. 2003
    ..Thus, lysins may be added to our armamentarium to control antibiotic-resistant bacteria...
  26. pmc Removal of group B streptococci colonizing the vagina and oropharynx of mice with a bacteriophage lytic enzyme
    Qi Cheng
    Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    Antimicrob Agents Chemother 49:111-7. 2005
    ....
  27. pmc First complete genome sequence of two Staphylococcus epidermidis bacteriophages
    Anu Daniel
    Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Bacteriol 189:2086-100. 2007
    ..Until now, no S. epidermidis phage genome sequences have been reported in the literature, and thus this study represents the first complete genomic and molecular description of two S. epidermidis phages...
  28. pmc Role of the C-terminal lysine residues of streptococcal surface enolase in Glu- and Lys-plasminogen-binding activities of group A streptococci
    Anne Derbise
    Laboratory of Bacterial Pathogenesis, Public Health Research Institute, International Center for Public Health, Newark, New Jersey 07103 3535, USA
    Infect Immun 72:94-105. 2004
    ....
  29. pmc Purification and characterization of LPXTGase from Staphylococcus aureus: the amino acid composition mirrors that found in the peptidoglycan
    Sung G Lee
    Laboratory of Bacterial Pathogenesis, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    J Bacteriol 188:389-98. 2006
    ..This suggests that enzymes responsible for wall assembly may also play a role in the construction of LPXTGase...
  30. ncbi request reprint Characterization of a unique glycosylated anchor endopeptidase that cleaves the LPXTG sequence motif of cell surface proteins of Gram-positive bacteria
    Sung G Lee
    Laboratory of Bacterial Pathogenesis Rockefeller University, New York, New York 10021, USA
    J Biol Chem 277:46912-22. 2002
    ....
  31. ncbi request reprint Mutagenesis of a bacteriophage lytic enzyme PlyGBS significantly increases its antibacterial activity against group B streptococci
    Qi Cheng
    The Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Appl Microbiol Biotechnol 74:1284-91. 2007
    ..A reduction in GBS colonization before delivery should significantly reduce neonatal GBS infection providing a safe alternative to IAP...
  32. pmc A novel spore protein, ExsM, regulates formation of the exosporium in Bacillus cereus and Bacillus anthracis and affects spore size and shape
    Monica M Fazzini
    Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, New York 10065, USA
    J Bacteriol 192:4012-21. 2010
    ..Insertional mutagenesis of exsM in Bacillus anthracis DeltaSterne resulted in a partial second exosporium and in smaller spores. In all, these findings suggest that ExsM plays a critical role in the formation of the exosporium...
  33. ncbi request reprint Presence of D-alanine in an endopeptidase from Streptococcus pyogenes
    Sung G Lee
    Laboratory of Bacterial Pathogenesis, Rockefeller University, New York, NY 10021, USA
    J Biol Chem 278:46649-53. 2003
    ....
  34. pmc Novel algorithms reveal streptococcal transcriptomes and clues about undefined genes
    Patricia A Ryan
    Department of Bacterial Pathogenesis and Immunology, Rockefeller University, New York, New York, USA
    PLoS Comput Biol 3:e132. 2007
    ..Neighbor clustering provides a more comprehensive view of the molecular responses of streptococci during pharyngeal cell adherence...
  35. pmc In vivo lysogenic conversion of Tox(-) Streptococcus pyogenes to Tox(+) with Lysogenic Streptococci or free phage
    Thomas B Broudy
    Laboratory of Bacterial Pathogenesis and Immunology, Rockefeller University, New York, New York 10021, USA
    Infect Immun 71:3782-6. 2003
    ..Ultimately, our findings demonstrate that the eukaryotic host serves as an essential component in the phage-mediated evolution of virulence within the microbial population...
  36. pmc Lysogeny of Streptococcus pneumoniae with MM1 phage: improved adherence and other phenotypic changes
    Jutta M Loeffler
    Laboratory of Bacterial Pathogenesis, The Rockefeller University, 1230 York Ave, New York, New York 10021, USA
    Infect Immun 74:4486-95. 2006
    ..By improving the adherence of pneumococci, this prophage may contribute to their fitness and possibly to their persistence in humans...
  37. pmc A structural basis for the allosteric regulation of non-hydrolysing UDP-GlcNAc 2-epimerases
    Lucas M Velloso
    Laboratory of Structural Microbiology, The Rockfeller University, New York, NY 10021, USA
    EMBO Rep 9:199-205. 2008
    ..This constitutes the first example to our knowledge, of an enzymatic allosteric activation by direct interaction between the substrate and the allosteric activator...
  38. pmc Synergistic killing of Streptococcus pneumoniae with the bacteriophage lytic enzyme Cpl-1 and penicillin or gentamicin depends on the level of penicillin resistance
    Svetolik Djurkovic
    Laboratory of Bacterial Pathogenesis, The Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    Antimicrob Agents Chemother 49:1225-8. 2005
    ..Activities of Cpl-1 and gentamicin were increasingly synergistic with a decreasing penicillin MIC, while Cpl-1 and penicillin showed synergy against an extremely penicillin-resistant strain...
  39. ncbi request reprint Reduced IFN-gamma responses associated with HLA-DR15 presentation of streptococcal cell wall proteins to dermal Th-1 cells in psoriasis
    Barbara S Baker
    Department of Dermatology, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, United Kingdom
    J Clin Immunol 23:407-14. 2003
    ..It is proposed that HLA-DR allelic variation may contribute to disease phenotype via effects on the immune response to group A streptococci...
  40. ncbi request reprint The 1.6 A crystal structure of the catalytic domain of PlyB, a bacteriophage lysin active against Bacillus anthracis
    Corrine J Porter
    Protein Crystallography Unit, Department of Biochemistry and Molecular Biology and The ARC Centre of Excellence for Structural and Functional Microbial Genomics, Monash University, Clayton, Melbourne, VIC 3800, Australia
    J Mol Biol 366:540-50. 2007
    ..PlyB therefore represents a new class of anthrax lysin and a new defensive tool in the armament against anthrax-mediated bioterrorism...
  41. pmc Cysteine protease activity and histamine release from the human mast cell line HMC-1 stimulated by recombinant streptococcal pyrogenic exotoxin B/streptococcal cysteine protease
    Yukino Watanabe
    Department of Immunology and Infectious Diseases, Institute of Gerontology, Nippon Medical School, Nakahara ku, Kawasaki 211 8533, Japan
    Infect Immun 70:3944-7. 2002
    ..This study may contribute to the understanding of the pathogenic role of SPE B/SCP in streptococcal infection and streptococcal toxic shock syndrome...
  42. doi request reprint Phage lytic enzyme Cpl-1 for antibacterial therapy in experimental pneumococcal meningitis
    Denis Grandgirard
    Institute for Infectious Diseases, University of Bern, Switzerland
    J Infect Dis 197:1519-22. 2008
    ..Intraperitoneal administration of Cpl-1 (200 mg/kg) led to an antibacterial effect in CSF of 2 orders of magnitude for 3 h. Cpl-1 may hold promise as an alternative treatment option in pneumococcal meningitis...
  43. ncbi request reprint PlyC, a novel bacteriophage lysin for compartment-dependent proteomics of group A streptococci
    Thomas Koller
    Department of Medical Microbiology and Hospital Hygiene, Hospital of Rostock University, Schillingallee 70, Rostock, Germany
    Proteomics 8:140-8. 2008
    ..Furthermore, our experimental design allowed us to delineate the actual localization of the proteins despite contamination with intracellular proteins...
  44. pmc Analysis of factors affecting surface expression and immunogenicity of recombinant proteins expressed by gram-positive commensal vectors
    Tove C Bolken
    SIGA Technologies Inc, Corvallis, Oregon 97333, USA
    Infect Immun 70:2487-91. 2002
    ..The results obtained should facilitate the design of improved vaccine candidates using this antigen delivery technology...
  45. ncbi request reprint Biochemical analysis of a common human polymorphism associated with age-related macular degeneration
    Jiamei Yu
    Department of Physiology and Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Biochemistry 46:8451-61. 2007
    ..This study reveals the fundamental properties of a common polymorphism of CFH and lays the groundwork for elucidating the role of CFH in AMD pathogenesis...
  46. pmc Novel strategy to prevent otitis media caused by colonizing Streptococcus pneumoniae
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS Pathog 3:e28. 2007
  47. pmc Clinical and microbiological responses of volunteers to combined intranasal and oral inoculation with a Streptococcus gordonii carrier strain intended for future use as a group A streptococcus vaccine
    Karen L Kotloff
    Department of Pediatrics, School of Medicine, University of Maryland, 685 West Baltimore St, HSF 480, Baltimore, MD 21201, USA
    Infect Immun 73:2360-6. 2005
    ..The results of these clinical trials provide encouragement that the use of S. gordonii as a live mucosal vaccine vector is a feasible strategy...

Research Grants20

  1. Pathogen-specific drug targets for weaponized bacteria
    Vincent Fischetti; Fiscal Year: 2007
    ..This proposal presents a concerted effort of three complementary groups at the Rockefeller University (Dr. Vincent Fischetti, Dr. Alexander Tomasz, and Dr. Erec Stebbins) to identify novel inhibitors of the Category A pathogens, B...
  2. Isolaton of new phage enzymes to kill B. anthracis
    Vincent Fischetti; Fiscal Year: 2007
    ..Because these enzymes may be an important line of defense against an attack with drug-resistant B. anthracis, having a number of enzymes at our disposal may allow for better decisions as to their use if necessary. ..
  3. PROPERTIES OF STREPTOCOCCAL M PROTEIN
    Vincent Fischetti; Fiscal Year: 2009
    ....
  4. PROPERTIES OF STREPTOCOCCAL M PROTEIN
    Vincent A Fischetti; Fiscal Year: 2010
    ....
  5. PROPERTIES OF STREPTOCOCCAL M-PROTEIN
    Vincent Fischetti; Fiscal Year: 1980
    ..At present, two serologically unrelated M proteins have been purified and partially sequenced. Physiocochemical and sequence data indicate that the M molecules have a close structure relationship with mammalian tropomysin. ..
  6. Isolation of new phage enzymes to kill B. anthracis
    Vincent A Fischetti; Fiscal Year: 2010
    ..This latest information changes our thinking about the versatility of these pathogens, allowing us to devise innovative strategies to control them both in the environment and during infection. ..