Susan Fischer

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc The chemopreventive efficacies of nonsteroidal anti-inflammatory drugs: the relationship of short-term biomarkers to long-term skin tumor outcome
    Carol D Mikulec
    The Department of Molecular Carcinogenesis, Science Park, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA
    Cancer Prev Res (Phila) 6:675-85. 2013
  2. pmc The role of the EP receptors for prostaglandin E2 in skin and skin cancer
    J E Rundhaug
    The Department of Molecular Carcinogenesis, Science Park, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA
    Cancer Metastasis Rev 30:465-80. 2011
  3. pmc Coxibs and other nonsteroidal anti-inflammatory drugs in animal models of cancer chemoprevention
    Susan M Fischer
    Department of Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Science Park, PO Box 389, Smithville, TX 78957, USA
    Cancer Prev Res (Phila) 4:1728-35. 2011
  4. ncbi request reprint Is cyclooxygenase-2 important in skin carcinogenesis?
    Susan M Fischer
    The University of Texas M D Anderson, Department of Carcinogenesis, Smithville 78957, USA
    J Environ Pathol Toxicol Oncol 21:183-91. 2002
  5. ncbi request reprint Celecoxib and difluoromethylornithine in combination have strong therapeutic activity against UV-induced skin tumors in mice
    Susan M Fischer
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, PO Box 389, Park Road 1C, Smithville 78957, USA
    Carcinogenesis 24:945-52. 2003
  6. pmc Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors
    Philippe Thuillier
    Department of Carcinogenesis, University of Texas M D Anderson Cancer Center, Smithville 78957, USA
    Biochem J 366:901-10. 2002
  7. pmc The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesis
    Imad Shureiqi
    Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Cancer Res 65:11486-92. 2005
  8. ncbi request reprint Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) gene expression in normal human prostate epithelial cells
    Shaohua Tang
    Department of Carcinogenesis, Science Park Research Division, The University of Texas MD Anderson Cancer Center, 1808 Park Rd 1C, Smithville, TX 78957, USA
    Oncogene 23:6942-53. 2004
  9. pmc The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells
    Imad Shureiqi
    Departments of Clinical Cancer Prevention, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:9968-73. 2003
  10. ncbi request reprint GATA-6 transcriptional regulation of 15-lipoxygenase-1 during NSAID-induced apoptosis in colorectal cancer cells
    Imad Shureiqi
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Cancer Res 62:1178-83. 2002

Research Grants

  1. VII International Skin Carcinogenesis Conference (ISCC)
    Susan Fischer; Fiscal Year: 2006
  2. Mouse Models of Skin Cancer
    Susan Fischer; Fiscal Year: 2007
  3. Prevention of Prostate Carcinogenesis in Transgenic Mice
    Susan Fischer; Fiscal Year: 2007
  4. COX-2 Driven Pancreatic Adenocarcinoma
    Susan Fischer; Fiscal Year: 2007
  5. 6th International Skin Carcinogenesis Conference
    Susan Fischer; Fiscal Year: 2004
  6. Cyclooxygenase-2 Induced Pancreatic Cancer
    Susan M Fischer; Fiscal Year: 2010
  7. COX-2 in Skin Carcinogenesis
    Susan Fischer; Fiscal Year: 2007
  8. 8 LOX AND SKIN CANCER SUSCEPTIBILITY
    Susan Fischer; Fiscal Year: 2004
  9. Obesity and Pancreatic Cancer: The Role of IGF-1
    Susan M Fischer; Fiscal Year: 2010

Collaborators

Detail Information

Publications52

  1. pmc The chemopreventive efficacies of nonsteroidal anti-inflammatory drugs: the relationship of short-term biomarkers to long-term skin tumor outcome
    Carol D Mikulec
    The Department of Molecular Carcinogenesis, Science Park, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA
    Cancer Prev Res (Phila) 6:675-85. 2013
    ..In testing short-term biomarkers, we found that agents that reduce UV-induced prostaglandin E2 synthesis and/or inhibit UV-induced keratinocyte proliferation yielded long-term tumor efficacy...
  2. pmc The role of the EP receptors for prostaglandin E2 in skin and skin cancer
    J E Rundhaug
    The Department of Molecular Carcinogenesis, Science Park, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA
    Cancer Metastasis Rev 30:465-80. 2011
    ..Understanding the role and mechanisms of action of the EP receptors potentially offers new targets for the prevention or therapy of NMSCs...
  3. pmc Coxibs and other nonsteroidal anti-inflammatory drugs in animal models of cancer chemoprevention
    Susan M Fischer
    Department of Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Science Park, PO Box 389, Smithville, TX 78957, USA
    Cancer Prev Res (Phila) 4:1728-35. 2011
    ..A comprehensive understanding of the results of coxibs and other NSAIDs in animal studies may help inform and shape human trials of these commonly employed, relatively inexpensive, and highly effective compounds...
  4. ncbi request reprint Is cyclooxygenase-2 important in skin carcinogenesis?
    Susan M Fischer
    The University of Texas M D Anderson, Department of Carcinogenesis, Smithville 78957, USA
    J Environ Pathol Toxicol Oncol 21:183-91. 2002
    ..Collectively, these studies suggest that prostaglandins play a critical role in skin cancer development...
  5. ncbi request reprint Celecoxib and difluoromethylornithine in combination have strong therapeutic activity against UV-induced skin tumors in mice
    Susan M Fischer
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, PO Box 389, Park Road 1C, Smithville 78957, USA
    Carcinogenesis 24:945-52. 2003
    ..It is concluded that the combination of celecoxib and DFMO are potent therapeutic agents for skin cancer, although the benefits are lost with the cessation of treatment...
  6. pmc Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors
    Philippe Thuillier
    Department of Carcinogenesis, University of Texas M D Anderson Cancer Center, Smithville 78957, USA
    Biochem J 366:901-10. 2002
    ..Ligand-binding studies revealed that the LOX inhibitors bind directly to PPARs and demonstrate a novel mechanism for these inhibitors in altering PPAR-mediated gene expression...
  7. pmc The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesis
    Imad Shureiqi
    Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Cancer Res 65:11486-92. 2005
    ..Therefore, 15-LOX-1 down-regulation rather than a shift in the balance of LOXs is likely the dominant alteration in LOX metabolism which contributes to colorectal tumorigenesis by repressing apoptosis...
  8. ncbi request reprint Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) gene expression in normal human prostate epithelial cells
    Shaohua Tang
    Department of Carcinogenesis, Science Park Research Division, The University of Texas MD Anderson Cancer Center, 1808 Park Rd 1C, Smithville, TX 78957, USA
    Oncogene 23:6942-53. 2004
    ..The results indicate that androgen does not directly regulate 15-LOX2 gene expression. Together, these observations provide insight on how 15-LOX2 gene expression may be regulated in NHP cells...
  9. pmc The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells
    Imad Shureiqi
    Departments of Clinical Cancer Prevention, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:9968-73. 2003
    ..Our findings indicate that the down-regulation of PPAR-delta by 15-LOX-1 through 13-S-HODE is an apoptotic signaling pathway that is activated by NSAIDs...
  10. ncbi request reprint GATA-6 transcriptional regulation of 15-lipoxygenase-1 during NSAID-induced apoptosis in colorectal cancer cells
    Imad Shureiqi
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Cancer Res 62:1178-83. 2002
    ..Ectopic GATA-6 expression blocked NSAID induction of 15-LOX-1 and apoptosis. NSAIDs down-regulate GATA-6 to transcriptionally up-regulate 15-LOX-1 and induce apoptosis in colorectal cancer cells...
  11. ncbi request reprint Critical role of IkappaB kinase alpha in embryonic skin development and skin carcinogenesis
    Feng Zhu
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Smithville, Texas, USA
    Histol Histopathol 24:265-71. 2009
    ..In this review, we will summarize these findings from our and other studies on the role that IKKalpha plays in development of the mouse embryonic skin and skin carcinogenesis...
  12. ncbi request reprint Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells
    Shaohua Tang
    Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    J Biol Chem 277:16189-201. 2002
    ..Taken together, these results suggest that 15-LOX2 could be a suppressor of prostate cancer development, which functions by restricting cell cycle progression...
  13. ncbi request reprint Thiazolidinediones inhibit insulin-like growth factor-i-induced activation of p70S6 kinase and suppress insulin-like growth factor-I tumor-promoting activity
    Guobin He
    Department of Carcinogenesis, University of Texas M D Anderson Cancer Center, Science Park Research Division, 1808 Park Road 1C, Smithville, TX 78957, USA
    Cancer Res 66:1873-8. 2006
    ..Collectively, these data suggest that thiazolidinediones specifically inhibit IGF-I tumor-promoting activity in mouse skin through activation of AMPK and subsequent inhibition of p70S6K...
  14. pmc A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas
    Bigang Liu
    Department of Carcinogenesis, University of Texas M D Anderson Cancer Center, Smithville, TX 78957, USA
    Proc Natl Acad Sci U S A 103:17202-7. 2006
    ..Thus, overexpression of IKKalpha in the epidermis antagonized chemical carcinogen-induced mitogenic and angiogenic activities, repressing tumor progression and metastases...
  15. ncbi request reprint A role for cyclooxygenase-2 in ultraviolet light-induced skin carcinogenesis
    Joyce E Rundhaug
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    Mol Carcinog 46:692-8. 2007
    ..Together these studies demonstrate that COX-2 expression/activity is critical to the development of UV-related nonmelanoma skin cancers...
  16. ncbi request reprint The effect of cyclooxygenase-2 overexpression on skin carcinogenesis is context dependent
    Joyce E Rundhaug
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    Mol Carcinog 46:981-92. 2007
    ..COX2 mice treated only with DMBA developed approximately 3.5 times more tumors than wild-type mice, suggesting that PGs have intrinsic tumor promoting activity. We conclude that the role of PGs in skin tumorigenesis is context dependent...
  17. doi request reprint IKKalpha is required to maintain skin homeostasis and prevent skin cancer
    Bigang Liu
    Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA
    Cancer Cell 14:212-25. 2008
    ..Thus, IKKalpha serves as an innate surveillant...
  18. ncbi request reprint Troglitazone induction of COX-2 expression is dependent on ERK activation in keratinocytes
    Guobin He
    Department of Carcinogenesis, Science Park Research Division, University of Texas M D Anderson Cancer Center, 1808 Park Road 1C, P O Box 389, Smithville, TX 78957, USA
    Prostaglandins Leukot Essent Fatty Acids 74:193-7. 2006
    ..These data suggest that troglitazone is capable of inducing COX-2 expression through an ERK-dependent mechanism in mouse skin keratinocytes...
  19. ncbi request reprint SAGE profiling of UV-induced mouse skin squamous cell carcinomas, comparison with acute UV irradiation effects
    Joyce E Rundhaug
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    Mol Carcinog 42:40-52. 2005
    ....
  20. ncbi request reprint Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas
    Eunmi Park
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Smithville, Texas 78957, USA
    Cancer Res 67:9158-68. 2007
    ..Our findings provide evidence that a reduction in IKKalpha expression promotes the development of papillomas and carcinomas and that the integrity of the Ikkalpha gene is required for suppressing skin carcinogenesis...
  21. ncbi request reprint Mutation frequencies in murine keratinocytes as a function of carcinogenic status
    Laura A Christensen
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas, USA
    Mol Carcinog 40:122-33. 2004
    ..These data suggested that a strong mutator phenotype was not required for progression to an advanced malignant phenotype in our model system...
  22. pmc Progressive metaplastic and dysplastic changes in mouse pancreas induced by cyclooxygenase-2 overexpression
    Jennifer Kl Colby
    Science Park Research Division, University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA
    Neoplasia 10:782-96. 2008
    ..The progressive nature of the metaplastic/dysplastic changes observed in this model make it a valuable tool for examining the transition from chronic inflammation to neoplasia...
  23. ncbi request reprint Black tea polyphenols inhibit IGF-I-induced signaling through Akt in normal prostate epithelial cells and Du145 prostate carcinoma cells
    Russell D Klein
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, PO Box 389, Smithville, TX 78957, USA
    Carcinogenesis 23:217-21. 2002
    ....
  24. ncbi request reprint Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma
    Kevin D Houston
    University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    Cancer Res 63:1221-7. 2003
    ..These results suggest that in uterine leiomyomas PPARgamma activation is growth inhibitory and that this inhibition is mediated at least in part by negative cross-talk between ER and PPAR signaling pathways...
  25. doi request reprint Vitamin E analog, alpha-tocopherol ether-linked acetic acid analog, alone and in combination with celecoxib, reduces multiplicity of ultraviolet-induced skin cancers in mice
    Shelley B Riedel
    Section of Molecular Genetics and Microbiology, The University of Texas, Austin, TX 78712, USA
    Anticancer Drugs 19:175-81. 2008
    ..In conclusion alpha-TEA is an effective late-stage chemopreventive agent for nonmelanoma skin cancer that exhibits lasting benefits...
  26. pmc Multiple signaling pathways are responsible for prostaglandin E2-induced murine keratinocyte proliferation
    Kausar M Ansari
    Science Park Research Division, The University of Texas M D Anderson Cancer Center, PO Box 389, Smithville, TX 78957, USA
    Mol Cancer Res 6:1003-16. 2008
    ..Our findings provide evidence for a link between cyclooxygenase-2 overexpression and EGFR-, ERK-, PI3K-, cAMP-mediated cell proliferation, and the tumor-promoting activity of PGE2 in mouse skin...
  27. ncbi request reprint An antitumorigenic role for murine 8S-lipoxygenase in skin carcinogenesis
    Eunjung Kim
    Science Park Research Division, University of Texas MD Anderson Cancer Center, 1808 Park Road 1C, PO Box 389, Smithville, TX 78957, USA
    Oncogene 24:1174-87. 2005
    ..Collectively, these data suggest that 8S-LOX plays a role as a prodifferentiating, antitumorigenic, and tumor suppressing gene in mouse skin carcinogenesis...
  28. ncbi request reprint Quantitative high-performance liquid chromatography/electrospray ionization tandem mass spectrometric analysis of 2- and 3-series prostaglandins in cultured tumor cells
    Peiying Yang
    Department of Experimental Therapeutics, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Anal Biochem 308:168-77. 2002
    ..Concomitantly, EPA increased formation of PGE(3) by 10-fold in A549 cells. This is the first report that unequivocally demonstrates that EPA can be converted to PGE(3) by cyclooxygenase in human cancer cells...
  29. pmc Peroxisome proliferator-activated receptor ligand MCC-555 suppresses intestinal polyps in ApcMin/+ mice via extracellular signal-regulated kinase and peroxisome proliferator-activated receptor-dependent pathways
    Kiyoshi Yamaguchi
    Department of Pathobiology, College of Veterinary Medicine, The University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Mol Cancer Ther 7:2779-87. 2008
    ..Overall, these results indicate that MCC-555 has a potent tumor suppressor activity in intestinal tumorigenesis, likely involving MUC2 up-regulation by ERK and PPARgamma pathways...
  30. ncbi request reprint Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development
    David K Bol
    Bristol Myers Squibb Pharmaceutical Research Institute, Department of Oncology Drug Discovery, Princeton, New Jersey 08543, USA
    Cancer Res 62:2516-21. 2002
    ..These results clearly raise questions regarding the role of COX-2 and elevated prostaglandin levels in skin tumor development...
  31. ncbi request reprint Regulation of transcription of the intracellular interleukin-1 receptor antagonist gene by AP-1 in mouse carcinoma cells
    Eunhye La
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    Mol Carcinog 33:237-43. 2002
    ..Moreover, electrophoretic mobility shift assay and cotransfection experiments showed that c-jun and c-fos proteins bound to the AP-1 site and functionally transactivated the icIL-1Ra promoter in mouse carcinoma CH72 cells...
  32. pmc Cyclooxygenase-2 expression is critical for chronic UV-induced murine skin carcinogenesis
    Susan M Fischer
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    Mol Carcinog 46:363-71. 2007
    ..UV-induced apoptosis, however, was greater in COX-2 heterozygous mice. Collectively, these results clearly establish the requirement for COX-2 in the development of skin tumors...
  33. ncbi request reprint Modulation of UVB-induced and basal cyclooxygenase-2 (COX-2) expression by apigenin in mouse keratinocytes: role of USF transcription factors
    Rukiyah T van Dross
    Department of Pharmacology and Toxicology, Leo Jenkins Cancer Center, East Carolina University, Greenville, North Carolina 27834, USA
    Mol Carcinog 46:303-14. 2007
    ..These results suggest that one pathway by which apigenin inhibits COX-2 expression is through modulation of USF transcriptional activity...
  34. ncbi request reprint Formation and antiproliferative effect of prostaglandin E(3) from eicosapentaenoic acid in human lung cancer cells
    Peiying Yang
    Pharmaceutical Development Center, The University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    J Lipid Res 45:1030-9. 2004
    ..These data indicate that exposure of lung cancer cells to EPA results in a decrease in the COX-2-mediated formation of PGE(2), an increase in the level of PGE(3), and PGE(3)-mediated inhibition of tumor cell proliferation...
  35. ncbi request reprint Selective cyclooxygenase-2 inhibitors inhibit growth and induce apoptosis of bladder cancer
    Jason Gee
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Oncol Rep 15:471-7. 2006
    ..Induction of apoptosis in all three cell lines by celecoxib was associated with downregulation of Bcl-2. These changes occur independently of COX-2 expression levels suggesting the presence of a COX-2 independent pathway...
  36. ncbi request reprint Lack of expression of the EP2 but not EP3 receptor for prostaglandin E2 results in suppression of skin tumor development
    You Me Sung
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, TX 78957, USA
    Cancer Res 65:9304-11. 2005
    ..Our data suggest that the EP2 receptor plays a significant role in the protumorigenic action of PGE2 in skin tumor development...
  37. ncbi request reprint The effect of PPARgamma ligands on UV- or chemically-induced carcinogenesis in mouse skin
    Guobin He
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    Mol Carcinog 43:198-206. 2005
    ..Collectively, our data suggest that PPARgamma ligands may not be useful in the prevention of chemically or UV-induced skin tumors...
  38. ncbi request reprint Transitional cell hyperplasia and carcinomas in urinary bladders of transgenic mice with keratin 5 promoter-driven cyclooxygenase-2 overexpression
    Russell D Klein
    Department of Human Nutrition and Internal Medicine, Ohio State University, Columbus, Ohio, USA
    Cancer Res 65:1808-13. 2005
    ..Therefore, inhibition of COX-2 should continue to be pursued as a potential chemopreventive and therapeutic strategy...
  39. ncbi request reprint Troglitazone inhibits cyclin D1 expression and cell cycling independently of PPARgamma in normal mouse skin keratinocytes
    Guobin He
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas, USA
    J Invest Dermatol 123:1110-9. 2004
    ..Given the important role of keratinocyte proliferation in skin carcinogenesis, our data suggest that TZD may be useful tumor preventive agents in skin...
  40. ncbi request reprint Helicobacter pylori stimulates host cyclooxygenase-2 gene transcription: critical importance of MEK/ERK-dependent activation of USF1/-2 and CREB transcription factors
    Stefan Jüttner
    Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Cell Microbiol 5:821-34. 2003
    ..pylori-dependent cox-2 gene expression in gastric epithelial cells, and may thus contribute to a better understanding of mechanisms underlying H. pylori pathogenicity...
  41. ncbi request reprint Evidence for downregulation of calcium signaling proteins in advanced mouse adenocarcinoma
    Viola C Ruddat
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
    Prostate 64:128-38. 2005
    ..Gleason grading is currently the predominant method for prediction, with only few biomarkers available. More biomarkers, especially as they relate to cancer progression are desirable...
  42. ncbi request reprint A dose-finding study of aspirin for chemoprevention utilizing rectal mucosal prostaglandin E(2) levels as a biomarker
    Dory Sample
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Epidemiol Biomarkers Prev 11:275-9. 2002
    ..No adverse events occurred in this short-term study. The 81-mg daily aspirin dose suppressed PGE(2) levels to an equivalent extent as did the 650-mg dose and supports the use of this dose for chemoprevention trials...
  43. ncbi request reprint Protein expression profiles in the epidermis of cyclooxygenase-2 transgenic mice by 2-dimensional gel electrophoresis and mass spectrometry
    Jianjun Shen
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    J Proteome Res 6:273-86. 2007
    ..The current data suggest that some of the differentially expressed proteins might increase apoptosis and cell cycle arrest, which, in turn, may provide insight into the role of COX-2 in skin tumorigenesis...
  44. pmc Loss of 15-hydroxyprostaglandin dehydrogenase expression disrupts urothelial differentiation
    Stephanie Tseng-Rogenski
    Department of Urology, University of Michigan, Ann Arbor, Michigan 48109 0330, USA
    Urology 71:346-50. 2008
    ..Urothelial differentiation is essential for the maintenance of urinary bladder function. We explored the expression and function of 15-hydroxyprostaglandin dehydrogenase (PGDH) during urothelial differentiation...
  45. doi request reprint Cyclo-oxygenase-2 plays a critical role in UV-induced skin carcinogenesis
    Joyce E Rundhaug
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, TX, USA
    Photochem Photobiol 84:322-9. 2008
    ..A combination of signaling from the PGE2 EP1, EP2 and/or EP4 receptors mediates the effects of COX-2 overexpression. These studies demonstrate the crucial role of COX-2 in the development of UV-related nonmelanoma skin cancers...
  46. ncbi request reprint The resistance to the tumor suppressive effects of COX inhibitors and COX-2 gene disruption in TRAMP mice is associated with the loss of COX expression in prostate tissue
    Xingya Wang
    Department of Human Nutrition and Molecular Carcinogenesis and Chemoprevention Program, The Ohio State University Comprehensive Cancer Center, The Ohio State University, 325 Campbell Hall, 1787 Neil Avenue, Columbus, OH 43210, USA
    Carcinogenesis 29:120-8. 2008
    ..Collectively, our results suggest that COX-2 may not play a tumorigenic role during prostate carcinogenesis in the TRAMP model...
  47. pmc Gemfibrozil, a lipid-lowering drug, inhibits the induction of nitric-oxide synthase in human astrocytes
    Kalipada Pahan
    Department of Oral Biology, University of Nebraska Medical Center, Lincoln, Nebraska 68583, USA
    J Biol Chem 277:45984-91. 2002
    ....
  48. ncbi request reprint Suppression of 15-hydroxyprostaglandin dehydrogenase messenger RNA concentration, protein expression, and enzymatic activity during human ureteral obstruction
    Travis J Jerde
    Department of Surgery, Division of Urology, University of Wisconsin Medical School, G5 339 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA
    J Pharmacol Exp Ther 309:398-403. 2004
    ..Modulation of prostanoid degradation may have therapeutic relevance in obstructive disorders of the ureter...
  49. ncbi request reprint Identification and characterization of a phorbol ester-responsive element in the murine 8S-lipoxygenase gene
    Eunjung Kim
    University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    J Biol Chem 279:11188-97. 2004
    ..These data suggest that increased binding of Sp1, Sp2, and Sp3 to the TRE of the 8S-LOX promoter is a mechanism by which TPA induces 8S-LOX expression in keratinocytes...
  50. ncbi request reprint Chemoprevention of skin carcinogenesis by phenylretinamides: retinoid receptor-independent tumor suppression
    Hui Xu
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center Shreveport and the Feist Weiller Cancer Center, Shreveport, Louisiana 17730, USA
    Clin Cancer Res 12:969-79. 2006
    ....
  51. ncbi request reprint Cyclooxygenase-2 deficiency increases epidermal apoptosis and impairs recovery following acute UVB exposure
    Jacqueline K Akunda
    Laboratory of Molecular Carcinogenesis, NIEHS NIH, Research Triangle Park, North Carolina 27709, USA
    Mol Carcinog 46:354-62. 2007
    ..The data indicate that COX-2 induction initially protects against the acute sunburn effects of UVB, but that continuous induction of COX-2 may contribute to skin cancer in chronic UVB exposure...
  52. ncbi request reprint Prostaglandin receptor EP2 is responsible for cyclooxygenase-2 induction by prostaglandin E2 in mouse skin
    Kausar M Ansari
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, PO Box 389, Smithville, TX 78957, USA
    Carcinogenesis 28:2063-8. 2007
    ..Taken together, EP2 activation of the PKA/CREB-signaling pathway is responsible for keratinocyte proliferation and our findings reveal a positive feedback loop between COX-2 and PGE2 that is mediated by the EP2 receptor...

Research Grants26

  1. VII International Skin Carcinogenesis Conference (ISCC)
    Susan Fischer; Fiscal Year: 2006
    ..The meeting will be held November 9-12, 2006 in Austin, TX. ..
  2. Mouse Models of Skin Cancer
    Susan Fischer; Fiscal Year: 2007
    ..3) Where indicated, models with multiple genetic alterations will be developed. ..
  3. Prevention of Prostate Carcinogenesis in Transgenic Mice
    Susan Fischer; Fiscal Year: 2007
    ..IGF-1 model. ..
  4. COX-2 Driven Pancreatic Adenocarcinoma
    Susan Fischer; Fiscal Year: 2007
    ..Because of the links between chronic inflammation, COX-2 and pancreatic cancer, the proposed work should contribute needed information on this disease. ..
  5. 6th International Skin Carcinogenesis Conference
    Susan Fischer; Fiscal Year: 2004
    ..The meeting will be held jointly with the Montagna Symposium on the Biology of Skin. ..
  6. Cyclooxygenase-2 Induced Pancreatic Cancer
    Susan M Fischer; Fiscal Year: 2010
    ....
  7. COX-2 in Skin Carcinogenesis
    Susan Fischer; Fiscal Year: 2007
    ..abstract_text> ..
  8. 8 LOX AND SKIN CANCER SUSCEPTIBILITY
    Susan Fischer; Fiscal Year: 2004
    ..tumors? (4) Do 8-HETE or 9-HODE exert their effects by binding to and activating one or more of the PPAR isoforms in keratinocytes? Is the PPAR alpha isoform required for 8-HETE effects on differentiation and skin tumor susceptibility? ..
  9. Obesity and Pancreatic Cancer: The Role of IGF-1
    Susan M Fischer; Fiscal Year: 2010
    ..This information should be useful in designing approaches or treatments that will counteract the effect of obesity on this very fatal human disease. ..