Richard S Finkel

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. pmc Candidate proteins, metabolites and transcripts in the Biomarkers for Spinal Muscular Atrophy (BforSMA) clinical study
    Richard S Finkel
    Department of Neurology and Pediatrics, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e35462. 2012
  2. pmc Read-through strategies for suppression of nonsense mutations in Duchenne/ Becker muscular dystrophy: aminoglycosides and ataluren (PTC124)
    Richard S Finkel
    Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Child Neurol 25:1158-64. 2010
  3. doi request reprint Intravenous levetiracetam terminates refractory focal status epilepticus
    Nicholas S Abend
    Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Neurocrit Care 10:83-6. 2009
  4. doi request reprint Serial casting for the management of ankle contracture in Duchenne muscular dystrophy
    Allan M Glanzman
    Department of Physical Therapy, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatr Phys Ther 23:275-9. 2011
  5. ncbi request reprint Laryngeal electromyography in the management of vocal cord mobility problems in children
    Ian N Jacobs
    Divisions of Pediatric Otolaryngology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, U S A
    Laryngoscope 112:1243-8. 2002
  6. pmc Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity
    Zhengyu Ma
    Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Biol 6:e43. 2008
  7. ncbi request reprint Evaluation of the presentation of systemic onset juvenile rheumatoid arthritis: data from the Pennsylvania Systemic Onset Juvenile Arthritis Registry (PASOJAR)
    Edward M Behrens
    Department of Pediatrics, Division of Rheumatology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    J Rheumatol 35:343-8. 2008
  8. pmc The receptor deformation model of TCR triggering
    Zhengyu Ma
    Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    FASEB J 22:1002-8. 2008
  9. ncbi request reprint Complement receptor 3 ligation of dendritic cells suppresses their stimulatory capacity
    Edward M Behrens
    Laboratory of Dendritic Cell Biology, Joseph Stokes, Jr Research Institute, Children s Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    J Immunol 178:6268-79. 2007
  10. ncbi request reprint Ligation of human CD4 interferes with antigen-induced activation of primary T cells
    Susanne Marschner
    Integrated Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    Immunol Lett 82:131-9. 2002

Collaborators

Detail Information

Publications25

  1. pmc Candidate proteins, metabolites and transcripts in the Biomarkers for Spinal Muscular Atrophy (BforSMA) clinical study
    Richard S Finkel
    Department of Neurology and Pediatrics, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e35462. 2012
    ..SMN2 copy number inversely correlates with disease severity. Identifying other novel biomarkers could inform clinical trial design and identify novel therapeutic targets...
  2. pmc Read-through strategies for suppression of nonsense mutations in Duchenne/ Becker muscular dystrophy: aminoglycosides and ataluren (PTC124)
    Richard S Finkel
    Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Child Neurol 25:1158-64. 2010
    ..Use of nonsense mutation suppression in Duchenne/Becker muscular dystrophy may offer the prospect of targeting the specific mutation causing the disease and correcting the fundamental pathophysiology...
  3. doi request reprint Intravenous levetiracetam terminates refractory focal status epilepticus
    Nicholas S Abend
    Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Neurocrit Care 10:83-6. 2009
    ....
  4. doi request reprint Serial casting for the management of ankle contracture in Duchenne muscular dystrophy
    Allan M Glanzman
    Department of Physical Therapy, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatr Phys Ther 23:275-9. 2011
    ..To evaluate the effect of serial casting in boys with Duchenne muscular dystrophy...
  5. ncbi request reprint Laryngeal electromyography in the management of vocal cord mobility problems in children
    Ian N Jacobs
    Divisions of Pediatric Otolaryngology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, U S A
    Laryngoscope 112:1243-8. 2002
    ....
  6. pmc Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity
    Zhengyu Ma
    Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Biol 6:e43. 2008
    ..Based on these observations, we propose the receptor deformation model of TCR triggering to explain the remarkable sensitivity and specificity of TCR triggering...
  7. ncbi request reprint Evaluation of the presentation of systemic onset juvenile rheumatoid arthritis: data from the Pennsylvania Systemic Onset Juvenile Arthritis Registry (PASOJAR)
    Edward M Behrens
    Department of Pediatrics, Division of Rheumatology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    J Rheumatol 35:343-8. 2008
    ..To characterize the initial clinical and laboratory features of patients with systemic onset juvenile rheumatoid arthritis (soJRA) through a Web-based registry...
  8. pmc The receptor deformation model of TCR triggering
    Zhengyu Ma
    Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    FASEB J 22:1002-8. 2008
    ..By introducing mechanical force into a model of T cell signal initiation, the receptor deformation model provides potential mechanistic solutions to the sensitivity and specificity of TCR triggering...
  9. ncbi request reprint Complement receptor 3 ligation of dendritic cells suppresses their stimulatory capacity
    Edward M Behrens
    Laboratory of Dendritic Cell Biology, Joseph Stokes, Jr Research Institute, Children s Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    J Immunol 178:6268-79. 2007
    ..We propose that CR3 provides a "nondanger" signal that suppresses the stimulatory capacity of DCs...
  10. ncbi request reprint Ligation of human CD4 interferes with antigen-induced activation of primary T cells
    Susanne Marschner
    Integrated Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    Immunol Lett 82:131-9. 2002
    ..These results suggest that in HIV infected patients the interaction of gp120 with CD4 induces unresponsiveness of CD4+ T cells to subsequent activation by antigen...
  11. ncbi request reprint Extensive replicative capacity of human central memory T cells
    Marcela V Maus
    Abramson Family Cancer Research Institute, University of Pennsylvania Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 172:6675-83. 2004
    ..In conclusion, aAPCs expand T(CM) that have extensive replicative capacity, and have potential applications in adoptive immunotherapy as well as for studying the biology of human MHC class II-restricted T cells...
  12. ncbi request reprint Chronic graft-versus-host reaction is associated with a decrease in Ig light chain receptor editing in bone marrow self-reactive B cells
    Nili Feuerstein
    Division of Rheumatology, The Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, 19104, USA
    Eur J Immunol 34:1361-70. 2004
    ..Thus, the autoimmunity induced by chronic GVH may ultimately result from the failure of B cell tolerance at multiple checkpoints...
  13. ncbi request reprint Chronic GVH prevents anergy in bone marrow self-reactive B cells: a selective increase in post-endoplasmic reticulum processing and trafficking to the cell surface of autoreactive IgM receptors
    Nili Feuerstein
    Division of Rheumatology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Int Immunol 15:975-85. 2003
    ....
  14. ncbi request reprint The gammac-cytokine regulated transcription factor, STAT5, increases HIV-1 production in primary CD4 T cells
    Nithianandan Selliah
    Division of Rheumatology, The Children s Hospital of Philadelphia, PA 19104, USA
    Virology 344:283-91. 2006
    ..These data may have implications for regulation of latency and therapeutic strategies for control of HIV disease...
  15. pmc Human CD8+ T cells do not require the polarization of lipid rafts for activation and proliferation
    Birgit Kovacs
    Division of Rheumatology, Department of Pediatrics, Children s Hospital of Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 99:15006-11. 2002
    ..It is possible that the lower stringency of CD8(+) T cell activation obviates a requirement for raft polarization...
  16. ncbi request reprint T cell signaling and apoptosis in HIV disease
    Nithianandan Selliah
    Division of Rheumatology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Immunol Res 27:247-60. 2003
    ..These studies will yield new insights into the pathogenesis of AIDS, identify cellular targets that regulate HIV-1 infection, and suggest novel therapeutic approaches to cure HIV infection...
  17. doi request reprint Association of the TRAF1-C5 locus on chromosome 9 with juvenile idiopathic arthritis
    Edward M Behrens
    The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Arthritis Rheum 58:2206-7. 2008
  18. doi request reprint The HIV-1 Vif protein mediates degradation of Vpr and reduces Vpr-induced cell cycle arrest
    JiangFang Wang
    Division of Rheumatology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    DNA Cell Biol 27:267-77. 2008
    ..Together, these data show that Vif mediates the degradation of Vpr and modulates Vpr-induced G2 arrest in HIV-1-infected T-cells...
  19. pmc Predictors of acquired lipodystrophy in juvenile-onset dermatomyositis and a gradient of severity
    April Bingham
    From Office of Clinical Research, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, Maryland 20892 1301, USA
    Medicine (Baltimore) 87:70-86. 2008
    ..Further study is warranted to investigate the pathogenesis of acquired LD in patients with DM...
  20. ncbi request reprint CXCR4 engagement is required for HIV-1-induced L-selectin shedding
    JiangFang Wang
    Division of Rheumatology, The Children s Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    Blood 103:1218-21. 2004
    ..These results indicate that engagement of both CD4 and CXCR4 is required for HIV-induced shedding of L-selectin on primary resting CD4(+) T cells...
  21. ncbi request reprint Tracking synapse-associated TCRs
    Terri H Finkel
    Nat Immunol 5:117; author reply 117. 2004
  22. ncbi request reprint Differential gene expression during HIV-1 infection analyzed by suppression subtractive hybridization
    Jiyi Yin
    Division of Rheumatology, The Children s Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
    AIDS 18:587-96. 2004
    ..Characterization of the effects of HIV-1 infection and apoptosis on cellular and viral gene expression...
  23. ncbi request reprint Effective gene suppression using small interfering RNA in hard-to-transfect human T cells
    Jiyi Yin
    Division of Rheumatology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Immunol Methods 312:1-11. 2006
    ..These studies demonstrate that the combination of SEC, siRNA expression vectors and Nucleofector technology can be successfully applied to hard-to-transfect human T cell lines and primary T cells to effectively silence genes...
  24. ncbi request reprint Ligation of CD28 by its natural ligand CD86 in the absence of TCR stimulation induces lipid raft polarization in human CD4 T cells
    Birgit Kovacs
    Division of Rheumatology, Children s Hospital of Philadelphia, and Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 175:7848-54. 2005
    ..This result has implications for mechanisms of T cell activation. Abnormalities in this process may alter T and B cell tolerance and susceptibility to infection...
  25. pmc Early growth response-1 is required for CD154 transcription
    Randy Q Cron
    Division of Rheumatology, Children s Hospital of Philadelphia, PA 19104, USA
    J Immunol 176:811-8. 2006
    ..This has implications for selective targeting of Egr family members to control abnormal expression of CD154 in autoimmune diseases such as systemic lupus erythematosus...