Isaiah J Fidler

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi request reprint The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited
    Isaiah J Fidler
    Department of Cancer Biology, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Rev Cancer 3:453-8. 2003
  2. doi request reprint Targeting the EGFR, VEGFR, and PDGFR on colon cancer cells and stromal cells is required for therapy
    Toshio Kuwai
    Department of Cancer Biology, Unit 173, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Clin Exp Metastasis 25:477-89. 2008
  3. pmc Phosphorylated epidermal growth factor receptor on tumor-associated endothelial cells is a primary target for therapy with tyrosine kinase inhibitors
    Toshio Kuwai
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Neoplasia 10:489-500. 2008
  4. pmc Inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation on tumor-associated endothelial cells leads to treatment of orthotopic human colon cancer in nude mice
    Takamitsu Sasaki
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Neoplasia 9:1066-77. 2007
  5. ncbi request reprint Therapy of multidrug resistant human prostate tumors in the prostate of nude mice by simultaneous targeting of the epidermal growth factor receptor and vascular endothelial growth factor receptor on tumor-associated endothelial cells
    J Erik Busby
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Prostate 66:1788-98. 2006
  6. pmc Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy
    Sun Jin Kim
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Neoplasia 13:286-98. 2011
  7. pmc Intratumoral heterogeneity for expression of tyrosine kinase growth factor receptors in human colon cancer surgical specimens and orthotopic tumors
    Toshio Kuwai
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Pathol 172:358-66. 2008
  8. pmc Modification of the primary tumor microenvironment by transforming growth factor alpha-epidermal growth factor receptor signaling promotes metastasis in an orthotopic colon cancer model
    Takamitsu Sasaki
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Am J Pathol 173:205-16. 2008
  9. ncbi request reprint Expression of epidermal growth factor (EGF)/transforming growth factor-alpha by human lung cancer cells determines their response to EGF receptor tyrosine kinase inhibition in the lungs of mice
    Wenjuan Wu
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 432, Houston, TX 77030, USA
    Mol Cancer Ther 6:2652-63. 2007
  10. pmc Targeting the expression of platelet-derived growth factor receptor by reactive stroma inhibits growth and metastasis of human colon carcinoma
    Yasuhiko Kitadai
    Department of Cancer Biology, Unit 173, The University of Texas M D Anderson Cancer Center, P O Box 302429, Houston, TX 77230 1429, USA
    Am J Pathol 169:2054-65. 2006

Detail Information

Publications96

  1. ncbi request reprint The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited
    Isaiah J Fidler
    Department of Cancer Biology, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Rev Cancer 3:453-8. 2003
    ..How has this field developed over the past century, and what major breakthroughs are most likely to lead to effective therapeutic approaches?..
  2. doi request reprint Targeting the EGFR, VEGFR, and PDGFR on colon cancer cells and stromal cells is required for therapy
    Toshio Kuwai
    Department of Cancer Biology, Unit 173, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Clin Exp Metastasis 25:477-89. 2008
    ....
  3. pmc Phosphorylated epidermal growth factor receptor on tumor-associated endothelial cells is a primary target for therapy with tyrosine kinase inhibitors
    Toshio Kuwai
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Neoplasia 10:489-500. 2008
    ....
  4. pmc Inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation on tumor-associated endothelial cells leads to treatment of orthotopic human colon cancer in nude mice
    Takamitsu Sasaki
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Neoplasia 9:1066-77. 2007
    ..These data demonstrate that targeting EGFR and VEGFR signaling on tumor-associated endothelial cells provides a viable approach for the treatment of colon cancer...
  5. ncbi request reprint Therapy of multidrug resistant human prostate tumors in the prostate of nude mice by simultaneous targeting of the epidermal growth factor receptor and vascular endothelial growth factor receptor on tumor-associated endothelial cells
    J Erik Busby
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Prostate 66:1788-98. 2006
    ..We determined whether tumor cells or tumor-associated endothelial cells were the primary target by treating multidrug-resistant (MDR) CaP growing in the prostate of nude mice...
  6. pmc Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy
    Sun Jin Kim
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Neoplasia 13:286-98. 2011
    ....
  7. pmc Intratumoral heterogeneity for expression of tyrosine kinase growth factor receptors in human colon cancer surgical specimens and orthotopic tumors
    Toshio Kuwai
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Pathol 172:358-66. 2008
    ..This heterogeneity in receptor expression among different tumor cells suggests that targeting a single tyrosine kinase may not yield eradication of the disease...
  8. pmc Modification of the primary tumor microenvironment by transforming growth factor alpha-epidermal growth factor receptor signaling promotes metastasis in an orthotopic colon cancer model
    Takamitsu Sasaki
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Am J Pathol 173:205-16. 2008
    ....
  9. ncbi request reprint Expression of epidermal growth factor (EGF)/transforming growth factor-alpha by human lung cancer cells determines their response to EGF receptor tyrosine kinase inhibition in the lungs of mice
    Wenjuan Wu
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 432, Houston, TX 77030, USA
    Mol Cancer Ther 6:2652-63. 2007
    ..Our findings provide an additional explanation for the susceptibility of lung cancers to treatment with EGFR tyrosine kinase inhibitors...
  10. pmc Targeting the expression of platelet-derived growth factor receptor by reactive stroma inhibits growth and metastasis of human colon carcinoma
    Yasuhiko Kitadai
    Department of Cancer Biology, Unit 173, The University of Texas M D Anderson Cancer Center, P O Box 302429, Houston, TX 77230 1429, USA
    Am J Pathol 169:2054-65. 2006
    ..These data demonstrate that blockade of PDGF-R signaling pathways in tumor-associated stromal cells and pericytes inhibits the progressive growth and metastasis of colon cancer cells...
  11. pmc Circulating monocytes expressing CD31: implications for acute and chronic angiogenesis
    Sun Jin Kim
    Department of Cancer Biology, Cancer MetastasisResearch Center, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Am J Pathol 174:1972-80. 2009
    ....
  12. doi request reprint Neoadjuvant platelet derived growth factor receptor inhibitor therapy combined with docetaxel and androgen ablation for high risk localized prostate cancer
    Paul Mathew
    Department of Genitourinary Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    J Urol 181:81-7; discussion 87. 2009
    ..Men with high risk localized prostate cancer were treated with platelet derived growth factor receptor inhibitor therapy, docetaxel and hormone ablation in the preoperative setting, and clinicopathological outcomes were evaluated...
  13. ncbi request reprint Effects of blocking platelet-derived growth factor-receptor signaling in a mouse model of experimental prostate cancer bone metastases
    Hisanori Uehara
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    J Natl Cancer Inst 95:458-70. 2003
    ..We examined the effects of STI571, given alone or with paclitaxel (Taxol), on tumor growth in a mouse model of prostate cancer metastasis...
  14. pmc Stromal metalloproteinase-9 is essential to angiogenesis and progressive growth of orthotopic human pancreatic cancer in parabiont nude mice
    Toru Nakamura
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1429, USA
    Neoplasia 9:979-86. 2007
    ..6pl tumor cells was similar in all parabionts, the data clearly demonstrate a major role for host-derived MMP-9 in angiogenesis and in the growth of human pancreatic cancer in the pancreas of nude mice...
  15. pmc Consistent interactions between tumor cell IL-6 and macrophage TNF-α enhance the growth of human prostate cancer cells in the bone of nude mouse
    Seung Wook Kim
    Department of Cancer Biology, Cancer Metastasis Research Center, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int Immunopharmacol 11:862-72. 2011
    ..Knocking down IL-6 in tumor cells and decreasing TAMs was associated with the lowest incidences of bone tumors and lymph node metastasis. These results suggest that TAMs enhance the growth of prostate cancer cells in the bone...
  16. pmc Selection of brain metastasis-initiating breast cancer cells determined by growth on hard agar
    Lixia Guo
    Department of Cancer Biology Cancer Metastasis Research Center, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Am J Pathol 178:2357-66. 2011
    ....
  17. ncbi request reprint Blockade of epidermal growth factor receptor signaling in tumor cells and tumor-associated endothelial cells for therapy of androgen-independent human prostate cancer growing in the bone of nude mice
    Sun Jin Kim
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 9:1200-10. 2003
    ....
  18. ncbi request reprint Inhibition of platelet-derived growth factor receptor signaling restricts the growth of human breast cancer in the bone of nude mice
    Dina Chelouche Lev
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas, USA
    Clin Cancer Res 11:306-14. 2005
    ..This study examined the effects of STI571 (imatinib mesylate), which inhibits PDGFR tyrosine kinase signaling, on the growth of human breast cancer cells in the bone of nude mice with consequent osteolysis...
  19. ncbi request reprint Zonal heterogeneity for gene expression in human pancreatic carcinoma
    Toru Nakamura
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77230 1429, USA
    Cancer Res 67:7597-604. 2007
    ....
  20. pmc Transforming growth factor-beta2 is a molecular determinant for site-specific melanoma metastasis in the brain
    Chenyu Zhang
    Department of Cancer Biology, Cancer Metastasis Research Center, The University of Texas MD Anderson Cancer Center, Houston, Texas 77230 1429, USA
    Cancer Res 69:828-35. 2009
    ..These data show that TGF-beta2 expression by murine melanoma cells is necessary for the establishment and growth of metastases in the brain parenchyma...
  21. ncbi request reprint Expression of activated platelet-derived growth factor receptor in stromal cells of human colon carcinomas is associated with metastatic potential
    Yasuhiko Kitadai
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230 1429, USA
    Int J Cancer 119:2567-74. 2006
    ..In conclusion, the expression of PDGF-Rbeta in stromal cells is influenced by the organ-specific microenvironment and is associated with metastatic potential...
  22. ncbi request reprint Simultaneous blockade of platelet-derived growth factor-receptor and epidermal growth factor-receptor signaling and systemic administration of paclitaxel as therapy for human prostate cancer metastasis in bone of nude mice
    Sun Jin Kim
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Cancer Res 64:4201-8. 2004
    ..Collectively, these data demonstrate that blockade of phosphorylation of EGF-R and PDGF-R coupled with administration of paclitaxel significantly suppresses experimental human prostate cancer bone metastasis...
  23. ncbi request reprint Targeting platelet-derived growth factor receptor on endothelial cells of multidrug-resistant prostate cancer
    Sun Jin Kim
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 98:783-93. 2006
    ..Because tumor cells and tumor-associated endothelial cells express activated PDGFR, the primary target for imatinib has been unclear...
  24. pmc Targeting receptor tyrosine kinase on lymphatic endothelial cells for the therapy of colon cancer lymph node metastasis
    Robert B Rebhun
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Neoplasia 8:747-57. 2006
    ....
  25. pmc Generation of an immortalized astrocyte cell line from H-2Kb-tsA58 mice to study the role of astrocytes in brain metastasis
    Robert R Langley
    Department of Cancer Biology, Unit 173, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Oncol 35:665-72. 2009
    ..Hence, the immortalized cell line will be useful for studying the role of astrocytes in disease processes in the brain, such as metastasis...
  26. ncbi request reprint Targeted therapy of orthotopic human lung cancer by combined vascular endothelial growth factor and epidermal growth factor receptor signaling blockade
    Wenjuan Wu
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Unit 97, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 6:471-83. 2007
    ....
  27. pmc Macitentan (ACT-064992), a tissue-targeting endothelin receptor antagonist, enhances therapeutic efficacy of paclitaxel by modulating survival pathways in orthotopic models of metastatic human ovarian cancer
    Sun Jin Kim
    Department of Cancer Biology, Cancer Metastasis Research Center, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA
    Neoplasia 13:167-79. 2011
    ....
  28. pmc Reactive astrocytes protect melanoma cells from chemotherapy by sequestering intracellular calcium through gap junction communication channels
    Qingtang Lin
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Neoplasia 12:748-54. 2010
    ....
  29. ncbi request reprint Epidermal growth factor receptor tyrosine kinase inhibitor does not improve paclitaxel effect in an orthotopic mouse model of lung cancer
    Amir Onn
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 10:8613-9. 2004
    ..The purpose is to evaluate whether inhibition of epidermal growth factor receptor (EGFR) activation by PKI166, an EGFR-tyrosine kinase inhibitor, affects growth of human lung cancer implanted orthotopically into the lungs of nude mice...
  30. ncbi request reprint Epidermal growth factor receptor blockade potentiates apoptosis mediated by Paclitaxel and leads to prolonged survival in a murine model of oral cancer
    F Christopher Holsinger
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Clin Cancer Res 9:3183-9. 2003
    ..A greater apoptotic fraction of tumor cells was found in tumors of mice treated with paclitaxel and PKI166 as compared with the other treatment groups (136.4 versus 37.8; P = 0.016)...
  31. ncbi request reprint Inhibition of platelet-derived growth factor receptor phosphorylation by STI571 (Gleevec) reduces growth and metastasis of human pancreatic carcinoma in an orthotopic nude mouse model
    Rosa F Hwang
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:6534-44. 2003
    ....
  32. ncbi request reprint Gene expression profile of metastatic human pancreatic cancer cells depends on the organ microenvironment
    Toru Nakamura
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230, USA
    Cancer Res 67:139-48. 2007
    ..These data suggest that investigations of the functional consequence of gene expression require accounting for experimental growth conditions...
  33. ncbi request reprint Inhibition of platelet-derived growth factor-mediated proliferation of osteosarcoma cells by the novel tyrosine kinase inhibitor STI571
    Eric C McGary
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77054, USA
    Clin Cancer Res 8:3584-91. 2002
    ..It has been reported previously that STI571 has specific activity in inhibiting select tyrosine kinase receptors, including PDGF and c-Kit. Osteosarcomas express low levels of c-Kit but abundant levels of PDGF receptor (PDGFR)...
  34. ncbi request reprint Blockade of the epidermal growth factor receptor signaling inhibits angiogenesis leading to regression of human renal cell carcinoma growing orthotopically in nude mice
    Daniel Kedar
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 8:3592-600. 2002
    ..Collectively, the data indicate that targeting activation of EGF-R on HRCC produces significant therapeutic benefits...
  35. ncbi request reprint Platelet-derived growth factor receptor inhibition and chemotherapy for castration-resistant prostate cancer with bone metastases
    Paul Mathew
    Department of Genitourinary Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 13:5816-24. 2007
    ....
  36. pmc Formation of solid tumors by a single multinucleated cancer cell
    Zhang Weihua
    Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, College of Natural Science and Mathematics, University of Houston, Houston, Texas, USA
    Cancer 117:4092-9. 2011
    ..Large multinucleated cells (MNCs) commonly exist in tumorigenic cancer cell lines that are used widely in research. However, the contributions of MNCs to tumorigenesis are unknown...
  37. ncbi request reprint Targeting the platelet-derived growth factor receptor in antivascular therapy for human ovarian carcinoma
    Sachin M Apte
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 10:897-908. 2004
    ..p. paclitaxel can inhibit the progression of tumors caused by human ovarian carcinoma cells growing in the peritoneal cavity of female nude mice...
  38. pmc Blockade of epidermal growth factor receptor signaling on tumor cells and tumor-associated endothelial cells for therapy of human carcinomas
    Cheryl H Baker
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Am J Pathol 161:929-38. 2002
    ..Collectively, these data suggest that expression of activated EGF-R by tumor-associated endothelial cells provides an important target for therapy...
  39. ncbi request reprint Blockade of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling for therapy of metastatic human pancreatic cancer
    Cheryl H Baker
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 62:1996-2003. 2002
    ..These results suggest that blockade of either epidermal growth factor receptor or VEGF receptor signaling combined with chemotherapy provides an effective approach to the therapy of pancreatic cancer...
  40. pmc Porous silicon nanocarriers for dual targeting tumor associated endothelial cells and macrophages in stroma of orthotopic human pancreatic cancers
    Kenji Yokoi
    Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner St, Houston, TX 77030, USA
    Cancer Lett 334:319-27. 2013
    ..5±1.8% with non-targeted nanocarriers. These results suggest that Ly6C (or CD59) can serve as a novel dual target to deliver therapeutic agents to the stroma of pancreatic tumors...
  41. pmc Antivascular therapy for multidrug-resistant ovarian tumors by macitentan, a dual endothelin receptor antagonist
    Sun Jin Kim
    Department of Cancer Biology, Metastasis Research Laboratory, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Transl Oncol 5:39-47. 2012
    ..This combined therapy led to a significant reduction in tumor weight...
  42. ncbi request reprint The role of the organ microenvironment in the biology and therapy of cancer metastasis
    Isaiah J Fidler
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Cell Biochem 101:927-36. 2007
    ..Treatment of metastasis can be directed against tumor cells and/or microenvironmental factors that support tumor growth, such as tumor-associated blood vessels...
  43. pmc Cross-species hybridization of microarrays for studying tumor transcriptome of brain metastasis
    Eun Sung Park
    Department of Systems Biology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 108:17456-61. 2011
    ..These observations provide proof of principle for competitive cross-species hybridization of microarray experiments to characterize the effect of the microenvironment on tumor cell behavior...
  44. doi request reprint Impact of sentinel lymphadenectomy on survival in a murine model of melanoma
    Robert B Rebhun
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Exp Metastasis 25:191-9. 2008
    ..We found no difference in the incidence of lung metastases produced by B16-BL6 melanoma cells growing exclusively within regional lymph nodes and cells growing within the pinna...
  45. pmc Targeted induction of lung endothelial cell apoptosis causes emphysema-like changes in the mouse
    Ricardo J Giordano
    University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 283:29447-60. 2008
    ..Finally, combinatorial screenings on immortalized cells followed by in vivo targeting establishes an experimental framework for discovery and validation of additional ligand-directed pharmacodelivery systems...
  46. pmc Nitric oxide-mediated tumoricidal activity of murine microglial cells
    Emily C Brantley
    Department of Cancer Biology, Cancer Metastasis Research Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Transl Oncol 3:380-8. 2010
    ..Collectively, these data demonstrate that brain metastasis-associated microglia are derived from circulating mononuclear cells and exhibit selective and specific tumoricidal activity...
  47. pmc Survival of cancer cells is maintained by EGFR independent of its kinase activity
    Zhang Weihua
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Cell 13:385-93. 2008
    ....
  48. ncbi request reprint Development of an orthotopic model to study the biology and therapy of primary human lung cancer in nude mice
    Amir Onn
    Department of Thoracic Head and Neck Medical Oncology, Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:5532-9. 2003
    ..This study was conducted to develop biologically relevant animal models of human lung cancer that are reproducible, inexpensive, and easy to perform...
  49. ncbi request reprint Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors
    Matus Studeny
    Section of Molecular Hematology and Therapy, Department of Blood and Marrow Transplantation, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 62:3603-8. 2002
    ..Our results indicate that MSCs may serve as a platform for delivery of biological agents in tumors...
  50. ncbi request reprint Hypoxia increases resistance of human pancreatic cancer cells to apoptosis induced by gemcitabine
    Kenji Yokoi
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 10:2299-306. 2004
    ....
  51. ncbi request reprint Tissue-specific microvascular endothelial cell lines from H-2K(b)-tsA58 mice for studies of angiogenesis and metastasis
    Robert R Langley
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 63:2971-6. 2003
    ..The immortalized endothelial cell lines established from H-2K(b)-tsA58 mice provide, for the first time, a cell culture system to examine factors regulating angiogenesis and tumor cell arrest in different organ systems...
  52. ncbi request reprint Activation of the platelet-derived growth factor-receptor enhances survival of murine bone endothelial cells
    Robert R Langley
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 64:3727-30. 2004
    ..The therapeutic combination of STI571 and Taxol may be a powerful tool for targeting tumor-associated endothelial cells in the skeletal compartment...
  53. ncbi request reprint Antivascular therapy of human follicular thyroid cancer experimental bone metastasis by blockade of epidermal growth factor receptor and vascular growth factor receptor phosphorylation
    Maher Nabil Younes
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Cancer Res 65:4716-27. 2005
    ..Collectively, these data show that blocking the phosphorylation of EGFR and VEGFR with AEE788 combined with paclitaxel can significantly inhibit experimental human FTC in the bone of nude mice...
  54. ncbi request reprint Antivascular therapy for orthotopic human ovarian carcinoma through blockade of the vascular endothelial growth factor and epidermal growth factor receptors
    Premal H Thaker
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77230 1439, USA
    Clin Cancer Res 11:4923-33. 2005
    ....
  55. ncbi request reprint Bioassay using epidermal keratinocytes to determine phosphorylation status of the epidermal growth factor receptor in distant neoplasms
    Corazon D Bucana
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Oncol 24:19-24. 2004
    ....
  56. doi request reprint The brain microenvironment and cancer metastasis
    Isaiah J Fidler
    Department of Cancer Biology, Cancer Metastasis Research Center, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Mol Cells 30:93-8. 2010
    ..The physiological role of astrocytes is to protect against neurotoxicity. Our current data demonstrate that activated astrocytes also protect tumor cells against chemotherapeutic drugs...
  57. pmc Loss of adhesion in the circulation converts amelanotic metastatic melanoma cells to melanotic by inhibition of AKT
    Weihua Zhang
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Neoplasia 8:543-50. 2006
    ..Collectively, these data suggest that the inhibition of AKT pathway due to loss of adhesion within the circulation renders a subpopulation of K-1735 cells to produce melanin...
  58. pmc Apoptotic cells initiate endothelial cell sprouting via electrostatic signaling
    Zhang Weihua
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, 77230, USA
    Cancer Res 65:11529-35. 2005
    ....
  59. ncbi request reprint Synchronous overexpression of epidermal growth factor receptor and HER2-neu protein is a predictor of poor outcome in patients with stage I non-small cell lung cancer
    Amir Onn
    Department of Thoracic, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 10:136-43. 2004
    ..Then we correlated these data with patient clinical outcome...
  60. ncbi request reprint Combination docetaxel and platelet-derived growth factor receptor inhibition with imatinib mesylate in prostate cancer
    Paul Mathew
    University of Texas M D Anderson Cancer Center, Department of Genitourinary Medical Oncology, Houston, 77030, USA
    Semin Oncol 31:24-9. 2004
    ..Clinical and translational data from these studies are likely to provide additional insights into the role of imatinib in combination therapy for prostate cancer...
  61. ncbi request reprint Administration of optimal biological dose and schedule of interferon alpha combined with gemcitabine induces apoptosis in tumor-associated endothelial cells and reduces growth of human pancreatic carcinoma implanted orthotopically in nude mice
    Carmen C Solorzano
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Clin Cancer Res 9:1858-67. 2003
    ..We determined whether chronic administration of IFN-alpha at optimal biological dose inhibits angiogenesis of human pancreatic carcinoma growing in the pancreas of nude mice...
  62. ncbi request reprint Overexpression of tropomysin-related kinase B in metastatic human pancreatic cancer cells
    Guido M Sclabas
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 11:440-9. 2005
    ..The mechanisms by which it invades and metastasizes are not known...
  63. ncbi request reprint Stat1 negatively regulates angiogenesis, tumorigenicity and metastasis of tumor cells
    Suyun Huang
    Department of Cancer Biology, Box 173, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas, TX 77030, USA
    Oncogene 21:2504-12. 2002
    ..Collectively, these data demonstrate that Stat1 expressed by tumor cells is a negative regulator of tumor angiogenesis and, hence, tumor growth and metastasis...
  64. ncbi request reprint Synergistic therapy of human ovarian carcinoma implanted orthotopically in nude mice by optimal biological dose of pegylated interferon alpha combined with paclitaxel
    Sean Tedjarati
    Departments of Cancer Biology and Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 8:2413-22. 2002
    ..Collectively, the data suggest that combining the optimal biological dose of PEG-IFN-alpha with paclitaxel may provide a novel and effective approach to the treatment of human ovarian carcinoma...
  65. pmc Identification and validation of SRC and phospho-SRC family proteins in circulating mononuclear cells as novel biomarkers for pancreatic cancer
    Kenji Yokoi
    Department of Cancer Biology, Cancer Metastasis Research Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Transl Oncol 4:83-91. 2011
    ..Although the specificity of the marker for pancreatic cancer was low, it could be used to monitor the disease or to select high-risk patients with chronic pancreatitis...
  66. doi request reprint The "seed and soil" hypothesis revisited
    Isaiah J Fidler
    Cancer Metastasis Research Center, MD Anderson Cancer Center, Houston, TX 77030, USA
    Lancet Oncol 9:808. 2008
  67. pmc Construction of a novel constitutively active chimeric EGFR to identify new targets for therapy
    Hua Cheng
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Neoplasia 7:1065-72. 2005
    ....
  68. doi request reprint The role of the organ microenvironment in brain metastasis
    Isaiah J Fidler
    Department of Cancer Biology, Cancer Metastasis Research Center, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Semin Cancer Biol 21:107-12. 2011
    ....
  69. ncbi request reprint Modulation of bone microenvironment with zoledronate enhances the therapeutic effects of STI571 and paclitaxel against experimental bone metastasis of human prostate cancer
    Sun Jin Kim
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer Res 65:3707-15. 2005
    ..The present data recommend the combination of a bisphosphonate agent with protein tyrosine kinase inhibitor and an anticycling drug for the treatment of prostate cancer bone metastasis...
  70. ncbi request reprint Dual inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation by AEE788 reduces growth and metastasis of human colon carcinoma in an orthotopic nude mouse model
    Kenji Yokoi
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77230 1429, USA
    Cancer Res 65:3716-25. 2005
    ....
  71. pmc Induction of apoptosis in tumor-associated endothelial cells and therapy of orthotopic human pancreatic carcinoma in nude mice
    Kenji Yokoi
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Neoplasia 7:696-704. 2005
    ....
  72. ncbi request reprint Tumor cell-organ microenvironment interactions in the pathogenesis of cancer metastasis
    Robert R Langley
    Department of Cancer Biology, Unit 173, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Endocr Rev 28:297-321. 2007
    ..The recent advances in our understanding of the biological basis of cancer metastasis present unprecedented possibilities for translating basic research to the clinical reality of cancer treatment...
  73. pmc Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine
    Monique B Nilsson
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77230 1429, USA
    Cancer Res 65:10794-800. 2005
    ..Collectively, the data indicate that ovarian tumor cells secreted IL-6, a highly angiogenic cytokine that supports progression of disease...
  74. pmc ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway
    Hsu Ping Kuo
    1Department of Molecular and Cellular Oncology, Unit 108, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Sci Signal 3:ra9. 2010
    ..Together, our findings suggest that ARD1 functions as an inhibitor of the mTOR pathway and that dysregulation of the ARD1-TSC2-mTOR axis may contribute to cancer development...
  75. pmc The seed and soil hypothesis revisited--the role of tumor-stroma interactions in metastasis to different organs
    Robert R Langley
    Department of Cancer Biology, Cancer Metastasis Research Center, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 128:2527-35. 2011
    ..In this review, we discuss how tumor-stromal interactions influence metastasis in each of these organs...
  76. ncbi request reprint Critical determinants of metastasis
    Isaiah J Fidler
    Department of Cancer Biology, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Semin Cancer Biol 12:89-96. 2002
    ..Therapy of metastasis should therefore be targeted against both the metastatic tumor cells and the homeostatic factors that promote metastasis...
  77. ncbi request reprint Targeted therapy against human lung cancer in nude mice by high-affinity recombinant antimesothelin single-chain Fv immunotoxin
    Dominic Fan
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cancer Ther 1:595-600. 2002
    ..Our data indicate that mesothelin-producing squamous cell carcinoma of the lung may be a good target for this immunotoxin...
  78. ncbi request reprint The organ microenvironment and cancer metastasis
    Isaiah J Fidler
    The University of Texas M D Anderson Cancer Center1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Differentiation 70:498-505. 2002
    ..Therapy of metastasis should therefore be targeted not only against tumor cells, but also against the host factors that contribute to and support the progressive growth and survival of metastatic cancer cells...
  79. ncbi request reprint An orthotopic nude mouse model of oral tongue squamous cell carcinoma
    Jeffrey N Myers
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Clin Cancer Res 8:293-8. 2002
    ..To analyze the molecular and cellular mechanisms of metastasis, we have developed an orthotopic nude mouse model of SCCOT...
  80. ncbi request reprint Contributions of stromal metalloproteinase-9 to angiogenesis and growth of human ovarian carcinoma in mice
    Suyun Huang
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    J Natl Cancer Inst 94:1134-42. 2002
    ..To investigate the contribution of MMP-9 expression in stromal cells to ovarian tumor growth, we examined angiogenesis and progressive growth of human ovarian cancer cells implanted into mice with and without the MMP-9 gene...
  81. ncbi request reprint Platelet-derived growth factor receptor inhibitor imatinib mesylate and docetaxel: a modular phase I trial in androgen-independent prostate cancer
    Paul Mathew
    Department of Genitourinary Medical Oncology, Unit 427, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Clin Oncol 22:3323-9. 2004
    ..Our goals were to (1) evaluate the toxicity and maximum-tolerated dose of docetaxel with imatinib, and (2) evaluate the decline of prostate-specific antigen (PSA) induced by imatinib alone, and imatinib and docetaxel...
  82. ncbi request reprint Specific immunotherapy against occult cancer metastases
    Weixin Lu
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 100:480-5. 2002
    ....
  83. ncbi request reprint Tumor cell and endothelial cell therapy of oral cancer by dual tyrosine kinase receptor blockade
    Orhan G Yigitbasi
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Cancer Res 64:7977-84. 2004
    ..These data recommend the consideration of patients with head and neck cancer for inclusion in clinical trials of AEE788...
  84. ncbi request reprint Targeted molecular therapy for oral cancer with epidermal growth factor receptor blockade: a preliminary report
    Jeffrey N Myers
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston 77030 4009, USA
    Arch Otolaryngol Head Neck Surg 128:875-9. 2002
    ..We examined in vitro and in vivo effects of PKI166, an orally administered EGF-R inhibitor, on 2 human squamous cell carcinoma of the oral cavity cell lines, Tu159 and MDA1986...
  85. ncbi request reprint Type-1 transforming growth factor-beta differentially modulates tumoricidal activity of murine peritoneal macrophages against metastatic variants of the B16 murine melanoma
    Dominic Fan
    Department of Cancer Biology 173, University of Texas, M D Anderson Cancer Center, 1515 Holcomble Boulevard, Houston, Texas 77030, USA
    J Exp Ther Oncol 2:286-97. 2002
    ..The order of tumoricidal susceptibility of the B16 melanoma lines to activated macrophages was B16F1 > B16F10 > B16BL6, in inverse order of metastatic potential...
  86. doi request reprint The biology of brain metastasis
    Robert R Langley
    Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Clin Chem 59:180-9. 2013
    ....
  87. ncbi request reprint Cancer biology is the foundation for therapy
    Isaiah J Fidler
    Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, Texas 7703, USA
    Cancer Biol Ther 4:1036-9. 2005
  88. pmc Biological heterogeneity of cancer: implication to therapy
    Isaiah J Fidler
    Department of Cancer Biology, Metastasis Research Center, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Hum Vaccin Immunother 8:1141-2. 2012
    ....
  89. ncbi request reprint Understanding bone metastases: the key to the effective treatment of prostate cancer
    Isaiah J Fidler
    Department of Cancer Biology, University of Texas M D Cancer Center, Houston, USA
    Clin Adv Hematol Oncol 1:278-9. 2003
  90. pmc Simultaneous inhibition of EGFR, VEGFR, and platelet-derived growth factor receptor signaling combined with gemcitabine produces therapy of human pancreatic carcinoma and prolongs survival in an orthotopic nude mouse model
    Kenji Yokoi
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77230 1429, USA
    Cancer Res 65:10371-80. 2005
    ....
  91. pmc Phosphorylated epidermal growth factor receptor on tumor-associated endothelial cells in human renal cell carcinoma is a primary target for therapy by tyrosine kinase inhibitors
    Cheryl H Baker
    Cancer Research Institute, M D Anderson Cancer Center Orlando, Orlando, FL 32806, USA
    Neoplasia 8:470-6. 2006
    ..These data suggest that the production of TGF-alpha by HRCC cells leads to the activation of EGFR on tumor-associated endothelial cells that serve as an essential target for therapy with tyrosine kinase inhibitors...
  92. ncbi request reprint Inhibition of PDGFR phosphorylation and Src and Akt activity by GN963 leads to therapy of human pancreatic cancer growing orthotopically in nude mice
    Cheryl H Baker
    Cancer Research Institute of M D Anderson Cancer Center Orlando, FL 32806, USA
    Int J Oncol 29:125-38. 2006
    ..Collectively, these data indicate that targeting PDGFR, Src, and Akt on tumor and tumor-associated endothelial cells may be an effective therapy for human pancreatic carcinoma...
  93. ncbi request reprint Inhibition of growth and metastasis of orthotopic human prostate cancer in athymic mice by combination therapy with pegylated interferon-alpha-2b and docetaxel
    Samuel F Huang
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Res 62:5720-6. 2002
    ....
  94. ncbi request reprint Phase I and pharmacologic study of PKI166, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies
    Ronald Hoekstra
    Department of Medical Oncology, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Clin Cancer Res 11:6908-15. 2005
    ..This phase I study was conducted to assess the tolerability, pharmacokinetics, and antitumor activity of the oral, selective epidermal growth factor receptor tyrosine kinase inhibitor PKI166 in patients with advanced solid malignancies...
  95. ncbi request reprint Production of interleukin 15 by human colon cancer cells is associated with induction of mucosal hyperplasia, angiogenesis, and metastasis
    Hiroki Kuniyasu
    Department of Oncological Pathology, Nara Medical University Cancer Center, Kashihara, Nara 634 8521, Japan
    Clin Cancer Res 9:4802-10. 2003
    ..The purpose of this study was to identify a mediator produced by human colon cancer cells that is responsible for the induction of hyperplasia in the adjacent mucosa...
  96. ncbi request reprint Antivascular therapy of cancer metastasis
    Isaiah J Fidler
    J Surg Oncol 94:178-80. 2006