Affiliation: The Ohio State University
- Cancer nanotechnology: opportunities and challengesMauro Ferrari
Division of Haematology and Oncology, 110U Davis Heart and Lung Research Institute, The Ohio State University, 473 West 12th Avenue, Columbus OH 43210 1002, USA
Nat Rev Cancer 5:161-71. 2005..These and other nanodevices can provide essential breakthroughs in the fight against cancer...
- Controlled-release microchipsSadhana Sharma
Davis Heart and Lung Research Institute, Ohio State University, 473 West 12th Avenue, Columbus, OH 43210, USA
Expert Opin Drug Deliv 3:379-94. 2006....
- Medical nanotechnology: shortening clinical trials and regulatory pathways?Mauro Ferrari
National Cancer Institute, Bethesda, Maryland, USAThe Ohio State University, Columbus, Ohio, USA
BioDrugs 19:203-10. 2005..These advances could be utilized to shave time and expense from multiple stages of the drug discovery and development effort...
- Application of physicochemically modified silicon substrates as reverse-phase protein microarraysA Jasper Nijdam
Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
J Proteome Res 8:1247-54. 2009..Here, we apply such substrates in a reverse-phase protein microarray setting in two model systems...
- Physicochemically modified silicon as a substrate for protein microarraysA Jasper Nijdam
Comprehensive Cancer Center, The Ohio State University, 473 W 12th Ave, 326 Columbus, OH 43210, USA
Biomaterials 28:550-8. 2007....
- Localization to atherosclerotic plaque and biodistribution of biochemically derivatized superparamagnetic iron oxide nanoparticles (SPIONs) contrast particles for magnetic resonance imaging (MRI)Bryan R Smith
Department of Biomedical Engineering, Ohio State University, 1080 Carmack Road, Columbus, OH 43210, USA
Biomed Microdevices 9:719-27. 2007..Thus, biologically targeted superparamagnetic contrast agents can contribute to non-invasive evaluation of cardiovascular lesions by simultaneously extracting morphological and biochemical data from them...
- Biomedical nanotechnology for cancerAmy Pope-Harman
Dorothy M Davis Heart and Lung Research Institute, Department of Internal Medicine, The Ohio State University College of Medicine and Public Health, Columbus, OH 43210, USA
Med Clin North Am 91:899-927. 2007....
- Release of biologically functional interferon-alpha from a nanochannel delivery systemGregory B Lesinski
Department of Human Cancer Genetics, Division of Hematology and Oncology, Arthur G James Cancer Hospital and Richard J Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA
Biomed Microdevices 7:71-9. 2005..This drug delivery platform could be used to develop alternative strategies for the treatment of unresectable tumors...
- Prospects for microtechnology and nanotechnology in bioengineering of replacement microvesselsNicanor I Moldovan
Biomedical Engineering Center and Dorothy M Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
Arch Pathol Lab Med 126:320-4. 2002..Due to its anticipated curative potential, therapeutic angiogenesis recently became a major preoccupation for the biomedical research community. Most of the related work reported to date employs either biochemical or genetic tools...
- Nanotechnologies for biomolecular detection and medical diagnosticsMark Ming Cheng Cheng
Division of Hematology and Oncology, Internal Medicine, The Ohio State University, 473 West 12 Avenue, Columbus OH 43210 1002, USA
Curr Opin Chem Biol 10:11-9. 2006....
- Fractionation of serum components using nanoporous substratesDavid Geho
Laboratory of Pathology, FDA NCI Clinical Proteomics Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Bioconjug Chem 17:654-61. 2006..These material surfaces could be employed in strategies for the harvesting and preservation of labile and carrier-protein-bound molecules in the blood...
- Object-oriented design tools for supramolecular devices and biomedical nanotechnologyStephen C Lee
Biomedical Engineering Center, The Ohio State University, Columbus, Ohio 43210, USA
Ann N Y Acad Sci 1013:110-23. 2004..The nested, hierarchical nature of object-oriented approaches allows treatment of devices as objects in higher-order structures, and so will facilitate concatenation of multiple devices into higher-order, higher-function nanosystems...
- The molecular analysis of breast cancer utilizing targeted nanoparticle based ultrasound contrast agentsJason H Sakamoto
Biomedical Engineering Center, The Ohio State University, Research Lab, Columbus, 43210, USA
Technol Cancer Res Treat 4:627-36. 2005..When fully developed, this could potentially help 32,000-63,000 women efficiently find their proper treatment strategy to fight and win their battle against breast cancer...
- Opportunities for nanotechnology-based innovation in tissue proteomicsDavid H Geho
FDA NCI Clinical Proteomics Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
Biomed Microdevices 6:231-9. 2004....
- Tailoring width of microfabricated nanochannels to solute size can be used to control diffusion kineticsFrank Martin
iMEDD Inc, Columbus, OH, USA
J Control Release 102:123-33. 2005..Such a nonmechanical device offers important advantages in drug delivery applications, including zero-order release and high loading capacity...
- Nanotechnology and tumor imaging: seizing an opportunityDaniel C Sullivan
Division of Cancer Treatment and Diagnosis, National Cancer Institute, EPN Room 6052, 6130 Executive Boulevard, Rockville, MD 20892 7412, USA
Mol Imaging 3:364-9. 2004..Appropriately labeled and targeted nanoparticles could lead to a paradigm change in which cancer detection, diagnosis, and therapy are combined in a single molecular complex...
- Nanovector therapeuticsMauro Ferrari
The Ohio State University, Columbus 43210 1002, USA
Curr Opin Chem Biol 9:343-6. 2005....
- Recommendations of the National Heart, Lung, and Blood Institute Nanotechnology Working GroupDenis B Buxton
Division of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
Circulation 108:2737-42. 2003..Finally, encouragement of small businesses to develop nanotechnology-based approaches to clinical problems was considered important...
- Micropatterning of endothelial cells by guided stimulation with angiogenic factorsSumant S Kulkarni
Biomedical Engineering Center, The Ohio State University, Columbus, OH 43210, USA
Biosens Bioelectron 19:1401-7. 2004..01 and 1.55 +/- 0.01 microm/min, respectively. Our approach could be used towards the fabrication of "designer" substrates or devices that not only allow patterned cell growth, but also permit dynamic cell repositioning...
- Mechanical spectral signatures of malignant disease? A small-sample, comparative study of continuum vs. nano-biomechanical data analysesJun Liu
Biomedical Engineering Center, The Ohio State University, 1080 Carmack Road, Columbus, OH 43210, USA
Dis Markers 18:175-83. 2002..In this paper, the validity of the nanomechanical approach to tissue characterization is discussed, and its potential extensions to biomolecular marker-based cancer diagnostics and therapeutics are considered...
- Antibiological barrier nanovector technology for cancer applicationsJason Sakamoto
Alliance for NanoHealth, 1825 Herman Pressler Street, Suite 537A, Houston, Texas 77030, USA
Expert Opin Drug Deliv 4:359-69. 2007..This novel, multi-stage strategy enables efficient localised delivery of chemotoxic drugs that may lead to significant improvements in therapy efficacy, reduced systemic toxicity and decreased total amount of injected drugs...
- nan'o.tech.nol'o.gy nThomas Theis
IBM Watson Research Center, USA
Nat Nanotechnol 1:8-10. 2006
- The transport of nanoparticles in blood vessels: the effect of vessel permeability and blood rheologyFrancesco Gentile
Center of Bio Nanotechnology and Engineering for Medicine BioNEM, University of Magna Graecia at Catanzaro, Viale Europa Loc Germaneto, 88100 Catanzaro, Italy
Ann Biomed Eng 36:254-61. 2008..An increase of xi(c) or pi has the effect of reducing Deff, and thus both the rheology of blood and the permeability of the vessels may constitute a physiological barrier to the intravascular delivery of nanoparticles...
- Design maps for nanoparticles targeting the diseased microvasculaturePaolo Decuzzi
BioNEM Center of Bio Nanotechnology and Engineering for Medicine, University of Magna Graecia, Viale Europa Loc Germaneto, 88100 Catanzaro, Italy
Biomaterials 29:377-84. 2008....
- Nanogeometry: beyond drug deliveryMauro Ferrari
Nat Nanotechnol 3:131-2. 2008
- Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applicationsEnnio Tasciotti
Nat Nanotechnol 3:151-7. 2008..The use of this system is envisioned to open new avenues for avoiding biological barriers and delivering more than one therapeutic agent to the target at a time, in a time-controlled fashion...
- NanoncologyMauro Ferrari
MD Anderson Cancer Center, Houston TX, USA
Tumori 94:197-9. 2008
- Interstitial stress and fluid pressure within a growing tumorMalisa Sarntinoranont
University of California at Berkeley, Department of Mechanical Engineering, Berkeley, CA, USA
Ann Biomed Eng 31:327-35. 2003..An application of this model includes a solid stress-based framework for predicting regions of vascular collapse within the tumor interior...
- Mathematical modeling of cancer progression and response to chemotherapySandeep Sanga
University of California, Department of Biomedical Engineering, Irvine, 3120, CA 92697 2715, USA
Expert Rev Anticancer Ther 6:1361-76. 2006....
- Dynamic model of biomolecular diffusion through two-dimensional nanochannelsCarlo Cosentino
Department of Experimental and Clinical Medicine, Università degli Studi Magna Graecia di Catanzaro, Via T Campanella 115, 88100 Catanzaro, Italy
J Phys Chem B 109:7358-64. 2005..Moreover, a physical description, derived from van der Waals equation of state, is presented, and it is compared with the results obtained by the mathematical model...
- Type II lumbar endoleaks: hemodynamic differentiation by contrast-enhanced ultrasound scanning and influence on aneurysm enlargement after endovascular aneurysm repairIrene Bargellini
Division of Diagnostic and Interventional Radiology, University of Pisa, Via Roma 67, 56127 Pisa, Italy
J Vasc Surg 41:10-8. 2005....
- Nanoporous surfaces as harvesting agents for mass spectrometric analysis of peptides in human plasmaMarco Gaspari
Department of Clinical and Experimental Medicine, Magna Graecia University, 88100 Catanzaro, Italy
J Proteome Res 5:1261-6. 2006..The same molecular cutoff effect was observed for mixtures of standard proteins and peptides incubated with silicon-based nanoporous surfaces...
- Duodenal duplication cyst causing severe pancreatitis: imaging findings and pathological correlationAlessandro Guarise
Department of Radiology, University of Verona, Policlinico G B Rossi, Piazzale L A Scuro 37134 Verona, Italy
World J Gastroenterol 12:1630-3. 2006..The diagnosis was confirmed by histology...
- Abdominal aortic aneurysm: contrast-enhanced US for missed endoleaks after endoluminal repairVinicio Napoli
Department of Oncology, Transplants and Advanced Technologies in Medicine, Division of Diagnostic and Interventional Radiology and Department of Vascular Surgery, University of Pisa, Via Roma 67, 56126 Pisa, Italy
Radiology 233:217-25. 2004....
- Adhesion of microfabricated particles on vascular endothelium: a parametric analysisPaolo Decuzzi
Center of Excellence in Computational Mechanics, Politecnico di Bari, Bari, Italy
Ann Biomed Eng 32:793-802. 2004..Criteria for the optimal design of particles are proposed...
- Morphologic instability and cancer invasionVittorio Cristini
Department of Biomedical Engineering, University of California, Irvine, California 92697 2715, USA
Clin Cancer Res 11:6772-9. 2005....