Guido Ferlazzo

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. pmc Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells
    Guido Ferlazzo
    Laboratorio di Immunoterapia Cellulare, Unità di Immunologia, Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy
    J Exp Med 195:343-51. 2002
  2. ncbi request reprint The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolytic
    Guido Ferlazzo
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Immunol 172:1455-62. 2004
  3. ncbi request reprint NK cell compartments and their activation by dendritic cells
    Guido Ferlazzo
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Immunol 172:1333-9. 2004
  4. pmc Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs
    Guido Ferlazzo
    Laboratory of Viral Immunobiology, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:16606-11. 2004
  5. pmc Human NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence
    Till Strowig
    Laboratory of Viral Immunobiology, and Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY, USA
    Blood 116:4158-67. 2010
  6. ncbi request reprint NK cells of human secondary lymphoid tissues enhance T cell polarization via IFN-gamma secretion
    Barbara Morandi
    Laboratory of Viral Immunobiology and Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    Eur J Immunol 36:2394-400. 2006
  7. ncbi request reprint Mature myeloid dendritic cell subsets have distinct roles for activation and viability of circulating human natural killer cells
    CHRISTIAN MUNZ
    Laboratory of Viral Immunobiology, The Rockefeller University, New York, NY 10021 6399, USA
    Blood 105:266-73. 2005
  8. ncbi request reprint Human antigen-presenting cells respond differently to gut-derived probiotic bacteria but mediate similar strain-dependent NK and T cell activation
    Lisbeth N Fink
    Center for Biological Sequence Analysis, BioCentrum DTU, Technical University of Denmark, Kgs Lyngby, Denmark
    FEMS Immunol Med Microbiol 51:535-46. 2007
  9. ncbi request reprint CD56brightCD16- killer Ig-like receptor- NK cells display longer telomeres and acquire features of CD56dim NK cells upon activation
    Chiara Romagnani
    Department of Clinical Immunology, German Rheumatism Research Centre, Deutsches Rheuma ForschungsZentrum Berlin, Berlin, Germany
    J Immunol 178:4947-55. 2007
  10. ncbi request reprint Distinct gut-derived lactic acid bacteria elicit divergent dendritic cell-mediated NK cell responses
    Lisbeth N Fink
    Center for Biological Sequence Analysis, BioCentrum DTU, Technical University of Denmark, Kongens Lyngby, Denmark
    Int Immunol 19:1319-27. 2007

Collaborators

  • Guido Frumento
  • Chiara Romagnani
  • CHRISTIAN MUNZ
  • William A Muller
  • Alessandro Moretta
  • Lorenzo Moretta
  • Maggi Pack
  • Ralph Marvin Steinman
  • A Uccelli
  • Andreas Thiel
  • Cristina Bottino
  • Daniela Pende
  • Lisbeth N Fink
  • Hanne R Christensen
  • Barbara Morandi
  • Giovanni Melioli
  • Paolo Carrega
  • Roberta Costa
  • Till Strowig
  • Giuliana Cangemi
  • Nadia Sessarego
  • Rita Rotondo
  • Maria Cristina Mingari
  • Mariella Della Chiesa
  • Carlo Magno
  • Obinna Chijioke
  • Frida Arrey
  • Patrick C Rämer
  • Sonja Meixlsperger
  • Annalisa Kunkl
  • Luca Mastracci
  • Daniela Oliveri
  • Francesco Grossi
  • Tiziana Piazza
  • Placido Bramanti
  • Gaia Barisione
  • Francesco Frassoni
  • Michele Navarra
  • Franca Dagna Bricarelli
  • Marina Podesta
  • Erika Montalto
  • Valentina Raviolo
  • Silvano Ferrini
  • Massimo Mogni
  • Giuseppe Forte
  • Mario Lituania
  • Maria P Sormani
  • Giovanni Battista Ratto
  • Alfredo Cesario
  • Giuseppe Altavilla
  • Simonetta Astigiano
  • Alessia Parodi
  • Gaetana Pezzino
  • Michela Cassanello
  • Irene Bonaccorsi
  • Federica Benvenuto
  • Giovanni B Ratto
  • Marina Fabbi
  • Gwenola Bougras
  • Silvia Parolini
  • Michela Falco
  • Andrea De Maria
  • Giovanni Ratto
  • Massimo Vitale
  • Cristiano Peri
  • Emanuele Crocetti
  • Paola Mereu
  • Marco Scala
  • Giovanni Margarino
  • Anna Maria Machì
  • Simona Carlomagno
  • Gianluca Damonte
  • Roberto Biassoni
  • Claudia Semino
  • Antonella D'Agostino
  • Romana Conte
  • Darwin Melloni
  • Giuseppe Mucciardi
  • Alessandro Galì
  • Giacomo Nicocia

Detail Information

Publications26

  1. pmc Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells
    Guido Ferlazzo
    Laboratorio di Immunoterapia Cellulare, Unità di Immunologia, Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy
    J Exp Med 195:343-51. 2002
    ..We suggest that DCs are able to control directly the expansion of NK cells and that the lysis of immature DCs can regulate the afferent limb of innate and adaptive immunity...
  2. ncbi request reprint The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolytic
    Guido Ferlazzo
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Immunol 172:1455-62. 2004
    ..These results also suggest secondary lymphoid organs as a possible site of NK cell differentiation and self-tolerance acquisition...
  3. ncbi request reprint NK cell compartments and their activation by dendritic cells
    Guido Ferlazzo
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Immunol 172:1333-9. 2004
  4. pmc Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs
    Guido Ferlazzo
    Laboratory of Viral Immunobiology, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:16606-11. 2004
    ..These results identify secondary lymphoid organs as a potential DC/NK cell interaction site and identify the distinct roles for DC-derived IL-12 and IL-15 in NK cell activation...
  5. pmc Human NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence
    Till Strowig
    Laboratory of Viral Immunobiology, and Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY, USA
    Blood 116:4158-67. 2010
    ..These data suggest that a functional, but resting, NK-cell compartment can be established in immune-compromised mice after human hematopoietic progenitor cell transfer...
  6. ncbi request reprint NK cells of human secondary lymphoid tissues enhance T cell polarization via IFN-gamma secretion
    Barbara Morandi
    Laboratory of Viral Immunobiology and Christopher H Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    Eur J Immunol 36:2394-400. 2006
    ..Our data suggest that NK cells in secondary lymphoid organs assist priming of Th1 cells via cytokine secretion and this effect should be harnessed during vaccination against viruses and tumors...
  7. ncbi request reprint Mature myeloid dendritic cell subsets have distinct roles for activation and viability of circulating human natural killer cells
    CHRISTIAN MUNZ
    Laboratory of Viral Immunobiology, The Rockefeller University, New York, NY 10021 6399, USA
    Blood 105:266-73. 2005
    ..Hence, the principal myeloid DCs differ in critical ways regarding the stimulation of NK and T lymphocytes and could be used or targeted accordingly in DC-based immunotherapies...
  8. ncbi request reprint Human antigen-presenting cells respond differently to gut-derived probiotic bacteria but mediate similar strain-dependent NK and T cell activation
    Lisbeth N Fink
    Center for Biological Sequence Analysis, BioCentrum DTU, Technical University of Denmark, Kgs Lyngby, Denmark
    FEMS Immunol Med Microbiol 51:535-46. 2007
    ..An inhibitory effect of certain strains on this IFN-gamma production was also mediated by all types of APC. The most potent responses were induced by monocyte-derived DC, which thus constitute a sensitive screening model...
  9. ncbi request reprint CD56brightCD16- killer Ig-like receptor- NK cells display longer telomeres and acquire features of CD56dim NK cells upon activation
    Chiara Romagnani
    Department of Clinical Immunology, German Rheumatism Research Centre, Deutsches Rheuma ForschungsZentrum Berlin, Berlin, Germany
    J Immunol 178:4947-55. 2007
    ....
  10. ncbi request reprint Distinct gut-derived lactic acid bacteria elicit divergent dendritic cell-mediated NK cell responses
    Lisbeth N Fink
    Center for Biological Sequence Analysis, BioCentrum DTU, Technical University of Denmark, Kongens Lyngby, Denmark
    Int Immunol 19:1319-27. 2007
    ..Combining IFN-gamma-inducing and non-inducing LAB completely abrogates DC-mediated IFN-gamma production by NK cells, and therefore LAB modulating IFN-gamma production in NK cells may be important regulators of the immune response...
  11. ncbi request reprint Distinctive lack of CD48 expression in subsets of human dendritic cells tunes NK cell activation
    Barbara Morandi
    Istituto Nazionale Ricerca sul Cancro, Genoa, Italy
    J Immunol 175:3690-7. 2005
    ..Moreover, the expression of CD48 depends on the anatomic location of DCs and might be related to the tissue-specific 2B4 function (activating or inhibitory) of the NK cells with which they interact...
  12. doi request reprint Natural killer cells infiltrating human nonsmall-cell lung cancer are enriched in CD56 bright CD16(-) cells and display an impaired capability to kill tumor cells
    Paolo Carrega
    Department of Experimental Medicine, University of Genoa, Italy
    Cancer 112:863-75. 2008
    ..Despite natural killer (NK) cells being originally identified and named because of their ability to kill tumor cells in vitro, only limited information is available on NK cells infiltrating malignant tumors, especially in humans...
  13. doi request reprint Isolation and analysis of human natural killer cell subsets
    Guido Ferlazzo
    School of Medicine, University of Messina, Italy
    Methods Mol Biol 415:197-213. 2008
    ....
  14. ncbi request reprint Effector and regulatory events during natural killer-dendritic cell interactions
    Lorenzo Moretta
    Direzione Scientifica, Istituto Giannina Gaslini, Largo G Gaslini, Genova Quarto, Italy
    Immunol Rev 214:219-28. 2006
    ..These interactions also determine the quality and strength of the subsequent adaptive responses. Remarkably, NK cells appear to play a key role in this complex network...
  15. ncbi request reprint Natural killer and dendritic cell liaison: recent insights and open questions
    Guido Ferlazzo
    Laboratory of Immunology, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Immunol Lett 101:12-7. 2005
    ..The most recent advances about NK/DC interplay are here reviewed and possible answers to still open questions in this field are considered...
  16. ncbi request reprint Update on natural killer cells: cross-talk with dendritic cells and role in the cure of acute myeloid leukemias
    Lorenzo Moretta
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Via L B Alberti 2 16132 Genova, Italy
    Cancer J 9:232-7. 2003
  17. ncbi request reprint The natural killer cell-mediated killing of autologous dendritic cells is confined to a cell subset expressing CD94/NKG2A, but lacking inhibitory killer Ig-like receptors
    Mariella Della Chiesa
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Italy
    Eur J Immunol 33:1657-66. 2003
    ..However, a small NK cell subset was capable of killing not only iDC but also mature DC...
  18. ncbi request reprint Human natural killer cell function and their interactions with dendritic cells
    Lorenzo Moretta
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Italy
    Vaccine 21:S38-42. 2003
    ..Thus, two important players of the innate immunity may be involved in a coordinated regulation of critical events occurring at the interface between innate and adaptive immunity...
  19. ncbi request reprint Expansion of natural killer cells in patients with head and neck cancer: detection of "noninhibitory" (activating) killer Ig-like receptors on circulating natural killer cells
    Giovanni Melioli
    Laboratorio di Immunoterapia Cellulare, Istituto Nazionale per la Ricerca sul Cancro, Largo Rosanna Benzi, 10, 16132 Genoa, Italy
    Head Neck 25:297-305. 2003
    ..In a group of patients with head and neck cancers (H&NC), the expansion of the population of CD3-,CD16+ natural killer (NK) cells in the peripheral blood was studied...
  20. ncbi request reprint The interaction between NK cells and dendritic cells in bacterial infections results in rapid induction of NK cell activation and in the lysis of uninfected dendritic cells
    Guido Ferlazzo
    Unità di Immunologia, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Eur J Immunol 33:306-13. 2003
    ..Activated NK cells, by limiting the supply of immature DC, may then exert a control on subsequent innate and adaptive immune responses...
  21. ncbi request reprint T lymphocytes express B7 family molecules following interaction with dendritic cells and acquire bystander costimulatory properties
    Guido Ferlazzo
    Laboratorio di Immunoterapia, Unità di Immunologia, Istituto Nazionale per la Ricerca sul Cancro, CBA, Largo Rosanna Benzi, 10, I 16132 Genova, Italy
    Eur J Immunol 32:3092-101. 2002
    ....
  22. doi request reprint Arginase 2 is expressed by human lung cancer, but it neither induces immune suppression, nor affects disease progression
    Rita Rotondo
    Department of Translational Oncology, National Institute for Cancer Research, Genoa, Italy
    Int J Cancer 123:1108-16. 2008
    ..Our results indicate that ARG2 is expressed in lung cancer, but it does not induce tumor immune escape and does not affect disease progression, most probably due to the lack of concomitant NOS expression...
  23. ncbi request reprint The anti-tumor activity of bacillus Calmette-Guerin in bladder cancer is associated with an increase in the circulating level of interleukin-2
    Carlo Magno
    Unità di Urologia, Universita degli Studi di Messina, Messina, Italy
    Immunol Lett 81:235-8. 2002
    ..Our results indicate that a specific type 1 immune response plays a major role in the anti-cancer activity of BCG. In addition, monitoring IL-2 plasma levels may offer a useful tool for predicting tumor recurrences...
  24. doi request reprint Multipotent mesenchymal stromal cells from amniotic fluid: solid perspectives for clinical application
    Nadia Sessarego
    Centro Cellule Staminali e Terapia Cellulare, Ospedale San Martino, L go R Benzi 10, 16132 Genova Italy
    Haematologica 93:339-46. 2008
    ..In this study, mesenchymal stromal cells were successfully isolated from second trimester amniotic fluid and analyzed for chromosomal stability to validate their safety for potential utilization as a cell therapy product...
  25. doi request reprint Role of natural killer cells in the pathogenesis and progression of multiple sclerosis
    Barbara Morandi
    Laboratory of Immunology and Biotherapy, Department of Human Pathology, University of Messina, Italy
    Pharmacol Res 57:1-5. 2008
    ..Whatever the case, the functional features of these cells and their potential role in regulation of autoimmunity suggest that NK cell-based therapies might be an interesting approach for the treatment of multiple sclerosis...
  26. ncbi request reprint IFN-alpha mediates the up-regulation of HLA class I on melanoma cells without switching proteasome to immunoproteasome
    Giuliana Cangemi
    Laboratorio di Analisi, Istituto Giannina Gaslini, 16148 Genoa, Italy
    Int Immunol 15:1415-21. 2003
    ..Altogether, these data demonstrate that IFN-alpha does not induce the switch from PS to iPS...