Affiliation: The Rockefeller University
- Spinophilin regulates the formation and function of dendritic spinesJ Feng
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 97:9287-92. 2000..In conclusion, spinophilin appears to be required for the regulation of the properties of dendritic spines...
- De-repression of the p21 promoter in prostate cancer cells by an isothiocyanate via inhibition of HDACs and c-MycL G Wang
NYU Cancer Institute, New York University School of Medicine, New York, NY 10010, USA
Int J Oncol 33:375-80. 2008..The PEITC-mediated growth attenuation of prostate cancer cells includes an interactive mechanism involving HDAC and c-Myc inhibition...
- D(2) dopamine receptors induce mitogen-activated protein kinase and cAMP response element-binding protein phosphorylation in neuronsZ Yan
Laboratory of Molecular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 96:11607-12. 1999..Our results suggest that MAPK and CREB signaling cascades are involved in the regulation of gene expression and other long-term effects of D(2) receptor activation...
- A third member of the synapsin gene familyH T Kao
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021 6399, USA
Proc Natl Acad Sci U S A 95:4667-72. 1998..On the basis of this localization and the well established neurobiological roles of the synapsins, synapsin III represents a candidate gene for schizophrenia...
- Oxidized low density lipoprotein decreases macrophage expression of scavenger receptor B-IJ Han
Center of Vascular Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
J Biol Chem 276:16567-72. 2001....
- Dual action on promoter demethylation and chromatin by an isothiocyanate restored GSTP1 silenced in prostate cancerL G Wang
NYU Cancer Institute, New York University School of Medicine, Manhattan VA Medical Center, New York, New York 10010, USA
Mol Carcinog 46:24-31. 2007..Consequently, new approaches could be developed, with isothiocyanates to prevent and inhibit malignancies...
- Single-tube method for determination of F508del genotype in the CFTR gene using bidirectional PCR amplification of specific allelesP Maciel
City of Hope National Medical Center Beckman Research Institute, Duarte, CA, USA
Biotechniques 34:460-2. 2003
- Systematic screening for mutations in the glycine receptor alpha2 subunit gene (GLRA2) in patients with schizophrenia and other psychiatric diseasesJ Feng
Department of Molecular Genetics, City of Hope National Medical Center Beckman Research Institute, Duarte, California 91010 3000, USA
Psychiatr Genet 11:45-8. 2001..These do not alter the structure or the expression of the protein. It is unlikely that mutations in the coding region and splice junction of GLRA2 gene are associated with schizophrenia and other psychiatric diseases...
- Distinct roles for spinophilin and neurabin in dopamine-mediated plasticityP B Allen
Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
Neuroscience 140:897-911. 2006..These data establish a requirement for synaptic scaffolding in dopamine-mediated responses, and further indicate that spinophilin and neurabin play distinct roles in dopaminergic signal transduction and psychostimulant response...
- Dentin phosphoprotein and dentin sialoprotein are cleavage products expressed from a single transcript coded by a gene on human chromosome 4. Dentin phosphoprotein DNA sequence determinationM MacDougall
University of Texas Health Science Center at San Antonio, Dental School, Department of Pediatric Dentistry, 78284 7888, USA
J Biol Chem 272:835-42. 1997..The location of the human dentin sialophosphoprotein gene on chromosome 4 suggests that this gene may be a strong candidate gene for the genetic disease dentinogenesis imperfecta type II...
- Impaired conditioned taste aversion learning in spinophilin knockout miceC A Stafstrom-Davis
Program in Neuroscience, Florida State University, Tallahassee, Florida 32306 4340 USA
Learn Mem 8:272-8. 2001..We conclude that spinophilin is a candidate molecule required for normal CTA learning...
- Elucidation of the sequence and the genomic organization of the human dentin matrix acidic phosphoprotein 1 (DMP1) gene: exclusion of the locus from a causative role in the pathogenesis of dentinogenesis imperfecta type IIK L Hirst
School of Biological Sciences, University of Manchester, United Kingdom
Genomics 42:38-45. 1997....
- Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinaseM Koyama
First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
FEBS Lett 475:197-200. 2000..Thus, CPI-17 as a substrate of Rho-kinase could be involved in the Ca(2+) sensitization of smooth muscle contraction as a downstream effector of Rho-kinase...
- Two mutant alleles of mukB, a gene essential for chromosome partition in Escherichia coliK Yamanaka
Department of Molecular Cell Biology, Kumamoto University School of Medicine, Japan
FEMS Microbiol Lett 123:27-31. 1994....
- Neural crest stem cell and cardiac endothelium defects in the TrkC null mouseY H Youn
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Mol Cell Neurosci 24:160-70. 2003....
- New killing system controlled by two genes located immediately upstream of the mukB gene in Escherichia coliJ Feng
Department of Molecular Cell Biology, Kumamoto University School of Medicine, Japan
Mol Gen Genet 243:136-47. 1994..It was also demonstrated that KicA and KicB can function as a post-segregational killing system, when the genes are transferred from the E. coli chromosome onto a plasmid...
- Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patientsJ Yan
Mol Psychiatry 10:329-32. 2005
- The phylogeny of Chinese indigenous pig breeds inferred from microsatellite markersM Fang
State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing 100094, China
Anim Genet 36:7-13. 2005..Our data also confirmed that Chinese pig breeds have a different origin from European/American breeds and can be utilized in programmes that aim to maintain Chinese indigenous pig breeds...
- Mutants defective in chromosome partitioning in E. coliS Hiraga
Department of Molecular Genetics, Kumamoto University Medical School, Japan
Res Microbiol 142:189-94. 1991..The mukC and mukD genes are located at 88 and 41 min of the chromosome map, respectively...
- CENP-F is a novel microtubule-binding protein that is essential for kinetochore attachments and affects the duration of the mitotic checkpoint delayJ Feng
Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
Chromosoma 115:320-9. 2006..The C-terminal microtubule-binding domain was found to stimulate microtubule polymerization in vitro. These activities provide a biochemical explanation for how CENP-F contributes to kinetochore attachments in vivo...
- Genetic distinctiveness of endangered dwarf blue sheep (Pseudois nayaur schaeferi): evidence from mitochondrial control region and Y-linked ZFY intron sequencesJ Feng
Department of Biological Sciences, State University of New York at Buffalo, 14260, USA
J Hered 92:9-15. 2001..Moreover, we found intraspecific sequence variation in ZFY intron for all three species examined. We propose that dwarf blue sheep be designated as a subspecies of blue sheep, P. n. schaeferi...
- Comparison of age-related differences in expression of antioxidant enzyme mRNA and activity in various tissues of pigsC L Xu
Key Laboratory of Molecular Animal Nutrition of Ministry of Education, Feed Science Institute, Zhejiang University, No 164 Qiutao North Road, Hangzhou, 310029, PR China
Comp Biochem Physiol B Biochem Mol Biol 147:445-51. 2007..In conclusion, expression of AOEs mRNA and activity exhibit different developmental profiles in various tissues of pigs, and the regulation of AOEs is not tightly coordinated in either tissue...
- ERCC1 mRNA levels and survival of advanced gastric cancer patients treated with a modified FOLFOX regimenJ Wei
Department of Oncology, Drum Tower Hospital, Clinical Cancer Institute of Nanjing University, Medical School of Nanjing University, Nanjing 210008, China
Br J Cancer 98:1398-402. 2008..1 months (P<0.0001). The hazard ratio for patients with high ERCC1 expression was 9.4 (P<0.0001). In patients with high mRNA levels of ERCC1, alternative chemotherapy regimens should be considered...
- Detection of mutations by single-strand conformation polymorphism (SSCP) analysis and SSCP-hybrid methodsW Warren
Institute of Cancer Research, Surrey, UK
Curr Protoc Hum Genet . 2001..4) Restriction endonuclease fingerprinting (REF) involves cleavage of the amplified target with five to six groups of restriction endonucleases...
- Comparison between cells and cancer stem-like cells isolated from glioblastoma and astrocytoma on expression of anti-apoptotic and multidrug resistance-associated protein genesF Jin
Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
Neuroscience 154:541-50. 2008....
- Phenotypic and suppressor analysis of defecation in clk-1 mutants reveals that reaction to changes in temperature is an active process in Caenorhabditis elegansR Branicky
Department of Biology, McGill University, Montreal, Quebec H3A 1B1, Canada
Genetics 159:997-1006. 2001..On the other hand, in the absence of clk-1 activity, we observe temperature compensation, a mechanism that maintains a constant defecation period in the face of changes in temperature...
- Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegansJ Feng
Department of Biology, McGill University, 1205 Avenue Dr Penfield, H3A 1B1, , , Canada
Dev Cell 1:633-44. 2001..These findings indicate that both isp-1 and daf-2 mutations increase life span by lowering oxidative stress and result in the maximum life span increase that can be produced in this way...
- Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptorsD Wang
Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Immunity 13:25-35. 2000..The results define a signal transduction pathway broadly utilized by immunoglobulin superfamily receptors...
- Five missense variants in the amino-terminal domain of the glucocorticoid receptor: no association with puerperal psychosis or schizophreniaJ Feng
Department of Molecular Genetics, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010 3000, USA
Am J Med Genet 96:412-7. 2000....
- Role of phosphorylated metabolic intermediates in the regulation of glutamine synthetase synthesis in Escherichia coliJ Feng
Department of Biochemistry, Wayne State University School of Medicine, Detroit, Michigan 48201
J Bacteriol 174:6061-70. 1992....
- Phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by protein kinase NT Hamaguchi
First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, 514 8507, Japan
Biochem Biophys Res Commun 274:825-30. 2000..Thus, CPI-17 is a substrate of PKN and might be involved in the Ca(2+) sensitization of smooth muscle contraction as a downstream effector of Rho and/or arachidonic acid...
- Cadherin-6 mediates the heterotypic interactions between the hemopoietic osteoclast cell lineage and stromal cells in a murine model of osteoclast differentiationG Mbalaviele
Department of Medicine, Division of Endocrinology and Metabolism, University of Texas Health Science Center, San Antonio, Texas 78284 7877, USA
J Cell Biol 141:1467-76. 1998....
- Molecular characterization of human SUR2-containing K(ATP) channelsR Davis-Taber
Neurological and Urological Diseases Research, Dept 47C, APgA, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
Gene 256:261-70. 2000..Collectively, our findings demonstrate that various SUR2 splice variants have distinct expression patterns and can form functional K(ATP) channels...
- Identification of rice black-streaked dwarf fijivirus in maize with rough dwarf disease in ChinaS Fang
National Laboratories for Agrobiotechnology, China Agricultural University, Beijing
Arch Virol 146:167-70. 2001..Based on these results, it is suggested that the virus which causes this maize disease in China is rice black-streaked dwarf virus...
- A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mappingM Fujioka
First Department of Internal Medicine, Mie University School of Medicine, Japan
Genomics 49:59-68. 1998..1, compared to the chromosomal location 12q15-q21-2 for MYPT1. It is suggested that the products of the two gene families of myosin phosphatase target subunit may be localized differently among various tissues...
- An in-frame deletion in the alpha(2C) adrenergic receptor is common in African--AmericansJ Feng
Department of Molecular Genetics, City of Hope National Medical Center and Beckman Research Institute, 1500 East Duarte Road, Duarte, CA 91010, USA
Mol Psychiatry 6:168-72. 2001..Although these data do not suggest an association of TIDRU(1) with schizophrenia, additional studies are needed to see whether TIDRU(1) confers a clinical phenotype...
- Protein kinase C-catalyzed phosphorylation of an inhibitory phosphoprotein of myosin phosphatase is involved in human platelet secretionY Watanabe
2nd and 1st Departments of Internal Medicine, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan
Blood 97:3798-805. 2001..Thus, CPI phosphorylation by PKC may participate in inhibiting myosin phosphatase, in addition to the Rho-kinase-mediated regulation of myosin phosphatase, during agonist-induced platelet secretion. (Blood. 2001;97:3798-3805)..
- Bovine natural resistance associated macrophage protein 1 (Nramp1) geneJ Feng
Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station 77843 4467, USA
Genome Res 6:956-64. 1996..Northern blotting indicated that bovine NRAMP1 was expressed primarily in macrophages and tissues of the recticuloendothelial system. Bovine NRAMP1 was mapped to BTA 2 within syntenic loci conserved on HSA 2q and MMU 1...
- Developmental expression of a voltage-dependent potassium channel (Kv3.1) in auditory neurons without cochlear inputJ Feng
Department of Biology, Southern Connecticut State University, New Haven, Connecticut, USA
J Neurosci Res 65:121-8. 2001..These results agree with other observations in the chick embryo in situ. They are consistent with previous work implicating Kv3.1 in cell migration during early development...
- Human peroxisome proliferator-activated receptor alpha (PPARalpha) supports the induction of peroxisome proliferation in PPARalpha-deficient mouse liverS Yu
Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611-3008, USA
J Biol Chem 276:42485-91. 2001....
- Further evidence for paternal inheritance of mitochondrial DNA in the sheep (Ovis aries)X Zhao
Department of Animal Science and Technology, China Agricultural University, Beijing 100094, China
Heredity (Edinb) 93:399-403. 2004..A total of 12 highly polymorphic microsatellite markers, which mapped on different chromosomes, were employed to type the sheep population to confirm family relationships. Possible mechanisms of paternal inheritance are discussed...