Akhlaq A Farooqui

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi request reprint Docosahexaenoic acid in the diet: its importance in maintenance and restoration of neural membrane function
    Lloyd A Horrocks
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH 43210, USA
    Prostaglandins Leukot Essent Fatty Acids 70:361-72. 2004
  2. ncbi request reprint Lovastatin modulates increased cholesterol and oxysterol levels and has a neuroprotective effect on rat hippocampal neurons after kainate injury
    Xin He
    Department of Anatomy, National University of Singapore, Singapore, and New England Biomedical Research Center and VA Connecticut Healthcare System, Newington, CT, USA
    J Neuropathol Exp Neurol 65:652-63. 2006
  3. ncbi request reprint Quinacrine abolishes increases in cytoplasmic phospholipase A2 mRNA levels in the rat hippocampus after kainate-induced neuronal injury
    Wei Yi Ong
    Department of Anatomy, National University of Singapore, Singapore 119260
    Exp Brain Res 148:521-4. 2003
  4. ncbi request reprint Plasmalogens, docosahexaenoic acid and neurological disorders
    Akhlaq A Farooqui
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA
    Adv Exp Med Biol 544:335-54. 2003
  5. doi request reprint Lipid mediators and their metabolism in the nucleous: implications for Alzheimer's disease
    Akhlaq A Farooqui
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio 43221, USA
    J Alzheimers Dis 30:S163-78. 2012
  6. doi request reprint Metabolic syndrome as a risk factor for neurological disorders
    Akhlaq A Farooqui
    Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, OH 43221, USA
    Cell Mol Life Sci 69:741-62. 2012
  7. ncbi request reprint n-3 fatty acid-derived lipid mediators in the brain: new weapons against oxidative stress and inflammation
    A A Farooqui
    Department of Molecular and Cellular Biochemistry, 3120 Herrick Road, Columbus, Ohio 43221, USA
    Curr Med Chem 19:532-43. 2012
  8. ncbi request reprint Comparison of biochemical effects of statins and fish oil in brain: the battle of the titans
    Akhlaq A Farooqui
    Department of Molecular and Cellular Biochemistry, The Ohio State University, 1645 Neil Avenue, Columbus, OH 43210, USA
    Brain Res Rev 56:443-71. 2007
  9. doi request reprint Lipid mediators in the neural cell nucleus: their metabolism, signaling, and association with neurological disorders
    Akhlaq A Farooqui
    Department of Molecular Cellular Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA
    Neuroscientist 15:392-407. 2009
  10. doi request reprint Studies on plasmalogen-selective phospholipase A2 in brain
    Akhlaq A Farooqui
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH 43210, USA
    Mol Neurobiol 41:267-73. 2010

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Docosahexaenoic acid in the diet: its importance in maintenance and restoration of neural membrane function
    Lloyd A Horrocks
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH 43210, USA
    Prostaglandins Leukot Essent Fatty Acids 70:361-72. 2004
    ..Also, improvements are seen in signal transduction processes associated with behavioral deficits, learning activity, peroxisomal disorders, and psychotic changes in schizophrenia, depression, hyperactivity, stroke, and Alzheimer disease...
  2. ncbi request reprint Lovastatin modulates increased cholesterol and oxysterol levels and has a neuroprotective effect on rat hippocampal neurons after kainate injury
    Xin He
    Department of Anatomy, National University of Singapore, Singapore, and New England Biomedical Research Center and VA Connecticut Healthcare System, Newington, CT, USA
    J Neuropathol Exp Neurol 65:652-63. 2006
    ..These results suggest that brain-permeable statins such as lovastatin could have a neuroprotective effect by limiting the levels of oxysterol in brain areas undergoing neurodegeneration...
  3. ncbi request reprint Quinacrine abolishes increases in cytoplasmic phospholipase A2 mRNA levels in the rat hippocampus after kainate-induced neuronal injury
    Wei Yi Ong
    Department of Anatomy, National University of Singapore, Singapore 119260
    Exp Brain Res 148:521-4. 2003
    ..These results show that in addition to its well-known effect of inhibition of PLA(2) activity, quinacrine could also inhibit cPLA(2) expression, and further supports a role for PLA(2) in kainate-induced neuronal injury...
  4. ncbi request reprint Plasmalogens, docosahexaenoic acid and neurological disorders
    Akhlaq A Farooqui
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA
    Adv Exp Med Biol 544:335-54. 2003
  5. doi request reprint Lipid mediators and their metabolism in the nucleous: implications for Alzheimer's disease
    Akhlaq A Farooqui
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio 43221, USA
    J Alzheimers Dis 30:S163-78. 2012
    ..Similarly, cholesterol-derived lipid mediators, hydroxycholesterol, produce apoptosis. Abnormal metabolism of lipid mediators may be closely associated with pathogenesis of Alzheimer's disease...
  6. doi request reprint Metabolic syndrome as a risk factor for neurological disorders
    Akhlaq A Farooqui
    Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, OH 43221, USA
    Cell Mol Life Sci 69:741-62. 2012
    ....
  7. ncbi request reprint n-3 fatty acid-derived lipid mediators in the brain: new weapons against oxidative stress and inflammation
    A A Farooqui
    Department of Molecular and Cellular Biochemistry, 3120 Herrick Road, Columbus, Ohio 43221, USA
    Curr Med Chem 19:532-43. 2012
    ....
  8. ncbi request reprint Comparison of biochemical effects of statins and fish oil in brain: the battle of the titans
    Akhlaq A Farooqui
    Department of Molecular and Cellular Biochemistry, The Ohio State University, 1645 Neil Avenue, Columbus, OH 43210, USA
    Brain Res Rev 56:443-71. 2007
    ..We speculate that there is an overlap between neurochemical events associated with neural cell injury in stroke and neurodegenerative diseases. This commentary compares the neurochemical effects of statins with those of fish oil...
  9. doi request reprint Lipid mediators in the neural cell nucleus: their metabolism, signaling, and association with neurological disorders
    Akhlaq A Farooqui
    Department of Molecular Cellular Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA
    Neuroscientist 15:392-407. 2009
    ..The nucleus has its own set of enzymes and lipid mediators that originate from the nuclear envelope and matrix. The purpose of this commentary is to describe basic and clinical information on lipid mediators in the nucleus...
  10. doi request reprint Studies on plasmalogen-selective phospholipase A2 in brain
    Akhlaq A Farooqui
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH 43210, USA
    Mol Neurobiol 41:267-73. 2010
    ..It is proposed that accumulation of ceramide and increased expression of cytokines may be responsible for the stimulation of PlsEtn-PLA(2) in Alzheimer disease...
  11. doi request reprint Lipid mediators in the nucleus: Their potential contribution to Alzheimer's disease
    Akhlaq A Farooqui
    Department of Molecular Cellular Biochemistry, The Ohio State University, Columbus, OH 43221, USA
    Biochim Biophys Acta 1801:906-16. 2010
    ..In addition, attempts have been made to explain cross-talk among glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators in neural cell death in Alzheimer's disease...
  12. ncbi request reprint Interactions between neural membrane glycerophospholipid and sphingolipid mediators: a recipe for neural cell survival or suicide
    Akhlaq A Farooqui
    Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci Res 85:1834-50. 2007
    ....
  13. ncbi request reprint Inhibitors of brain phospholipase A2 activity: their neuropharmacological effects and therapeutic importance for the treatment of neurologic disorders
    Akhlaq A Farooqui
    Department of Molecular and Cellular Biochemistry, The Ohio State University, 1645 Neil Avenue, Columbus, OH 43210 1218, USA
    Pharmacol Rev 58:591-620. 2006
    ..This also suggests that phospholipase A(2) inhibitors can be used as neuroprotectants and anti-inflammatory agents against neurodegenerative processes in neurodegenerative diseases...
  14. ncbi request reprint Biochemical aspects of neurodegeneration in human brain: involvement of neural membrane phospholipids and phospholipases A2
    Akhlaq A Farooqui
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA
    Neurochem Res 29:1961-77. 2004
    ..The synthesis of phospholipases A2 inhibitors that cross the blood-brain barrier without harm may be useful for the treatment of acute neural trauma and neurodegenerative diseases...
  15. ncbi request reprint Retinoic acid-mediated phospholipase A2 signaling in the nucleus
    Akhlaq A Farooqui
    Department of Molecular and Cellular Biochemistry, The Ohio State University, 1645 Neil Ave, Columbus, OH 43210, USA
    Brain Res Brain Res Rev 45:179-95. 2004
    ....
  16. ncbi request reprint Brain phospholipases A2: a perspective on the history
    Akhlaq A Farooqui
    Department of Molecular and Cellular Biochemistry, The Ohio State University, 1645 Neil Avenue, 465 Hamilton Hall, Columbus, OH 43210 1218, USA
    Prostaglandins Leukot Essent Fatty Acids 71:161-9. 2004
    ..Under pathological conditions, high levels of lipid metabolites generated by phospholipase A2 are involved in neuroinflammation, oxidative stress, and neural cell injury...
  17. ncbi request reprint Signaling and interplay mediated by phospholipases A2, C, and D in LA-N-1 cell nuclei
    Akhlaq A Farooqui
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH 43210, USA
    Reprod Nutr Dev 45:613-31. 2005
    ....
  18. ncbi request reprint Phospholipase A2-generated lipid mediators in the brain: the good, the bad, and the ugly
    Akhlaq A Farooqui
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, 43210, USA
    Neuroscientist 12:245-60. 2006
    ..The authors hope that this discussion will jump-start more studies not only on the involvement of PLA2 in neurological disorders but also on the importance of PLA2-generated lipid mediators in physiological and pathological processes...
  19. ncbi request reprint Neuroprotection abilities of cytosolic phospholipase A2 inhibitors in kainic acid-induced neurodegeneration
    Akhlaq A Farooqui
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, 43210, USA
    Curr Drug Targets Cardiovasc Haematol Disord 4:85-96. 2004
    ....
  20. doi request reprint Aging: an important factor for the pathogenesis of neurodegenerative diseases
    Tahira Farooqui
    Department of Entomology, The Ohio State University, Columbus, OH 43210, USA
    Mech Ageing Dev 130:203-15. 2009
    ....
  21. ncbi request reprint Modulation of inflammation in brain: a matter of fat
    Akhlaq A Farooqui
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurochem 101:577-99. 2007
    ..The dietary intake of docosahexaenoic acid offers the possibility of counter-balancing the harmful effects of high levels of AA-derived pro-inflammatory lipid mediators...
  22. ncbi request reprint Beneficial effects of propolis on human health and neurological diseases
    Tahira Farooqui
    Department of Entomology, The Ohio State University, Columbus, OH, 43210, USA
    Front Biosci (Elite Ed) 4:779-93. 2012
    ..This overview is an attempt to discuss the molecular mechanism underlying the potential beneficial effects of propolis on human health and neurological diseases...
  23. pmc Lipid-mediated oxidative stress and inflammation in the pathogenesis of Parkinson's disease
    Tahira Farooqui
    Department of Entomology Center for Molecular Neurobiology, The Ohio State University, Columbus, OH 43210, USA
    Parkinsons Dis 2011:247467. 2011
    ..Proinflammatory lipid mediators include prostaglandins and platelet activating factor, together with cytokines may play a prominent role in mediating the progressive neurodegeneration in PD...
  24. ncbi request reprint The roles of NADPH oxidase and phospholipases A2 in oxidative and inflammatory responses in neurodegenerative diseases
    Grace Y Sun
    Department of Biochemistry, University of Missouri, Columbia, Missouri, USA
    J Neurochem 103:1-16. 2007
    ....
  25. ncbi request reprint Iron, neuroinflammation, and Alzheimer's disease
    Wei Yi Ong
    Department of Anatomy, National University of Singapore, Singapore 119260
    J Alzheimers Dis 8:183-200; discussion 209-15. 2005
    ....
  26. ncbi request reprint Injury and recovery of pyramidal neurons in the rat hippocampus after a single episode of oxidative stress induced by intracerebroventricular injection of ferrous ammonium citrate
    Wei Yi Ong
    Department of Anatomy, National University of Singapore, Lower Kent Ridge Road, Singapore 119260, Singapore
    Reprod Nutr Dev 45:647-62. 2005
    ....
  27. ncbi request reprint Ca2+-independent phospholipases A2 and production of arachidonic acid in nuclei of LA-N-1 cell cultures: a specific receptor activation mediated with retinoic acid
    Pierre Antony
    Laboratoire de Neurobiologie Moleculaire des Interactions Cellulaires, Institut de Chimie Biologique, Faculte de Medecine, 11 rue Humann, Strasbourg, France
    Brain Res Mol Brain Res 115:187-95. 2003
    ..Our results also support earlier studies in which atRA induces morphologic differentiation through the stimulation of PLA2-generated second messengers such as arachidonic acid and eicosanoids...
  28. ncbi request reprint Increase in cholesterol and cholesterol oxidation products, and role of cholesterol oxidation products in kainate-induced neuronal injury
    Wei Yi Ong
    Department of Anatomy, National University of Singapore, Singapore
    Brain Pathol 13:250-62. 2003
    ....
  29. ncbi request reprint Differential effects of polyunsaturated fatty acids on membrane capacitance and exocytosis in rat pheochromocytoma-12 cells
    Wee Liat Ong
    Institute of Microelectronics, A STAR, Singapore
    Neurochem Res 31:41-8. 2006
    ..It is postulated that besides arachidonic acid, eicosapentaenoic acid could also play an important role in exocytosis and neurotransmitter release, in neurons and hormone-secreting cells...
  30. ncbi request reprint Distribution of calcium-independent phospholipase A2 (iPLA 2) in monkey brain
    Wei Yi Ong
    Department of Anatomy, National University of Singapore, Singapore
    J Neurocytol 34:447-58. 2005
    ..In addition, the localization of iPLA(2) in dendrites and axon terminals suggests a role of the enzyme in neuronal signaling...
  31. ncbi request reprint Expression, activity, and role of serine palmitoyltransferase in the rat hippocampus after kainate injury
    Xin He
    Department of Anatomy, National University of Singapore, Singapore
    J Neurosci Res 85:423-32. 2007
    ..They also suggest that SPT activity might contribute to neuronal injury after kainate excitotoxicity...
  32. ncbi request reprint Changes in cytochrome P450 side chain cleavage expression in the rat hippocampus after kainate injury
    Wan Jie Chia
    Department of Anatomy, National University of Singapore, Singapore, 119260, Singapore
    Exp Brain Res 186:143-9. 2008
    ..2006). Together, they indicate that increased cholesterol in the kainate lesioned hippocampus is mostly metabolized to oxysterols, and not neurosteroids...
  33. ncbi request reprint Intracerebroventricular injection of phospholipases A2 inhibitors modulates allodynia after facial carrageenan injection in mice
    Jin Fei Yeo
    Department of Oral and Maxillofacial Surgery, National University of Singapore, Lower Kent Ridge Road, Singapore, Singapore 119260
    Pain 112:148-55. 2004
    ..The above results support an important role of central nervous PLA2s in neurotransmission and pain transmission...
  34. ncbi request reprint Role of calcium-independent phospholipase A2 in cortex striatum thalamus cortex circuitry-enzyme inhibition causes vacuous chewing movements in rats
    Li Yen Lee
    Department of Anatomy, National University of Singapore, Singapore, 119260, Singapore
    Psychopharmacology (Berl) 195:387-95. 2007
    ..High levels of calcium independent phospholipase A2 (iPLA2) are present in certain regions of the brain, including the cerebral cortex, striatum, and cerebellum (Ong et al. 2005)...