Research Topics
| Mark L FaillaSummaryAffiliation: The Ohio State University Country: USA Publications
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Detail Information
Publications
Bioaccessibility of pro-vitamin A carotenoids is minimally affected by non pro-vitamin a xanthophylls in maize (Zea mays sp.)Sagar K Thakkar
The Ohio State University, Columbus, 43210, USA
J Agric Food Chem 56:11441-6. 2008..Taken together, these results suggest that the bioaccessibility of pro-VA carotenoids in maize is likely to be minimally affected by the relative levels of xanthophylls lacking pro-VA activity present in cultivars of maize...- Retention during processing and bioaccessibility of β-carotene in high β-carotene transgenic cassava rootMark L Failla
Department of Human Nutrition, The Ohio State University, 1787 Neil Ave, Columbus, OH 43210, United States
J Agric Food Chem 60:3861-6. 2012..These results suggest that transgenic high βC cassava will provide individuals with greater quantities of bioaccessible βC... 
In vitro micellarization and intestinal cell uptake of cis isomers of lycopene exceed those of all-trans lycopeneMark L Failla
Department of Human Nutrition, The Ohio State University, Columbus, OH 43210, USA
J Nutr 138:482-6. 2008....- In vitro bioaccessibility of beta-carotene in orange fleshed sweet potato (Ipomoea batatas, Lam.)Mark L Failla
Interdisciplinary PhD Program in Nutrition, Department of Human Nutrition, The Ohio State University, Columbus, OH 43210, USA
J Agric Food Chem 57:10922-7. 2009..These results indicate the need for further efforts to elucidate the basis for relatively poor bioaccessibility of BC from OFSP... - In vitro screening of relative bioaccessibility of carotenoids from foodsMark L Failla
Department of Human Nutrition, 325 Campbell Hall, 1787 Neil Ave Columbus, OH 43210, USA
Asia Pac J Clin Nutr 17:200-3. 2008.... - Trace elements and host defense: recent advances and continuing challengesMark L Failla
Department of Human Nutrition, Ohio State University, Columbus, OH 43210, USA
J Nutr 133:1443S-7S. 2003.... - Isoflavonoid glucosides are deconjugated and absorbed in the small intestine of human subjects with ileostomiesKelly R Walsh
Interdisciplinary PhD Program in Nutrition, The Ohio State University, Columbus, OH, USA
Am J Clin Nutr 85:1050-6. 2007..Isoflavonoid absorption from the gut requires deconjugation of glucosides to aglycones... - Supplementation of test meals with fat-free phytosterol products can reduce cholesterol micellarization during simulated digestion and cholesterol accumulation by Caco-2 cellsTorsten Bohn
Department of Food Science and Technology, Interdisciplinary Ph D Program in Nutrition, and Department of Human Nutrition, The Ohio State University, Columbus, Ohio 43210, USA
J Agric Food Chem 55:267-72. 2007..This is most likely explained by inhibition of cholesterol micellarization... - Impact of fatty acyl composition and quantity of triglycerides on bioaccessibility of dietary carotenoidsTianyao Huo
Department of Human Nutrition, The Ohio State University, 1787 Neil Avenue, Columbus, Ohio 43210, USA
J Agric Food Chem 55:8950-7. 2007..In contrast, fatty acyl chain length has limited if any impact on carotenoid uptake by small intestinal epithelial cells. These data suggest that the amount of TG in a typical meal does not limit the bioaccessibility of carotenoids... - Assessment of lutein bioavailability from meals and a supplement using simulated digestion and caco-2 human intestinal cellsChureeporn Chitchumroonchokchai
Department of Food Science and Technology, Ohio State University, Columbus, OH, USA
J Nutr 134:2280-6. 2004..These data support the use of simulated digestion and the Caco-2 cell model as effective tools for identifying factors affecting absorption of dietary carotenoids... - Impact of style of processing on retention and bioaccessibility of beta-carotene in cassava (Manihot esculanta, Crantz)Sagar K Thakkar
Interdisciplinary Ph D Program in Nutrition, The Ohio State University, Columbus, Ohio 43210, USA
J Agric Food Chem 57:1344-8. 2009.... - Gastrointestinal absorption and metabolism of soy isoflavonoids in ileal-canulated swineKelly R Walsh
The Ohio State University Interdisciplinary PhD Program in Nutrition, Columbus, OH, USA
Mol Nutr Food Res 53:277-86. 2009..These findings suggest extensive preabsorptive conversion of IFN glucosides to aglycones in the small intestine and relatively efficient microbial metabolism of IFN in weaned swine... - Digestive stability and transport of norbixin, a 24-carbon carotenoid, across monolayers of Caco-2 cellsKarina Polar-Cabrera
Department of Food Science and Technology, The Ohio State University, Columbus, Ohio 43210, USA
J Agric Food Chem 58:5789-94. 2010..The results suggest that ingested norbixin is stable during gastric and small intestinal phases of digestion and that both cis and all-trans isomers are bioavailable... - Susceptibility of anthocyanins to ex vivo degradation in human salivaKom Kamonpatana
OSU Interdisciplinary Ph D Program in Nutrition, The Ohio State University, Columbus, OH 43210, USA
Food Chem 135:738-47. 2012..These results suggest that anthocyanin degradation in the mouth is structure-dependent and largely mediated by oral microbiota... - Transport and metabolism of equol by Caco-2 human intestinal cellsKelly R Walsh
Program in Nutrition, The Ohio State University, Columbus, Ohio 43210, USA
J Agric Food Chem 57:8297-302. 2009..These results suggest that differences in the synthesis and efflux of equol conjugates may contribute to the marked variance in the bioavailability of equol in "producer" phenotype... - Beta-carotene micellarization during in vitro digestion and uptake by Caco-2 cells is directly proportional to beta-carotene content in different genotypes of cassavaSagar K Thakkar
Interdisciplinary PhD Program in Nutrition, The Ohio State University, Columbus, OH 43210, USA
J Nutr 137:2229-33. 2007.... 
Xanthones in mangosteen juice are absorbed and partially conjugated by healthy adultsChureeporn Chitchumroonchokchai
Department of Human Nutrition, The Ohio State University, Columbus, OH, USA
J Nutr 142:675-80. 2012..These results show that xanthones in mangosteen juice are absorbed when ingested along with a high-fat meal, although release of xanthones from pericarp particles during digestion may be limited...- Hydrolysis of zeaxanthin esters by carboxyl ester lipase during digestion facilitates micellarization and uptake of the xanthophyll by Caco-2 human intestinal cellsChureeporn Chitchumroonchokchai
Interdisciplinary Ph.D. Program in Nutrition, The Ohio State University, Columbus, USA
J Nutr 136:588-94. 2006..These data suggest that dietary Zea esters are hydrolyzed by CEL during the small intestinal phase of digestion and that this conversion enhances Zea bioavailability... - Stability and bioaccessibility of isoflavones from soy bread during in vitro digestionKelly R Walsh
Interdisciplinary Ph.D. Program in Nutrition, The Ohio State University, Columbus, Ohio 43210, USA
J Agric Food Chem 51:4603-9. 2003..We propose that the bioavailability of isoflavones from foods containing fat and protein may exceed that of supplements due to enhanced bile secretion... - Stability of black raspberry anthocyanins in the digestive tract lumen and transport efficiency into gastric and small intestinal tissues in the ratJian He
Department of Food Science and Technology, The Ohio State University, Columbus, Ohio 43210, USA
J Agric Food Chem 57:3141-8. 2009..Selective decrease of cyanidin 3-glucoside in the small intestinal content likely resulted from beta-glucosidase activity. Urinary anthocyanin profiles reflected profiles present in the GI at the time of absorption... - High-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry determination of cholesterol uptake by Caco-2 cellsQingguo Tian
Department of Food Science and Technology, The Ohio State University, Columbus, OH 43210, USA
Rapid Commun Mass Spectrom 20:3056-60. 2006..This method provides an effective tool for rapid determination of cholesterol uptake by cells with increased selectivity and sensitivity in comparison to previously reported LC/APCI-MS analysis using selected ion monitoring (SIM)... - Xanthophylls and alpha-tocopherol decrease UVB-induced lipid peroxidation and stress signaling in human lens epithelial cellsChureeporn Chitchumroonchokchai
Ohio State University Interdisciplinary PhD Program in Nutrition, Ohio State University, Columbus, OH 43210, USA
J Nutr 134:3225-32. 2004..3 nmol alpha-TC/mg protein was required to significantly decrease UVB-induced stress signaling. These data suggest that xanthophylls are more potent than alpha-TC for protecting human lens epithelial cells against UVB insult... - Isolation and characterization of primary canine lens epithelial cellsAmy C Long
Interdisciplinary PhD Program in Nutrition, The Ohio State University, Columbus, OH 43210, USA
Vet Ophthalmol 11:38-42. 2008..The purpose of this study was to characterize the proliferation and differentiation of primary canine lens epithelial cells (LEC) under standard culture conditions... - Isoflavone retention during processing, bioaccessibility, and transport by Caco-2 cells: effects of source and amount of fat in a soy soft pretzelAmber L Simmons
Interdisciplinary Ph D Program in Nutrition, The Ohio State University, Columbus, OH 43210, USA
J Agric Food Chem 60:12196-203. 2012..These results suggest that the isoflavone structure, but not source or amount of lipid in a soy pretzel, may affect bioavailability of isoflavones... - Sodium copper chlorophyllin: in vitro digestive stability and accumulation by Caco-2 human intestinal cellsMario G Ferruzzi
Department of Food Science and Technology, The Ohio State University, 110 Parker Food Science and Technology Building, 2015 Fyffe Road, Columbus, Ohio 43210-1007, USA
J Agric Food Chem 50:2173-9. 2002..Stability of Cu(II)chlorin e(4) during in vitro digestion and effective uptake by Caco-2 enterocyte-like cells support the likelihood that a portion of this SCC component or its metabolites is absorbed from the human intestine... - Impact of the stage of ripening and dietary fat on in vitro bioaccessibility of beta-carotene in 'Ataulfo' mangoJ De Jesus Ornelas-Paz
Centro de Investigacion en Alimentacion y Desarrollo, A C, Hermosillo, Sonora, Mexico
J Agric Food Chem 56:1511-6. 2008..Finally, the uptake of beta-carotene in micelles generated during simulated digestion by Caco-2 human intestinal cells confirmed the bioaccessibility of the provitamin A carotenoid in mango... - Micellarization and intestinal cell uptake of beta-carotene and lutein from drumstick (Moringa oleifera) leavesRaghu Pullakhandam
Department of Biophysics, National Institute of Nutrition, Hyderabad, India
J Med Food 10:252-7. 2007.... - Assessment of coenzyme Q10 absorption using an in vitro digestion-Caco-2 cell modelHemmi N Bhagavan
Tishcon Corporation, Westbury, NY 11590, USA
Int J Pharm 333:112-7. 2007.... - Might oral zinc protect pancreatic B-cells against oxidative insults?Mark L Failla
Exp Biol Med (Maywood) 227:435. 2002