Mark L Failla

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. doi request reprint Bioaccessibility of pro-vitamin A carotenoids is minimally affected by non pro-vitamin a xanthophylls in maize (Zea mays sp.)
    Sagar K Thakkar
    The Ohio State University, Columbus, 43210, USA
    J Agric Food Chem 56:11441-6. 2008
  2. ncbi request reprint In vitro micellarization and intestinal cell uptake of cis isomers of lycopene exceed those of all-trans lycopene
    Mark L Failla
    Department of Human Nutrition, The Ohio State University, Columbus, OH 43210, USA
    J Nutr 138:482-6. 2008
  3. ncbi request reprint Unsaturated fatty acids promote bioaccessibility and basolateral secretion of carotenoids and α-tocopherol by Caco-2 cells
    Mark L Failla
    Department of Human Sciences, Human Nutrition Program, The Ohio State University, 352 Campbell Hall, 1787 Neil Ave, Columbus, OH 43210, USA
    Food Funct 5:1101-12. 2014
  4. ncbi request reprint Retention during processing and bioaccessibility of β-carotene in high β-carotene transgenic cassava root
    Mark L Failla
    Department of Human Nutrition, The Ohio State University, 1787 Neil Ave, Columbus, OH 43210, United States
    J Agric Food Chem 60:3861-6. 2012
  5. ncbi request reprint Trace elements and host defense: recent advances and continuing challenges
    Mark L Failla
    Department of Human Nutrition, Ohio State University, Columbus, OH 43210, USA
    J Nutr 133:1443S-7S. 2003
  6. ncbi request reprint In vitro screening of relative bioaccessibility of carotenoids from foods
    Mark L Failla
    Department of Human Nutrition, 325 Campbell Hall, 1787 Neil Ave Columbus, OH 43210, USA
    Asia Pac J Clin Nutr 17:200-3. 2008
  7. doi request reprint In vitro bioaccessibility of beta-carotene in orange fleshed sweet potato (Ipomoea batatas, Lam.)
    Mark L Failla
    Interdisciplinary PhD Program in Nutrition, Department of Human Nutrition, The Ohio State University, Columbus, OH 43210, USA
    J Agric Food Chem 57:10922-7. 2009
  8. ncbi request reprint Isoflavonoid glucosides are deconjugated and absorbed in the small intestine of human subjects with ileostomies
    Kelly R Walsh
    Interdisciplinary PhD Program in Nutrition, The Ohio State University, Columbus, OH, USA
    Am J Clin Nutr 85:1050-6. 2007
  9. ncbi request reprint Supplementation of test meals with fat-free phytosterol products can reduce cholesterol micellarization during simulated digestion and cholesterol accumulation by Caco-2 cells
    Torsten Bohn
    Department of Food Science and Technology, Interdisciplinary Ph D Program in Nutrition, and Department of Human Nutrition, The Ohio State University, Columbus, Ohio 43210, USA
    J Agric Food Chem 55:267-72. 2007
  10. pmc Anti-tumorigenicity of dietary α-mangostin in an HT-29 colon cell xenograft model and the tissue distribution of xanthones and their phase II metabolites
    Chureeporn Chitchumroonchokchai
    Department of Human Nutrition, The Ohio State University, Columbus, OH 43210, USA
    Mol Nutr Food Res 57:203-11. 2013

Collaborators

Detail Information

Publications39

  1. doi request reprint Bioaccessibility of pro-vitamin A carotenoids is minimally affected by non pro-vitamin a xanthophylls in maize (Zea mays sp.)
    Sagar K Thakkar
    The Ohio State University, Columbus, 43210, USA
    J Agric Food Chem 56:11441-6. 2008
    ..Taken together, these results suggest that the bioaccessibility of pro-VA carotenoids in maize is likely to be minimally affected by the relative levels of xanthophylls lacking pro-VA activity present in cultivars of maize...
  2. ncbi request reprint In vitro micellarization and intestinal cell uptake of cis isomers of lycopene exceed those of all-trans lycopene
    Mark L Failla
    Department of Human Nutrition, The Ohio State University, Columbus, OH 43210, USA
    J Nutr 138:482-6. 2008
    ....
  3. ncbi request reprint Unsaturated fatty acids promote bioaccessibility and basolateral secretion of carotenoids and α-tocopherol by Caco-2 cells
    Mark L Failla
    Department of Human Sciences, Human Nutrition Program, The Ohio State University, 352 Campbell Hall, 1787 Neil Ave, Columbus, OH 43210, USA
    Food Funct 5:1101-12. 2014
    ..These results suggest that dietary fats/oils rich in unsaturated fatty acids promote carotenoid and α-TC bioavailability by enhancing their micellarization during digestion and intestinal transport...
  4. ncbi request reprint Retention during processing and bioaccessibility of β-carotene in high β-carotene transgenic cassava root
    Mark L Failla
    Department of Human Nutrition, The Ohio State University, 1787 Neil Ave, Columbus, OH 43210, United States
    J Agric Food Chem 60:3861-6. 2012
    ..These results suggest that transgenic high βC cassava will provide individuals with greater quantities of bioaccessible βC...
  5. ncbi request reprint Trace elements and host defense: recent advances and continuing challenges
    Mark L Failla
    Department of Human Nutrition, Ohio State University, Columbus, OH 43210, USA
    J Nutr 133:1443S-7S. 2003
    ....
  6. ncbi request reprint In vitro screening of relative bioaccessibility of carotenoids from foods
    Mark L Failla
    Department of Human Nutrition, 325 Campbell Hall, 1787 Neil Ave Columbus, OH 43210, USA
    Asia Pac J Clin Nutr 17:200-3. 2008
    ....
  7. doi request reprint In vitro bioaccessibility of beta-carotene in orange fleshed sweet potato (Ipomoea batatas, Lam.)
    Mark L Failla
    Interdisciplinary PhD Program in Nutrition, Department of Human Nutrition, The Ohio State University, Columbus, OH 43210, USA
    J Agric Food Chem 57:10922-7. 2009
    ..These results indicate the need for further efforts to elucidate the basis for relatively poor bioaccessibility of BC from OFSP...
  8. ncbi request reprint Isoflavonoid glucosides are deconjugated and absorbed in the small intestine of human subjects with ileostomies
    Kelly R Walsh
    Interdisciplinary PhD Program in Nutrition, The Ohio State University, Columbus, OH, USA
    Am J Clin Nutr 85:1050-6. 2007
    ..Isoflavonoid absorption from the gut requires deconjugation of glucosides to aglycones...
  9. ncbi request reprint Supplementation of test meals with fat-free phytosterol products can reduce cholesterol micellarization during simulated digestion and cholesterol accumulation by Caco-2 cells
    Torsten Bohn
    Department of Food Science and Technology, Interdisciplinary Ph D Program in Nutrition, and Department of Human Nutrition, The Ohio State University, Columbus, Ohio 43210, USA
    J Agric Food Chem 55:267-72. 2007
    ..This is most likely explained by inhibition of cholesterol micellarization...
  10. pmc Anti-tumorigenicity of dietary α-mangostin in an HT-29 colon cell xenograft model and the tissue distribution of xanthones and their phase II metabolites
    Chureeporn Chitchumroonchokchai
    Department of Human Nutrition, The Ohio State University, Columbus, OH 43210, USA
    Mol Nutr Food Res 57:203-11. 2013
    ....
  11. doi request reprint Gastrointestinal absorption and metabolism of soy isoflavonoids in ileal-canulated swine
    Kelly R Walsh
    The Ohio State University Interdisciplinary PhD Program in Nutrition, Columbus, OH, USA
    Mol Nutr Food Res 53:277-86. 2009
    ..These findings suggest extensive preabsorptive conversion of IFN glucosides to aglycones in the small intestine and relatively efficient microbial metabolism of IFN in weaned swine...
  12. doi request reprint Impact of style of processing on retention and bioaccessibility of beta-carotene in cassava (Manihot esculanta, Crantz)
    Sagar K Thakkar
    Interdisciplinary Ph D Program in Nutrition, The Ohio State University, Columbus, Ohio 43210, USA
    J Agric Food Chem 57:1344-8. 2009
    ....
  13. ncbi request reprint Assessment of lutein bioavailability from meals and a supplement using simulated digestion and caco-2 human intestinal cells
    Chureeporn Chitchumroonchokchai
    Department of Food Science and Technology, Ohio State University, Columbus, OH, USA
    J Nutr 134:2280-6. 2004
    ..These data support the use of simulated digestion and the Caco-2 cell model as effective tools for identifying factors affecting absorption of dietary carotenoids...
  14. ncbi request reprint Impact of fatty acyl composition and quantity of triglycerides on bioaccessibility of dietary carotenoids
    Tianyao Huo
    Department of Human Nutrition, The Ohio State University, 1787 Neil Avenue, Columbus, Ohio 43210, USA
    J Agric Food Chem 55:8950-7. 2007
    ..In contrast, fatty acyl chain length has limited if any impact on carotenoid uptake by small intestinal epithelial cells. These data suggest that the amount of TG in a typical meal does not limit the bioaccessibility of carotenoids...
  15. pmc Saponins from soy and chickpea: stability during beadmaking and in vitro bioaccessibility
    Luca Serventi
    Department of Food Science and Technology and Department of Human Nutrition, The Ohio State University, Columbus, Ohio 43210, United States
    J Agric Food Chem 61:6703-10. 2013
    ..These findings suggest that saponin structure and food matrix affect the stability of saponins during processing and digestion and that uptake of saponins by enterocyte-like cells is poor despite moderate apparent bioaccessibility. ..
  16. pmc Biological activities and bioavailability of mangosteen xanthones: a critical review of the current evidence
    Fabiola Gutierrez-Orozco
    Interdisciplinary PhD Program in Nutrition, The Ohio State University, Columbus, OH 43210, USA
    Nutrients 5:3163-83. 2013
    ....
  17. pmc Digestive stability and transport of norbixin, a 24-carbon carotenoid, across monolayers of Caco-2 cells
    Karina Polar-Cabrera
    Department of Food Science and Technology, The Ohio State University, Columbus, Ohio 43210, USA
    J Agric Food Chem 58:5789-94. 2010
    ..The results suggest that ingested norbixin is stable during gastric and small intestinal phases of digestion and that both cis and all-trans isomers are bioavailable...
  18. doi request reprint Isoflavone retention during processing, bioaccessibility, and transport by Caco-2 cells: effects of source and amount of fat in a soy soft pretzel
    Amber L Simmons
    Interdisciplinary Ph D Program in Nutrition, The Ohio State University, Columbus, OH 43210, USA
    J Agric Food Chem 60:12196-203. 2012
    ..These results suggest that the isoflavone structure, but not source or amount of lipid in a soy pretzel, may affect bioavailability of isoflavones...
  19. pmc Susceptibility of anthocyanins to ex vivo degradation in human saliva
    Kom Kamonpatana
    OSU Interdisciplinary Ph D Program in Nutrition, The Ohio State University, Columbus, OH 43210, USA
    Food Chem 135:738-47. 2012
    ..These results suggest that anthocyanin degradation in the mouth is structure-dependent and largely mediated by oral microbiota...
  20. doi request reprint Transport and metabolism of equol by Caco-2 human intestinal cells
    Kelly R Walsh
    Program in Nutrition, The Ohio State University, Columbus, Ohio 43210, USA
    J Agric Food Chem 57:8297-302. 2009
    ..These results suggest that differences in the synthesis and efflux of equol conjugates may contribute to the marked variance in the bioavailability of equol in "producer" phenotype...
  21. ncbi request reprint Beta-carotene micellarization during in vitro digestion and uptake by Caco-2 cells is directly proportional to beta-carotene content in different genotypes of cassava
    Sagar K Thakkar
    Interdisciplinary PhD Program in Nutrition, The Ohio State University, Columbus, OH 43210, USA
    J Nutr 137:2229-33. 2007
    ....
  22. pmc Xanthones in mangosteen juice are absorbed and partially conjugated by healthy adults
    Chureeporn Chitchumroonchokchai
    Department of Human Nutrition, The Ohio State University, Columbus, OH, USA
    J Nutr 142:675-80. 2012
    ..These results show that xanthones in mangosteen juice are absorbed when ingested along with a high-fat meal, although release of xanthones from pericarp particles during digestion may be limited...
  23. pmc Dietary α-mangostin, a xanthone from mangosteen fruit, exacerbates experimental colitis and promotes dysbiosis in mice
    Fabiola Gutierrez-Orozco
    Department of Human Sciences, The Ohio State University, Columbus, OH, USA Food Innovation Center, The Ohio State University, Columbus, OH, USA
    Mol Nutr Food Res 58:1226-38. 2014
    ..We evaluated the impact of dietary α-MG on murine experimental colitis and on the gut microbiota of healthy mice...
  24. ncbi request reprint Hydrolysis of zeaxanthin esters by carboxyl ester lipase during digestion facilitates micellarization and uptake of the xanthophyll by Caco-2 human intestinal cells
    Chureeporn Chitchumroonchokchai
    Interdisciplinary Ph D Program in Nutrition, The Ohio State University, Columbus, USA
    J Nutr 136:588-94. 2006
    ..These data suggest that dietary Zea esters are hydrolyzed by CEL during the small intestinal phase of digestion and that this conversion enhances Zea bioavailability...
  25. pmc α-Mangostin: anti-inflammatory activity and metabolism by human cells
    Fabiola Gutierrez-Orozco
    Interdisciplinary Ph D Program in Nutrition, The Ohio State University, Columbus, OH 43210, USA
    J Agric Food Chem 61:3891-900. 2013
    ..The anti-inflammatory activities of xanthones and their metabolites in different tissues merit consideration...
  26. doi request reprint Stability of black raspberry anthocyanins in the digestive tract lumen and transport efficiency into gastric and small intestinal tissues in the rat
    Jian He
    Department of Food Science and Technology, The Ohio State University, Columbus, Ohio 43210, USA
    J Agric Food Chem 57:3141-8. 2009
    ..Selective decrease of cyanidin 3-glucoside in the small intestinal content likely resulted from beta-glucosidase activity. Urinary anthocyanin profiles reflected profiles present in the GI at the time of absorption...
  27. ncbi request reprint Stability and bioaccessibility of isoflavones from soy bread during in vitro digestion
    Kelly R Walsh
    Interdisciplinary Ph D Program in Nutrition, The Ohio State University, Columbus, Ohio 43210, USA
    J Agric Food Chem 51:4603-9. 2003
    ..We propose that the bioavailability of isoflavones from foods containing fat and protein may exceed that of supplements due to enhanced bile secretion...
  28. pmc Adipocyte reporter assays: application for identification of anti-inflammatory and antioxidant properties of mangosteen xanthones
    Qiwen Shen
    Department of Human Sciences, The Ohio State University, Columbus, OH, USA
    Mol Nutr Food Res 58:239-47. 2014
    ....
  29. ncbi request reprint High-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry determination of cholesterol uptake by Caco-2 cells
    Qingguo Tian
    Department of Food Science and Technology, The Ohio State University, Columbus, OH 43210, USA
    Rapid Commun Mass Spectrom 20:3056-60. 2006
    ..This method provides an effective tool for rapid determination of cholesterol uptake by cells with increased selectivity and sensitivity in comparison to previously reported LC/APCI-MS analysis using selected ion monitoring (SIM)...
  30. ncbi request reprint Xanthophylls and alpha-tocopherol decrease UVB-induced lipid peroxidation and stress signaling in human lens epithelial cells
    Chureeporn Chitchumroonchokchai
    Ohio State University Interdisciplinary PhD Program in Nutrition, Ohio State University, Columbus, OH 43210, USA
    J Nutr 134:3225-32. 2004
    ..3 nmol alpha-TC/mg protein was required to significantly decrease UVB-induced stress signaling. These data suggest that xanthophylls are more potent than alpha-TC for protecting human lens epithelial cells against UVB insult...
  31. doi request reprint Isolation and characterization of primary canine lens epithelial cells
    Amy C Long
    Interdisciplinary PhD Program in Nutrition, The Ohio State University, Columbus, OH 43210, USA
    Vet Ophthalmol 11:38-42. 2008
    ..The purpose of this study was to characterize the proliferation and differentiation of primary canine lens epithelial cells (LEC) under standard culture conditions...
  32. ncbi request reprint Anthocyanin structure determines susceptibility to microbial degradation and bioavailability to the buccal mucosa
    Kom Kamonpatana
    OSU Interdisciplinary Ph D Program in Nutrition, Food Innovation Center, Division of Periodontology, College of Dentistry, and Department of Food Science and Technology, The Ohio State University, Columbus, Ohio 43210, United States
    J Agric Food Chem 62:6903-10. 2014
    ..These results suggest that anthocyanin structure affects stability and buccal cell uptake and therefore the potential efficacy of anthocyanin-rich products for the promotion of oral health. ..
  33. ncbi request reprint Sodium copper chlorophyllin: in vitro digestive stability and accumulation by Caco-2 human intestinal cells
    Mario G Ferruzzi
    Department of Food Science and Technology, The Ohio State University, 110 Parker Food Science and Technology Building, 2015 Fyffe Road, Columbus, Ohio 43210 1007, USA
    J Agric Food Chem 50:2173-9. 2002
    ..Stability of Cu(II)chlorin e(4) during in vitro digestion and effective uptake by Caco-2 enterocyte-like cells support the likelihood that a portion of this SCC component or its metabolites is absorbed from the human intestine...
  34. pmc Zinc deficiency augments leptin production and exacerbates macrophage infiltration into adipose tissue in mice fed a high-fat diet
    Ming Jie Liu
    Dorothy M Davis Heart and Lung Research Institute, Columbus, Ohio, USA
    J Nutr 143:1036-45. 2013
    ..Our results demonstrate that Zn deficiency increases leptin production and exacerbates macrophage infiltration into adipose tissue in obese mice, indicating the importance of Zn in metabolic and immune dysregulation in obesity. ..
  35. ncbi request reprint Increased Bioavailability of Ubiquinol Compared to That of Ubiquinone Is Due to More Efficient Micellarization during Digestion and Greater GSH-Dependent Uptake and Basolateral Secretion by Caco-2 Cells
    Mark L Failla
    Human Nutrition Program, The Ohio State University, Columbus, Ohio 43210, United States
    J Agric Food Chem 62:7174-82. 2014
    ....
  36. ncbi request reprint Impact of the stage of ripening and dietary fat on in vitro bioaccessibility of beta-carotene in 'Ataulfo' mango
    J De Jesus Ornelas-Paz
    Centro de Investigacion en Alimentacion y Desarrollo, A C, Hermosillo, Sonora, Mexico
    J Agric Food Chem 56:1511-6. 2008
    ..Finally, the uptake of beta-carotene in micelles generated during simulated digestion by Caco-2 human intestinal cells confirmed the bioaccessibility of the provitamin A carotenoid in mango...
  37. ncbi request reprint Micellarization and intestinal cell uptake of beta-carotene and lutein from drumstick (Moringa oleifera) leaves
    Raghu Pullakhandam
    Department of Biophysics, National Institute of Nutrition, Hyderabad, India
    J Med Food 10:252-7. 2007
    ....
  38. ncbi request reprint Assessment of coenzyme Q10 absorption using an in vitro digestion-Caco-2 cell model
    Hemmi N Bhagavan
    Tishcon Corporation, Westbury, NY 11590, USA
    Int J Pharm 333:112-7. 2007
    ....
  39. ncbi request reprint Might oral zinc protect pancreatic B-cells against oxidative insults?
    Mark L Failla
    Exp Biol Med (Maywood) 227:435. 2002