Douglas B Evans

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc The added value of multidisciplinary care for patients with pancreatic cancer
    Douglas B Evans
    Ann Surg Oncol 15:2078-80. 2008
  2. ncbi request reprint Invited commentary: medullary thyroid cancer: the importance of RET testing
    Douglas B Evans
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Surgery 141:96-9. 2007
  3. ncbi request reprint Preoperative chemoradiation for pancreatic cancer
    Douglas B Evans
    The Department of Surgical Oncology and the Pancreatic Cancer Study Group, The University of Texas M D Anderson Cancer Center, Houston, 77030 4009, USA
    Semin Oncol 32:S25-9. 2005
  4. ncbi request reprint On "Posterior retroperitoneoscopic adrenalectomy--results of 560 procedures in 520 patients"
    Douglas B Evans
    University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Surgery 140:951-2. 2006
  5. doi request reprint Preoperative gemcitabine-based chemoradiation for patients with resectable adenocarcinoma of the pancreatic head
    Douglas B Evans
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 26:3496-502. 2008
  6. doi request reprint Polymorphisms of p16, p27, p73, and MDM2 modulate response and survival of pancreatic cancer patients treated with preoperative chemoradiation
    Jinyun Chen
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Ann Surg Oncol 16:431-9. 2009
  7. ncbi request reprint Overexpression of tropomysin-related kinase B in metastatic human pancreatic cancer cells
    Guido M Sclabas
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 11:440-9. 2005
  8. pmc Secreted interleukin-1alpha induces a metastatic phenotype in pancreatic cancer by sustaining a constitutive activation of nuclear factor-kappaB
    Davide Melisi
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer Res 7:624-33. 2009
  9. ncbi request reprint HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas
    Michael J Gray
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcomb Boulevard, Houston, TX 77030, USA
    Oncogene 24:3110-20. 2005
  10. doi request reprint Preoperative gemcitabine and cisplatin followed by gemcitabine-based chemoradiation for resectable adenocarcinoma of the pancreatic head
    Gauri R Varadhachary
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 426, Houston, TX 77030, USA
    J Clin Oncol 26:3487-95. 2008

Detail Information

Publications101 found, 100 shown here

  1. pmc The added value of multidisciplinary care for patients with pancreatic cancer
    Douglas B Evans
    Ann Surg Oncol 15:2078-80. 2008
  2. ncbi request reprint Invited commentary: medullary thyroid cancer: the importance of RET testing
    Douglas B Evans
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Surgery 141:96-9. 2007
  3. ncbi request reprint Preoperative chemoradiation for pancreatic cancer
    Douglas B Evans
    The Department of Surgical Oncology and the Pancreatic Cancer Study Group, The University of Texas M D Anderson Cancer Center, Houston, 77030 4009, USA
    Semin Oncol 32:S25-9. 2005
    ..Clinical trials involving patients with localized pancreatic cancer are needed that use accurate, reproducible pretreatment staging techniques, and standardized pathologic evaluation of surgical specimens...
  4. ncbi request reprint On "Posterior retroperitoneoscopic adrenalectomy--results of 560 procedures in 520 patients"
    Douglas B Evans
    University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Surgery 140:951-2. 2006
  5. doi request reprint Preoperative gemcitabine-based chemoradiation for patients with resectable adenocarcinoma of the pancreatic head
    Douglas B Evans
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 26:3496-502. 2008
    ..We conducted a phase II trial to assess the outcomes of patients who received preoperative gemcitabine-based chemoradiation and pancreaticoduodenectomy (PD) for stage I/II pancreatic adenocarcinoma...
  6. doi request reprint Polymorphisms of p16, p27, p73, and MDM2 modulate response and survival of pancreatic cancer patients treated with preoperative chemoradiation
    Jinyun Chen
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Ann Surg Oncol 16:431-9. 2009
    ..13 (1.04-4.36), 3.18 (1.37-7.39), and 10.09 (3.17-32.05), respectively. These findings suggest these polymorphisms in the cell cycle genes are promising prognostic markers for patients with pancreatic cancer...
  7. ncbi request reprint Overexpression of tropomysin-related kinase B in metastatic human pancreatic cancer cells
    Guido M Sclabas
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 11:440-9. 2005
    ..The mechanisms by which it invades and metastasizes are not known...
  8. pmc Secreted interleukin-1alpha induces a metastatic phenotype in pancreatic cancer by sustaining a constitutive activation of nuclear factor-kappaB
    Davide Melisi
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer Res 7:624-33. 2009
    ..Our findings further support the possible link between inflammation and cancer and suggest that IL-1alpha may be a potential therapeutic target for treating pancreatic adenocarcinoma...
  9. ncbi request reprint HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas
    Michael J Gray
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcomb Boulevard, Houston, TX 77030, USA
    Oncogene 24:3110-20. 2005
    ..These data suggest that the binding of both STAT3 and HIF-1alpha to the VEGF promoter is required for maximum transcription of VEGF mRNA following hypoxia...
  10. doi request reprint Preoperative gemcitabine and cisplatin followed by gemcitabine-based chemoradiation for resectable adenocarcinoma of the pancreatic head
    Gauri R Varadhachary
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 426, Houston, TX 77030, USA
    J Clin Oncol 26:3487-95. 2008
    ..We conducted a phase II trial of preoperative gemcitabine and cisplatin chemotherapy in addition to chemoradiation (Gem-Cis-XRT) and pancreaticoduodenectomy (PD) for patients with stage I/II pancreatic adenocarcinoma...
  11. ncbi request reprint Inhibition of constitutive NF-kappa B activity by I kappa B alpha M suppresses tumorigenesis
    Shuichi Fujioka
    Department of Surgical Oncology, The University of Texas, Houston 77030, USA
    Oncogene 22:1365-70. 2003
    ..Taken together, these results suggest that the inhibition of NF-kappa B signaling can suppress tumorigenesis of pancreatic cancer cells and that the NF-kappa B signaling pathway is a potential target for anticancer agents...
  12. pmc NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity
    Shuichi Fujioka
    Department of Surgical Oncology, Box 107, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mol Cell Biol 24:7806-19. 2004
    ..Thus, our study revealed a distinct and essential role of NF-kappaB in participating in the regulation of elk-1, c-fos, and VEGF expression...
  13. ncbi request reprint Stabilization of p53 is a novel mechanism for proapoptotic function of NF-kappaB
    Shuichi Fujioka
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 279:27549-59. 2004
    ..Thus, these findings reveal a mechanism of NF-kappaB-regulated proapoptotic signaling...
  14. ncbi request reprint Regulatory role of c-Met in insulin-like growth factor-I receptor-mediated migration and invasion of human pancreatic carcinoma cells
    Todd W Bauer
    Department of Surgical Oncology, Unit 444, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 5:1676-82. 2006
    ..Elucidation of the signaling pathways that contribute to tumor progression and metastasis should provide a foundation for the development of targeted therapies for pancreatic carcinoma...
  15. doi request reprint Survival and quality of life of patients with resected pancreatic adenocarcinoma treated with adjuvant interferon-based chemoradiation: a phase II trial
    Matthew H G Katz
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, USA
    Ann Surg Oncol 18:3615-22. 2011
    ..We conducted a phase II trial to assess the survival duration and quality of life of patients who received adjuvant interferon-based chemoradiation for pancreatic adenocarcinoma after pancreaticoduodenectomy...
  16. ncbi request reprint Borderline resectable pancreatic cancer: definitions, management, and role of preoperative therapy
    Gauri R Varadhachary
    Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Ann Surg Oncol 13:1035-46. 2006
    ....
  17. ncbi request reprint Intraductal papillary mucinous neoplasms of the pancreas: effect of invasion and pancreatic margin status on recurrence and survival
    Chandrajit P Raut
    Department of Surgical Oncology, Unit 444, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Ann Surg Oncol 13:582-94. 2006
    ..This study evaluated the outcome after pancreatectomy for IPMN according to the pancreatic transection margin status and the presence or absence of invasive carcinoma...
  18. pmc Effects of base excision repair gene polymorphisms on pancreatic cancer survival
    Donghui Li
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 1402, USA
    Int J Cancer 120:1748-54. 2007
    ..These observations need to be confirmed in a larger study of homogenous patient population...
  19. ncbi request reprint Role of adjuvant chemoradiation therapy in adenocarcinomas of the ampulla of vater
    Sunil Krishnan
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Int J Radiat Oncol Biol Phys 70:735-43. 2008
    ..We retrospectively compared treatment outcomes in patients treated with pancreaticoduodenectomy alone versus those who received additional adjuvant CRT...
  20. ncbi request reprint Targeting of urokinase plasminogen activator receptor in human pancreatic carcinoma cells inhibits c-Met- and insulin-like growth factor-I receptor-mediated migration and invasion and orthotopic tumor growth in mice
    Todd W Bauer
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 65:7775-81. 2005
    ..Our study shows the importance of the uPA/uPAR system in pancreatic carcinoma cell migration and invasion. These findings suggest that uPAR is a potential target for therapy in patients with pancreatic cancer...
  21. pmc Long-term survival after multidisciplinary management of resected pancreatic adenocarcinoma
    Matthew H G Katz
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 16:836-47. 2009
    ..We evaluated long-term survival and patterns of recurrence in patients treated for PC with contemporary staging and multimodality therapy...
  22. pmc Concurrent capecitabine and upper abdominal radiation therapy is well tolerated
    Prajnan Das
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, USA
    Radiat Oncol 1:41. 2006
    ..Therefore, capecitabine and concurrent radiotherapy to the upper abdomen appears to be well tolerated. Capecitabine may serve as an alternative to bolus or infusional 5-FU during chemoradiation for upper gastrointestinal malignancies...
  23. ncbi request reprint Induction chemotherapy selects patients with locally advanced, unresectable pancreatic cancer for optimal benefit from consolidative chemoradiation therapy
    Sunil Krishnan
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Cancer 110:47-55. 2007
    ....
  24. pmc Impact of resection status on pattern of failure and survival after pancreaticoduodenectomy for pancreatic adenocarcinoma
    Chandrajit P Raut
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Ann Surg 246:52-60. 2007
    ..To better understand the impact of a microscopically positive margin (R1) on patterns of disease recurrence and survival after pancreaticoduodenectomy (PD) for pancreatic adenocarcinoma...
  25. pmc Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer
    Oliver Stoeltzing
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Am J Pathol 163:1001-11. 2003
    ..02). Our results suggest that autocrine activation of the IGF-IR system significantly affects VEGF expression and angiogenesis in human pancreatic cancer. Thus, IGF-IR may be a valid target in the treatment of pancreatic cancer...
  26. doi request reprint Borderline resectable pancreatic cancer: the importance of this emerging stage of disease
    Matthew H G Katz
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230 1402, USA
    J Am Coll Surg 206:833-46; discussion 846-8. 2008
    ..There is no optimal treatment schema for this distinct stage of disease, so the role of surgery is undefined...
  27. pmc Significant effect of homologous recombination DNA repair gene polymorphisms on pancreatic cancer survival
    Donghui Li
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77230 1402, USA
    Cancer Res 66:3323-30. 2006
    ..These observations suggest that polymorphisms of genes involved in the repair of DNA double-strand breaks significantly affect the clinical outcome of patients with pancreatic cancer...
  28. ncbi request reprint Phase I trial evaluating the safety of bevacizumab with concurrent radiotherapy and capecitabine in locally advanced pancreatic cancer
    Christopher H Crane
    Department of Radiation Oncology, Unit 97, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 24:1145-51. 2006
    ..To study the safety of bevacizumab with capecitabine-based chemoradiotherapy...
  29. doi request reprint Expression of MAP4K4 is associated with worse prognosis in patients with stage II pancreatic ductal adenocarcinoma
    John J Liang
    Department of Pathology, The University of Texas M D Anderson Cancer, Houston, TX 77030, USA
    Clin Cancer Res 14:7043-9. 2008
    ..MAP4K4 plays an important role in transformation, invasiveness, adhesion, and cell migration. However, the expression of MAP4K4 and its significance in pancreatic ductal adenocarcinoma (PDA) has not been studied...
  30. pmc Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 426, Houston, TX 77030, USA
    Carcinogenesis 27:103-11. 2006
    ..9, 95% CI: 1.2-6.9) and among females (AOR: 2.5, 95% CI: 1.1-5.7). These data suggest that polymorphisms of the CYP1A2 and NAT1 genes modify the risk of pancreatic cancer...
  31. pmc TrkBT1 induces liver metastasis of pancreatic cancer cells by sequestering Rho GDP dissociation inhibitor and promoting RhoA activation
    Zhongkui Li
    Departments of Surgical Oncology and Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 69:7851-9. 2009
    ..Therefore, our results showed that TrkBT1 overexpression induces liver metastasis of pancreatic cancer and uncovered a unique signaling mechanism by which TrkBT1 sequesters GDI and activates RhoA signaling...
  32. ncbi request reprint Pheochromocytoma and medullary thyroid carcinoma: a new genotype-phenotype correlation of the RET protooncogene 891 germline mutation
    Camilo Jimenez
    The University of Texas MD Anderson Cancer Center, Department of Endocrine Neoplasia and Hormonal Disorders, 1515 Holcombe Boulevard, Unit 435, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 89:4142-5. 2004
    ..These findings indicate that patients with this mutation should be screened for pheochromocytoma...
  33. doi request reprint Achieving eugastrinemia in MEN1 patients: both duodenal inspection and formal lymph node dissection are important
    Paxton V Dickson
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4008, USA
    Surgery 150:1143-52. 2011
    ..Controversy exists regarding the role and extent of operation for patients with multiple endocrine neoplasia type 1 (MEN1) and hypergastrinemia...
  34. ncbi request reprint Function of nuclear factor kappaB in pancreatic cancer metastasis
    Shuichi Fujioka
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:346-54. 2003
    ....
  35. ncbi request reprint Neuropilin-1 suppresses tumorigenic properties in a human pancreatic adenocarcinoma cell line lacking neuropilin-1 coreceptors
    Michael J Gray
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 21201, USA
    Cancer Res 65:3664-70. 2005
    ..Thus, NRP-1 may play distinct growth regulatory roles in different tumor types, and altering NRP-1 expression or function may be a means of influencing the growth of pancreatic cancers...
  36. pmc Risk factors for pancreatic cancer: case-control study
    Manal M Hassan
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Am J Gastroenterol 102:2696-707. 2007
    ..We evaluated the independent effects of multiple risk factors for pancreatic cancer and determined whether the magnitude of cigarette smoking was modified by other risk factors in men and women...
  37. pmc Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology Unit 426, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1402, USA
    J Clin Oncol 24:1720-8. 2006
    ..Our goal was to determine whether single nucleotide polymorphisms (SNPs) in DNA repair genes influence the clinical outcome of pancreatic cancer...
  38. pmc Selected polymorphisms of DNA repair genes and risk of pancreatic cancer
    Li Jiao
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Detect Prev 30:284-91. 2006
    ....
  39. pmc Ultrasonography should not guide the timing of thyroidectomy in pediatric patients diagnosed with multiple endocrine neoplasia syndrome 2A through genetic screening
    Lilah F Morris
    Section of Surgical Endocrinology, Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 20:53-9. 2013
    ..We hypothesized that normal US would not exclude a final pathology diagnosis of medullary thyroid cancer (MTC)...
  40. pmc Histologic tumor involvement of superior mesenteric vein/portal vein predicts poor prognosis in patients with stage II pancreatic adenocarcinoma treated with neoadjuvant chemoradiation
    Jiansheng Wang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 118:3801-11. 2012
    ..However, the prognostic significance of tumor involvement of the resected vein in patients who received neoadjuvant therapy is unclear...
  41. doi request reprint Recurrence of adrenal cortical carcinoma following resection: surgery alone can achieve results equal to surgery plus mitotane
    Elizabeth G Grubbs
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 17:263-70. 2010
    ..Because of the limitations of this study, we investigated the influences of surgery and adjuvant mitotane in a large series of ACC patients evaluated and treated at a single referral center...
  42. doi request reprint Routine pre-operative ultrasonography for papillary thyroid cancer: effects on cervical recurrence
    Christy L Marshall
    Department of Surgical Oncology, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Surgery 146:1063-72. 2009
    ..We report the follow-up of patients with PTC in whom pre-operative US was used to accurately stage the extent of neck disease...
  43. ncbi request reprint Nuclear factor kappa B activation is a potential target for preventing pancreatic carcinoma by aspirin
    Guido M Sclabas
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 103:2485-90. 2005
    ..The aims of the current study were to determine the effects of aspirin on pancreatic carcinoma prevention and to reveal a possible mechanism of aspirin-mediated cancer chemoprevention...
  44. ncbi request reprint Future chemoradiation strategies in pancreatic cancer
    Christopher H Crane
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Semin Oncol 34:335-46. 2007
    ..Herein, we discuss the relative merits of strategies that seek to improve outcome through these novel means and present recent data from novel strategies that will provide the background for future trials...
  45. ncbi request reprint Neoadjuvant therapy for resectable pancreatic cancer
    Chandrajit P Raut
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Surg Oncol Clin N Am 13:639-61, ix. 2004
    ..Future clinical trials for resectable pancreatic cancer will lead to progress only if the principles of multidisciplinary cancer care and quality assurance are incorporated into their design and conduct...
  46. pmc XRCC2 and XRCC3 gene polymorphism and risk of pancreatic cancer
    Li Jiao
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Gastroenterol 103:360-7. 2008
    ..We hypothesized that the altered HR repair capacity conferred by single nucleotide polymorphisms (SNPs) would modify individual susceptibility to sporadic pancreatic cancer...
  47. ncbi request reprint Pancreaticoduodenectomy with vascular resection: margin status and survival duration
    Jennifer F Tseng
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Gastrointest Surg 8:935-49; discussion 949-50. 2004
    ....
  48. ncbi request reprint Mechanisms of synthetic serine protease inhibitor (FUT-175)-mediated cell death
    Tadashi Uwagawa
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 109:2142-53. 2007
    ....
  49. ncbi request reprint Src activation of Stat3 is an independent requirement from NF-kappaB activation for constitutive IL-8 expression in human pancreatic adenocarcinoma cells
    Jose G Trevino
    Department of Cancer Biology, Unit 179, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Angiogenesis 9:101-10. 2006
    ..We therefore suggest that Src activation, through phosphorylation of STAT3, and NF-kappaB are all required for expression of IL-8 a critical angiogenic-promoting factor in pancreatic adenocarcinomas...
  50. ncbi request reprint Delayed recovery after pancreaticoduodenectomy: a major factor impairing the delivery of adjuvant therapy?
    Thomas A Aloia
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230 1402, USA
    J Am Coll Surg 204:347-55. 2007
    ..This study reexamined the frequency of delayed recovery and assessed other factors associated with adjuvant therapy administration after PD at a high-volume center...
  51. doi request reprint Postoperative radiotherapy for advanced medullary thyroid cancer--local disease control in the modern era
    David L Schwartz
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Head Neck 30:883-8. 2008
    ..The purpose of this study is to catalog modern-era postoperative radiotherapy (external beam radiotherapy [EBRT]) outcomes for advanced medullary thyroid cancer...
  52. doi request reprint Development of an integrated biospecimen bank and multidisciplinary clinical database for pancreatic cancer
    Rosa F Hwang
    Department of Surgical Oncology, Unit 444, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Ann Surg Oncol 15:1356-66. 2008
    ..We describe the development of an integrated pancreatic tissue bank (PTB) and clinical database for patients with pancreatic cancer and other pancreatic disorders...
  53. pmc Single-nucleotide polymorphisms of DNA damage response genes are associated with overall survival in patients with pancreatic cancer
    Taro Okazaki
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 14:2042-8. 2008
    ....
  54. doi request reprint Posterior retroperitoneoscopic adrenalectomy is a safe and effective alternative to transabdominal laparoscopic adrenalectomy for pheochromocytoma
    Paxton V Dickson
    Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Surgery 150:452-8. 2011
    ..Posterior retroperitoneoscopic adrenalectomy (PRA) is an alternative minimally invasive technique; however, there is a lack of data regarding the appropriateness of this approach in patients with PHEO...
  55. ncbi request reprint Inhibition of platelet-derived growth factor receptor phosphorylation by STI571 (Gleevec) reduces growth and metastasis of human pancreatic carcinoma in an orthotopic nude mouse model
    Rosa F Hwang
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:6534-44. 2003
    ....
  56. ncbi request reprint Role of preoperative ultrasonography in the surgical management of patients with thyroid cancer
    Maria A Kouvaraki
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Surgery 134:946-54; discussion 954-5. 2003
    ..We retrospectively compared preoperative transcutaneous ultrasonography and physical examination (PE) results in the detection of local-regional metastases (lymph node and soft tissue) in patients with thyroid cancer...
  57. doi request reprint High levels of nucleolar expression of nucleolin are associated with better prognosis in patients with stage II pancreatic ductal adenocarcinoma
    Lan Peng
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 16:3734-42. 2010
    ..However, the expression and significance of nucleolin in pancreatic ductal adenocarcinoma (PDA) have not been studied...
  58. doi request reprint Overexpression of receptor tyrosine kinase Axl promotes tumor cell invasion and survival in pancreatic ductal adenocarcinoma
    Xianzhou Song
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 117:734-43. 2011
    ..Although previous studies have identified the role of Axl in the transformation, proliferation, survival, and invasion in cancers, the expression and functions of Axl in pancreatic cancer have not been studied in detail...
  59. doi request reprint One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States
    James C Yao
    Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Clin Oncol 26:3063-72. 2008
    ..Clinicians need to be become familiar with the natural history and patterns of disease progression, which are characteristic of these tumors...
  60. doi request reprint Efficacy of 4D-CT preoperative localization in 2 patients with MEN 2A
    Maria Philip
    Department of Endocrine Surgery and Surgical Ontology, M D Anderson Cancer Center, University of Texas Medical School, Houston, TX 77230, USA
    J Surg Educ 65:182-5. 2008
    ..We recommend the use of 4D-CT scanning because of its capacity to identify hyperfunctional parathyroid glands and to provide anatomic information important in preoperative planning...
  61. doi request reprint Do the recent American Thyroid Association (ATA) Guidelines accurately guide the timing of prophylactic thyroidectomy in MEN2A?
    Elizabeth G Grubbs
    Department of Surgical Oncology, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Surgery 148:1302-9; discussion 1309-10. 2010
    ..The aim of this study was to assess whether the clinical guidelines outlined in the ATA recommendations added to the specific mutation risk level could predict the presence of MTC on final pathology...
  62. ncbi request reprint Improved preoperative planning for directed parathyroidectomy with 4-dimensional computed tomography
    Steven E Rodgers
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Surgery 140:932-40; discussion 940-1. 2006
    ..The purpose of this study was to compare 4D-CT with sestamibi imaging and ultrasonography as methods for the accurate preoperative localization of hyperfunctioning parathyroid glands before parathyroidectomy...
  63. ncbi request reprint Surgical treatment of non-functioning pancreatic islet cell tumors
    Maria A Kouvaraki
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    J Surg Oncol 89:170-85. 2005
    ..Treatment of metastatic disease includes biologic agents, cytotoxic chemotherapy, and liver-directed therapies...
  64. ncbi request reprint Elevated expression of vascular endothelial growth factor correlates with increased angiogenesis and decreased progression-free survival among patients with low-grade neuroendocrine tumors
    Jun Zhang
    Department of Gastrointestinal Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 109:1478-86. 2007
    ..Vascular endothelial growth factor (VEGF) is a critical proangiogenic factor in solid tumors. However, its expression and role in human neuroendocrine tumor development and progression remains unclear...
  65. ncbi request reprint The argument for pre-operative chemoradiation for localized, radiographically resectable pancreatic cancer
    Christopher H Crane
    Department of Radiation Oncology, Unit 97, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Best Pract Res Clin Gastroenterol 20:365-82. 2006
    ..Herein, we discuss the rationale for the use of pre-operative chemoradiation in pancreatic cancer, the results of treatment, and future strategies to address the pattern of disease recurrence...
  66. ncbi request reprint Mechanisms of proinflammatory cytokine-induced biphasic NF-kappaB activation
    Christian Schmidt
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cell 12:1287-300. 2003
    ..These findings provide further insight into the regulation of cytokine-induced specific and temporal gene expression...
  67. ncbi request reprint RET proto-oncogene: a review and update of genotype-phenotype correlations in hereditary medullary thyroid cancer and associated endocrine tumors
    Maria A Kouvaraki
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77230 1402, USA
    Thyroid 15:531-44. 2005
    ..Recommendations on the timing of prophylactic thyroidectomy and the extent of surgery are based upon a model that utilizes genotype- phenotype correlations to stratify mutations into three risk levels...
  68. ncbi request reprint Localized adenocarcinoma of the pancreas: the rationale for preoperative chemoradiation
    Jeffrey D Wayne
    The Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Oncologist 7:34-45. 2002
    ..This paper examines the factors pertinent to clinical trial design for resectable pancreatic cancer, and carefully reviews the existing data supporting adjuvant and neoadjuvant therapy for potentially resectable disease...
  69. pmc The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk
    Li Jiao
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Unit 426, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Lett 245:61-8. 2007
    ..24-0.88) (P for interaction=0.03). The (312)Asp-(751)Gln was identified as the putative at risk haplotype. Our study shows that the XPD gene polymorphism could be a genetic risk modifier for smoking-related pancreatic cancer...
  70. doi request reprint Tumor-node-metastasis staging of pancreatic adenocarcinoma
    Matthew H G Katz
    Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    CA Cancer J Clin 58:111-25. 2008
    ....
  71. ncbi request reprint Overexpression of synuclein-gamma in pancreatic adenocarcinoma
    Zhongkui Li
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, PO Box 424, Houston, TX 77030, USA
    Cancer 101:58-65. 2004
    ..To identify the gene expression profile of pancreatic carcinoma, an important step in the process of developing new diagnostic and therapeutic strategies, the authors investigated the alteration of gene expression in this disease...
  72. ncbi request reprint Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells
    Bailu Peng
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 8:3628-38. 2002
    ..We seek to determine the role of Smad4/DPC4 in the suppression of tumor cell growth and in the regulation of TGF-beta-mediated expression of cell-cycle regulatory genes p15(ink4b) and p21(waf1)...
  73. ncbi request reprint Fluorouracil, doxorubicin, and streptozocin in the treatment of patients with locally advanced and metastatic pancreatic endocrine carcinomas
    Maria A Kouvaraki
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Clin Oncol 22:4762-71. 2004
    ....
  74. ncbi request reprint Preventable reoperations for persistent and recurrent papillary thyroid carcinoma
    Maria A Kouvaraki
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77230, USA
    Surgery 136:1183-91. 2004
    ..This retrospective study was designed to determine the frequency of inadequate surgical or medical therapy as a cause of persistent or recurrent PTC...
  75. ncbi request reprint The function of multiple IkappaB : NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosis
    Qiang G Dong
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, TX 77030, USA
    Oncogene 21:6510-9. 2002
    ....
  76. ncbi request reprint Improvement of sleep disturbance and neurocognitive function after parathyroidectomy in patients with primary hyperparathyroidism
    Elizabeth A Mittendorf
    Department of Surgical Oncology, University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Endocr Pract 13:338-44. 2007
    ..To investigate the frequency of the nontraditional symptoms of sleep disturbance and impaired cognitive functioning in patients with primary hyper-parathyroidism (PHPT) and to assess changes in such patients after parathyroidectomy...
  77. ncbi request reprint Medullary thyroid carcinoma: results of a standardized surgical approach in a contemporary series of 80 consecutive patients
    Tina W F Yen
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Surgery 134:890-9; discussion 899-901. 2003
    ..The surgical management and follow-up strategy in patients with medullary thyroid carcinoma (MTC) remain controversial because of the lack of data on the natural history of these tumors and their patterns of progression...
  78. ncbi request reprint Parathyroid carcinoma: a 22-year experience
    Naifa L Busaidy
    joint Baylor College of Medicine The University of Texas M D Anderson Cancer Center Training Program in Endocrinology, Diabetes, and Metabolism, Houston, Texas, USA
    Head Neck 26:716-26. 2004
    ..Treatment strategies generally derive from clinical and anecdotal experiences. We report our experience with this entity...
  79. doi request reprint Clinical significance of distinguishing between follicular lesion and follicular neoplasm in thyroid fine-needle aspiration biopsy
    Michelle D Williams
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 16:3146-53. 2009
    ..The purpose of this study was to evaluate a single institution's experience with indeterminate thyroid FNA results to determine if subclassification (neoplasm versus lesion) aids in identifying patients at higher risk for malignancy...
  80. ncbi request reprint Restoring apoptosis in pancreatic cancer cells by targeting the nuclear factor-kappaB signaling pathway with the anti-epidermal growth factor antibody IMC-C225
    Guido M Sclabas
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Gastrointest Surg 7:37-43; discussion 43. 2003
    ..Therefore, targeting the NF-kappaB signaling pathway with an anti-EGFR antibody may be one strategy to restore apoptosis in human pancreatic cancer cells, thereby enhancing the effect of chemotherapy and radiation therapy...
  81. ncbi request reprint Expression and regulation of the novel vascular endothelial growth factor receptor neuropilin-1 by epidermal growth factor in human pancreatic carcinoma
    Alexander A Parikh
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 98:720-9. 2003
    ....
  82. pmc Significant associations of mismatch repair gene polymorphisms with clinical outcome of pancreatic cancer
    Xiaoqun Dong
    Department of Gastrointestinal Medical Oncology, Surgical Oncology, Pathology, and Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Clin Oncol 27:1592-9. 2009
    ..DNA mismatch repair (MMR) is critical in maintaining genomic stability and may modulate the cellular response to gemcitabine. We hypothesized that genetic variations in MMR may affect the clinical outcome of patients with pancreatic cancer...
  83. ncbi request reprint Is the therapeutic index better with gemcitabine-based chemoradiation than with 5-fluorouracil-based chemoradiation in locally advanced pancreatic cancer?
    Christopher H Crane
    Pancreatic Tumor Study Group, Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 52:1293-302. 2002
    ..To retrospectively compare the toxicity and efficacy of concurrent gemcitabine-based chemoradiation with that of concurrent 5-fluorouracil (5-FU)-based chemoradiation in patients with unresectable pancreatic cancer...
  84. pmc Dietary mutagen exposure and risk of pancreatic cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:655-61. 2007
    ..09 and 0.099, respectively. These data support the hypothesis that dietary mutagen exposure alone and in interaction with other factors contribute to the development of pancreatic cancer...
  85. pmc Postoperative external beam radiotherapy for differentiated thyroid cancer: outcomes and morbidity with conformal treatment
    David L Schwartz
    Department of Radiation Oncology, UT MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 74:1083-91. 2009
    ..To review institutional outcomes for patients treated for differentiated thyroid cancer with postoperative conformal external beam radiotherapy (EBRT)...
  86. ncbi request reprint Preoperative paclitaxel and concurrent rapid-fractionation radiation for resectable pancreatic adenocarcinoma: toxicities, histologic response rates, and event-free outcome
    Peter W T Pisters
    Pancreatic Tumor Study Group, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Clin Oncol 20:2537-44. 2002
    ....
  87. pmc Glutathione S-transferase gene polymorphisms and risk and survival of pancreatic cancer
    Li Jiao
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 109:840-8. 2007
    ..The authors hypothesized that genetic variants of glutathione S-transferase (GST) affect detoxification of carcinogens and anticancer agents in the human pancreas and, thus, the risk and survival of pancreatic cancer...
  88. ncbi request reprint Genotype-phenotype analysis in multiple endocrine neoplasia type 1
    Maria A Kouvaraki
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Arch Surg 137:641-7. 2002
    ..The syndrome demonstrates variable expressivity and considerable genetic heterogeneity. Patient data were examined for possible associations between genotype and phenotype...
  89. doi request reprint Adjuvant therapy for adenocarcinoma of the pancreas: analysis of reported trials and recommendations for future progress
    Robert A Wolff
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 426, Houston, TX, 77030, USA
    Ann Surg Oncol 15:2773-86. 2008
    ..A critical analysis of completed adjuvant trials will be provided and a framework for the conduct of future trials of adjuvant therapy proposed...
  90. ncbi request reprint Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 9:991-7. 2003
    ..The purpose of this study was to investigate the expression and copy number alteration of STK15 in pancreatic cancer...
  91. ncbi request reprint Prognostic factors in patients with unresectable locally advanced pancreatic adenocarcinoma treated with chemoradiation
    Sunil Krishnan
    Department of Radiation Oncology, The University of Texas, M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 107:2589-96. 2006
    ..Prognostic factors are inadequately defined for disease-free survival and overall survival in patients with LAPC who are receiving chemoradiation, so more definitive prognostic factors would be very useful for designing clinical trials...
  92. pmc Population-based study of islet cell carcinoma
    James C Yao
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Ann Surg Oncol 14:3492-500. 2007
    ..We examine the epidemiology, natural history, and prognostic factors that affect the duration of survival for islet cell carcinoma by using population-based registries...
  93. ncbi request reprint Failure to recognize multiple endocrine neoplasia 2B: more common than we think?
    Curtis J Wray
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Ann Surg Oncol 15:293-301. 2008
    ..However, the diagnosis of MEN2B is often delayed beyond childhood, at which time medullary thyroid carcinoma (MTC) may be regionally advanced or metastatic. We examined the extent of this delay and its impact on the treatment of MTC...
  94. pmc Patterns of self-reported symptoms in pancreatic cancer patients receiving chemoradiation
    Cielito C Reyes-Gibby
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    J Pain Symptom Manage 34:244-52. 2007
    ..This study demonstrates the feasibility and usefulness of symptom assessment in chemoradiation protocols. Future studies with larger cohorts are needed to further characterize multiple symptoms associated with chemoradiation...
  95. ncbi request reprint The role of intraoperative radiotherapy in pancreatic cancer
    Christopher H Crane
    Gastrointestinal Section, Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 97, Houston, TX 77030, USA
    Surg Oncol Clin N Am 12:965-77. 2003
    ....
  96. ncbi request reprint Radiation dose considerations in the palliative treatment of locally advanced adenocarcinoma of the pancreas
    Adrian A Wong
    The University of Texas Medical School at San Antonio, San Antonio, Texas, USA
    Am J Clin Oncol 28:227-33. 2005
    ....
  97. ncbi request reprint Administration of optimal biological dose and schedule of interferon alpha combined with gemcitabine induces apoptosis in tumor-associated endothelial cells and reduces growth of human pancreatic carcinoma implanted orthotopically in nude mice
    Carmen C Solorzano
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Clin Cancer Res 9:1858-67. 2003
    ..We determined whether chronic administration of IFN-alpha at optimal biological dose inhibits angiogenesis of human pancreatic carcinoma growing in the pancreas of nude mice...
  98. ncbi request reprint 5,10-Methylenetetrahydrofolate reductase polymorphisms and the risk of pancreatic cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Cancer Epidemiol Biomarkers Prev 14:1470-6. 2005
    ..23 (0.88-20.3) for heavy drinkers with the TT genotype compared with nondrinkers with the CC/CT genotypes. These observations support a role for folate metabolism in pancreatic cancer, especially among smokers and heavy drinkers...
  99. pmc ESPAC-1 trial of adjuvant therapy for resectable adenocarcinoma of the pancreas
    Douglas B Evans
    Ann Surg 236:694; author reply 694-6. 2002
  100. ncbi request reprint Combined-modality treatment for operable pancreatic adenocarcinoma
    Peter W T Pisters
    The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Oncology (Williston Park) 19:393-404, 409; discussion 409-10, 412-6. 2005
    ..Many newer chemotherapeutic agents with efficacy in gastrointestinal cancers have yet to be investigated in the adjuvant and neoadjuvant settings...
  101. ncbi request reprint Cisplatin, fluorouracil, interferon-alpha, and radiation as adjuvant therapy for resected pancreatic cancer: is there a future for this regimen and/or should we change our approach to research and treatment of patients with pancreatic cancer?
    Peter W T Pisters
    Ann Surg 248:152-3. 2008