Carol Etzel

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc Comparison of therapeutic dosimetric data from passively scattered proton and photon craniospinal irradiations for medulloblastoma
    Rebecca M Howell
    Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Radiat Oncol 7:116. 2012
  2. pmc Meta-analysis of the impact of human papillomavirus (HPV) on cancer risk and overall survival in head and neck squamous cell carcinomas (HNSCC)
    Farshid Dayyani
    Department of Thoracic Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Head Neck Oncol 2:15. 2010
  3. pmc Comparison of genome-wide single-nucleotide polymorphism linkage analyses in Caucasian and Hispanic NARAC families
    Wei V Chen
    Department of Epidemiology, Anderson Cancer Center, Houston, Texas 77030, USA
    BMC Proc 1:S97. 2007
  4. pmc Use of tree-based models to identify subgroups and increase power to detect linkage to cardiovascular disease traits
    Tracy Jennifer Costello
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
    BMC Genet 4:S66. 2003
  5. pmc Rapid method for determination of DNA repair capacity in human peripheral blood lymphocytes amongst smokers
    Randa A El-Zein
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    BMC Cancer 10:439. 2010
  6. pmc Meta-analysis of genetic-linkage analysis of quantitative-trait loci
    Carol J Etzel
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Am J Hum Genet 71:56-65. 2002
  7. ncbi request reprint Genome-wide meta-analysis for rheumatoid arthritis
    Carol J Etzel
    Department of Epidemiology, UT MD Anderson Cancer Center, 1155 Pressler Street Unit 1340, Houston, TX 77030, USA
    Hum Genet 119:634-41. 2006
  8. pmc Development and validation of a lung cancer risk prediction model for African-Americans
    Carol J Etzel
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 1:255-65. 2008
  9. pmc An updated meta-analysis approach for genetic linkage
    Carol J Etzel
    The Department of Epidemiology, UT MD Anderson Cancer Center, Houston, TX, USA
    BMC Genet 6:S43. 2005
  10. ncbi request reprint Risk for smoking-related cancer among relatives of lung cancer patients
    Carol J Etzel
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 63:8531-5. 2003

Collaborators

Detail Information

Publications37

  1. pmc Comparison of therapeutic dosimetric data from passively scattered proton and photon craniospinal irradiations for medulloblastoma
    Rebecca M Howell
    Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Radiat Oncol 7:116. 2012
    ....
  2. pmc Meta-analysis of the impact of human papillomavirus (HPV) on cancer risk and overall survival in head and neck squamous cell carcinomas (HNSCC)
    Farshid Dayyani
    Department of Thoracic Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Head Neck Oncol 2:15. 2010
    ..HPV is important in a subset of HNSCC. Our meta-analysis determined the clinical characteristics of HPV-related HNSCC...
  3. pmc Comparison of genome-wide single-nucleotide polymorphism linkage analyses in Caucasian and Hispanic NARAC families
    Wei V Chen
    Department of Epidemiology, Anderson Cancer Center, Houston, Texas 77030, USA
    BMC Proc 1:S97. 2007
    ..A larger sample size of the Hispanic group is needed to identify linkage regions...
  4. pmc Use of tree-based models to identify subgroups and increase power to detect linkage to cardiovascular disease traits
    Tracy Jennifer Costello
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
    BMC Genet 4:S66. 2003
    ..The focus of this method is not to claim identification of significant linkage to a particular locus but to show that tree models can be used to identify subgroups for use in selected sib-pair sampling schemes...
  5. pmc Rapid method for determination of DNA repair capacity in human peripheral blood lymphocytes amongst smokers
    Randa A El-Zein
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    BMC Cancer 10:439. 2010
    ..It has been previously reported that smokers with low hOGG1 activity had significantly higher risk of developing lung cancer as compared to smokers with high hOGG1 activity...
  6. pmc Meta-analysis of genetic-linkage analysis of quantitative-trait loci
    Carol J Etzel
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Am J Hum Genet 71:56-65. 2002
    ..The approach can be applied under other conditions, provided that the various studies use the same linkage statistic...
  7. ncbi request reprint Genome-wide meta-analysis for rheumatoid arthritis
    Carol J Etzel
    Department of Epidemiology, UT MD Anderson Cancer Center, 1155 Pressler Street Unit 1340, Houston, TX 77030, USA
    Hum Genet 119:634-41. 2006
    ..This procedure provided marginal evidence (P<0.05) of linkage on chromosome 1, 2, 5 and 18, strong evidence (P<0.01) on chromosomes 8 and 16, and overwhelming evidence in the HLA region of chromosome 6...
  8. pmc Development and validation of a lung cancer risk prediction model for African-Americans
    Carol J Etzel
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 1:255-65. 2008
    ..These findings highlight the importance of conducting further ethnic-specific analyses of disease risk...
  9. pmc An updated meta-analysis approach for genetic linkage
    Carol J Etzel
    The Department of Epidemiology, UT MD Anderson Cancer Center, Houston, TX, USA
    BMC Genet 6:S43. 2005
    ..The MAGS procedure provided little to no evidence of linkage to the disease modifier genes on chromosomes 2 and 10...
  10. ncbi request reprint Risk for smoking-related cancer among relatives of lung cancer patients
    Carol J Etzel
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 63:8531-5. 2003
    ..77) of lung cancer among relatives of never-smokers. These findings support the need for additional study in the characterization and identification of genetic factors that influence and modulate cancer susceptibility in humans...
  11. ncbi request reprint Gender differences in sociodemographic and behavioral influences of physical activity in mexican-origin adolescents
    Larkin L Strong
    Dept of Health Disparities Research, University of Texas M D Anderson Cancer Center, Houston, TX
    J Phys Act Health 9:829-39. 2012
    ..Understanding the factors that contribute to physical activity (PA) in Mexican-origin adolescents is essential to the design of effective efforts to enhance PA participation in this population...
  12. pmc Association and interactions between DNA repair gene polymorphisms and adult glioma
    Yanhong Liu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 18:204-14. 2009
    ..95; 95% confidence intervals, 2.21-16.65). Taken together, these results suggest that polymorphisms in DNA repair genes may act individually or together to contribute to glioma risk...
  13. ncbi request reprint Cytokine genes and pain severity in lung cancer: exploring the influence of TNF-alpha-308 G/A IL6-174G/C and IL8-251T/A
    Cielito C Reyes-Gibby
    Department of Epidemiology, Division of Cancer Prevention, The University of Texas M D Anderson Cancer Center, Unit 1340, 1155 Pressler Street, Houston, TX 77030 4009, USA
    Cancer Epidemiol Biomarkers Prev 16:2745-51. 2007
    ..We explored if polymorphisms in candidate cytokine genes could explain variability in self-reported pain in lung cancer patients of all stages...
  14. pmc Hepatocellular carcinoma risk prediction model for the general population: the predictive power of transaminases
    Chi Pang Wen
    Institute of Population Science, National Health Research Institutes, Zhunan, Taiwan
    J Natl Cancer Inst 104:1599-611. 2012
    ..We developed five simple risk prediction models based on clinically available data from the general population...
  15. pmc Gender differences in sociodemographic and behavioral influences of physical activity in Mexican-origin adolescents
    Larkin L Strong
    Department of Health Disparities Research, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Phys Act Health 9:829-39. 2012
    ..Understanding the factors that contribute to physical activity (PA) in Mexican-origin adolescents is essential to the design of effective efforts to enhance PA participation in this population...
  16. ncbi request reprint Dietary zinc, copper and selenium, and risk of lung cancer
    Somdat Mahabir
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 120:1108-15. 2007
    ..Given the known limitations of case-control studies, these findings must be interpreted with caution and warrant further investigation...
  17. pmc Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Am J Hum Genet 78:464-79. 2006
    ....
  18. pmc Risk of radiogenic second cancers following volumetric modulated arc therapy and proton arc therapy for prostate cancer
    Laura A Rechner
    Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Phys Med Biol 57:7117-32. 2012
    ..We conclude that the predicted risk of cancer in the bladder or rectum following proton arc therapy for prostate cancer is either less than or approximately equal to the risk following VMAT, depending on which risk model is applied...
  19. pmc Cytokinesis-blocked micronucleus cytome assay biomarkers identify lung cancer cases amongst smokers
    Randa A El-Zein
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 1439, USA
    Cancer Epidemiol Biomarkers Prev 17:1111-9. 2008
    ..9-100.0), PPV = 98.7 and NPV = 95.6. The simplicity, rapidity, and sensitivity of the assay together with potential for automation make it a valuable tool for screening and prioritizing potential cases for intensive screening...
  20. ncbi request reprint Matched-pair analysis of survival of never smokers and ever smokers with squamous cell carcinoma of the head and neck
    Kristen B Pytynia
    The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
    J Clin Oncol 22:3981-8. 2004
    ..To compare survival rates between patients with squamous cell carcinoma of the head and neck (SCCHN) without a history of smoking (never smokers) and those with a current or previous history of smoking (ever smokers)...
  21. ncbi request reprint Matched analysis of survival in patients with squamous cell carcinoma of the head and neck diagnosed before and after 40 years of age
    Kristen B Pytynia
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Arch Otolaryngol Head Neck Surg 130:869-73. 2004
    ..In 2 previous matched-pair analyses, the patients had been matched for tumor stage, site, sex, and date of presentation but not type of treatment...
  22. ncbi request reprint Bladder cancer risk as modified by family history and smoking
    Jie Lin
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 107:705-11. 2006
    ..The authors investigated the role of family history in association with the risk of BC...
  23. ncbi request reprint Effect of winsorization on power and type 1 error of variance components and related methods of QTL detection
    Sanjay Shete
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Behav Genet 34:153-9. 2004
    ..A robust version of the LRT that adjusts for sample kurtosis showed the best power for nonnormal data. Finally, phenotype winsorization of nonnormal data reduces the bias in estimation of the major gene variance component...
  24. ncbi request reprint Human papillomavirus type 16 infection and squamous cell carcinoma of the head and neck in never-smokers: a matched pair analysis
    Kristina R Dahlstrom
    Departments of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:2620-6. 2003
    ..Serum was collected from study subjects and assayed for IgG reactivity to HPV-16 L1 virus-like particles by using an ELISA...
  25. ncbi request reprint Evaluation of glutathione S-transferase polymorphisms and mutagen sensitivity as risk factors for the development of second primary tumors in patients previously diagnosed with early-stage head and neck cancer
    Charles G Minard
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 106:2636-44. 2006
    ..Data were available for 303 patients who were enrolled in a placebo-controlled chemoprevention trial of low-dose 13-cis-retinoic acid to reduce the occurrence of SPTs...
  26. pmc Dietary magnesium and DNA repair capacity as risk factors for lung cancer
    Somdat Mahabir
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Unit 1340, CPB4 3241, 1155 Pressler Boulevard, Houston, TX 77030, USA
    Carcinogenesis 29:949-56. 2008
    ..These intriguing results need to be confirmed in prospective studies...
  27. ncbi request reprint Human sensitivity to PhIP: a novel marker for prostate cancer risk
    Randa El-Zein
    Department of Epidemiology, Unit 1340, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    Mutat Res 601:1-10. 2006
    ..00-1.45) among those with no family history of PC. Results from this pilot study demonstrate differential sensitivity to PhIP among subgroups and therefore, this assay have potential as a susceptibility marker for prostate cancer risk...
  28. ncbi request reprint Interplay between mutagen sensitivity and epidemiological factors in modulatinglung cancer risk
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 120:2687-95. 2007
    ..This new integrative approach should facilitate identification of high-risk subgroups and has important implications in LC prevention...
  29. ncbi request reprint Genetic variations in radiation and chemotherapy drug action pathways predict clinical outcomes in esophageal cancer
    Xifeng Wu
    Department of Epidemiology, Experimental Therapeutics, GI Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 24:3789-98. 2006
    ..Understanding how specific genetic variants modify drug action pathways may provide informative blueprints for individualized chemotherapy...
  30. ncbi request reprint Projecting individualized probabilities of developing bladder cancer in white individuals
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 25:4974-81. 2007
    ..There has been no risk assessment model for bladder cancer (BC). We developed the first model incorporating mutagen sensitivity and epidemiologic factors to predict BC risk...
  31. pmc Aggregation of cancer in first-degree relatives of patients with glioma
    Michael E Scheurer
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 1439, USA
    Cancer Epidemiol Biomarkers Prev 16:2491-5. 2007
    ..Previous studies have been inconclusive in estimating the risk of different cancer sites among close relatives of glioma patients; however, malignant melanoma has consistently been described...
  32. ncbi request reprint Cytokinesis-blocked micronucleus assay as a novel biomarker for lung cancer risk
    Randa A El-Zein
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 1439, USA
    Cancer Res 66:6449-56. 2006
    ..Our study indicates that the CBMN assay is extremely sensitive to NNK-induced genetic damage and may serve as a strong predictor of lung cancer risk...
  33. ncbi request reprint A risk model for prediction of lung cancer
    Margaret R Spitz
    Department of Epidemiology Unit 1340, The University of Texas M D Anderson Cancer Center, PO Box 301439, Houston, TX 77230 1439, USA
    J Natl Cancer Inst 99:715-26. 2007
    ..Reliable risk prediction tools for estimating individual probability of lung cancer have important public health implications. We constructed and validated a comprehensive clinical tool for lung cancer risk prediction by smoking status...
  34. ncbi request reprint Linkage analyses of rheumatoid arthritis and related quantitative phenotypes: the GAW15 experience
    Saurabh Ghosh
    Human Genetics Unit, Indian Statistical Institute, 203 B T Road, Kolkata 700 108, India
    Genet Epidemiol 31:S86-95. 2007
    ..In this report, we discuss the different strategies explored by the different investigators with the common goal of improving the power to detect linkage...
  35. ncbi request reprint Do current government policies sufficiently regulate the interaction between viewing smoking in movies and adolescent smoking behavior?
    Sumesh Kachroo
    Am J Addict 16:532-3. 2007
  36. ncbi request reprint An epidemiologic study of early onset lung cancer
    Carol J Etzel
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, USA
    Lung Cancer 52:129-34. 2006
    ..001). These findings support the need for further study in the characterization and identification of genetic factors that influence and modulate early onset lung cancer risk and outcome...
  37. doi request reprint Trends in prevalence of prognostic factors and survival in lung cancer patients from 1985 to 2004 at a tertiary care center
    Sumesh Kachroo
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Detect Prev 32:101-8. 2008
    ..The goal of this study was to assess changes over 20 years in the prevalence of known risk factors for lung cancer and to elucidate possible predictors associated with lung cancer survival...

Research Grants8

  1. Multiple Imputation Methods for Missing Genetic Data
    Carol Etzel; Fiscal Year: 2005
    ..After an optimal method to impute missing marker values has been identified, I will implement imputation in the lung study data in order to facilitate the development of a risk assessment model for lung cancer. ..
  2. Chromosomal Aberrations and Risk for Familial Lung Cancer
    Carol Etzel; Fiscal Year: 2007
    ..These proposed susceptibility markers may be useful as biomarkers to identify high-risk populations that could then be targeted for intensive smoking-cessation programs and could be enrolled into chemoprevention screening trials. ..
  3. Risk models:environment versus metabolic polymorphisms
    Carol Etzel; Fiscal Year: 2007
    ..abstract_text> ..
  4. Validation and extension of an existing risk model for lung cancer
    Carol Etzel; Fiscal Year: 2009
    ..Evaluation of these chromosomal endpoints in an independent sample will provide proof-of-principle for subsequent inclusion of additional functional phenotypes and genotypes into the model. ..
  5. Chromosomal Aberrations and Risk for Familial Lung Cancer
    Carol Etzel; Fiscal Year: 2009
    ..These proposed susceptibility markers may be useful as biomarkers to identify high-risk populations that could then be targeted for intensive smoking-cessation programs and could be enrolled into chemoprevention screening trials. ..
  6. Validation and extension of an existing risk model for lung cancer
    Carol J Etzel; Fiscal Year: 2010
    ..Evaluation of these chromosomal endpoints in an independent sample will provide proof-of-principle for subsequent inclusion of additional functional phenotypes and genotypes into the model. ..