Marcos R H Estecio

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancer
    Marcos R H Estecio
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Genome Res 20:1369-82. 2010
  2. pmc SINE retrotransposons cause epigenetic reprogramming of adjacent gene promoters
    Marcos R H Estecio
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cancer Res 10:1332-42. 2012
  3. pmc Dissecting DNA hypermethylation in cancer
    Marcos R H Estecio
    Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX 77030, United States
    FEBS Lett 585:2078-86. 2011
  4. pmc High-throughput methylation profiling by MCA coupled to CpG island microarray
    Marcos R H Estecio
    Department of Leukemia, UT M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genome Res 17:1529-36. 2007
  5. pmc A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements
    Allen S Yang
    Department of Leukemia, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Nucleic Acids Res 32:e38. 2004
  6. pmc Aberrant DNA methylation is associated with disease progression, resistance to imatinib and shortened survival in chronic myelogenous leukemia
    Jaroslav Jelinek
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 6:e22110. 2011
  7. pmc LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability
    Marcos R H Estecio
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 2:e399. 2007
  8. ncbi request reprint CpG island methylation profiling in human melanoma cell lines
    Carmen S Tellez
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Melanoma Res 19:146-55. 2009
  9. pmc Sensitive and specific detection of early gastric cancer with DNA methylation analysis of gastric washes
    Yoshiyuki Watanabe
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Gastroenterology 136:2149-58. 2009
  10. pmc Frequent alteration of MLL3 frameshift mutations in microsatellite deficient colorectal cancer
    Yoshiyuki Watanabe
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 6:e23320. 2011

Detail Information

Publications22

  1. pmc Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancer
    Marcos R H Estecio
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Genome Res 20:1369-82. 2010
    ....
  2. pmc SINE retrotransposons cause epigenetic reprogramming of adjacent gene promoters
    Marcos R H Estecio
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cancer Res 10:1332-42. 2012
    ..In summary, our work supports the concept that SINE repeats interfere negatively with gene expression and that their presence near gene promoters is counter-selected, except when the promoter is protected by an insulator element...
  3. pmc Dissecting DNA hypermethylation in cancer
    Marcos R H Estecio
    Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX 77030, United States
    FEBS Lett 585:2078-86. 2011
    ..In this review article, we discuss the technologies available to study DNA methylation and the endogenous and exogenous factors that influence the onset of de novo methylation in cancer...
  4. pmc High-throughput methylation profiling by MCA coupled to CpG island microarray
    Marcos R H Estecio
    Department of Leukemia, UT M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genome Res 17:1529-36. 2007
    ..In summary, MCAM is a suitable technique to discover methylated genes and to profile methylation changes in clinical samples in a high-throughput fashion...
  5. pmc A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements
    Allen S Yang
    Department of Leukemia, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Nucleic Acids Res 32:e38. 2004
    ..This method can be used as a surrogate marker of genome-wide methylation changes. In addition, it is less labor intensive and requires less DNA than previous methods of assessing global DNA methylation...
  6. pmc Aberrant DNA methylation is associated with disease progression, resistance to imatinib and shortened survival in chronic myelogenous leukemia
    Jaroslav Jelinek
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 6:e22110. 2011
    ..Finally, DNA methylation of PDLIM4 may help identify a subset of CML patients that would benefit from treatment with Src/Abl inhibitors...
  7. pmc LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability
    Marcos R H Estecio
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 2:e399. 2007
    ..This study was performed to determine the relationship between DNA hypomethylation, hypermethylation and microsatellite instability in cancer...
  8. ncbi request reprint CpG island methylation profiling in human melanoma cell lines
    Carmen S Tellez
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Melanoma Res 19:146-55. 2009
    ..We conclude that aberrant hypermethylation, is frequent in melanoma cell lines, directly correlated with global DNA methylation, and independent of BRAF and NRAS mutations...
  9. pmc Sensitive and specific detection of early gastric cancer with DNA methylation analysis of gastric washes
    Yoshiyuki Watanabe
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Gastroenterology 136:2149-58. 2009
    ..We hypothesized that methylation analysis of DNA recovered from gastric washes could be used to detect gastric cancer...
  10. pmc Frequent alteration of MLL3 frameshift mutations in microsatellite deficient colorectal cancer
    Yoshiyuki Watanabe
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 6:e23320. 2011
    ..Mutations in MLL3 were found in a whole genome analysis of colorectal cancer but have not been confirmed by a separate study...
  11. pmc An Sp1/Sp3 binding polymorphism confers methylation protection
    Yanis A Boumber
    Department of Leukemia, MD Anderson Cancer Center, University of Texas, Houston, Texas, United States of America
    PLoS Genet 4:e1000162. 2008
    ..Our finding demonstrates that, in some genes, hypermethylation in cancer is dictated by protein-DNA interactions at the promoters and provides a novel mechanism by which genetic polymorphisms can influence an epigenetic state...
  12. pmc Repetitive elements and enforced transcriptional repression co-operate to enhance DNA methylation spreading into a promoter CpG-island
    Yan Zhang
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Nucleic Acids Res 40:7257-68. 2012
    ....
  13. pmc DNA methylation does not stably lock gene expression but instead serves as a molecular mark for gene silencing memory
    Noel J M Raynal
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Cancer Res 72:1170-81. 2012
    ..These findings define chromatin as an important druggable target for cancer epigenetic therapy and suggest that removal of DNA methylation signals is required to achieve long-term gene reactivation...
  14. pmc Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse
    Heike Kroeger
    Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Blood 112:1366-73. 2008
    ..0% to 15.2% (median 10.6%) genes in relapse (P < .001). Our data suggest that DNA methylation is involved in AML progression and provide a rationale for the use of epigenetic agents in remission maintenance...
  15. ncbi request reprint Hypomethylation of LINE-1 and Alu in well-differentiated neuroendocrine tumors (pancreatic endocrine tumors and carcinoid tumors)
    In Seon Choi
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4095, USA
    Mod Pathol 20:802-10. 2007
    ....
  16. ncbi request reprint Methylation and regulation of expression of different retinoic acid receptor beta isoforms in human colon cancer
    Emile M Youssef
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Biol Ther 3:82-6. 2004
    ....
  17. ncbi request reprint Fusobacterium in colonic flora and molecular features of colorectal carcinoma
    Tomomitsu Tahara
    Authors Affiliations Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake First Departments of Internal Medicine and Molecular Biology, Sapporo Medical University, Sapporo Department of Gastroenterology, Akita Red Cross Hospital, Akita Department of Pathology, Iwate Medical University, Morioka Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan Division of OVP, Department of Clinical Cancer Prevention, Cancer Prevention and Population Sciences Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston and Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, Texas
    Cancer Res 74:1311-8. 2014
    ..Taken together, our findings show that Fusobacterium enrichment is associated with specific molecular subsets of colorectal cancers, offering support for a pathogenic role in colorectal cancer for this gut microbiome component...
  18. ncbi request reprint TET1 is a maintenance DNA demethylase that prevents methylation spreading in differentiated cells
    Chunlei Jin
    The Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA 19140, USA
    Nucleic Acids Res 42:6956-71. 2014
    ..Thus, our results identify TET1 as a maintenance DNA demethylase that does not purposely decrease methylation levels, but specifically prevents aberrant methylation spreading into CGIs in differentiated cells. ..
  19. ncbi request reprint DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia
    Allen S Yang
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 66:5495-503. 2006
    ..In conclusion, we show dose-dependent hypomethylation after decitabine at low doses. Increasing the dose, which has been shown previously to result in a reduced response rate, was not accompanied by further hypomethylation...
  20. doi request reprint Methylated CpG Island Amplification and Microarray (MCAM) for High-Throughput Analysis of DNA Methylation
    Marcos R H Estecio
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    CSH Protoc 2008:pdb.prot4974. 2008
    ..Subsequently, a comparative hybridization of reference and test samples (typically normal and tumor DNA specimens) is done on a microarray platform...
  21. ncbi request reprint Comment on "Chromosomal instability and tumors promoted by DNA hypomethylation" and "Induction of tumors in nice by genomic hypomethylation"
    Allen S Yang
    Department of Leukemia, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Science 302:1153; author reply 1153. 2003