Research Topics
Species | Linda M ErnstSummaryAffiliation: The Children's Hospital of Philadelphia Country: USA Publications
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Detail Information
Publications
Interlobular bile duct loss in pediatric cholestatic disease is associated with aberrant cytokeratin 7 expression by hepatocytesLinda M Ernst
Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Pediatr Dev Pathol 10:383-90. 2007..Aberrant CK7 expression may reflect a metaplastic change to a "stem cell" phenotype induced by loss of contact with the more distal biliary tree...- Bacterial etiology for chronic villitis is not supported by polymerase chain reaction for 16S rRNA DNALinda M Ernst
Department of Pathology, Room 5203, Children s Hospital of Philadelphia, 324 South 34th Street, Philadelphia, PA 19104, USA
Pediatr Dev Pathol 8:647-53. 2005..The assay was sensitive down to approximately 1500 bacteria per specimen. In conclusion, these data do not support a bacterial etiology for chronic villitis... - The value of the metabolic autopsy in the pediatric hospital settingLinda M Ernst
Department of Pathology, Metabolic Disease Laboratory, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
J Pediatr 148:779-83. 2006..To determine the utility of the metabolic autopsy in the hospitalized pediatric patient... - Novel oral findings in Schimmelpenning syndromeLinda M Ernst
Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Am J Med Genet A 143:881-3. 2007..Also found were multiple complex odontomas, bilateral maxillary fibro-osseous lesions and recurrent central giant cell granulomas of the jaws... - Familial perinatal liver disease and fetal thrombotic vasculopathyLinda M Ernst
Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Pediatr Dev Pathol 11:160-3. 2008..Fetal thrombotic vasculopathy is an underrecognized association with perinatal liver disease that may be associated with abnormal liver perfusion and that may recur in families, especially when a genetic thrombophilia is present... 
Intradural inclusion cysts following in utero closure of myelomeningocele: clinical implications and follow-up findingsEnrico Danzer
The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Neurosurg Pediatr 2:406-13. 2008..The goal in this study was to evaluate the incidence and clinical implications of the development of cutaneously derived intradural inclusion cysts (ICs) following fetal myelomeningocele (fMMC) closure...- Hamartomatous tongue lesions in childrenPortia A Kreiger
Department of Pathology, The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Am J Surg Pathol 31:1186-90. 2007..Eight cases were congenital in origin. Females outnumbered males by 2:1. The majority of lesions (16/18) were dorsal in location, and 4 patients had a syndromic association, all oral-facial-digital syndrome... - A potential screening tool for IPEX syndromeMeredith Lee Heltzer
Division of Allergy and Immunology, Department of Pediatrics, University of Pennsylvania School of Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
Pediatr Dev Pathol 10:98-105. 2007..This screening test provides a valuable tool for diagnosing IPEX syndrome in extremely ill patients who may not tolerate a delay in therapeutic intervention... - Intrauterine fetal death of a monochorionic twin with peripheral pulmonary infarcts: potential thromboembolic events following death of co-twinAmy A Lo
Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
Pediatr Dev Pathol 15:142-5. 2012..This case highlights the potential for thromboembolic events (TBEs) associated with monochorionic gestations to include pulmonary TBE and infarction among the risks for fetal morbidity and mortality... - Mutations in long-chain 3-hydroxyacyl coenzyme a dehydrogenase are associated with placental maternal floor infarction/massive perivillous fibrin depositionAdrienne Carruth Griffin
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Pediatr Dev Pathol 15:368-74. 2012..Given a background incidence of heterozygosity for LCHAD mutations of approximately 1 in 220, these findings lend support to the hypothesis that LCHAD mutations may be directly associated with and potentially causative of MFI/MPVFD... - Pathologic examination of fetal and placental tissue obtained by dilation and evacuationLinda M Ernst
Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Arch Pathol Lab Med 137:326-37. 2013..Many D&E specimens are examined in surgical pathology, and there is little information available in surgical pathology textbooks or the literature to assist pathologists in these examinations... 
Mechanisms of mosaicism, chimerism and uniparental disomy identified by single nucleotide polymorphism array analysisLaura K Conlin
Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Hum Mol Genet 19:1263-75. 2010....- Fetal thrombotic vasculopathy in twin placentas with complete hydatidiform moleLinda M Ernst
The Children s Hospital of Philadelphia, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, PA, USA
Pediatr Dev Pathol 12:63-7. 2009..Fetal placental thrombotic lesions seen in the coexistent twin circulation, associated with a complete hydatidiform mole, may play a heretofore unrecognized role in the morbidity and mortality of the fetus... - ALK expression in rhabdomyosarcomas: correlation with histologic subtype and fusion statusDiana A Corao
Department of Pathology, A I duPont Hospital for Children, Wilmington, DE, USA
Pediatr Dev Pathol 12:275-83. 2009..We conclude that there is ALK overexpression in RMS, more commonly in ARMS than in ERMS, most likely independent of fusion status. Amplification or upregulation of ALK may underlie ALK protein overexpression... - In utero meconium passage in fetuses and newborns with myelomeningoceleEnrico Danzer
The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
J Neurosurg Pediatr 3:141-6. 2009..The authors retrospectively investigated whether midgestational fetal myelomeningocele (fMMC) repair alters intrauterine meconium exposure... - Inflammation-induced preterm birth in a murine model is associated with increases in fetal macrophages and circulating erythroid precursorsLinda M Ernst
Department of Pathology and Laboratory Medicine, The Children s Hospital of Pennsylvania, and University of Pennsylvania, Philadelphia, PA, USA
Pediatr Dev Pathol 13:273-81. 2010.... - What new information pediatric autopsies can provide: a retrospective evaluation of 100 consecutive autopsies using family-centered criteriaJames A Feinstein
Department of General Pediatrics, 3535 Market, Room 1523, The Children s Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
Arch Pediatr Adolesc Med 161:1190-6. 2007..To determine the proportions of pediatric autopsies yielding various types of new information (eg, genetic diagnosis, additional explanation) that might be valued by families... - Can placental pathology explain second-trimester pregnancy loss and subsequent pregnancy outcomes?Sindhu K Srinivas
Department of Obstetrics and Gynecology, University of Pennsylvania Health System, Philadelphia, PA, USA
Am J Obstet Gynecol 199:402.e1-5. 2008..This study sought to determine whether specific placental pathology may provide further insight into the mechanisms of second-trimester pregnancy loss, particularly in cases without inflammation... - Five cases of caudal regression with an aberrant abdominal umbilical artery: Further support for a caudal regression-sirenomelia spectrumSara M Duesterhoeft
Department of Laboratories, Children s Hospital and Regional Medical Center, Seattle, Washington, USA
Am J Med Genet A 143:3175-84. 2007.... - Placental pathology in fetal bartter syndromeLinda M Ernst
Department of Anatomic Pathology, Yale University School of Medicine, PO Box 208070, New Haven, CT 06520, USA
Pediatr Dev Pathol 5:76-9. 2002....