Affiliation: The Ohio State University
Enyeart J, Enyeart J. Ca2+ and K+ channels of normal human adrenal zona fasciculata cells: properties and modulation by ACTH and AngII. J Gen Physiol. 2013;142:137-55 pubmed publisher
..These findings also suggest a model for cortisol secretion in human AZF cells wherein ACTH and AngII receptor activation is coupled to membrane depolarization and the activation of Cav3.2 channels through inhibition of hTREK-1. ..
Enyeart J, Enyeart J. Adrenal fasciculata cells express T-type and rapidly and slowly activating L-type Ca2+ channels that regulate cortisol secretion. Am J Physiol Cell Physiol. 2015;308:C899-918 pubmed publisher
..Regardless, the well-correlated selective inhibition of T- and L-type currents and ACTH- and ANG II-stimulated cortisol secretion by TTA-P2 and nifedipine establish the critical importance of these channels in AZF cell physiology. ..
Enyeart J, Gomora J, Xu L, Enyeart J. Adenosine triphosphate activates a noninactivating K+ current in adrenal cortical cells through nonhydrolytic binding. J Gen Physiol. 1997;110:679-92 pubmed
Enyeart J, Xu L, Danthi S, Enyeart J. An ACTH- and ATP-regulated background K+ channel in adrenocortical cells is TREK-1. J Biol Chem. 2002;277:49186-99 pubmed
..The activation of I(AC) by ATP indicates that native bTREK-1 channels may function as sensors that couple the metabolic state of the cell to membrane potential, perhaps through an associated ATP-binding protein. ..
Enyeart J, Danthi S, Enyeart J. Corticotropin induces the expression of TREK-1 mRNA and K+ current in adrenocortical cells. Mol Pharmacol. 2003;64:132-42 pubmed
Enyeart J, Danthi S, Enyeart J. TREK-1 K+ channels couple angiotensin II receptors to membrane depolarization and aldosterone secretion in bovine adrenal glomerulosa cells. Am J Physiol Endocrinol Metab. 2004;287:E1154-65 pubmed
..Overall, these results identify bTREK-1 K(+) channels as a pivotal control point where ANG II receptor activation is transduced to depolarization-dependent Ca(2+) entry and aldosterone secretion. ..
Enyeart J, Danthi S, Liu H, Enyeart J. Angiotensin II inhibits bTREK-1 K+ channels in adrenocortical cells by separate Ca2+- and ATP hydrolysis-dependent mechanisms. J Biol Chem. 2005;280:30814-28 pubmed
..The novel Ca2+-dependent pathway is distinctive in its lack of ATP dependence, and is clearly different from the calmodulin kinase-dependent mechanism by which AngII modulates T-type Ca2+ channels in these cells. ..
Enyeart J, Liu H, Enyeart J. cAMP analogs and their metabolites enhance TREK-1 mRNA and K+ current expression in adrenocortical cells. Mol Pharmacol. 2010;77:469-82 pubmed publisher
..These findings raise significant questions regarding the specificity of 8-(4-chlorophenylthio)-cAMP analogs as cAMP mimetics...
Enyeart J, Liu H, Enyeart J. Calcium-dependent inhibition of adrenal TREK-1 channels by angiotensin II and ionomycin. Am J Physiol Cell Physiol. 2011;301:C619-29 pubmed publisher
..bTREK-1 is the first two-pore K(+) channel shown to be inhibited by Ca(2+) through activation of a G protein-coupled receptor...