CHARIS E ENG

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers
    Eitan Friedman
    The Suzanne Levy Gertner Oncogenetics Unit, The Chaim Sheba Medical Center, Tel Hashomer, Israel, and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Breast Cancer Res 8:R15. 2006
  2. ncbi Mutation of the RET proto-oncogene is correlated with RET immunostaining in subpopulations of cells in sporadic medullary thyroid carcinoma
    C Eng
    Cancer Research Campaign Human Cancer Genetics Research Group, University of Cambridge, United Kingdom
    J Clin Endocrinol Metab 83:4310-3. 1998
  3. ncbi Genetic testing for cancer predisposition
    C Eng
    Clinical Cancer Genetics and Human Cancer Genetics Programs, Comprehensive Cancer Center, and Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Annu Rev Med 52:371-400. 2001
  4. pmc Interpreting epidemiological research: blinded comparison of methods used to estimate the prevalence of inherited mutations in BRCA1
    C Eng
    Clinical Cancer Genetics and Human Cancer Genetics Programs, Comprehensive Cancer Center, and Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Med Genet 38:824-33. 2001
  5. ncbi A role for mitochondrial enzymes in inherited neoplasia and beyond
    Charis Eng
    Clinical Cancer Genetics Program, Comprehensive Cancer Center, and Division of Human Genetics, Department of Internal Medicine, The Ohio State University, 420 W 12th Avenue, Ste 690 TMRF, Columbus, Ohio 43210, USA
    Nat Rev Cancer 3:193-202. 2003
  6. ncbi PTEN: one gene, many syndromes
    Charis Eng
    Clinical Cancer Genetics Program and Human Cancer Genetics Program, Comprehensive Cancer Center, Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Hum Mutat 22:183-98. 2003
  7. ncbi RET proto-oncogene in the development of human cancer
    C Eng
    Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    J Clin Oncol 17:380-93. 1999
  8. ncbi Constipation, polyps, or cancer? Let PTEN predict your future
    Charis Eng
    Clinical Cancer Genetics Program and Human Cancer Genetics Program, Comprehensive Cancer Center, Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Am J Med Genet A 122:315-22. 2003
  9. ncbi Mutations of the RET proto-oncogene in the multiple endocrine neoplasia type 2 syndromes, related sporadic tumours, and hirschsprung disease
    C Eng
    Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115 6084, USA
    Hum Mutat 9:97-109. 1997
  10. ncbi The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis
    C Eng
    Division of Cancer Epidemiology and Control, Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115 6084, USA
    JAMA 276:1575-9. 1996

Collaborators

Detail Information

Publications42

  1. pmc Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers
    Eitan Friedman
    The Suzanne Levy Gertner Oncogenetics Unit, The Chaim Sheba Medical Center, Tel Hashomer, Israel, and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Breast Cancer Res 8:R15. 2006
    ....
  2. ncbi Mutation of the RET proto-oncogene is correlated with RET immunostaining in subpopulations of cells in sporadic medullary thyroid carcinoma
    C Eng
    Cancer Research Campaign Human Cancer Genetics Research Group, University of Cambridge, United Kingdom
    J Clin Endocrinol Metab 83:4310-3. 1998
    ..If these preliminary results prove true, then given our data, we can further explore the feasibility of RET immunocytochemistry as a rapid assessment for the presence of somatic codon 918 for molecular diagnostic and prognostic purposes...
  3. ncbi Genetic testing for cancer predisposition
    C Eng
    Clinical Cancer Genetics and Human Cancer Genetics Programs, Comprehensive Cancer Center, and Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Annu Rev Med 52:371-400. 2001
    ..Thorough medical care requires the identification of families likely to have a hereditary cancer susceptibility syndrome for referral to cancer genetics professionals...
  4. pmc Interpreting epidemiological research: blinded comparison of methods used to estimate the prevalence of inherited mutations in BRCA1
    C Eng
    Clinical Cancer Genetics and Human Cancer Genetics Programs, Comprehensive Cancer Center, and Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Med Genet 38:824-33. 2001
    ..The findings of this comparison provide a basis for interpreting studies of mutations in susceptibility genes across many inherited cancer syndromes...
  5. ncbi A role for mitochondrial enzymes in inherited neoplasia and beyond
    Charis Eng
    Clinical Cancer Genetics Program, Comprehensive Cancer Center, and Division of Human Genetics, Department of Internal Medicine, The Ohio State University, 420 W 12th Avenue, Ste 690 TMRF, Columbus, Ohio 43210, USA
    Nat Rev Cancer 3:193-202. 2003
    ..Understanding this link between inherited cancer syndromes and neurological disease could provide further insights into the mechanisms by which mitochondrial deficiencies lead to tumour development...
  6. ncbi PTEN: one gene, many syndromes
    Charis Eng
    Clinical Cancer Genetics Program and Human Cancer Genetics Program, Comprehensive Cancer Center, Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Hum Mutat 22:183-98. 2003
    ..Further functional work could reveal more effective means of molecular-directed therapy and prevention...
  7. ncbi RET proto-oncogene in the development of human cancer
    C Eng
    Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    J Clin Oncol 17:380-93. 1999
    ..Whether the presence of somatic RET mutation is associated with a poor prognosis is currently being investigated as another tool for molecular medicine...
  8. ncbi Constipation, polyps, or cancer? Let PTEN predict your future
    Charis Eng
    Clinical Cancer Genetics Program and Human Cancer Genetics Program, Comprehensive Cancer Center, Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Am J Med Genet A 122:315-22. 2003
    ..In contrast, JPS and PJS have increased risk of gastrointestinal cancers in particular. Thus, molecular-based diagnoses to differentiate each of these syndromes are important for medical management...
  9. ncbi Mutations of the RET proto-oncogene in the multiple endocrine neoplasia type 2 syndromes, related sporadic tumours, and hirschsprung disease
    C Eng
    Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115 6084, USA
    Hum Mutat 9:97-109. 1997
    ..In contrast to MEN 2, approximately 25% of patients with Hirschsprung disease have germline mutations scattered throughout the length of RET...
  10. ncbi The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis
    C Eng
    Division of Cancer Epidemiology and Control, Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115 6084, USA
    JAMA 276:1575-9. 1996
    ..The purpose of this study was to establish the relationship between specific mutations and the presence of certain disease features in MEN 2 which could help in clinical decision making...
  11. ncbi Over-representation of a germline variant in the gene encoding RET co-receptor GFRalpha-1 but not GFRalpha-2 or GFRalpha-3 in cases with sporadic medullary thyroid carcinoma
    O Gimm
    Clinical Cancer Genetics and Human Cancer Genetics Programs, Comprehensive Cancer Centre, and Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, OH 43210, USA
    Oncogene 20:2161-70. 2001
    ....
  12. ncbi Mutation analysis reveals novel sequence variants in NTRK1 in sporadic human medullary thyroid carcinoma
    O Gimm
    Comprehensive Cancer Center, Ohio State University, Columbus 43210, USA
    J Clin Endocrinol Metab 84:2784-7. 1999
    ....
  13. ncbi PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome
    D J Marsh
    Clinical Cancer Genetics and Human Cancer Genetics Programs, Ohio State University Comprehensive Cancer Center, 690C Medical Research Facility, 420 West 12th Avenue, Columbus, OH 43210, USA
    Hum Mol Genet 8:1461-72. 1999
    ..Thus, PTEN mutation-positive CS and BRR may be different presentations of a single syndrome and, hence, both should receive equal attention with respect to cancer surveillance...
  14. ncbi Genomic structure and chromosomal localization of the human GDNFR-alpha gene
    C Eng
    Dana Farber Cancer Institute, Richard and Sara Smith Laboratories, Boston, Massachusetts 02115, USA
    Oncogene 16:597-601. 1998
    ..The human GDNFR-alpha gene comprises 9 exons. GDNFR-alpha PAC clones were used for FISH analysis to map this gene to 10q26...
  15. pmc Demographic and phenotypic features of 70 families segregating Barrett's oesophagus and oesophageal adenocarcinoma
    C M Drovdlic
    Clinical Cancer Genetics Program, The Ohio State University, Columbus, OH 43210, USA
    J Med Genet 40:651-6. 2003
    ..oesophagus (BO) and oesophageal adenocarcinoma (OAC) likely follows an autosomal dominant model of most inherited cancer syndromes...
  16. pmc Referral for cancer genetics consultation: a review and compilation of risk assessment criteria
    H Hampel
    Clinical Cancer Genetics Program, The Ohio State University, Columbus, Ohio 43221, USA
    J Med Genet 41:81-91. 2004
    ..To assist health care professionals in deciding when a cancer genetics consultation is appropriate, available reports were critically reviewed in order to develop a single set of risk assessment criteria...
  17. ncbi Mutation analysis of NTRK2 and NTRK3, encoding 2 tyrosine kinase receptors, in sporadic human medullary thyroid carcinoma reveals novel sequence variants
    O Gimm
    Clinical Cancer Genetics Program, Division of Human Genetics, Department of Internal Medicine, Ohio State University, Columbus 43210, USA
    Int J Cancer 92:70-4. 2001
    ..17 and 1 vs. 0, p > 0.05). We conclude that sequence variants in NTRK2 and NTRK3 are not likely to be responsible for large differences in expression at the protein level, but we cannot exclude very low penetrance effects...
  18. pmc Mutation and deletion analysis of GFR alpha-1, encoding the co-receptor for the GDNF/RET complex, in human brain tumours
    O Gimm
    Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Br J Cancer 80:383-6. 1999
    ..Our data suggest that intragenic point mutations of GDNF or GFRalpha-1 are not a common aetiologic event in brain tumours. However, either deletion of GFRalpha-1 and/or nearby genes may contribute to the pathogenesis of these tumours...
  19. ncbi Germline dinucleotide mutation in codon 883 of the RET proto-oncogene in multiple endocrine neoplasia type 2B without codon 918 mutation
    O Gimm
    Translational Research Laboratory, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    J Clin Endocrinol Metab 82:3902-4. 1997
    ..Our data demonstrate a novel etiologic event which may have roles in predisposition to MEN 2B when present in the germline and in the pathogenesis of sporadic MTC when somatic...
  20. ncbi Opposite association of two PPARG variants with cancer: overrepresentation of H449H in endometrial carcinoma cases and underrepresentation of P12A in renal cell carcinoma cases
    W M Smith
    Clinical Cancer Genetics Program, Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus OH 43210, USA
    Hum Genet 109:146-51. 2001
    ....
  21. pmc Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes
    X P Zhou
    Clinical Cancer Genetics and Human Cancer Genetics Programs, Comprehensive Cancer Center, and the Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    Am J Hum Genet 69:704-11. 2001
    ..Thus, germline BMPR1A mutations cause a significant proportion of cases of JPS and might define a small subset of cases of CS/BRRS with specific colonic phenotype...
  22. ncbi Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation
    D J Marsh
    Department of Adult Oncology and Charles A Dana Human Cancer Genetics Unit, Dana Farber Cancer Institute, Boston, MA 02115 6084, USA Molecular Oncology Laboratory, Institut Bergo
    Hum Mol Genet 7:507-15. 1998
    ..However, these observations would need to be confirmed by studying a larger number of CD families...
  23. ncbi Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors
    P L Dahia
    Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115 6084, USA
    Cancer Res 57:4710-3. 1997
    ..quot; Alternatively, other tumor suppressor genes mapping to chromosome 10q22-23 could be the actual targets for such deletions and thus represent the various hits in the pathway of multistep carcinogenesis...
  24. pmc Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors
    F Weber
    Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Br J Cancer 92:1922-6. 2005
    ..Those organ-specific mutational spectra and potential targets in the cancer-associated stroma might influence the efficacy of TKI therapy...
  25. pmc Will the real Cowden syndrome please stand up (again)? Expanding mutational and clinical spectra of the PTEN hamartoma tumour syndrome
    R Pilarski
    Clinical Cancer Genetics Program, Comprehensive Cancer Center, Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Med Genet 41:323-6. 2004
  26. pmc Rapid design of denaturing gradient-based two-dimensional electrophoretic gene mutational scanning tests
    N J van Orsouw
    Molecular Genetics Section, Gerontology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard Institutes of Medicine, Suite 921, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Nucleic Acids Res 26:2398-406. 1998
    ..Designs were generated for the RB1 , TP53 , MLH1 and BRCA1 genes that can be readily implemented in research and clinical laboratories as low cost genetic screening tests...
  27. pmc Germline PTEN mutations in Cowden syndrome-like families
    D J Marsh
    Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115 6084, USA
    J Med Genet 35:881-5. 1998
    ..In addition, our data would suggest that, for the most part, the strict International Cowden Consortium operational diagnostic criteria for CS are quite robust and should remain in place...
  28. ncbi Mutational scanning of large genes by extensive PCR multiplexing and two-dimensional electrophoresis: application to the RB1 gene
    N J van Orsouw
    Department of Medicine, Beth Israel Hospital, Boston, MA 02215, USA
    Hum Mol Genet 5:755-61. 1996
    ..These results suggest that 2-D electrophoresis in this format provides a generally applicable, practical and fast way to diagnose with high accuracy large genes for a broad spectrum of possible disease-causing mutations...
  29. ncbi Genetic model of multi-step breast carcinogenesis involving the epithelium and stroma: clues to tumour-microenvironment interactions
    K Kurose
    Clinical Cancer Genetics and Human Cancer Genetics Programs, Comprehensive Cancer Centre, and Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    Hum Mol Genet 10:1907-13. 2001
    ....
  30. ncbi Somatic and occult germ-line mutations in SDHD, a mitochondrial complex II gene, in nonfamilial pheochromocytoma
    O Gimm
    Department of Internal Medicine, The Ohio State University, Columbus 43210, USA
    Cancer Res 60:6822-5. 2000
    ....
  31. ncbi Microsatellite instability and hMLH1/hMSH2 expression in Barrett esophagus-associated adenocarcinoma
    M H Kulke
    Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cancer 91:1451-7. 2001
    ..This study sought to determine the prevalence of MSI in 80 primary Barrett esophagus-associated adenocarcinomas (BEAd) and to examine the relation of MSI with the clinical and pathologic features of the tumors...
  32. ncbi Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers
    G L Mutter
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Natl Cancer Inst 92:924-30. 2000
    ..Testing the hypothesis that altered PTEN function precedes the appearance of endometrial adenocarcinoma has been difficult, however, partly because of uncertainties in precancer diagnosis...
  33. pmc Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas
    K Kurose
    Clinical Cancer Genetics and Human Cancer Genetics Programs, The Ohio State University, Columbus, Ohio 43210, USA
    Am J Pathol 158:2097-106. 2001
    ..Alternatively, these observations could also suggest that pathways involving other than Akt, p27 and cyclin D1 that lie downstream of PTEN play roles in ovarian carcinogenesis...
  34. pmc Allelic loss of 10q23, the PTEN tumour suppressor gene locus, in Barrett's oesophagus-associated adenocarcinoma
    M H Kulke
    Department of Adult Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
    Br J Cancer 84:748-53. 2001
    ..It is possible that PTEN is inactivated through other mechanisms in BOAd...
  35. ncbi PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model
    L P Weng
    Clinical Cancer Genetics Program, Comprehensive Cancer Center, Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    Hum Mol Genet 10:599-604. 2001
    ....
  36. ncbi Loss-of-function mutations in PPAR gamma associated with human colon cancer
    P Sarraf
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 3:799-804. 1999
    ..These data indicate that colon cancer in humans is associated with loss-of-function mutations in PPAR gamma...
  37. ncbi Comprehensive mutation analysis of TSC1 using two-dimensional DNA electrophoresis with DGGE
    S L Dabora
    Division of Hematology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Ann Hum Genet 62:491-504. 1998
    ..During this study, we identified 2 new mutations (exon 8 and exon 15), a new polymorphism (intron 4), and the first variant identified in a non-coding exon (exon 2)...
  38. ncbi Somatic mutation and germline variants of MINPP1, a phosphatase gene located in proximity to PTEN on 10q23.3, in follicular thyroid carcinomas
    O Gimm
    Clinical Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    J Clin Endocrinol Metab 86:1801-5. 2001
    ..These results suggest a role for MINPP1 in the pathogenesis of at least a subset of malignant follicular thyroid tumors, and MINPP1 might act as a low penetrance predisposition allele for FTC...
  39. ncbi A highly conserved processed PTEN pseudogene is located on chromosome band 9p21
    P L Dahia
    Department of Adult Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Oncogene 16:2403-6. 1998
    ..The high sequence homology of psiPTEN with the PTEN transcript may potentially lead to misinterpretation when performing mutation analyses based on cDNA templates. Caution should be exerted when using such screening approaches...
  40. pmc Gene expression in papillary thyroid carcinoma reveals highly consistent profiles
    Y Huang
    Human Cancer Genetics Program, Comprehensive Cancer Center, Department of Pathology, Divisions of Sensory Biophysics and Endocrinology and Nuclear Medicine, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 98:15044-9. 2001
    ..We conclude that, despite its clinical heterogeneity, PTC is characterized by consistent and specific molecular changes. These findings reveal clues to the molecular pathways involved in PTC and may provide biomarkers for clinical use...
  41. ncbi PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model
    L P Weng
    Clinical Cancer Genetics Program, Comprehensive Cancer Center, Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    Hum Mol Genet 10:605-16. 2001
    ....
  42. ncbi Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies
    D J Smiraglia
    Division of Human Cancer Genetics, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, 420 West 12th Avenue, Columbus, OH 43210, USA
    Hum Mol Genet 10:1413-9. 2001
    ..These data indicate that most CpG island hypermethylation observed in cancer cell lines is due to an intrinsic property of cell lines as opposed to the malignant tissue from which they originated...